DE60318159D1 - Pharmazeutische Salze von Lokalanästhetischen zusammen mit antiinflammatorischen Verbindungen und Verfahren zur Herstellung der Salze - Google Patents

Pharmazeutische Salze von Lokalanästhetischen zusammen mit antiinflammatorischen Verbindungen und Verfahren zur Herstellung der Salze

Info

Publication number
DE60318159D1
DE60318159D1 DE60318159T DE60318159T DE60318159D1 DE 60318159 D1 DE60318159 D1 DE 60318159D1 DE 60318159 T DE60318159 T DE 60318159T DE 60318159 T DE60318159 T DE 60318159T DE 60318159 D1 DE60318159 D1 DE 60318159D1
Authority
DE
Germany
Prior art keywords
salts
preparation
local anesthetic
inflammatory compounds
pharmaceutical salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60318159T
Other languages
English (en)
Other versions
DE60318159T2 (de
Inventor
Fang-Yu Lee
Shan-Chiung Chen
Bin-Ken Chen
Chiung-Ju Tsai
Yen-Ling Yi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yung Shin Pharm Industries Co Ltd
Original Assignee
Yung Shin Pharm Industries Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yung Shin Pharm Industries Co Ltd filed Critical Yung Shin Pharm Industries Co Ltd
Application granted granted Critical
Publication of DE60318159D1 publication Critical patent/DE60318159D1/de
Publication of DE60318159T2 publication Critical patent/DE60318159T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60318159T 2002-10-02 2003-10-02 Pharmazeutische Salze von Lokalanästhetischen zusammen mit antiinflammatorischen Verbindungen und Verfahren zur Herstellung der Salze Expired - Lifetime DE60318159T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US262098 2002-10-02
US10/262,098 US7166641B2 (en) 2002-10-02 2002-10-02 Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same

Publications (2)

Publication Number Publication Date
DE60318159D1 true DE60318159D1 (de) 2008-01-31
DE60318159T2 DE60318159T2 (de) 2008-04-10

Family

ID=31993546

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60318159T Expired - Lifetime DE60318159T2 (de) 2002-10-02 2003-10-02 Pharmazeutische Salze von Lokalanästhetischen zusammen mit antiinflammatorischen Verbindungen und Verfahren zur Herstellung der Salze

Country Status (10)

Country Link
US (1) US7166641B2 (de)
EP (1) EP1405646B1 (de)
JP (1) JP4819309B2 (de)
CN (1) CN100574753C (de)
AT (1) ATE381348T1 (de)
CA (1) CA2444208C (de)
DE (1) DE60318159T2 (de)
HK (1) HK1064937A1 (de)
SG (2) SG138443A1 (de)
TW (1) TWI254636B (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7132452B2 (en) * 2003-03-10 2006-11-07 Fang-Yu Lee Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection
US20050137262A1 (en) * 2003-12-22 2005-06-23 Hu Patrick C. Highly concentrated pourable aqueous solutions of potassium ibuprofen, their preparation and their uses
CN1909929B (zh) * 2004-01-29 2011-04-20 美德阿利克斯株式会社 消炎镇痛外用药
US8377906B2 (en) 2004-06-04 2013-02-19 Ethicon, Inc. Compositions and methods for preventing or reducing postoperative ileus and gastric stasis
US8129359B2 (en) * 2004-06-04 2012-03-06 Ethicon, Inc. Composition and method for treating post-surgical pain
EP1782831B1 (de) 2004-08-18 2011-10-19 Medrx Co., Ltd. Topisches präparat
US20060253100A1 (en) * 2004-10-22 2006-11-09 Medtronic, Inc. Systems and Methods to Treat Pain Locally
CA2587792C (en) * 2004-12-23 2010-07-06 Roxro Pharma, Inc. Therapeutic compositions for intranasal administration of ketorolac
CN103271083B (zh) * 2005-10-07 2017-08-11 阿拉巴马大学 多功能离子液体组合物
US20070190190A1 (en) * 2006-02-14 2007-08-16 Ramirez Jose E Conditioning compositions and methods of use thereof
WO2007103555A2 (en) * 2006-03-08 2007-09-13 Nuviance, Inc. Transdermal drug delivery compositions and topical compositions for application on the skin
US8337883B2 (en) 2006-11-03 2012-12-25 Durect Corporation Transdermal delivery systems
JP5360751B2 (ja) * 2007-01-29 2013-12-04 株式会社 メドレックス 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途
TW200918094A (en) * 2007-08-29 2009-05-01 Yung Shin Pharmaceutical Ind Co Ltd Pharmaceutical acceptable composition containing non-steroidal anti-inflammatory drug and local anesthetics
US8920843B2 (en) * 2007-11-07 2014-12-30 Svip5 Llc Slow release of organic salts of local anesthetics for pain relief
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
WO2010078258A1 (en) * 2008-12-29 2010-07-08 The Board Of Trustees Of The University Of Alabama Compounds comprising two or more biologically functional ions and method of treating parkinson's disease
WO2010078300A1 (en) 2008-12-29 2010-07-08 The Board Of Trustees Of The University Of Alabama Dual functioning ionic liquids and salts thereof
WO2010087947A2 (en) * 2009-01-30 2010-08-05 Kydes Pharmaceuticals, Llc Transdermal delivery of diclofenac, carbamazepine and benzydamine
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
TWI418347B (zh) * 2009-10-21 2013-12-11 Yung Shin Pharm Ind Co Ltd 治療疱疹病毒感染的方法
JP5748346B2 (ja) 2009-12-15 2015-07-15 帝國製薬株式会社 ピロキシカム含有経皮吸収製剤
JP2011006465A (ja) * 2010-09-01 2011-01-13 Medorekkusu:Kk イオン性の薬物の経皮吸収性を高めた外用剤
US11786455B2 (en) 2011-05-10 2023-10-17 Itochu Chemical Frontier Corporation Non-aqueous patch
MX368747B (es) 2011-05-10 2019-10-14 Itochu Chemical Frontier Corp Parche no acuoso de lidocaína y un agente de disolución que comprende un ácido orgánico y un polialcohol que están contenidos en un emplaste para usarse en el tratamiento de dolor muscular a través de la piel.
US9925264B2 (en) 2011-05-10 2018-03-27 Itochu Chemical Frontier Corporation Non-aqueous patch
JP6021269B2 (ja) 2011-09-27 2016-11-09 伊藤忠ケミカルフロンティア株式会社 非水性貼付剤
US10813897B2 (en) * 2011-12-27 2020-10-27 Cmpd Licensing, Llc Composition and method for compounded therapy
US9962391B2 (en) 2011-12-27 2018-05-08 Cmpd Licensing, Llc Composition and method for compounded therapy
US9468599B2 (en) * 2011-12-27 2016-10-18 Cmpd Licensing, Llc Composition and method for compounded therapy
US11213500B2 (en) 2011-12-27 2022-01-04 Cmpd Licensing, Llc Composition and method for compounded therapy
US11213501B2 (en) 2011-12-27 2022-01-04 Cmpd Licensing, Llc Composition and method for compounded therapy
US20140161972A1 (en) * 2012-12-09 2014-06-12 National Sun Yat-Sen University Method for forming conductive film at room temperature
PL3097907T3 (pl) * 2015-05-28 2019-03-29 Abdi Ibrahim Ilac Sanayi Ve Ticaret A.S. Preparat żelowy zawierający środki przeciwbólowe i znieczulające
AU2017267590A1 (en) * 2016-05-17 2019-01-17 Alberta Veterinary Laboratories Ltd Topical composition for the control of pain in animals
CN106680391B (zh) * 2016-12-23 2019-11-19 中国农业科学院兰州畜牧与兽药研究所 一种牛奶中双氯芬酸钠残留量的检测方法
WO2018141661A1 (en) 2017-01-31 2018-08-09 Grünenthal GmbH Pharmaceutical patch comprising lidocaine and diclofenac for treating neuropathic pain
WO2018141662A1 (en) 2017-01-31 2018-08-09 Grünenthal GmbH Administration regimen for a pharmaceutical patch comprising lidocaine and diclofenac
WO2018230687A1 (ja) * 2017-06-16 2018-12-20 株式会社 メドレックス 消炎鎮痛外用剤
EP3900713A4 (de) * 2018-12-19 2022-08-10 MEDRx Co., Ltd. Antiinflammatorische analgetische äusserliche zubereitung
CN111807985A (zh) * 2020-06-17 2020-10-23 西安医学院 一种利多卡因非甾体抗炎药离子液体及其制备方法
RU2749264C1 (ru) * 2020-07-10 2021-06-07 Андрей Александрович Чубаев Фармацевтическая композиция, обладающая противовоспалительным и местноанестезирующим действием
CN112198262B (zh) * 2020-11-04 2022-10-04 宁夏医科大学 水样中非甾体类抗炎药物的检测方法
CN116840378B (zh) * 2023-07-11 2024-03-22 加立(深圳)生物科技有限公司 一种检测罗哌卡因/美洛昔康盐的一水合物含量的方法
CN117420095B (zh) * 2023-12-15 2024-03-01 乐比(广州)健康产业有限公司 一种鼻腔喷雾剂成分检测方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR6915470D0 (pt) * 1969-03-24 1973-03-13 Syntex Corp Processo para preparar derivados de acido 2-(6'substituido 2'naftil)propionico e de seus sais
DE2055853C3 (de) * 1970-11-13 1979-10-04 Dr.Med. Hans Voigt, Pharmazeutische Fabrik Gmbh, 6250 Limburg Procain-Phenylbutazon, Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen
CA1029305A (en) * 1974-01-31 1978-04-11 Johanna Bickel Infusion solution for the treatment of tachycardiac disturbances of heart rhythm and use thereof
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
DE3328401A1 (de) * 1983-08-05 1985-02-21 Merckle GmbH, 7902 Blaubeuren Injizierbare loesung zur behandlung von entzuendungen
DE3446873A1 (de) * 1984-12-21 1986-07-10 Merckle Gmbh Fluessige diclofenac-zubereitungen
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
US5414011A (en) * 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations
US5411738A (en) * 1989-03-17 1995-05-02 Hind Health Care, Inc. Method for treating nerve injury pain associated with shingles (herpes-zoster and post-herpetic neuralgia) by topical application of lidocaine
IT1242642B (it) * 1990-04-17 1994-05-16 Alfa Wassermann Spa Formulazioni iniettabili contenenti naproxen sale sodico.
IT1250691B (it) * 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
US5883115A (en) * 1992-11-09 1999-03-16 Pharmetrix Division Technical Chemicals & Products, Inc. Transdermal delivery of the eutomer of a chiral drug
AU7604194A (en) * 1993-09-07 1995-03-27 Procter & Gamble Company, The Compositions containing an amino acid salt of propionic acid non-steroidal anti-inflammatory agents and caffeine
EP0719156A1 (de) * 1993-09-07 1996-07-03 The Procter & Gamble Company Zusammensetzungen, welche aminosäure salzen von propionsäure nichtsteroiden antiinflammatorischen arzneimitteln mit wenigstens einer von decongestiva, expectantien, antihistaminika und antitussiva enthalten
US5534242A (en) * 1994-05-02 1996-07-09 Henry; Richard A. Lidocaine-vasoconstrictor aerosol preparation
US5955504A (en) * 1995-03-13 1999-09-21 Loma Linda University Medical Center Colorectal chemoprotective composition and method of preventing colorectal cancer
CA2232855C (en) * 1997-04-10 2007-10-09 Roche Consumer Health (Worldwide) Sa Pharmaceutical formulation
WO1998052540A1 (en) * 1997-05-22 1998-11-26 The Boots Company Plc Pharmaceutical compositions
BR9812660A (pt) * 1997-09-19 2000-08-22 Procter & Gamble Composições e métodos para tratar distúrbios respiratórios
EP1021204B1 (de) * 1997-09-26 2005-12-28 Noven Pharmaceuticals, Inc. Biologische kleber und verfahren zur topischen verabreichung von wirkstoffen
US5900249A (en) * 1998-02-09 1999-05-04 Smith; David J. Multicomponent pain relief topical medication
US6090368A (en) * 1998-03-03 2000-07-18 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Pharmaceutical compositions for intranasal spray administration of ketorolac tromethamine
US6368618B1 (en) * 1999-07-01 2002-04-09 The University Of Georgia Research Foundation, Inc. Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs
US20030181426A1 (en) * 2002-02-11 2003-09-25 Eisenach James C. Compositions and methods for treating pain using cyclooxygenase-1 inhibitors

Also Published As

Publication number Publication date
SG155042A1 (en) 2009-09-30
SG138443A1 (en) 2008-01-28
HK1064937A1 (en) 2005-02-08
ATE381348T1 (de) 2008-01-15
CA2444208A1 (en) 2004-04-02
EP1405646A3 (de) 2004-04-21
TW200410676A (en) 2004-07-01
EP1405646B1 (de) 2007-12-19
JP2004285044A (ja) 2004-10-14
US7166641B2 (en) 2007-01-23
DE60318159T2 (de) 2008-04-10
CN1486690A (zh) 2004-04-07
CN100574753C (zh) 2009-12-30
US20040068007A1 (en) 2004-04-08
CA2444208C (en) 2009-02-24
JP4819309B2 (ja) 2011-11-24
EP1405646A2 (de) 2004-04-07
TWI254636B (en) 2006-05-11

Similar Documents

Publication Publication Date Title
DE60318159D1 (de) Pharmazeutische Salze von Lokalanästhetischen zusammen mit antiinflammatorischen Verbindungen und Verfahren zur Herstellung der Salze
MA23170A1 (fr) Procede de preparation d'un nouveau compose .
RU95112575A (ru) Соль арилпропионовой кислоты, способ ее получения и фармацевтическая композиция
ES2102132T3 (es) Amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos.
JPS56100714A (en) Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane
DE69231359T2 (de) Ibuprofen-salz enthaltende pharmazeutische zusammensetzung
FI873225A0 (fi) Menetelmä suun kautta annettavan galeenisen naprokseenikoostumuksen valmistamiseksi, josta aktiiviyhdiste vapautuu ohjelmoidusti
BR9510168A (pt) Composto poliaminoácido composição forma unitária de dosagem e método par epreparar uma composição
DE69822327D1 (de) Transdermales arzneistoff-abgabesystem für ein entzündungshemmendes analgetisches mittel enthaltend diclofenac diethylammonium salz, und verfahren zu dessen herstellung
ES2152485T3 (es) Procedimiento para preparar comprimidos que contienen amoxicilina y clavulanato recubiertos de una pelicula polimerica acuosa.
UY25148A1 (es) Método para producir una composición farmacéutica que comprende un análogo de ácido gama aminobutírico (gaba) y una droga antiinflamatoria no esteroide (nsaid)
NZ275673A (en) Use of phenylacetic acid derivatives optionally in combination with other therapeutic agents for treating neoplastic conditions
JP2019142964A5 (de)
SE9201299L (sv) Farmaceutiskt preparat och förfarande för dess framställning
ATE376551T1 (de) Peptidborsäuren und deren verwendung in der herstellung von salzen derselben
DE602007008385D1 (de) Verwendung von valproinsäure zur topischen behandlung von leichter bis mittelschwerer akne vulgaris
DE69615984T2 (de) Verwendung von Ursolsäure zur Herstellung eines Arzneimittels zur Unterdrückung von Metastasen
DE59905075D1 (de) S-substituierte 11beta-benzaldoxim-estra-4,9-dien-kohlensäurethiolester, verfahren zu deren herstellung und diese verbindungen enthaltene pharmazeutische zubereitungen
BR0318201A (pt) regime de dosagem de fármaco antiinflamatório não-esteroidal
TW200724138A (en) Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use
ATE538782T1 (de) Modifizierte aminosaeure 5-cnac zur hemmung der thrombozytenaggregation
AR034398A1 (es) Homologos de 15-hete con 3-heteroatomos sustituidos y dos atomos de carbono del acido hidroxieicosatetraenoico, composicion que los contiene y el uso de la misma para la manufactura de un medicamento
IT1229489B (it) Composizioni farmaceutiche lipidiche per uso topico atte a veicolare un principio attivo antiinfiammatorio idrosolubile
WO2005079747A8 (en) Pharmaceutical preparation for the oral cavity
BR0305070A (pt) Uso de derivado amida de ge 2270 fator a3 para tratamento da acne

Legal Events

Date Code Title Description
8364 No opposition during term of opposition