DE60303370T2 - Bifunktionelle metallocene, verwendung zur markierung von biomolekülen - Google Patents

Bifunktionelle metallocene, verwendung zur markierung von biomolekülen Download PDF

Info

Publication number
DE60303370T2
DE60303370T2 DE60303370T DE60303370T DE60303370T2 DE 60303370 T2 DE60303370 T2 DE 60303370T2 DE 60303370 T DE60303370 T DE 60303370T DE 60303370 T DE60303370 T DE 60303370T DE 60303370 T2 DE60303370 T2 DE 60303370T2
Authority
DE
Germany
Prior art keywords
sub
metallocene
group
synthesis
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60303370T
Other languages
German (de)
English (en)
Other versions
DE60303370D1 (de
Inventor
Carole Chaix-Bauvais
Corinne Moustrou
Aude-Emmanuelle Navarro
Hugues Brisset
Francis Garnier
Bernard Mandrand
Nicolas Spinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomerieux SA
Original Assignee
Biomerieux SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomerieux SA filed Critical Biomerieux SA
Application granted granted Critical
Publication of DE60303370D1 publication Critical patent/DE60303370D1/de
Publication of DE60303370T2 publication Critical patent/DE60303370T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60303370T 2002-02-14 2003-02-14 Bifunktionelle metallocene, verwendung zur markierung von biomolekülen Expired - Lifetime DE60303370T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0201858 2002-02-14
FR0201858A FR2835836B1 (fr) 2002-02-14 2002-02-14 Metallocenes bifonctionnalises, procede d'obtention, utilisation pour le marquage de molecules biologiques
PCT/FR2003/000484 WO2003068787A1 (fr) 2002-02-14 2003-02-14 Metallocenes bifonctionnalises, utilisation pour le marquage de molecules biologiques

Publications (2)

Publication Number Publication Date
DE60303370D1 DE60303370D1 (de) 2006-04-13
DE60303370T2 true DE60303370T2 (de) 2006-11-16

Family

ID=27620220

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60303370T Expired - Lifetime DE60303370T2 (de) 2002-02-14 2003-02-14 Bifunktionelle metallocene, verwendung zur markierung von biomolekülen

Country Status (9)

Country Link
US (1) US7301041B2 (es)
EP (1) EP1474430B1 (es)
JP (2) JP4623969B2 (es)
AT (1) ATE316535T1 (es)
AU (1) AU2003222915A1 (es)
DE (1) DE60303370T2 (es)
ES (1) ES2256729T3 (es)
FR (1) FR2835836B1 (es)
WO (1) WO2003068787A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
GB0316075D0 (en) * 2003-07-09 2003-08-13 Molecular Sensing Plc Protease detection assay
WO2005087784A1 (ja) * 2004-02-24 2005-09-22 Japan Science And Technology Agency 電気化学的に活性な配列特異的二本鎖核酸分子検出用リガンド
FR2888240B1 (fr) * 2005-07-11 2007-09-07 Biomerieux Sa Monomeres electropolymerisables solubles en solution aqueuse et sondes electroactives susceptibles d'etre obtenues avec de tels monomeres
GB0801319D0 (en) * 2008-01-25 2008-03-05 Npil Pharmaceuticals Uk Ltd Compounds and their use
FR2987359B1 (fr) 2012-02-27 2014-04-25 Univ Claude Bernard Lyon Derives du diaminophenothiazinium pour le marquage de biomolecules, procede et support de marquage d'oligonucleotides et oligonucleotides obtenus

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2607507B1 (fr) 1986-12-02 1990-04-13 Centre Nat Rech Scient Nouveaux derives a-d-oligonucleotides, leur preparation et leur emploi
DE19533093C1 (de) 1995-09-07 1996-12-05 Deutsches Krebsforsch Metallocen-Phosphoramidit-Konjugate, Verfahren zu ihrer Herstellung sowie deren Verwendung
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
WO1999057319A1 (en) * 1998-05-06 1999-11-11 Clinical Micro Sensors Electronic detection of nucleic acids using monolayers
CA2351479A1 (en) 1998-11-19 2000-06-02 Bio Merieux Electrically conductive electroactive functionalized conjugated polymers, and uses thereof
KR100367463B1 (ko) * 1999-03-03 2003-01-14 주식회사 엘지화학 메탈로센 화합물 및 이를 이용한 올레핀 중합
FR2808024B1 (fr) 2000-04-21 2006-09-15 Bio Merieux Complexe electroactif, sonde electroactive et procede de preparation
WO2003085082A2 (en) * 2001-04-03 2003-10-16 Clinical Micro Sensors, Inc. Nucleic acid reactions using labels with different redox potentials

Also Published As

Publication number Publication date
WO2003068787A1 (fr) 2003-08-21
JP4623969B2 (ja) 2011-02-02
FR2835836A1 (fr) 2003-08-15
JP2005517709A (ja) 2005-06-16
ATE316535T1 (de) 2006-02-15
US7301041B2 (en) 2007-11-27
EP1474430B1 (fr) 2006-01-25
ES2256729T3 (es) 2006-07-16
US20050038234A1 (en) 2005-02-17
FR2835836B1 (fr) 2006-03-17
DE60303370D1 (de) 2006-04-13
AU2003222915A1 (en) 2003-09-04
JP2011036248A (ja) 2011-02-24
EP1474430A1 (fr) 2004-11-10

Similar Documents

Publication Publication Date Title
EP0399330B1 (de) Modifiziertes Phosphoramidit-Verfahren zur Herstellung von modifizierten Nukleinsäuren
EP0152459B1 (de) Verfahren zur herstellung von oligonucleotiden
DE3751947T2 (de) Nucleosidderivate und ihre Verwendung in der Oligonucleotid-Synthese
DE69307689T2 (de) Oligonukleotide synthese
JP3172178B2 (ja) 合成オリゴヌクレオチドに対する多重リポータ基の組込み
DE69111807T2 (de) Phosphoramidit derivate, ihre herstellung und ihre verwendung zum einbau der markengruppen zum oligonukleotidenaufbau.
DE69632456T2 (de) Nukleinsäuresynthese unter verwendung von mittels licht abspaltbaren schutzgruppen
DE69007968T2 (de) Derivate von polyhydroxylierten molekülen, welche die einführung von mindestens einer verzweigung in ein oligonukleotid erlauben.
DE69724218T2 (de) Universale feste träger und verfahren zu ihrer verwendung
JPS59141598A (ja) 保護剤を結合したオリゴヌクレオチド連鎖を含む新規化合物、及び該新規化合物の製造方法
DE60124637T2 (de) Neues Reagens zur Markierung von Nukleinsäuren
EP0707591A1 (de) Methylphosphonsäureester, verfahren zu deren herstellung und deren verwendung
DE68906890T2 (de) Nukleoside derivate, nützlich für die synthese von markierten oligonukleotiden, mit diesen derivaten hergestellte oligonukleotide und ihre synthese.
AU2022291626A1 (en) Improved process for preparing imetelstat
DE60303370T2 (de) Bifunktionelle metallocene, verwendung zur markierung von biomolekülen
DE69400807T2 (de) Bausteine mit carbamate luternukleosidverbindungen und oligonukleotide abgeleitet davon
US6166239A (en) Oligonucleotide protecting groups
DE69401136T2 (de) Modifizierte Oligodeoxyribonukleotide, ihre Herstellung und ihre therapeutische Verwendung
EP1268492A1 (de) Reaktive monomere für die oligonucleotid- und polynucleotidsynthese, modifizierte oligonucleotide und polynucleotide und deren herstellung
EP1626952B1 (de) Multifunktionales reagenz zur synthese von thiolmodifizierten oligomeren
DE3881691T2 (de) Polydeoxyribonukleotide, pharmazeutische zusammensetzungen, verwendung und herstellung von polydeoxyribonukleotiden.
EP0124561B1 (de) Verfahren zur herstellung von oligonucleosidphosphonaten
US6107479A (en) Process for the preparation of an oligomeric compound
DE3824110A1 (de) Verfahren zur herstellung und reinigung von an ihrem 5'-ende phosphorylierten oligo- und jpolynukleotidsequenzen und reagenz zur durchfuehrung des verfahrens
Richter et al. A programmed five-membered cyclic phosphorylating reagent for the synthesis of oligonucleotides and its use

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: WITTE, WELLER & PARTNER, 70178 STUTTGART