DE60220424D1 - NEUE LIGANDEN FÜR DIE HisB10 Zn2+ STELLEN DES INSULIN-HEXAMERS IN DER R-KONFORMATION - Google Patents
NEUE LIGANDEN FÜR DIE HisB10 Zn2+ STELLEN DES INSULIN-HEXAMERS IN DER R-KONFORMATIONInfo
- Publication number
- DE60220424D1 DE60220424D1 DE60220424T DE60220424T DE60220424D1 DE 60220424 D1 DE60220424 D1 DE 60220424D1 DE 60220424 T DE60220424 T DE 60220424T DE 60220424 T DE60220424 T DE 60220424T DE 60220424 D1 DE60220424 D1 DE 60220424D1
- Authority
- DE
- Germany
- Prior art keywords
- hisb10
- insulin
- conformation
- hexamers
- insulin hexamers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101337 | 2001-09-14 | ||
| DK200101337 | 2001-09-14 | ||
| US32392501P | 2001-09-21 | 2001-09-21 | |
| US323925P | 2001-09-21 | ||
| DKPA200201066 | 2002-07-05 | ||
| DK200201066 | 2002-07-05 | ||
| US39605102P | 2002-07-10 | 2002-07-10 | |
| US396051P | 2002-07-10 | ||
| PCT/DK2002/000595 WO2003027081A2 (en) | 2001-09-14 | 2002-09-13 | NOVEL LIGANDS FOR THE HisB10 Zn2+ SITES OF THE R-STATE INSULIN HEXAMER |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60220424D1 true DE60220424D1 (de) | 2007-07-12 |
| DE60220424T2 DE60220424T2 (de) | 2008-03-06 |
Family
ID=27439845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60220424T Expired - Lifetime DE60220424T2 (de) | 2001-09-14 | 2002-09-13 | NEUE LIGANDEN FÜR DIE HisB10 Zn2+ STELLEN DES INSULIN-HEXAMERS IN DER R-KONFORMATION |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7879893B2 (de) |
| EP (1) | EP1429763B1 (de) |
| JP (1) | JP4554207B2 (de) |
| CN (1) | CN1558762A (de) |
| AT (1) | ATE363278T1 (de) |
| BR (1) | BR0212522A (de) |
| CA (1) | CA2460541A1 (de) |
| CZ (1) | CZ2004313A3 (de) |
| DE (1) | DE60220424T2 (de) |
| ES (1) | ES2288195T3 (de) |
| HU (1) | HUP0401492A3 (de) |
| MX (1) | MXPA04002404A (de) |
| NO (1) | NO20041494L (de) |
| PL (1) | PL369119A1 (de) |
| WO (1) | WO2003027081A2 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070060606A1 (en) * | 1999-10-07 | 2007-03-15 | Robertson Harold A | Compounds and methods for modulating phosphodiesterase 10A |
| US7078423B2 (en) * | 2002-07-18 | 2006-07-18 | Inotek Pharmaceuticals Corporation | 5-Aryltetrazole compounds, compositions thereof, and uses therefor |
| US7087631B2 (en) * | 2002-07-18 | 2006-08-08 | Inotek Pharmaceuticals Corporation | Aryltetrazole compounds, and compositions thereof |
| US20040063098A1 (en) * | 2002-09-26 | 2004-04-01 | Hargreaves John S. | Methods for producing multilayer ligand arrays |
| AU2003291024A1 (en) * | 2002-11-13 | 2004-06-03 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
| US20050065066A1 (en) * | 2002-12-20 | 2005-03-24 | Kaarsholm Niels Christian | Stabilised insulin compositions |
| ES2297227T3 (es) * | 2002-12-20 | 2008-05-01 | Novo Nordisk A/S | Composiciones farmaceuticas conteniendo insulina y ligandos del hexamero de insulina. |
| US7781464B2 (en) | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
| US7521465B2 (en) | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| EP1610812A1 (de) * | 2003-03-11 | 2006-01-04 | Novo Nordisk A/S | Pharmazeutische zusammnesetzungen enthaltend insulin stabilisiert mit einer säure |
| US20060258561A1 (en) * | 2003-03-13 | 2006-11-16 | Novo Nordisk A/S | Novel NPH insulin preparations |
| CA2733145C (en) * | 2003-07-02 | 2012-06-19 | Corus Pharma, Inc. | Aztreonam l-lysine and method of determining impurities therein |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
| US7037927B2 (en) * | 2003-10-16 | 2006-05-02 | Abbott Laboratories | Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| CN102816228A (zh) | 2003-12-03 | 2012-12-12 | 诺和诺德公司 | 单链胰岛素 |
| EP1757591A4 (de) | 2004-05-26 | 2010-05-05 | Eisai R&D Man Co Ltd | Zimtsäureamidverbindung |
| BRPI0512988A (pt) | 2004-07-08 | 2008-04-22 | Novo Nordisk As | método para aumentar a meia-vida plasmática de uma molécula, composto, uso do mesmo, e, composição farmacêutica |
| EP1768694A1 (de) * | 2004-07-09 | 2007-04-04 | Novo Nordisk A/S | Pharmazeutische zubereitungen mit insulin |
| CA2575329A1 (en) * | 2004-08-05 | 2006-02-09 | F. Hoffmann-La Roche Ag | Indole, indazole or indoline derivatives |
| EP1791554A2 (de) * | 2004-09-17 | 2007-06-06 | Novo Nordisk A/S | Pharmazeutische zusammensetzungen mit insulin und insulinotropem peptid |
| AU2005288080B2 (en) * | 2004-09-28 | 2011-10-13 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compound |
| JPWO2006046575A1 (ja) | 2004-10-26 | 2008-05-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シンナミド化合物の非晶質体 |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| TW200800978A (en) * | 2006-03-23 | 2008-01-01 | Otsuka Pharma Co Ltd | Carbazole compound |
| JP5191155B2 (ja) * | 2006-03-27 | 2013-04-24 | 大塚製薬株式会社 | カルボスチリル化合物からなる医薬 |
| TW200848054A (en) | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| AU2008292390B2 (en) | 2007-08-31 | 2013-04-04 | Eisai R & D Management Co., Ltd. | Polycyclic compound |
| EP2817298A1 (de) | 2012-02-21 | 2014-12-31 | Bayer Intellectual Property GmbH | Herbizid wirksame 4-nitro substituierte n-(tetrazol-5-yl)-, n-(triazol-5-yl)- und n-(1,3,4-oxadiazol-2-yl)arylcarbonsäureamide |
| US9447069B2 (en) * | 2012-04-30 | 2016-09-20 | Innov17 Llc | ROR modulators and their uses |
| KR101942752B1 (ko) * | 2012-11-05 | 2019-01-28 | 주식회사 엘지화학 | Ｇｐｒ120 효능제로서의 티오아릴 유도체 |
| JP6156845B2 (ja) * | 2014-03-04 | 2017-07-05 | 株式会社島津製作所 | マトリックス支援レーザ脱離イオン化質量分析用マトリックス |
| CA2968884A1 (en) * | 2014-12-10 | 2016-06-16 | Massachusetts Institute Of Technology | Fused 1,3-azole derivatives useful for the treatment of proliferative diseases |
| WO2016094846A1 (en) | 2014-12-11 | 2016-06-16 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis and related methods |
| WO2016154255A1 (en) * | 2015-03-23 | 2016-09-29 | University Of Miami | Inhibitors of the notch transcriptional activation complex and methods for use of the same |
| US10106555B2 (en) | 2016-02-16 | 2018-10-23 | Massachusetts Institute Of Technology | Max binders as MYC modulators and uses thereof |
| CN109563053B (zh) * | 2016-06-28 | 2023-02-28 | 肯塔基大学研究基金会 | 前列腺素e合成酶抑制剂及使用其的方法 |
| EP3558992A4 (de) | 2016-12-15 | 2020-12-02 | ONO Pharmaceutical Co., Ltd. | Aktivator von trek (twik-assoziierten k+ kanälen)-kanälen |
| AU2019236215B2 (en) * | 2018-03-16 | 2024-07-25 | The Board Of Regents Of The University Of Oklahoma | Agonists of peroxisome proliferator-activated receptor alpha and methods of use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DOP1982004086A (es) | 1981-08-27 | 1988-03-22 | Lilly Co Eli | Formula farmaceutica que comprende insulina humana y proinsulina humana |
| US5646120A (en) * | 1990-10-24 | 1997-07-08 | Allelix Biopharmaceuticals, Inc. | Peptide-based inhibitors of HIV replication |
| US5830999A (en) | 1995-01-26 | 1998-11-03 | Regents Of The University Of California | Stabilization of insulin through ligand binding interations |
| DE69914934T2 (de) * | 1998-11-18 | 2005-01-05 | Novo Nordisk A/S | Stabile, wässrige insulin-präparate ohne phenol und cresol |
-
2002
- 2002-09-13 CA CA002460541A patent/CA2460541A1/en not_active Abandoned
- 2002-09-13 EP EP02774468A patent/EP1429763B1/de not_active Expired - Lifetime
- 2002-09-13 ES ES02774468T patent/ES2288195T3/es not_active Expired - Lifetime
- 2002-09-13 HU HU0401492A patent/HUP0401492A3/hu unknown
- 2002-09-13 JP JP2003530671A patent/JP4554207B2/ja not_active Expired - Fee Related
- 2002-09-13 DE DE60220424T patent/DE60220424T2/de not_active Expired - Lifetime
- 2002-09-13 US US10/332,541 patent/US7879893B2/en not_active Expired - Fee Related
- 2002-09-13 MX MXPA04002404A patent/MXPA04002404A/es not_active Application Discontinuation
- 2002-09-13 BR BR0212522-6A patent/BR0212522A/pt not_active IP Right Cessation
- 2002-09-13 PL PL02369119A patent/PL369119A1/xx not_active Application Discontinuation
- 2002-09-13 WO PCT/DK2002/000595 patent/WO2003027081A2/en active IP Right Grant
- 2002-09-13 CZ CZ2004313A patent/CZ2004313A3/cs unknown
- 2002-09-13 CN CNA028203402A patent/CN1558762A/zh active Pending
- 2002-09-13 AT AT02774468T patent/ATE363278T1/de not_active IP Right Cessation
-
2004
- 2004-04-13 NO NO20041494A patent/NO20041494L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1429763A2 (de) | 2004-06-23 |
| WO2003027081A3 (en) | 2004-03-25 |
| ATE363278T1 (de) | 2007-06-15 |
| CZ2004313A3 (cs) | 2004-07-14 |
| HUP0401492A2 (hu) | 2004-11-29 |
| WO2003027081A2 (en) | 2003-04-03 |
| MXPA04002404A (es) | 2004-05-31 |
| CN1558762A (zh) | 2004-12-29 |
| DE60220424T2 (de) | 2008-03-06 |
| US7879893B2 (en) | 2011-02-01 |
| EP1429763B1 (de) | 2007-05-30 |
| CA2460541A1 (en) | 2003-04-03 |
| US20030229120A1 (en) | 2003-12-11 |
| NO20041494L (no) | 2004-04-13 |
| HUP0401492A3 (en) | 2008-05-28 |
| JP2005508335A (ja) | 2005-03-31 |
| JP4554207B2 (ja) | 2010-09-29 |
| BR0212522A (pt) | 2004-08-10 |
| PL369119A1 (en) | 2005-04-18 |
| ES2288195T3 (es) | 2008-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8381 | Inventor (new situation) |
Inventor name: OLSEN, HELLE BIRK, ALLEROED, DK Inventor name: KAARSHOLM, NIELS C., VANLOESE, DK Inventor name: MADSEN, PETER, BAGSVAERD, DK Inventor name: OESTERGAARD, SOEREN, BROENSHOEJ, DK Inventor name: LUDVIGSEN, SVEND, LYNGE, DK Inventor name: JAKOBSEN, PALLE, VAERLOESE, DK Inventor name: PETERSEN, ANDERS KLARSKOV, NAERUM, DK Inventor name: STEENSGAARD, DORTE BJERRE, KOEBENHAVN, DK |
|
| 8364 | No opposition during term of opposition |