DE60319568T2 - Polyalkylenglykolderivat - Google Patents

Polyalkylenglykolderivat Download PDF

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Publication number
DE60319568T2
DE60319568T2 DE60319568T DE60319568T DE60319568T2 DE 60319568 T2 DE60319568 T2 DE 60319568T2 DE 60319568 T DE60319568 T DE 60319568T DE 60319568 T DE60319568 T DE 60319568T DE 60319568 T2 DE60319568 T2 DE 60319568T2
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DE
Germany
Prior art keywords
compound
group
reaction
formula
molecular weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60319568T
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German (de)
English (en)
Other versions
DE60319568D1 (de
Inventor
Ken-ichiro Kawasaki-shi NAKAMOTO
Shunsuke Kawasaki-shi OHHASHI
Yuji Kawasaki-shi YAMAMOTO
Kenji Kawasaki-shi Sakanoue
Chika Kawasaki-shi ITOH
Tohru Kawasaki-shi Yasukohchi
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NOF Corp
Original Assignee
NOF Corp
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Filing date
Publication date
Application filed by NOF Corp filed Critical NOF Corp
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Publication of DE60319568D1 publication Critical patent/DE60319568D1/de
Publication of DE60319568T2 publication Critical patent/DE60319568T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
    • C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
    • C08G65/2609—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups containing aliphatic hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DE60319568T 2002-11-20 2003-11-20 Polyalkylenglykolderivat Expired - Lifetime DE60319568T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002337113 2002-11-20
JP2002337113 2002-11-20
PCT/JP2003/014844 WO2004046222A1 (ja) 2002-11-20 2003-11-20 修飾された生体関連物質、その製造方法および中間体

Publications (2)

Publication Number Publication Date
DE60319568D1 DE60319568D1 (de) 2008-04-17
DE60319568T2 true DE60319568T2 (de) 2009-04-02

Family

ID=32321831

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60319568T Expired - Lifetime DE60319568T2 (de) 2002-11-20 2003-11-20 Polyalkylenglykolderivat

Country Status (11)

Country Link
US (4) US20050058620A1 (enExample)
EP (3) EP1911788B1 (enExample)
JP (2) JP4412461B2 (enExample)
KR (1) KR100988733B1 (enExample)
CN (1) CN100402580C (enExample)
AT (1) ATE388186T1 (enExample)
AU (1) AU2003302031A1 (enExample)
CA (1) CA2502948C (enExample)
DE (1) DE60319568T2 (enExample)
IL (2) IL168238A (enExample)
WO (1) WO2004046222A1 (enExample)

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US8268967B2 (en) 2004-09-10 2012-09-18 Novo Nordisk A/S Glycopegylated interferon α
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Also Published As

Publication number Publication date
US8034981B2 (en) 2011-10-11
EP1564236A4 (en) 2006-01-25
WO2004046222A1 (ja) 2004-06-03
EP1911789B1 (en) 2016-04-27
US7851491B2 (en) 2010-12-14
JP5273589B2 (ja) 2013-08-28
JP2009102649A (ja) 2009-05-14
US20110082277A1 (en) 2011-04-07
CN100402580C (zh) 2008-07-16
CA2502948C (en) 2013-04-02
EP1911788B1 (en) 2019-03-27
IL168238A (en) 2009-09-22
AU2003302031A1 (en) 2004-06-15
ATE388186T1 (de) 2008-03-15
US20050058620A1 (en) 2005-03-17
EP1911789A1 (en) 2008-04-16
JP2004197077A (ja) 2004-07-15
EP1564236B1 (en) 2008-03-05
EP1564236A1 (en) 2005-08-17
US20050288490A1 (en) 2005-12-29
IL194501A (en) 2011-11-30
EP1911788A1 (en) 2008-04-16
US7524875B2 (en) 2009-04-28
CN1714116A (zh) 2005-12-28
CA2502948A1 (en) 2004-06-03
DE60319568D1 (de) 2008-04-17
KR100988733B1 (ko) 2010-10-20
JP4412461B2 (ja) 2010-02-10
US20090192320A1 (en) 2009-07-30
KR20050083923A (ko) 2005-08-26

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