CY1123161T1 - Παραγωγα δι(φαινυλοπροπανοειδους) γλυκερολης για τη θεραπεια του καρκινου - Google Patents
Παραγωγα δι(φαινυλοπροπανοειδους) γλυκερολης για τη θεραπεια του καρκινουInfo
- Publication number
- CY1123161T1 CY1123161T1 CY20201100724T CY201100724T CY1123161T1 CY 1123161 T1 CY1123161 T1 CY 1123161T1 CY 20201100724 T CY20201100724 T CY 20201100724T CY 201100724 T CY201100724 T CY 201100724T CY 1123161 T1 CY1123161 T1 CY 1123161T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cancer
- alkylcarbonyloxy
- alkoxy
- phenylpropanoid
- glycerol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει μια μέθοδο για τη θεραπεία ενός καρκίνου σε ένα άτομο, η οποία περιλαμβάνει τη χορήγηση στο άτομο μιας ένωσης του τύπου (II) ή (ΙΙ’): όπου τα R1, R2, R3, R4, R5, R6 και R7 είναι ανεξάρτητα Η, ΟΗ, αλκοξυ ή αλκυλοκαρβονυλοξυ, ή ένα φαρμακευτικώς αποδεκτό άλας αυτών. Παρέχεται επίσης μία ένωση του τύπου (II) ή (II)', όπου τα R1 και R2 είναι ανεξάρτητα ΟΗ, αλκοξυ ή αλκυλοκαρβονυλοξυ, τα R3 και R4 είναι ανεξάρτητα Η, ΟΗ, αλκοξυ ή αλκυλοκαρβονυλοξυ, το R6 είναι Η, αλκοξυ ή αλκυλοκαρβονυλοξυ, το R5 είναι Η, ΟΗ ή αλκυλοκαρβονυλοξυ, το R6 είναι Η ή αλκοξυ, και το R είναι Η, ή ένα φαρμακευτικώς αποδεκτό άλας αυτών.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25028709P | 2009-10-09 | 2009-10-09 | |
| PCT/CA2010/001613 WO2011041907A1 (en) | 2009-10-09 | 2010-10-08 | Derivatives of di(phenylpropanoid) glycerol for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123161T1 true CY1123161T1 (el) | 2021-10-29 |
Family
ID=43352967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100724T CY1123161T1 (el) | 2009-10-09 | 2020-08-05 | Παραγωγα δι(φαινυλοπροπανοειδους) γλυκερολης για τη θεραπεια του καρκινου |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9061993B2 (el) |
| EP (1) | EP2486026B1 (el) |
| JP (1) | JP5529280B2 (el) |
| CN (1) | CN102264713A (el) |
| BR (1) | BR112012008204A2 (el) |
| CA (1) | CA2715662C (el) |
| CY (1) | CY1123161T1 (el) |
| DK (1) | DK2486026T3 (el) |
| ES (1) | ES2810906T3 (el) |
| HR (1) | HRP20201217T1 (el) |
| HU (1) | HUE051549T2 (el) |
| LT (1) | LT2486026T (el) |
| MX (1) | MX360417B (el) |
| MY (2) | MY160378A (el) |
| PL (1) | PL2486026T3 (el) |
| PT (1) | PT2486026T (el) |
| RS (1) | RS60667B1 (el) |
| SI (1) | SI2486026T1 (el) |
| WO (1) | WO2011041907A1 (el) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8907117B2 (en) * | 2011-09-08 | 2014-12-09 | Henry Lowe | Anti-tumor and anti-inflammatory dicinnamoyl-glycerol esters and their analogues |
| US20160106721A1 (en) | 2014-10-21 | 2016-04-21 | Life Plus, LLC | Human therapeutic agents |
| US9907786B2 (en) | 2014-10-21 | 2018-03-06 | Ions Pharmaceutical S.À R.L. | Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof |
| US10092550B2 (en) | 2014-10-21 | 2018-10-09 | Ions Pharmaceutical S.À R.L. | Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3857873A (en) * | 1974-02-11 | 1974-12-31 | Warner Lambert Co | 3-hydroxy-5-(3-(substituted-amino)-2-hydroxypropoxy)-benzyl alcohols |
| CH648753A5 (de) * | 1981-07-22 | 1985-04-15 | Givaudan & Cie Sa | Lichtschutzmittel. |
| CN1238333C (zh) * | 2003-06-18 | 2006-01-25 | 清华大学 | 药物化合物菠萝酰酯及其制备方法和用途 |
| US7713556B2 (en) * | 2006-12-08 | 2010-05-11 | Henry Lowe | Anti-tumor and anti-inflammatory extracts of plant biomass and their uses |
| KR101563370B1 (ko) * | 2007-01-08 | 2015-10-26 | 앤드로사이언스 코포레이션 | (치환된 페닐)-프로페날 잔기를 갖는 화합물, 이의 유도체, 생물학적 활성, 및 이의 용도 |
| TWI383251B (zh) * | 2008-01-16 | 2013-01-21 | Eternal Chemical Co Ltd | 感光型聚醯亞胺 |
| KR101074149B1 (ko) * | 2009-04-15 | 2011-10-17 | 한밭대학교 산학협력단 | 신규 폴리페놀/폴리페놀 컨쥬게이트 화합물 및 그의 용도 |
| US8907117B2 (en) * | 2011-09-08 | 2014-12-09 | Henry Lowe | Anti-tumor and anti-inflammatory dicinnamoyl-glycerol esters and their analogues |
-
2010
- 2010-10-08 MX MX2012004160A patent/MX360417B/es active IP Right Grant
- 2010-10-08 MY MYPI2012001601A patent/MY160378A/en unknown
- 2010-10-08 BR BR112012008204A patent/BR112012008204A2/pt not_active Application Discontinuation
- 2010-10-08 DK DK10821532.8T patent/DK2486026T3/da active
- 2010-10-08 PT PT108215328T patent/PT2486026T/pt unknown
- 2010-10-08 EP EP10821532.8A patent/EP2486026B1/en active Active
- 2010-10-08 MY MYPI2016000361A patent/MY187188A/en unknown
- 2010-10-08 CA CA2715662A patent/CA2715662C/en active Active
- 2010-10-08 RS RS20200931A patent/RS60667B1/sr unknown
- 2010-10-08 ES ES10821532T patent/ES2810906T3/es active Active
- 2010-10-08 JP JP2012532432A patent/JP5529280B2/ja active Active
- 2010-10-08 SI SI201032026T patent/SI2486026T1/sl unknown
- 2010-10-08 WO PCT/CA2010/001613 patent/WO2011041907A1/en active Application Filing
- 2010-10-08 LT LTEP10821532.8T patent/LT2486026T/lt unknown
- 2010-10-08 PL PL10821532T patent/PL2486026T3/pl unknown
- 2010-10-08 CN CN201080003781XA patent/CN102264713A/zh active Pending
- 2010-10-08 HU HUE10821532A patent/HUE051549T2/hu unknown
- 2010-10-08 US US12/901,113 patent/US9061993B2/en active Active
-
2015
- 2015-05-17 US US14/714,318 patent/US10052301B2/en active Active
-
2020
- 2020-08-03 HR HRP20201217TT patent/HRP20201217T1/hr unknown
- 2020-08-05 CY CY20201100724T patent/CY1123161T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20201217T1 (hr) | 2020-12-11 |
| MY187188A (en) | 2021-09-09 |
| CA2715662C (en) | 2013-05-07 |
| EP2486026A4 (en) | 2015-07-01 |
| US20150246014A1 (en) | 2015-09-03 |
| US10052301B2 (en) | 2018-08-21 |
| WO2011041907A1 (en) | 2011-04-14 |
| DK2486026T3 (da) | 2020-08-17 |
| EP2486026A1 (en) | 2012-08-15 |
| EP2486026B1 (en) | 2020-06-24 |
| MX360417B (es) | 2018-10-25 |
| JP5529280B2 (ja) | 2014-06-25 |
| PT2486026T (pt) | 2020-08-21 |
| CN102264713A (zh) | 2011-11-30 |
| CA2715662A1 (en) | 2010-12-14 |
| BR112012008204A2 (pt) | 2017-07-18 |
| MX2012004160A (es) | 2012-09-07 |
| US9061993B2 (en) | 2015-06-23 |
| LT2486026T (lt) | 2020-09-10 |
| ES2810906T3 (es) | 2021-03-09 |
| JP2013507327A (ja) | 2013-03-04 |
| US20110086912A1 (en) | 2011-04-14 |
| MY160378A (en) | 2017-03-15 |
| SI2486026T1 (sl) | 2020-10-30 |
| HUE051549T2 (hu) | 2021-10-28 |
| PL2486026T3 (pl) | 2020-11-02 |
| RS60667B1 (sr) | 2020-09-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1123161T1 (el) | Παραγωγα δι(φαινυλοπροπανοειδους) γλυκερολης για τη θεραπεια του καρκινου | |
| CY1118572T1 (el) | Παραγωγο κυκλοαλκανιου | |
| CY1111721T1 (el) | Ακυλαμινοπυραζολια ως αναστολεις fgfr | |
| CY1119939T1 (el) | Παραγωγα 2,3-διϋδρο-βενζο[1,4]οξαζιν και σχετικες ενωσεις οπως αναστολεις φωσφοϊνοσιτινης-3 κινασης (ρι3κ) για τη θεραπεια παραδειγματος χαρην της ρευματοειδους αρθριτιδας | |
| CY1115902T1 (el) | Συνδυαστικη θεραπεια καρκινου με ανασταλτικες ενωσεις hps90 | |
| EA201100971A1 (ru) | Производные пиримидининдола для лечения злокачественного новообразования | |
| EA200970935A1 (ru) | Способы лечения с применением хинаксолиновых ингибиторов pi3k-альфа | |
| CY1118739T1 (el) | Ενωσεις αμφι(φθoρoαλκυλ)-1,4-βενζoδιαζεπινoνης ως αναστολεις toy notch | |
| CY1117719T1 (el) | Παραγωγα αμινοπυριμιδινης ως διαμορφωτες της lrrk2 | |
| CY1116628T1 (el) | Ενωσεις σπειρο-οξινδολιου και χρηση αυτων ως θεραπευτικοι παραγοντες | |
| CY1123627T1 (el) | Παραγωγα διυδροϊμιδαζοπυραζινονης χρησιμα στη θεραπευτικη αντιμετωπιση του καρκινου | |
| EA200970932A1 (ru) | Способы лечения с применением пиридопиримидиноновых ингибиторов pi3k альфа | |
| EA201400111A1 (ru) | Ингибиторы mek и способы их применения | |
| CY1117776T1 (el) | Εναντιομερη ενωσεων σπειρο-οξινδολιου και οι χρησεις τους ως θεραπευτικοι παραγοντες | |
| EA201390085A1 (ru) | Композиции ингибиторов киназ для лечения рака | |
| CY1114140T1 (el) | Ενωσεις 4-πυριδινονης και η χρηση αυτων για τον καρκινο | |
| CY1120619T1 (el) | Χημικες οντοτητες | |
| EA201500300A1 (ru) | Способы применения с-мет-модуляторов | |
| CY1119642T1 (el) | Csf-1r αναστολεις για την θεραπεια ογκων του εγκεφαλου | |
| TR201900306T4 (tr) | Mek inhibitörlerini kullanma yöntemleri. | |
| EA201270752A1 (ru) | Ингибиторы киназы и способ лечения злокачественной опухоли с их помощью | |
| RU2016122731A (ru) | Функционализированные и замещенные индолы в качестве противораковых агентов | |
| AR072442A1 (es) | Metodo para la terapia del cancer, uso, kit | |
| CY1109734T1 (el) | Ενωσεις για τη θεραπευτικη αντιμετωπιση της σχιζοφρενειας και/ή διαταραχων της ρυθμισης της γλυκοζης | |
| EA201991894A1 (ru) | ПИПЕРИДИН-ЗАМЕЩЕННЫЕ ИНГИБИТОРЫ Mnk И СВЯЗАННЫЕ С НИМИ СПОСОБЫ |