ATE504597T1 - Leuchtende stammzellen und ihre verwendung - Google Patents

Leuchtende stammzellen und ihre verwendung

Info

Publication number
ATE504597T1
ATE504597T1 AT07713411T AT07713411T ATE504597T1 AT E504597 T1 ATE504597 T1 AT E504597T1 AT 07713411 T AT07713411 T AT 07713411T AT 07713411 T AT07713411 T AT 07713411T AT E504597 T1 ATE504597 T1 AT E504597T1
Authority
AT
Austria
Prior art keywords
stem cells
methods
identifying
specific cell
cell lineage
Prior art date
Application number
AT07713411T
Other languages
English (en)
Inventor
Silvia Cainarca
Cinzia Nucci
Sabrina Corazza
Stefan Lohmer
Original Assignee
Axxam Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP06000452A external-priority patent/EP1808441A1/de
Application filed by Axxam Spa filed Critical Axxam Spa
Application granted granted Critical
Publication of ATE504597T1 publication Critical patent/ATE504597T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT07713411T 2006-01-11 2007-01-10 Leuchtende stammzellen und ihre verwendung ATE504597T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06000452A EP1808441A1 (de) 2006-01-11 2006-01-11 Lumineszierende Stammzellen, transgene Säugetiere und deren Verwendung
EP06022458 2006-10-27
PCT/IT2007/000021 WO2007080622A2 (en) 2006-01-11 2007-01-10 Luminescent stem cells and uses thereof

Publications (1)

Publication Number Publication Date
ATE504597T1 true ATE504597T1 (de) 2011-04-15

Family

ID=37963683

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07713411T ATE504597T1 (de) 2006-01-11 2007-01-10 Leuchtende stammzellen und ihre verwendung
AT07706220T ATE510849T1 (de) 2006-01-11 2007-01-10 Transgene nichtmenschliche leuchttiere, abkömmling, zellderivate und verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT07706220T ATE510849T1 (de) 2006-01-11 2007-01-10 Transgene nichtmenschliche leuchttiere, abkömmling, zellderivate und verwendung

Country Status (11)

Country Link
US (1) US20090286695A1 (de)
EP (2) EP1973937B1 (de)
JP (2) JP2009523025A (de)
KR (2) KR20080107353A (de)
AT (2) ATE504597T1 (de)
AU (2) AU2007205659A1 (de)
CA (2) CA2636891A1 (de)
DE (1) DE602007013695D1 (de)
IL (2) IL192445A0 (de)
RU (2) RU2008132859A (de)
WO (2) WO2007080622A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5374840B2 (ja) 2006-07-20 2013-12-25 Ｊｎｃ株式会社 カルシウム結合発光蛋白質、それをコードする遺伝子およびその用途
JP5304275B2 (ja) * 2009-01-29 2013-10-02 Ｊｎｃ株式会社 アポクライティン−ｉｉをコードするコドン最適化核酸およびその使用方法
CN102822333A (zh) 2010-03-23 2012-12-12 奥林巴斯株式会社 监控干细胞的分化状态的方法
CN102816854A (zh) * 2012-08-31 2012-12-12 北京天辰空间生物医药研发有限公司 一种空间诱变机制的研究方法及其所使用生物遗传突变分子报告模型
US9412006B1 (en) * 2013-02-25 2016-08-09 Flagship Biosciences, Inc. Continuous tissue analysis scoring scheme based on cell classifications
US9424459B1 (en) * 2013-02-25 2016-08-23 Flagship Biosciences, Inc. Computerized methods for cell-based pattern recognition
JP6454478B2 (ja) 2013-09-12 2019-01-16 オリンパス株式会社 心筋細胞への分化をモニタリングする方法
JP6824594B2 (ja) * 2014-09-11 2021-02-03 Jnc株式会社 合成遺伝子の設計方法
JP2019500849A (ja) * 2015-10-30 2019-01-17 サーントル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク （セエンエールエス） 特別なカルシウム感受性及び向上した生物発光強度を有する遺伝子変異イクオリンベースのバイオセンサ

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714666A (en) * 1993-02-09 1998-02-03 Children's Hospital Of Philadelphia Measurement of intracellular calcium using bioluminescent apoaequorin expressed in mammalian cells
US6117679A (en) * 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
WO1998035022A1 (en) * 1997-02-06 1998-08-13 Osiris Therapeutics, Inc. p21?CIP1 OR p27KIP1¿ EFFECTS ON THE REGULATION OF DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS
GB9824357D0 (en) * 1998-11-07 1998-12-30 Univ Wales Medicine Protein and DNA coding therefor
AU2589500A (en) * 1999-09-03 2001-04-10 Xenogen Corporation Targeting constructs and transgenic animals produced therewith
EP1226752A4 (de) * 1999-11-05 2004-05-06 Kyowa Hakko Kogyo Kk Transgene nicht-humane tiere zur überwachung einer veränderung der kalzium-ionenkonzentration in zellen
ES2237643T3 (es) * 2002-10-21 2005-08-01 Axxam S.R.L. Fotoproteina con bioluminiscencia mejorada.
EP1700865A1 (de) * 2005-03-11 2006-09-13 AXXAM S.r.l. Photoproteine mit erhöhter Biolumineszenz und deren Verwendung als intrazelluläre Calcium-Indikatoren

Also Published As

Publication number Publication date
EP1973937B1 (de) 2011-05-25
CA2636888A1 (en) 2007-07-19
KR20080107353A (ko) 2008-12-10
DE602007013695D1 (de) 2011-05-19
AU2007205658A1 (en) 2007-07-19
CA2636891A1 (en) 2007-07-19
WO2007080621A8 (en) 2007-10-25
ATE510849T1 (de) 2011-06-15
EP1973937A1 (de) 2008-10-01
WO2007080622A8 (en) 2009-07-23
WO2007080622A3 (en) 2007-09-27
RU2008132865A (ru) 2010-02-20
US20090286695A1 (en) 2009-11-19
KR20080100420A (ko) 2008-11-18
WO2007080622A2 (en) 2007-07-19
JP2009523025A (ja) 2009-06-18
JP2009523024A (ja) 2009-06-18
IL192484A0 (en) 2009-02-11
EP1973938A2 (de) 2008-10-01
RU2008132859A (ru) 2010-02-20
EP1973938B1 (de) 2011-04-06
IL192445A0 (en) 2008-12-29
AU2007205659A1 (en) 2007-07-19
WO2007080621A1 (en) 2007-07-19

Similar Documents

Publication Publication Date Title
ATE504597T1 (de) Leuchtende stammzellen und ihre verwendung
Li et al. 7-((5-Nitrothiophen-2-yl) methoxy)-3 H-phenoxazin-3-one as a spectroscopic off–on probe for highly sensitive and selective detection of nitroreductase
ATE519757T1 (de) 3 hydroxyflavon-derivate zur erkennung und quantifizierung von zell-apoptosen
HK1114883A1 (en) Skin aging marker and technique for use thereof
CY1120087T1 (el) Συνθεση εξωκυτταριας θεμελιας ουσιας (ecm, extra cellular matrix), πλατφορμα μικροπεριβαλλοντος ογκου και οι μεθοδοι τους
UA116618C2 (uk) СКОНСТРУЙОВАНЕ НА ОСНОВІ ЦИСТЕЇНУ АНТИТІЛО ПРОТИ CD79b
Glas et al. Calcification acidifies the microenvironment of a benthic foraminifer (Ammonia sp.)
MX356756B (es) Células madre pluripotentes en microportadores.
BR112012014925A2 (pt) compostos promotores de replicação de células beta e métodos de uso dos mesmos
WO2007120302A3 (en) Liquid crystalline substrates for culturing cells
EP2588594A4 (de) Verfahren zur kultivierung undifferenzierter zellen mithilfe von zusammensetzungen mit verzögerter freisetzung
CR8547A (es) Composiciones y metodos relacionados con el cultivo de celulas madre neurales con celulas estromales de medula osea
ATE465637T1 (de) Cysteingranulate und ihre verwendung als wachstumsstimulanzien für bifidobaceterium animalis lactis
MX2013006838A (es) Composiciones efervescentes y uso de las mismas.
Gu et al. Effects of pH on the growth and NH4-N uptake of Skeletonema costatum and Nitzschia closterium
DE602005007241D1 (de) 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit
WO2004016766A3 (en) Real time measurement of cellular responses
ATE505539T1 (de) Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahren
MX2010005079A (es) Metodos para medir la viabilidad celular sin usar celulas de control.
AR070933A1 (es) Ensayo basado en fluorescencia para detectar compuestos que modulan el modo inverso del intercambiador de sodio /calcio (ncx)
MX2009008874A (es) Metodos para identificar activadores de cinasa lyn.
WO2006094200A3 (en) Method of obtaining a desired localization for cellular imaging with the use of peptidoconjugates
Zheng et al. Effects of calcium ion concentration on calcification rates of six stony corals: A mesocosm study
WO2006052852A3 (en) Kit for in process quality control to predict and determine engraftment and multilineage reconstitution potential of hematopoietic cells and cord blood storage
EA201200925A1 (ru) Способ определения функционального состояния биологической ткани и применение этого способа для определения ее жизнеспособности и/или степени некротизации

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties