ATE395088T1 - Kontrastmittel zur nahes-infrarot-fluoreszenz und methode zur fluoreszenzabbildung - Google Patents

Kontrastmittel zur nahes-infrarot-fluoreszenz und methode zur fluoreszenzabbildung

Info

Publication number
ATE395088T1
ATE395088T1 AT03706606T AT03706606T ATE395088T1 AT E395088 T1 ATE395088 T1 AT E395088T1 AT 03706606 T AT03706606 T AT 03706606T AT 03706606 T AT03706606 T AT 03706606T AT E395088 T1 ATE395088 T1 AT E395088T1
Authority
AT
Austria
Prior art keywords
represent
near infrared
contrast agent
fluorescence
alkyl group
Prior art date
Application number
AT03706606T
Other languages
English (en)
Inventor
Masayuki Kawakami
Hiroshi Kitaguchi
Kai Licha
Christin Perlitz
Hiroaki Eguchi
Natsuko Tsuda
Kazuhiro Aikawa
Original Assignee
Fujifilm Corp
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp, Bayer Schering Pharma Ag filed Critical Fujifilm Corp
Application granted granted Critical
Publication of ATE395088T1 publication Critical patent/ATE395088T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Endoscopes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT03706606T 2002-03-07 2003-03-07 Kontrastmittel zur nahes-infrarot-fluoreszenz und methode zur fluoreszenzabbildung ATE395088T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2002109794A JP2003261464A (ja) 2002-03-07 2002-03-07 近赤外蛍光造影剤および蛍光造影法

Publications (1)

Publication Number Publication Date
ATE395088T1 true ATE395088T1 (de) 2008-05-15

Family

ID=27785574

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03706606T ATE395088T1 (de) 2002-03-07 2003-03-07 Kontrastmittel zur nahes-infrarot-fluoreszenz und methode zur fluoreszenzabbildung

Country Status (20)

Country Link
US (2) US7473415B2 (de)
EP (1) EP1480683B1 (de)
JP (2) JP2003261464A (de)
KR (1) KR20040099301A (de)
CN (1) CN100340298C (de)
AT (1) ATE395088T1 (de)
AU (1) AU2003208700B2 (de)
BR (1) BR0308217A (de)
CA (1) CA2478272A1 (de)
DE (1) DE60320952D1 (de)
DK (1) DK1480683T3 (de)
ES (1) ES2305444T3 (de)
HK (1) HK1079110A1 (de)
MX (1) MXPA04008664A (de)
NO (1) NO20044244L (de)
PL (1) PL370918A1 (de)
PT (1) PT1480683E (de)
RU (1) RU2350355C9 (de)
WO (1) WO2003074091A2 (de)
ZA (1) ZA200408072B (de)

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US7682602B2 (en) * 2003-12-19 2010-03-23 Konica Minolta Medical & Graphic, Inc. Near-infrared fluorescent contrast medium
US7233392B2 (en) * 2004-03-25 2007-06-19 Opotek, Inc. Spectral imaging device with tunable light source
US7910753B2 (en) * 2004-09-10 2011-03-22 Anaspec Incorporated Cyanine dyes and their applications as luminescence quenching compounds
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
US20110262354A1 (en) * 2007-07-13 2011-10-27 Emory University Cyanine-containing compounds for cancer imaging and treatment
GB0718957D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Optical imaging agents
US20090214436A1 (en) * 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
US20090240143A1 (en) * 2008-03-12 2009-09-24 Mauna Kea Technologies Method and an optical probe for in vivo imaging of a mucosa in a biliary or pancreatic system and a method for selectively operating a tissue sampling of a mucosa in a biliary or pancreatic system
CN102099059B (zh) * 2008-06-13 2015-09-23 西塞医疗中心 用于癌症靶向治疗的小分子配体-药物轭合物
EP2419478B1 (de) * 2009-04-17 2018-02-28 Li-Cor, Inc. Fluoreszenzbasierte bildgebung mit substituierten cyaninfarbstoffen
CN101574529B (zh) * 2009-06-04 2011-04-20 中国人民解放军第三军医大学 近红外荧光化合物在制备用于淋巴结成像和血管造影的药物中的用途
US8401618B2 (en) 2009-08-28 2013-03-19 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
JP2011046663A (ja) 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
JP2011046662A (ja) * 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
US8401619B2 (en) * 2009-09-22 2013-03-19 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
JP5462596B2 (ja) * 2009-11-12 2014-04-02 富士フイルム株式会社 蛍光画像撮像装置
US8273875B2 (en) 2009-11-16 2012-09-25 University Of Notre Dame Du Lac High performance luminescent compounds
WO2012054784A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Fluorescent imaging with substituted cyanine dyes
EP2599428B1 (de) 2011-03-15 2017-09-06 Olympus Corporation Medizinische vorrichtung
CN103153155B (zh) 2011-03-15 2014-09-10 奥林巴斯医疗株式会社 医疗装置
WO2013112554A1 (en) 2012-01-23 2013-08-01 Washington University Goggle imaging systems and methods
US10743768B2 (en) 2012-10-15 2020-08-18 Visen Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
BR112016015198A2 (pt) 2013-12-31 2017-08-08 Memorial Sloan Kettering Cancer Center Sistemas, métodos e aparelho para a produção de imagens multicanal de fontes fluorescentes em tempo real
ES2794778T3 (es) 2014-12-15 2020-11-19 Memorial Sloan Kettering Cancer Center Péptidos cíclicos con selectividad mejorada de unión a los nervios, nanoparticulos unidas con dichos péptidos cíclicos y uso de los mismos para imágenes en vivo de tejidos nerviosos en tiempo real
KR20160086481A (ko) * 2015-01-09 2016-07-20 차의과학대학교 산학협력단 신규 유기 화합물 및 이를 포함하는 근적외선 형광 조영제, 그리고 조영제의 나노입자화 방법
US10806804B2 (en) 2015-05-06 2020-10-20 Washington University Compounds having RD targeting motifs and methods of use thereof
CN108495655A (zh) 2015-12-15 2018-09-04 纪念斯隆凯特琳癌症中心 用于组织区分例如用于术中可视化的成像系统和方法
JP6752582B2 (ja) * 2016-02-08 2020-09-09 キヤノン株式会社 光音響イメージング用造影剤
US11660354B2 (en) 2016-11-30 2023-05-30 Memorial Sloan Kettering Cancer Center Inhibitor-functionalized ultrasmall nanoparticles and methods thereof
WO2018119204A1 (en) * 2016-12-21 2018-06-28 Profusa, Inc. Polymerizable near-ir dyes
EP3773153A4 (de) 2018-03-30 2021-11-17 Perkinelmer Health Sciences Inc. Systeme und verfahren zur 3d-rekonstruktion anatomischer organe und einschlüsse mittels kurzwelliger infrarot (swir)-projektionstomografie
CN109824871B (zh) * 2019-01-08 2021-04-16 南京邮电大学 一种近红外二区荧光醌式聚合物、制备方法及其应用
WO2021119423A1 (en) 2019-12-13 2021-06-17 Washington University Near infrared fluorescent dyes, formulations and related methods
EP4015004A1 (de) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglykanspezifische verzweigte peptide
WO2023210645A1 (ja) * 2022-04-27 2023-11-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｉｃｇ脂質誘導体及びこれを含む脂質微粒子

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DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
DE19957007A1 (de) 1999-11-26 2001-05-31 Few Chemicals Gmbh Wolfen Cyaninfarbstoffe
US6395257B1 (en) 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
JP2001288197A (ja) * 2000-04-10 2001-10-16 Fuji Photo Film Co Ltd 蛍光ヌクレオチド
US6939975B2 (en) * 2000-08-08 2005-09-06 Fuji Photo Film Co., Ltd. Cyanine dyes
US6663847B1 (en) 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
JP2003261464A (ja) * 2002-03-07 2003-09-16 Fuji Photo Film Co Ltd 近赤外蛍光造影剤および蛍光造影法

Also Published As

Publication number Publication date
DK1480683T3 (da) 2008-08-18
US7473415B2 (en) 2009-01-06
CA2478272A1 (en) 2003-09-12
HK1079110A1 (en) 2006-03-31
US20050226815A1 (en) 2005-10-13
RU2004129766A (ru) 2005-08-10
WO2003074091A2 (en) 2003-09-12
AU2003208700A1 (en) 2003-09-16
CN100340298C (zh) 2007-10-03
US20090041670A1 (en) 2009-02-12
JP2005519977A (ja) 2005-07-07
BR0308217A (pt) 2004-12-21
PL370918A1 (en) 2005-06-13
WO2003074091A3 (en) 2004-03-11
RU2350355C9 (ru) 2009-05-27
RU2350355C2 (ru) 2009-03-27
CN1638810A (zh) 2005-07-13
DE60320952D1 (de) 2008-06-26
ZA200408072B (en) 2006-06-28
ES2305444T3 (es) 2008-11-01
EP1480683A2 (de) 2004-12-01
AU2003208700B2 (en) 2007-12-20
EP1480683B1 (de) 2008-05-14
MXPA04008664A (es) 2004-12-06
KR20040099301A (ko) 2004-11-26
PT1480683E (pt) 2008-07-24
JP2003261464A (ja) 2003-09-16
NO20044244L (no) 2004-12-06

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