DE602007012299D1 - Pyridinderivate für die behandlung von stoffwechselstörungen, die mit insulinresistenz oder hyperglykämie in zusammenhang stehen - Google Patents

Pyridinderivate für die behandlung von stoffwechselstörungen, die mit insulinresistenz oder hyperglykämie in zusammenhang stehen

Info

Publication number
DE602007012299D1
DE602007012299D1 DE602007012299T DE602007012299T DE602007012299D1 DE 602007012299 D1 DE602007012299 D1 DE 602007012299D1 DE 602007012299 T DE602007012299 T DE 602007012299T DE 602007012299 T DE602007012299 T DE 602007012299T DE 602007012299 D1 DE602007012299 D1 DE 602007012299D1
Authority
DE
Germany
Prior art keywords
hyperglycemia
treatment
insulin resistance
pyridine derivatives
interactions related
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007012299T
Other languages
English (en)
Inventor
Nabajyoti Deka
Sivaramakrishnan Hariharan
Swapnil Ramesh Bajare
Rosalind Adaikalasamy Marita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Piramal Enterprises Ltd
Original Assignee
PIRAMAL LIVE SCIENCE Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PIRAMAL LIVE SCIENCE Ltd filed Critical PIRAMAL LIVE SCIENCE Ltd
Publication of DE602007012299D1 publication Critical patent/DE602007012299D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
DE602007012299T 2006-09-21 2007-09-20 Pyridinderivate für die behandlung von stoffwechselstörungen, die mit insulinresistenz oder hyperglykämie in zusammenhang stehen Active DE602007012299D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84619406P 2006-09-21 2006-09-21
US87567206P 2006-12-18 2006-12-18
PCT/IB2007/053811 WO2008035305A2 (en) 2006-09-21 2007-09-20 Pyridine derivatives for the treatment of metabolic disorders related to insulin resistance or hyperglycemia

Publications (1)

Publication Number Publication Date
DE602007012299D1 true DE602007012299D1 (de) 2011-03-10

Family

ID=39048032

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007012299T Active DE602007012299D1 (de) 2006-09-21 2007-09-20 Pyridinderivate für die behandlung von stoffwechselstörungen, die mit insulinresistenz oder hyperglykämie in zusammenhang stehen

Country Status (19)

Country Link
US (5) US8030324B2 (de)
EP (2) EP2094663B1 (de)
JP (2) JP2010504321A (de)
KR (2) KR20090074775A (de)
AR (2) AR062940A1 (de)
AT (1) ATE496890T1 (de)
AU (2) AU2007298539B2 (de)
BR (2) BRPI0718510A2 (de)
CA (2) CA2663943A1 (de)
DE (1) DE602007012299D1 (de)
DK (1) DK2094663T3 (de)
IL (2) IL197694A0 (de)
MX (2) MX2009002905A (de)
NZ (2) NZ576197A (de)
PL (1) PL2094663T3 (de)
PT (1) PT2094663E (de)
RU (2) RU2448093C2 (de)
TW (2) TW200820970A (de)
WO (2) WO2008035306A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2567959B1 (de) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamid-derivate als kinaseinhibitoren
WO2013117963A1 (en) 2012-02-09 2013-08-15 Piramal Enterprises Limited Stable oral tablet dosage form of an antidiabetic compound
ES2948192T3 (es) 2013-06-27 2023-09-01 Pfizer Compuestos heteroaromáticos y su uso como ligandos de dopamina D1
WO2014207508A1 (en) * 2013-06-27 2014-12-31 Piramal Enterprises Limited Pyridyl compound suitable for the treatment of metabolic disorders
EA028614B1 (ru) * 2014-05-22 2017-12-29 Общество С Ограниченной Ответственностью "Русские Фармацевтические Технологии" Селективные ингибиторы, нарушающие взаимодействие рецептора фактора роста фибробластов и frs2, для профилактики и лечения рака
EP2974729A1 (de) 2014-07-17 2016-01-20 Abivax Chinolinderivate zur Verwendung bei der Behandlung von Entzündungskrankheiten

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084085A (en) * 1986-08-20 1992-01-28 Fmc Corporation Herbicidal aryloxyphenyltriazolinones and related compounds
UA58494C2 (uk) * 1995-06-07 2003-08-15 Зенека Лімітед Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
US6583157B2 (en) * 1998-01-29 2003-06-24 Tularik Inc. Quinolinyl and benzothiazolyl modulators
CZ20013834A3 (cs) * 1999-04-28 2002-04-17 Aventis Pharma Deutschland Gmbh Deriváty kyselin se třemi arylovými zbytky jako ligandy receptorů PPAR a farmaceutické prostředky, které je obsahují
US7041691B1 (en) * 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
ES2437103T3 (es) * 1999-06-30 2014-01-08 Amgen Inc. Compuestos para la modulacion de la actividad de PPAR gamma
CZ302982B6 (cs) * 2000-06-28 2012-02-01 Amgen Inc. 3-Chinolinylfenylsulfonamidová sloucenina, tato sloucenina pro použití jako lécivo a použití této slouceniny pri výrobe léciva
WO2004111031A1 (en) * 2003-06-12 2004-12-23 Novo Nordisk A/S Pyridinyl carbamates as hormone-sensitive lipase inhibitors
US7223761B2 (en) * 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound
KR100927563B1 (ko) * 2004-08-06 2009-11-23 오쓰까 세이야꾸 가부시키가이샤 방향족 화합물
AU2005291561B2 (en) * 2004-10-04 2010-02-25 F. Hoffmann-La Roche Ag Alkil-pyridines as 11-beta inhibitors for diabetes

Also Published As

Publication number Publication date
US20090247574A1 (en) 2009-10-01
RU2448093C2 (ru) 2012-04-20
WO2008035305A3 (en) 2008-06-12
US8269010B2 (en) 2012-09-18
RU2009114545A (ru) 2010-10-27
AU2007298540B2 (en) 2013-02-21
TW200820970A (en) 2008-05-16
EP2094687A1 (de) 2009-09-02
KR20090074775A (ko) 2009-07-07
JP2010504322A (ja) 2010-02-12
AR062940A1 (es) 2008-12-17
US20110312970A1 (en) 2011-12-22
US20120309786A1 (en) 2012-12-06
BRPI0717106A2 (pt) 2013-10-08
WO2008035305A8 (en) 2009-03-12
NZ576197A (en) 2011-12-22
US8030324B2 (en) 2011-10-04
IL197694A0 (en) 2009-12-24
AU2007298540A1 (en) 2008-03-27
AU2007298539B2 (en) 2013-05-02
RU2009114544A (ru) 2010-10-27
MX2009002906A (es) 2009-06-30
JP2010504321A (ja) 2010-02-12
TW200817364A (en) 2008-04-16
PL2094663T3 (pl) 2011-07-29
US8349862B2 (en) 2013-01-08
DK2094663T3 (da) 2011-04-26
NZ576196A (en) 2011-12-22
PT2094663E (pt) 2011-04-19
CA2663943A1 (en) 2008-03-27
US20130040988A1 (en) 2013-02-14
IL197695A0 (en) 2009-12-24
JP5331953B2 (ja) 2013-10-30
RU2460729C2 (ru) 2012-09-10
MX2009002905A (es) 2009-06-19
WO2008035305A2 (en) 2008-03-27
EP2094663B1 (de) 2011-01-26
WO2008035306A1 (en) 2008-03-27
AU2007298539A1 (en) 2008-03-27
CA2663901A1 (en) 2008-03-27
BRPI0718510A2 (pt) 2013-11-19
EP2094663A2 (de) 2009-09-02
AR062941A1 (es) 2008-12-17
KR20090075827A (ko) 2009-07-09
US20100022554A1 (en) 2010-01-28
ATE496890T1 (de) 2011-02-15

Similar Documents

Publication Publication Date Title
CY1121153T1 (el) Παραγωγα εξενδινης-4 ως διπλοι glp1/gιp- ή τριγωνικοι αγωνιστες glp1/gιp/γλυκαγονης
MX2010004450A (es) Derivados heterociclo biciclicos y su uso como moduladores de la actividad de gpr119.
IL244668A0 (en) Preparations and formulations for the prevention and treatment of diabetes and obesity, and methods for their production and use in the control of glucose and calories
IL219529A (en) Annotated 4-aminocyclohexane history, medications containing them and the use of history to prepare pain medication
MX2009011359A (es) Derivados de pirimidinona y sus metodos de uso.
ATE523508T1 (de) Für die behandlung von zellproliferativen erkrankungen geeignete pyridin- und pyrazinderivate
CR20110485A (es) 2-acetamido-5-aril-1,2,4-triazolonas sustituidas y su uso
WO2009068214A3 (de) Heteroaryl-substituierte piperidine
DK3460644T3 (da) Elektronisk blodsukkermåleanordning
DK2163273T3 (da) Doseringsenhed og ambulant infusionsapparat med doseringsenhed
DE602007012299D1 (de) Pyridinderivate für die behandlung von stoffwechselstörungen, die mit insulinresistenz oder hyperglykämie in zusammenhang stehen
BRPI0923412A2 (pt) método, e, produto de programa de computador.
BR112012001344A2 (pt) derivados de 17hidróxi-17-pentafluoroetil-estra-4,9(10)-dieno-11-arila, método de produção destes e uso destes para o tratamento de doenças
FI20095893L (fi) Kovettuva koostumus, kovettunut tuote sekä laminaatti
PL2254870T3 (pl) Pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób opartych na ekspresji MCP-1, CX3CR1
BRPI1006145A2 (pt) "composição e método para tratamento de diabetes".
IL212707A0 (en) Compounds, pharmaceutical composition and methods for use in treating metabolic disorders
ATE547954T1 (de) Zusammensetzung für die ernährung von säuglingen mit fettgradient
PL2318026T3 (pl) Kompozycja przeznaczona do kontrolowania wzrostu stężenia glukozy we krwi
ZA201006795B (en) Novel opaque modifiers in corn and related methods
DK2158201T3 (da) Derivater af 7-alkynyl-1,8-naphthyridon, fremgangsmåde til fremstilling deraf og anvendelse deraf i terapi
IL207278A0 (en) 1 - benzyl - 3 - hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp - 1, and cx3cr1
BRPI0820955A2 (pt) Método, e, produto de programa de computador
BR112013030171A2 (pt) composição comestível, método para reduzir a amplitude de pico de glicose pós-prandial no sangue ou resposta glicêmica em uma pessoa não diabética, método para tratar uma pessoa com necessidade de tratamento para diabetes do tipo 2 e uso da composição
PT2459207E (pt) Composição farmacêutica para tratamento de condições médicas e um método para tratamento de distúrbios alimentares e doenças relacionadas

Legal Events

Date Code Title Description
R082 Change of representative

Ref document number: 2094663

Country of ref document: EP

Representative=s name: PATENTANWAELTE WALLACH, KOCH & PARTNER, DE

R082 Change of representative

Ref document number: 2094663

Country of ref document: EP

Representative=s name: PATENTANWAELTE WALLACH, KOCH & PARTNER, DE

R081 Change of applicant/patentee

Ref document number: 2094663

Country of ref document: EP

Owner name: PIRAMAL ENTERPRISES LTD., IN

Free format text: FORMER OWNER: PIRAMAL HEALTHCARE LTD., MUMBAI, IN

Effective date: 20121203

R082 Change of representative

Ref document number: 2094663

Country of ref document: EP

Representative=s name: PATENTANWAELTE WALLACH, KOCH & PARTNER, DE

Effective date: 20121203