ATE505539T1 - Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahren - Google Patents

Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahren

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Publication number
ATE505539T1
ATE505539T1 AT04787726T AT04787726T ATE505539T1 AT E505539 T1 ATE505539 T1 AT E505539T1 AT 04787726 T AT04787726 T AT 04787726T AT 04787726 T AT04787726 T AT 04787726T AT E505539 T1 ATE505539 T1 AT E505539T1
Authority
AT
Austria
Prior art keywords
neural stem
stem cells
stem cell
methods
proliferation
Prior art date
Application number
AT04787726T
Other languages
English (en)
Inventor
Hideyuki Okano
James H Okano
Masanori Sakaguchi
H Mizusawa
S Ishibashi
Original Assignee
Univ Keio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Keio filed Critical Univ Keio
Application granted granted Critical
Publication of ATE505539T1 publication Critical patent/ATE505539T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/59—Lectins
AT04787726T 2003-09-09 2004-09-08 Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahren ATE505539T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003317379 2003-09-09
PCT/JP2004/013043 WO2005026343A1 (ja) 2003-09-09 2004-09-08 神経幹細胞の生存及び／又は増殖及び神経突起伸張を促進する方法並びに促進剤、神経幹細胞を含む医薬組成物、検定方法、スクリーニング方法

Publications (1)

Publication Number Publication Date
ATE505539T1 true ATE505539T1 (de) 2011-04-15

Family

ID=34308479

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04787726T ATE505539T1 (de) 2003-09-09 2004-09-08 Verfahren zur förderung des überlebens und/oder der proliferation einer neuralen stammzelle und zur förderung der neuritenverlängerung, promotor dafür, die neurale stammzelle enthaltende pharmazeutische zusammensetzung, testverfahren und screening-verfahren

Country Status (6)

Country Link
US (1) US7785596B2 (de)
EP (1) EP1674566B1 (de)
JP (2) JP5099288B2 (de)
AT (1) ATE505539T1 (de)
DE (1) DE602004032248D1 (de)
WO (1) WO2005026343A1 (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4997432B2 (ja) * 2006-02-10 2012-08-08 学校法人慶應義塾 神経幹細胞の増殖抑制剤
JP4925262B2 (ja) * 2006-04-05 2012-04-25 学校法人慶應義塾 シグナル伝達系活性化剤
WO2008036717A2 (en) * 2006-09-19 2008-03-27 Emory University Use of soluble galectin-3 (gal-3) for cancer treatment
AU2007326171B2 (en) 2006-11-30 2012-11-15 Medipost Co., Ltd. Use of a composition contaning human umbilical cord blood-derived mesenchymal stem cell for inducing differentiation and proliferation of neural precursor cells or neural stem cells to neural cells
CA2676323A1 (en) * 2007-01-18 2008-07-24 Suomen Punainen Risti, Veripalvelu Novel methods and reagents directed to production of cells
US20100120142A1 (en) 2008-07-11 2010-05-13 Suomen Punainen Risti Veripalvelu Culture of human embryonic cells
EP2315828B1 (de) * 2008-07-11 2015-07-01 Glykos Finland Oy Verfahren zur Kultivierung von induzierten pluripotenten Stammzellen mit einem Lektin
KR20100054711A (ko) 2008-11-14 2010-05-25 메디포스트(주) 간엽 줄기세포 또는 이의 배양액을 포함하는 신경질환의 예방 또는 치료용 조성물
JP2012029684A (ja) * 2010-06-30 2012-02-16 Cell Aid Kenkyusho:Kk 細胞の製造方法
US9694049B2 (en) * 2011-08-11 2017-07-04 Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The Unitversity Of Nevada, Reno Methods for treating muscular dystrophy
BR112017022715A2 (pt) 2015-04-21 2018-07-17 Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet variante do polipeptídeo gal-1, ácido nucleico, composição farmacêutica, método para modular uma resposta imunológica e método para tratamento de um sujeito
JP2019537432A (ja) 2016-10-04 2019-12-26 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 標的化エフェクタータンパク質およびその使用
US11407797B2 (en) 2017-10-11 2022-08-09 University Of Florida Research Foundation, Incorporated Modified gal-1 proteins and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
EP1122311A4 (de) * 1998-07-31 2002-04-17 Kirin Brewery Heilverfahren der neuropathie, welche als aktiven inhaltsstoff galektin-1 oder seine derivate beinhalten
US6436389B1 (en) * 1998-12-11 2002-08-20 The Salk Institute For Biological Studies Stimulation of cell proliferation by glycosylated cystatin C
EP1302533A4 (de) * 2000-05-16 2004-11-17 Kyowa Hakko Kogyo Kk Neue methode zur induktion der differenzierung von embryonalen stammzellen in ektodermale zellen und deren verwendungen
EP1425297B1 (de) * 2001-04-20 2009-01-07 Children's Hospital Of Orange County Isolierung von nervenstammzellen unter verwendung von gangliosiden und anderen oberflächenmarkern
JP2002325571A (ja) * 2001-04-27 2002-11-12 Purotekku:Kk 網膜の分化誘導方法
JP3566941B2 (ja) * 2001-05-31 2004-09-15 独立行政法人 科学技術振興機構 ＭｕｓａｓｈｉによるＮｕｍｂタンパク質発現抑制剤
CN1458273A (zh) * 2002-01-16 2003-11-26 中国医学科学院中国协和医科大学血液学研究所 人胎儿背根神经节干细胞的分离、制备及应用
US8043853B2 (en) * 2002-08-14 2011-10-25 The Regents Of The University Of Michigan Postnatal gut neural crest stem cells
EP1540348A4 (de) * 2002-08-27 2006-10-11 Stemcells California Inc Angereicherte stammzellen- und vorläuferzellpopulationen des zentralen nervensystems und identifizierungs-, isolierungs- und anreicherungsverfahren für solche populationen

Also Published As

Publication number Publication date
EP1674566B1 (de) 2011-04-13
EP1674566A4 (de) 2007-01-17
JPWO2005026343A1 (ja) 2007-11-08
US7785596B2 (en) 2010-08-31
DE602004032248D1 (de) 2011-05-26
JP5099288B2 (ja) 2012-12-19
US20070098701A1 (en) 2007-05-03
JP2012077092A (ja) 2012-04-19
EP1674566A1 (de) 2006-06-28
WO2005026343A1 (ja) 2005-03-24

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