DE602007013695D1 - Leuchtende stammzellen und ihre verwendung - Google Patents

Leuchtende stammzellen und ihre verwendung

Info

Publication number
DE602007013695D1
DE602007013695D1 DE602007013695T DE602007013695T DE602007013695D1 DE 602007013695 D1 DE602007013695 D1 DE 602007013695D1 DE 602007013695 T DE602007013695 T DE 602007013695T DE 602007013695 T DE602007013695 T DE 602007013695T DE 602007013695 D1 DE602007013695 D1 DE 602007013695D1
Authority
DE
Germany
Prior art keywords
stem cells
methods
identifying
specific cell
cell lineage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007013695T
Other languages
English (en)
Inventor
Silvia Cainarca
Cinzia Nucci
Sabrina Corazza
Stefan Lohmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AXXAM SpA
Original Assignee
AXXAM SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP06000452A external-priority patent/EP1808441A1/de
Application filed by AXXAM SpA filed Critical AXXAM SpA
Publication of DE602007013695D1 publication Critical patent/DE602007013695D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
DE602007013695T 2006-01-11 2007-01-10 Leuchtende stammzellen und ihre verwendung Active DE602007013695D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06000452A EP1808441A1 (de) 2006-01-11 2006-01-11 Lumineszierende Stammzellen, transgene Säugetiere und deren Verwendung
EP06022458 2006-10-27
PCT/IT2007/000021 WO2007080622A2 (en) 2006-01-11 2007-01-10 Luminescent stem cells and uses thereof

Publications (1)

Publication Number Publication Date
DE602007013695D1 true DE602007013695D1 (de) 2011-05-19

Family

ID=37963683

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007013695T Active DE602007013695D1 (de) 2006-01-11 2007-01-10 Leuchtende stammzellen und ihre verwendung

Country Status (11)

Country Link
US (1) US20090286695A1 (de)
EP (2) EP1973937B1 (de)
JP (2) JP2009523024A (de)
KR (2) KR20080107353A (de)
AT (2) ATE504597T1 (de)
AU (2) AU2007205659A1 (de)
CA (2) CA2636888A1 (de)
DE (1) DE602007013695D1 (de)
IL (2) IL192445A0 (de)
RU (2) RU2008132865A (de)
WO (2) WO2007080622A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5374840B2 (ja) 2006-07-20 2013-12-25 Ｊｎｃ株式会社 カルシウム結合発光蛋白質、それをコードする遺伝子およびその用途
JP5304275B2 (ja) * 2009-01-29 2013-10-02 Ｊｎｃ株式会社 アポクライティン−ｉｉをコードするコドン最適化核酸およびその使用方法
CN102822333A (zh) 2010-03-23 2012-12-12 奥林巴斯株式会社 监控干细胞的分化状态的方法
CN102816854A (zh) * 2012-08-31 2012-12-12 北京天辰空间生物医药研发有限公司 一种空间诱变机制的研究方法及其所使用生物遗传突变分子报告模型
US9424459B1 (en) * 2013-02-25 2016-08-23 Flagship Biosciences, Inc. Computerized methods for cell-based pattern recognition
US9412006B1 (en) * 2013-02-25 2016-08-09 Flagship Biosciences, Inc. Continuous tissue analysis scoring scheme based on cell classifications
JP6454478B2 (ja) 2013-09-12 2019-01-16 オリンパス株式会社 心筋細胞への分化をモニタリングする方法
JP6824594B2 (ja) * 2014-09-11 2021-02-03 Jnc株式会社 合成遺伝子の設計方法
US20180319855A1 (en) * 2015-10-30 2018-11-08 Centre National De La Recherche Scientifique (Cnrs) Genetically mutated aequorin-based biosensors with extra sensitivity to calcium and improved bioluminescence intensity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714666A (en) * 1993-02-09 1998-02-03 Children's Hospital Of Philadelphia Measurement of intracellular calcium using bioluminescent apoaequorin expressed in mammalian cells
US6117679A (en) * 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
AU6144498A (en) * 1997-02-06 1998-08-26 Osiris Therapeutics, Inc. P21cip1 or p27kip1 effects on the regulation of differentiation of human mesenchymal stem cells
GB9824357D0 (en) * 1998-11-07 1998-12-30 Univ Wales Medicine Protein and DNA coding therefor
AU2589500A (en) * 1999-09-03 2001-04-10 Xenogen Corporation Targeting constructs and transgenic animals produced therewith
JP4851041B2 (ja) * 1999-11-05 2012-01-11 協和発酵キリン株式会社 細胞内のカルシウムイオンの濃度変化をモニターするトランスジェニック非ヒト哺乳動物
ES2237643T3 (es) * 2002-10-21 2005-08-01 Axxam S.R.L. Fotoproteina con bioluminiscencia mejorada.
EP1700865A1 (de) * 2005-03-11 2006-09-13 AXXAM S.r.l. Photoproteine mit erhöhter Biolumineszenz und deren Verwendung als intrazelluläre Calcium-Indikatoren

Also Published As

Publication number Publication date
RU2008132865A (ru) 2010-02-20
JP2009523024A (ja) 2009-06-18
EP1973938A2 (de) 2008-10-01
RU2008132859A (ru) 2010-02-20
IL192445A0 (en) 2008-12-29
ATE510849T1 (de) 2011-06-15
EP1973938B1 (de) 2011-04-06
CA2636888A1 (en) 2007-07-19
AU2007205659A1 (en) 2007-07-19
EP1973937B1 (de) 2011-05-25
WO2007080621A1 (en) 2007-07-19
WO2007080621A8 (en) 2007-10-25
WO2007080622A8 (en) 2009-07-23
AU2007205658A1 (en) 2007-07-19
IL192484A0 (en) 2009-02-11
ATE504597T1 (de) 2011-04-15
EP1973937A1 (de) 2008-10-01
KR20080100420A (ko) 2008-11-18
US20090286695A1 (en) 2009-11-19
JP2009523025A (ja) 2009-06-18
WO2007080622A2 (en) 2007-07-19
CA2636891A1 (en) 2007-07-19
KR20080107353A (ko) 2008-12-10
WO2007080622A3 (en) 2007-09-27

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