DE602007010019D1 - Stabile zelllinien und verfahren zur beurteilung der aufnahme von chemikalien im magen-darm-trakt - Google Patents

Stabile zelllinien und verfahren zur beurteilung der aufnahme von chemikalien im magen-darm-trakt

Info

Publication number
DE602007010019D1
DE602007010019D1 DE602007010019T DE602007010019T DE602007010019D1 DE 602007010019 D1 DE602007010019 D1 DE 602007010019D1 DE 602007010019 T DE602007010019 T DE 602007010019T DE 602007010019 T DE602007010019 T DE 602007010019T DE 602007010019 D1 DE602007010019 D1 DE 602007010019D1
Authority
DE
Germany
Prior art keywords
cell lines
chemicals
darm
assessing
stomach
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007010019T
Other languages
English (en)
Inventor
Albert J Owen Iii
Ismael J Hidalgo
Jibin Li
Wei Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Absorption Systems Group LLC
Original Assignee
Absorption Systems Group LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Absorption Systems Group LLC filed Critical Absorption Systems Group LLC
Publication of DE602007010019D1 publication Critical patent/DE602007010019D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/12—Applications; Uses in screening processes in functional genomics, i.e. for the determination of gene function
DE602007010019T 2006-11-10 2007-11-09 Stabile zelllinien und verfahren zur beurteilung der aufnahme von chemikalien im magen-darm-trakt Active DE602007010019D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85793806P 2006-11-10 2006-11-10
US89266507P 2007-03-02 2007-03-02
PCT/US2007/023688 WO2008060489A2 (en) 2006-11-10 2007-11-09 Stable cell lines and methods for evaluating gastrointestinal absorption of chemicals

Publications (1)

Publication Number Publication Date
DE602007010019D1 true DE602007010019D1 (de) 2010-12-02

Family

ID=39402218

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007010019T Active DE602007010019D1 (de) 2006-11-10 2007-11-09 Stabile zelllinien und verfahren zur beurteilung der aufnahme von chemikalien im magen-darm-trakt

Country Status (10)

Country Link
US (4) US7795019B2 (de)
EP (1) EP2084529B1 (de)
JP (3) JP5324456B2 (de)
AT (1) ATE485512T1 (de)
CA (1) CA2669013C (de)
DE (1) DE602007010019D1 (de)
DK (1) DK2084529T3 (de)
PA (1) PA8755401A1 (de)
SI (1) SI2084529T1 (de)
WO (1) WO2008060489A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100047907A1 (en) * 2008-08-19 2010-02-25 Absorption System Group LLC Methods of transporting epithelial cell monolayers
EP2659404B1 (de) * 2010-12-29 2018-08-08 Sigma-Aldrich Co., LLC Zellen mit gestörter expression von in adme und toxikologieverfahren involvierten proteinen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU217108B (hu) * 1994-08-31 1999-11-29 SOLVO Biotechnológiai Kft. Eljárás daganatok multidrogrezisztenciáját okozó fehérje aktivitásának in vitro mennyiségi kimutatására biológiai mintákban
US7601494B2 (en) * 1999-03-17 2009-10-13 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
US20050048468A1 (en) * 2003-08-27 2005-03-03 Bio-Rad Laboratories, Inc. Multiconstituent liquid lgG and IgM calibrators
US20070270488A1 (en) * 2004-03-12 2007-11-22 The Queen's University Of Belfast Treatment and Assays
NZ553910A (en) * 2004-08-26 2009-05-31 Engeneic Molecular Delivery Pty Delivering functional nucleic acids to mammalian cells via bacterially derived, intact minicells

Also Published As

Publication number Publication date
US20100317049A1 (en) 2010-12-16
WO2008060489A3 (en) 2008-10-30
US8105828B2 (en) 2012-01-31
JP2013240341A (ja) 2013-12-05
WO2008060489A2 (en) 2008-05-22
US8110398B2 (en) 2012-02-07
EP2084529B1 (de) 2010-10-20
JP2013240340A (ja) 2013-12-05
US20080124734A1 (en) 2008-05-29
CA2669013C (en) 2015-04-14
US7795019B2 (en) 2010-09-14
US20100311082A1 (en) 2010-12-09
US20120142008A1 (en) 2012-06-07
ATE485512T1 (de) 2010-11-15
WO2008060489A9 (en) 2009-06-18
EP2084529A2 (de) 2009-08-05
CA2669013A1 (en) 2008-05-22
DK2084529T3 (da) 2011-02-07
PA8755401A1 (es) 2009-07-23
SI2084529T1 (sl) 2011-02-28
JP2010508849A (ja) 2010-03-25
JP5324456B2 (ja) 2013-10-23

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