CU23451B7 - Proceso por reacción de alcaloides y uso de la reacción de productos en la preparación de medicamentos - Google Patents

Proceso por reacción de alcaloides y uso de la reacción de productos en la preparación de medicamentos

Info

Publication number
CU23451B7
CU23451B7 CU20040105A CU20040105A CU23451B7 CU 23451 B7 CU23451 B7 CU 23451B7 CU 20040105 A CU20040105 A CU 20040105A CU 20040105 A CU20040105 A CU 20040105A CU 23451 B7 CU23451 B7 CU 23451B7
Authority
CU
Cuba
Prior art keywords
reaction
alcaloids
medicines
products
preparation
Prior art date
Application number
CU20040105A
Other languages
English (en)
Inventor
Wassyl Nowicky
Original Assignee
Nowicky Wassili
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nowicky Wassili filed Critical Nowicky Wassili
Publication of CU23451B7 publication Critical patent/CU23451B7/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G5/00—Alkaloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564—Three-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención consiste en un proceso para la reacción de alcaloides que comprende la adición de un derivado de fósforo a una solución orgánica que contienen los productos de reacción de los alcaloides y los residuos sin reaccionar del derivado de fósforo. Los productos de reacción obtenidos son adecuados como fármacos.
CU20040105A 2001-11-15 2004-05-17 Proceso por reacción de alcaloides y uso de la reacción de productos en la preparación de medicamentos CU23451B7 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH02094/01A CH695417A5 (de) 2001-11-15 2001-11-15 Verfahren zur Umsetzung von Alkaloiden.

Publications (1)

Publication Number Publication Date
CU23451B7 true CU23451B7 (es) 2009-10-16

Family

ID=4567486

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20040105A CU23451B7 (es) 2001-11-15 2004-05-17 Proceso por reacción de alcaloides y uso de la reacción de productos en la preparación de medicamentos

Country Status (39)

Country Link
US (1) US20050043340A1 (es)
EP (1) EP1443943B1 (es)
JP (1) JP2005509006A (es)
KR (1) KR100849488B1 (es)
CN (1) CN100436462C (es)
AR (1) AR037527A1 (es)
AT (1) ATE485826T1 (es)
AU (1) AU2002346888B2 (es)
BR (1) BR0214173A (es)
CA (1) CA2465723C (es)
CH (1) CH695417A5 (es)
CO (1) CO5580784A2 (es)
CR (1) CR7340A (es)
CU (1) CU23451B7 (es)
CY (1) CY1111139T1 (es)
DE (1) DE60238134D1 (es)
DK (1) DK1443943T3 (es)
EA (1) EA007097B1 (es)
EC (1) ECSP045107A (es)
ES (1) ES2353207T3 (es)
GE (1) GEP20053701B (es)
HK (1) HK1054041A1 (es)
HR (1) HRP20040430A2 (es)
HU (1) HU229688B1 (es)
IL (2) IL161766A0 (es)
IS (1) IS2812B (es)
MA (1) MA26232A1 (es)
MX (1) MXPA04004643A (es)
NO (1) NO334701B1 (es)
NZ (1) NZ532941A (es)
PL (1) PL212111B1 (es)
PT (1) PT1443943E (es)
RS (1) RS51219B (es)
SA (1) SA02230496B1 (es)
TN (1) TNSN04084A1 (es)
TW (1) TWI262080B (es)
UA (1) UA76535C2 (es)
WO (1) WO2003041721A1 (es)
ZA (1) ZA200403371B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1459753A1 (en) 2003-03-18 2004-09-22 Nowicky, Wassyl, Dipl.-Ing. DDr. Quaternary chelidonine and alkaloid derivatives, process for their preparation and their use in the manufacture of medicaments
WO2006053680A1 (en) * 2004-11-19 2006-05-26 Nowicky Wassili Ex vivo cancer diagnostic method
WO2006053649A1 (en) * 2004-11-19 2006-05-26 Nowicky Wassili Method for the detection of cancer
WO2007073919A2 (en) 2005-12-28 2007-07-05 Nowicky Wassili Method and kit for the detection of cancer
ITMI20080284A1 (it) * 2008-02-22 2009-08-23 Indena Spa Agenti antitumorali a struttura benzofenantridinica e formulazioni che li contengono
CA2941315C (en) * 2016-08-12 2018-03-06 Api Labs Inc. High thebaine poppy and methods of producing the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU368254A1 (ru) 1969-06-16 1973-01-26 А. И. Потопальский , В. М. Новицкий Львовский государственный медицинский институт Способ получения соединений тиофосфамида с алкалоидами чистотела большого
US3865830A (en) * 1969-06-16 1975-02-11 Nikolai Mikhailovich Turkevich Thiophosphamide derivatives of isoquinoline alkaloids, method of producing and application thereof
AT354644B (de) * 1975-12-19 1980-01-25 Nowicky Wassili Verfahren zur herstellung von neuen salzen von alkaloidderivaten von thiophosphorsaeure
AT377988B (de) * 1976-06-28 1985-05-28 Nowicky Wassili Verfahren zur herstellung von neuen phosphorderivaten von alkaloiden
DE3128018A1 (de) * 1981-07-13 1983-04-07 Wassyl 1060 Wien Nowicky "verfahren zum diagnostizieren und fuer die therapeutische behandlung von tumoren und/oder infektioesen krankheiten verschiedenster art unter praeparativem einsatz von alkaloid-verbindungen bzw. deren salze"
US4970212A (en) * 1982-05-18 1990-11-13 Nowicky Wassili Method of treating human illnesses which compromise the ability to mount an effective immunological response
AT407608B (de) * 1994-03-18 2001-05-25 Nowicky Wassili Mittel zur behandlung von osteoporose
AT407833B (de) * 1995-06-01 2001-06-25 Nowicky Wassyl Dr Mittel zur behandlung von strahlenschäden
AT408719B (de) * 2000-03-22 2002-02-25 Nowicky Wassili Mittel zur behandlung von hepatitis c

Also Published As

Publication number Publication date
CN100436462C (zh) 2008-11-26
RS51219B (sr) 2010-12-31
IL161766A0 (en) 2005-11-20
EP1443943A1 (en) 2004-08-11
DK1443943T3 (da) 2011-02-14
UA76535C2 (en) 2006-08-15
DE60238134D1 (de) 2010-12-09
ZA200403371B (en) 2005-05-04
WO2003041721A1 (en) 2003-05-22
NZ532941A (en) 2006-08-31
EA007097B1 (ru) 2006-06-30
CO5580784A2 (es) 2005-11-30
CH695417A5 (de) 2006-05-15
NO334701B1 (no) 2014-05-12
GEP20053701B (en) 2005-12-12
HUP0402365A2 (hu) 2005-02-28
AR037527A1 (es) 2004-11-17
IL161766A (en) 2009-11-18
MXPA04004643A (es) 2005-03-14
CY1111139T1 (el) 2015-06-11
CA2465723C (en) 2010-01-05
IS7245A (is) 2004-04-30
PT1443943E (pt) 2010-12-03
KR100849488B1 (ko) 2008-07-31
KR20050040859A (ko) 2005-05-03
EP1443943B1 (en) 2010-10-27
ES2353207T3 (es) 2011-02-28
NO20041845D0 (no) 2004-05-05
ECSP045107A (es) 2004-06-28
TNSN04084A1 (en) 2006-06-01
EA200400679A1 (ru) 2004-10-28
AU2002346888B2 (en) 2007-03-22
US20050043340A1 (en) 2005-02-24
CR7340A (es) 2004-12-06
MA26232A1 (fr) 2004-07-01
RS40804A (en) 2006-12-15
HU229688B1 (en) 2014-04-28
ATE485826T1 (de) 2010-11-15
JP2005509006A (ja) 2005-04-07
HRP20040430A2 (en) 2004-08-31
PL212111B1 (pl) 2012-08-31
IS2812B (is) 2012-11-15
NO20041845L (no) 2004-06-25
AU2002346888C1 (en) 2003-05-26
CA2465723A1 (en) 2003-05-22
PL368879A1 (en) 2005-04-04
CN1422859A (zh) 2003-06-11
HRP20040430B1 (es) 2012-11-30
SA02230496B1 (ar) 2008-09-10
TWI262080B (en) 2006-09-21
BR0214173A (pt) 2004-09-28
HK1054041A1 (en) 2003-11-14

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