DE60238134D1 - Verfahren zur reagieren von alkaloiden und verwendung der reaktionsproduckte in der bereitstellung von medikamenten - Google Patents

Verfahren zur reagieren von alkaloiden und verwendung der reaktionsproduckte in der bereitstellung von medikamenten

Info

Publication number
DE60238134D1
DE60238134D1 DE60238134T DE60238134T DE60238134D1 DE 60238134 D1 DE60238134 D1 DE 60238134D1 DE 60238134 T DE60238134 T DE 60238134T DE 60238134 T DE60238134 T DE 60238134T DE 60238134 D1 DE60238134 D1 DE 60238134D1
Authority
DE
Germany
Prior art keywords
alkaloids
medicaments
responding
provision
reaction products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60238134T
Other languages
English (en)
Inventor
Wassyl Nowicky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE60238134D1 publication Critical patent/DE60238134D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G5/00—Alkaloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564—Three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60238134T 2001-11-15 2002-10-28 Verfahren zur reagieren von alkaloiden und verwendung der reaktionsproduckte in der bereitstellung von medikamenten Expired - Lifetime DE60238134D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH02094/01A CH695417A5 (de) 2001-11-15 2001-11-15 Verfahren zur Umsetzung von Alkaloiden.
PCT/EP2002/012003 WO2003041721A1 (en) 2001-11-15 2002-10-28 Process for reacting alkaloids and use of the reaction products in the preparation of medicaments

Publications (1)

Publication Number Publication Date
DE60238134D1 true DE60238134D1 (de) 2010-12-09

Family

ID=4567486

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60238134T Expired - Lifetime DE60238134D1 (de) 2001-11-15 2002-10-28 Verfahren zur reagieren von alkaloiden und verwendung der reaktionsproduckte in der bereitstellung von medikamenten

Country Status (39)

Country Link
US (1) US20050043340A1 (de)
EP (1) EP1443943B1 (de)
JP (1) JP2005509006A (de)
KR (1) KR100849488B1 (de)
CN (1) CN100436462C (de)
AR (1) AR037527A1 (de)
AT (1) ATE485826T1 (de)
AU (1) AU2002346888B2 (de)
BR (1) BR0214173A (de)
CA (1) CA2465723C (de)
CH (1) CH695417A5 (de)
CO (1) CO5580784A2 (de)
CR (1) CR7340A (de)
CU (1) CU23451B7 (de)
CY (1) CY1111139T1 (de)
DE (1) DE60238134D1 (de)
DK (1) DK1443943T3 (de)
EA (1) EA007097B1 (de)
EC (1) ECSP045107A (de)
ES (1) ES2353207T3 (de)
GE (1) GEP20053701B (de)
HK (1) HK1054041A1 (de)
HR (1) HRP20040430A2 (de)
HU (1) HU229688B1 (de)
IL (2) IL161766A0 (de)
IS (1) IS2812B (de)
MA (1) MA26232A1 (de)
MX (1) MXPA04004643A (de)
NO (1) NO334701B1 (de)
NZ (1) NZ532941A (de)
PL (1) PL212111B1 (de)
PT (1) PT1443943E (de)
RS (1) RS51219B (de)
SA (1) SA02230496B1 (de)
TN (1) TNSN04084A1 (de)
TW (1) TWI262080B (de)
UA (1) UA76535C2 (de)
WO (1) WO2003041721A1 (de)
ZA (1) ZA200403371B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1459753A1 (de) 2003-03-18 2004-09-22 Nowicky, Wassyl, Dipl.-Ing. DDr. Quaternäre Chelidonin- und Alkaloidderivate, Verfahren zu deren Herstellung und deren Verwendung in der Herstellung von Arzneimitteln
WO2006053649A1 (en) * 2004-11-19 2006-05-26 Nowicky Wassili Method for the detection of cancer
WO2006053680A1 (en) * 2004-11-19 2006-05-26 Nowicky Wassili Ex vivo cancer diagnostic method
WO2007073919A2 (en) 2005-12-28 2007-07-05 Nowicky Wassili Method and kit for the detection of cancer
ITMI20080284A1 (it) * 2008-02-22 2009-08-23 Indena Spa Agenti antitumorali a struttura benzofenantridinica e formulazioni che li contengono
CA2941315C (en) * 2016-08-12 2018-03-06 Api Labs Inc. High thebaine poppy and methods of producing the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU368254A1 (ru) * 1969-06-16 1973-01-26 А. И. Потопальский , В. М. Новицкий Львовский государственный медицинский институт Способ получения соединений тиофосфамида с алкалоидами чистотела большого
US3865830A (en) * 1969-06-16 1975-02-11 Nikolai Mikhailovich Turkevich Thiophosphamide derivatives of isoquinoline alkaloids, method of producing and application thereof
AT354644B (de) * 1975-12-19 1980-01-25 Nowicky Wassili Verfahren zur herstellung von neuen salzen von alkaloidderivaten von thiophosphorsaeure
AT377988B (de) * 1976-06-28 1985-05-28 Nowicky Wassili Verfahren zur herstellung von neuen phosphorderivaten von alkaloiden
DE3128018A1 (de) * 1981-07-13 1983-04-07 Wassyl 1060 Wien Nowicky "verfahren zum diagnostizieren und fuer die therapeutische behandlung von tumoren und/oder infektioesen krankheiten verschiedenster art unter praeparativem einsatz von alkaloid-verbindungen bzw. deren salze"
US4970212A (en) * 1982-05-18 1990-11-13 Nowicky Wassili Method of treating human illnesses which compromise the ability to mount an effective immunological response
AT407608B (de) * 1994-03-18 2001-05-25 Nowicky Wassili Mittel zur behandlung von osteoporose
AT407833B (de) * 1995-06-01 2001-06-25 Nowicky Wassyl Dr Mittel zur behandlung von strahlenschäden
AT408719B (de) * 2000-03-22 2002-02-25 Nowicky Wassili Mittel zur behandlung von hepatitis c

Also Published As

Publication number Publication date
IS2812B (is) 2012-11-15
EP1443943B1 (de) 2010-10-27
CN1422859A (zh) 2003-06-11
AU2002346888B2 (en) 2007-03-22
MA26232A1 (fr) 2004-07-01
HRP20040430A2 (en) 2004-08-31
JP2005509006A (ja) 2005-04-07
IS7245A (is) 2004-04-30
CY1111139T1 (el) 2015-06-11
CN100436462C (zh) 2008-11-26
GEP20053701B (en) 2005-12-12
HU229688B1 (en) 2014-04-28
EA007097B1 (ru) 2006-06-30
AR037527A1 (es) 2004-11-17
NZ532941A (en) 2006-08-31
PL212111B1 (pl) 2012-08-31
NO20041845D0 (no) 2004-05-05
HK1054041A1 (en) 2003-11-14
TNSN04084A1 (en) 2006-06-01
KR20050040859A (ko) 2005-05-03
RS40804A (en) 2006-12-15
EA200400679A1 (ru) 2004-10-28
IL161766A0 (en) 2005-11-20
CU23451B7 (es) 2009-10-16
MXPA04004643A (es) 2005-03-14
HUP0402365A2 (hu) 2005-02-28
US20050043340A1 (en) 2005-02-24
CO5580784A2 (es) 2005-11-30
BR0214173A (pt) 2004-09-28
EP1443943A1 (de) 2004-08-11
TWI262080B (en) 2006-09-21
HRP20040430B1 (de) 2012-11-30
KR100849488B1 (ko) 2008-07-31
NO334701B1 (no) 2014-05-12
CA2465723C (en) 2010-01-05
UA76535C2 (en) 2006-08-15
PT1443943E (pt) 2010-12-03
ECSP045107A (es) 2004-06-28
CR7340A (es) 2004-12-06
NO20041845L (no) 2004-06-25
PL368879A1 (en) 2005-04-04
ZA200403371B (en) 2005-05-04
ATE485826T1 (de) 2010-11-15
IL161766A (en) 2009-11-18
CH695417A5 (de) 2006-05-15
DK1443943T3 (da) 2011-02-14
ES2353207T3 (es) 2011-02-28
RS51219B (sr) 2010-12-31
CA2465723A1 (en) 2003-05-22
WO2003041721A1 (en) 2003-05-22
SA02230496B1 (ar) 2008-09-10
AU2002346888C1 (en) 2003-05-26

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