PA8755401A1 - Lineas celulares estables y metodos para evaluar la absorcion gastrointestinal de quimicos - Google Patents

Lineas celulares estables y metodos para evaluar la absorcion gastrointestinal de quimicos

Info

Publication number
PA8755401A1
PA8755401A1 PA20078755401A PA8755401A PA8755401A1 PA 8755401 A1 PA8755401 A1 PA 8755401A1 PA 20078755401 A PA20078755401 A PA 20078755401A PA 8755401 A PA8755401 A PA 8755401A PA 8755401 A1 PA8755401 A1 PA 8755401A1
Authority
PA
Panama
Prior art keywords
methods
chemical absorption
cellular lines
stable cellular
gastrointestinal
Prior art date
Application number
PA20078755401A
Other languages
English (en)
Inventor
J Owen Albert Iii
J Hidalgo Ismael
Li Jibin
Zhang Wei
Original Assignee
Absorption Systems Group Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Absorption Systems Group Llc filed Critical Absorption Systems Group Llc
Publication of PA8755401A1 publication Critical patent/PA8755401A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/12—Applications; Uses in screening processes in functional genomics, i.e. for the determination of gene function

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

SE PROPORCIONAN ACIDOS NUCLEICOS Y VECTORES PARA INTERFERIR CON LA EXPRESION DE PROTEINAS TRANSPORTADORAS DE FLUJO A TRAVES DE MEMBRANA EN CELULAS QUE EXPRESAN DICHAS PROTEINAS. SE PROPORCIONAN TAMBIEN CELULAS Y LINEAS CELULARES QUE COMPRENDEN DICHOS ACIDOS NUCLEICOS Y VECTORES. ASIMISMO SE PROPORCIONAN METODOS PARA MONITOREAR QUIMICOS Y BIOMOLECULARES PARA LA ABSORCION GASTROINTESTINAL EN ANIMALES Y EQUIPOS PARA PRACTICAR DICHOS METODOS.
PA20078755401A 2006-11-10 2007-11-12 Lineas celulares estables y metodos para evaluar la absorcion gastrointestinal de quimicos PA8755401A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85793806P 2006-11-10 2006-11-10
US89266507P 2007-03-02 2007-03-02

Publications (1)

Publication Number Publication Date
PA8755401A1 true PA8755401A1 (es) 2009-07-23

Family

ID=39402218

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20078755401A PA8755401A1 (es) 2006-11-10 2007-11-12 Lineas celulares estables y metodos para evaluar la absorcion gastrointestinal de quimicos

Country Status (10)

Country Link
US (4) US7795019B2 (es)
EP (1) EP2084529B1 (es)
JP (3) JP5324456B2 (es)
AT (1) ATE485512T1 (es)
CA (1) CA2669013C (es)
DE (1) DE602007010019D1 (es)
DK (1) DK2084529T3 (es)
PA (1) PA8755401A1 (es)
SI (1) SI2084529T1 (es)
WO (1) WO2008060489A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010022151A1 (en) * 2008-08-19 2010-02-25 Absorption Systems Group Llc Methods of transporting epithelial cell monolayers
EP2659404B1 (en) * 2010-12-29 2018-08-08 Sigma-Aldrich Co., LLC Cells having disrupted expression of proteins involved in adme and toxicology processes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU217108B (hu) 1994-08-31 1999-11-29 SOLVO Biotechnológiai Kft. Eljárás daganatok multidrogrezisztenciáját okozó fehérje aktivitásának in vitro mennyiségi kimutatására biológiai mintákban
US7601494B2 (en) * 1999-03-17 2009-10-13 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
US20050048468A1 (en) * 2003-08-27 2005-03-03 Bio-Rad Laboratories, Inc. Multiconstituent liquid lgG and IgM calibrators
EP1723259A2 (en) * 2004-03-12 2006-11-22 The Queens University of Belfast Cancer treatment and assays for determiming resistance to platinum-based chemotherapeutic agent
WO2006021894A2 (en) * 2004-08-26 2006-03-02 Engeneic Gene Therapy Pty Limited Delivering functional nucleic acids to mammalian cells via bacterially derived, intact minicells

Also Published As

Publication number Publication date
EP2084529A2 (en) 2009-08-05
WO2008060489A9 (en) 2009-06-18
JP2010508849A (ja) 2010-03-25
EP2084529B1 (en) 2010-10-20
US8105828B2 (en) 2012-01-31
US20100317049A1 (en) 2010-12-16
SI2084529T1 (sl) 2011-02-28
CA2669013A1 (en) 2008-05-22
DE602007010019D1 (de) 2010-12-02
JP2013240341A (ja) 2013-12-05
DK2084529T3 (da) 2011-02-07
US20100311082A1 (en) 2010-12-09
WO2008060489A2 (en) 2008-05-22
JP5324456B2 (ja) 2013-10-23
US20080124734A1 (en) 2008-05-29
WO2008060489A3 (en) 2008-10-30
JP2013240340A (ja) 2013-12-05
US20120142008A1 (en) 2012-06-07
ATE485512T1 (de) 2010-11-15
US8110398B2 (en) 2012-02-07
CA2669013C (en) 2015-04-14
US7795019B2 (en) 2010-09-14

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