DE68906890T2 - Nukleoside derivate, nützlich für die synthese von markierten oligonukleotiden, mit diesen derivaten hergestellte oligonukleotide und ihre synthese. - Google Patents

Nukleoside derivate, nützlich für die synthese von markierten oligonukleotiden, mit diesen derivaten hergestellte oligonukleotide und ihre synthese.

Info

Publication number
DE68906890T2
DE68906890T2 DE89907771T DE68906890T DE68906890T2 DE 68906890 T2 DE68906890 T2 DE 68906890T2 DE 89907771 T DE89907771 T DE 89907771T DE 68906890 T DE68906890 T DE 68906890T DE 68906890 T2 DE68906890 T2 DE 68906890T2
Authority
DE
Germany
Prior art keywords
synthesis
derivatives
oligonucleotides
useful
produced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89907771T
Other languages
English (en)
Other versions
DE68906890D1 (de
Inventor
Andre Roget
Robert Teoule
Herve Bazin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIS Bio International SA
Original Assignee
CIS Bio International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CIS Bio International SA filed Critical CIS Bio International SA
Application granted granted Critical
Publication of DE68906890D1 publication Critical patent/DE68906890D1/de
Publication of DE68906890T2 publication Critical patent/DE68906890T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
DE89907771T 1988-06-20 1989-06-19 Nukleoside derivate, nützlich für die synthese von markierten oligonukleotiden, mit diesen derivaten hergestellte oligonukleotide und ihre synthese. Expired - Fee Related DE68906890T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8808240A FR2632955B1 (fr) 1988-06-20 1988-06-20 Derives de nucleosides utilisables pour la synthese d'oligonucleotides marques, oligonucleotides obtenus a partir de ces derives et leur synthese

Publications (2)

Publication Number Publication Date
DE68906890D1 DE68906890D1 (de) 1993-07-08
DE68906890T2 true DE68906890T2 (de) 1993-12-02

Family

ID=9367476

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89907771T Expired - Fee Related DE68906890T2 (de) 1988-06-20 1989-06-19 Nukleoside derivate, nützlich für die synthese von markierten oligonukleotiden, mit diesen derivaten hergestellte oligonukleotide und ihre synthese.

Country Status (6)

Country Link
EP (1) EP0422090B1 (de)
JP (1) JP2835630B2 (de)
AU (1) AU3866089A (de)
DE (1) DE68906890T2 (de)
FR (1) FR2632955B1 (de)
WO (1) WO1989012642A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262536A (en) * 1988-09-15 1993-11-16 E. I. Du Pont De Nemours And Company Reagents for the preparation of 5'-tagged oligonucleotides
DE4037363A1 (de) * 1990-04-09 1991-10-10 Europ Lab Molekularbiolog 2-0-alkylnukleotide sowie polymere, die solche nukleotide enthalten
US5658731A (en) * 1990-04-09 1997-08-19 Europaisches Laboratorium Fur Molekularbiologie 2'-O-alkylnucleotides as well as polymers which contain such nucleotides
CN104945509A (zh) 2009-09-16 2015-09-30 弗·哈夫曼-拉罗切有限公司 包含卷曲螺旋和/或系链的蛋白质复合体及其用途
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
CN103384681B (zh) 2010-12-23 2018-05-18 霍夫曼-拉罗奇有限公司 结合剂
EP2655413B1 (de) 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Polypeptid-polynukleotid-komplex und verwendung bei der gezielten effektorrest-bereitstellung
WO2012085064A1 (en) 2010-12-23 2012-06-28 Roche Diagnostics Gmbh Detection of a posttranslationally modified polypeptide by a bi-valent binding agent
WO2013119966A2 (en) 2012-02-10 2013-08-15 Genentech, Inc. Single-chain antibodies and other heteromultimers
CN102718822A (zh) * 2012-05-18 2012-10-10 大连大学 微波辅助下4-硫胸腺嘧啶核苷及其类似物的合成方法
WO2014001325A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
JP6203838B2 (ja) 2012-06-27 2017-09-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 少なくとも２つの異なる結合実体を含む、テーラーメイドの高度に選択的かつ多重特異的なターゲティング実体を選択および作製するための方法、ならびにその使用
PL3227332T3 (pl) 2014-12-03 2020-06-15 F. Hoffmann-La Roche Ag Wielospecyficzne przeciwciała
CN110669088B (zh) * 2018-07-02 2023-03-28 成都阿奇生物医药科技有限公司 N-(2-乙基胺)苯磺酰胺基虫草素衍生物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1219824A (en) * 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
WO1984001394A1 (en) * 1982-09-30 1984-04-12 Iro Ab Yarn storing, feeding and measuring device
AU596068B2 (en) * 1983-02-22 1990-04-26 Syngene, Inc. Defined sequence single strand oligonucleotides incorporating reporter groups, process for the chemical synthesis thereof, and nucleosides useful in such synthesis
JPH0723393B2 (ja) * 1985-05-15 1995-03-15 アモコ・コーポレーション シチジン同族体
FR2601956B1 (fr) * 1986-07-22 1989-11-03 Pasteur Institut Nouveaux derives de desoxy-2' adenosine, leur procede d'obtention par voie de synthese et leurs applications biologiques
FR2620122B1 (fr) * 1987-09-03 1989-12-29 Pasteur Institut Procede d'obtention par voie chimique d'oligonucleotides marques et applications biologiques
DE19928872A1 (de) * 1999-06-24 2001-01-18 Rockwool Mineralwolle Dämmstoffelement

Also Published As

Publication number Publication date
JPH03505209A (ja) 1991-11-14
AU3866089A (en) 1990-01-12
DE68906890D1 (de) 1993-07-08
FR2632955B1 (fr) 1991-12-27
EP0422090A1 (de) 1991-04-17
WO1989012642A1 (fr) 1989-12-28
FR2632955A1 (fr) 1989-12-22
JP2835630B2 (ja) 1998-12-14
EP0422090B1 (de) 1993-06-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee