DE602007008748D1 - Fluorierte catharanthinderivate, ihre herstellung und ihre verwendung als dimere vorstufen für vincaalkaloide - Google Patents

Fluorierte catharanthinderivate, ihre herstellung und ihre verwendung als dimere vorstufen für vincaalkaloide

Info

Publication number
DE602007008748D1
DE602007008748D1 DE602007008748T DE602007008748T DE602007008748D1 DE 602007008748 D1 DE602007008748 D1 DE 602007008748D1 DE 602007008748 T DE602007008748 T DE 602007008748T DE 602007008748 T DE602007008748 T DE 602007008748T DE 602007008748 D1 DE602007008748 D1 DE 602007008748D1
Authority
DE
Germany
Prior art keywords
vincalal
dimere
fluorated
previews
alkaloids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007008748T
Other languages
English (en)
Inventor
Lionel Moisan
Sebastien Comesse
Emerson Giovanelli
Bernard Rousseau
Eric Doris
Paul Hellier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Pierre Fabre Medicament SA
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA, Pierre Fabre Medicament SA, Commissariat a lEnergie Atomique et aux Energies Alternatives CEA filed Critical Commissariat a lEnergie Atomique CEA
Publication of DE602007008748D1 publication Critical patent/DE602007008748D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
DE602007008748T 2006-09-20 2007-09-20 Fluorierte catharanthinderivate, ihre herstellung und ihre verwendung als dimere vorstufen für vincaalkaloide Active DE602007008748D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82624506P 2006-09-20 2006-09-20
FR0608226A FR2905949B1 (fr) 2006-09-20 2006-09-20 Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca
PCT/EP2007/059991 WO2008034882A1 (en) 2006-09-20 2007-09-20 Fluorinated catharanthine derivatives, their preparation and their utilisation as vinca dimeric alkaloid precursors

Publications (1)

Publication Number Publication Date
DE602007008748D1 true DE602007008748D1 (de) 2010-10-07

Family

ID=37982436

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007008748T Active DE602007008748D1 (de) 2006-09-20 2007-09-20 Fluorierte catharanthinderivate, ihre herstellung und ihre verwendung als dimere vorstufen für vincaalkaloide

Country Status (22)

Country Link
US (1) US8101748B2 (de)
EP (1) EP2078017B9 (de)
JP (1) JP5280364B2 (de)
KR (1) KR20090063256A (de)
CN (1) CN101522679B (de)
AT (1) ATE478871T1 (de)
AU (1) AU2007298920B2 (de)
BR (1) BRPI0717063A2 (de)
CA (1) CA2664040A1 (de)
DE (1) DE602007008748D1 (de)
ES (1) ES2349387T3 (de)
FR (1) FR2905949B1 (de)
IL (1) IL197640A (de)
MA (1) MA31134B1 (de)
MX (1) MX2009003121A (de)
NO (1) NO20091491L (de)
NZ (1) NZ575884A (de)
PL (1) PL2078017T3 (de)
PT (1) PT2078017E (de)
RU (1) RU2448957C2 (de)
TN (1) TN2009000097A1 (de)
WO (1) WO2008034882A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5542972B2 (ja) * 2010-02-22 2014-07-09 ザ スクリプス リサーチ インスティテュート Ｍｄｒがん細胞に対する強化された生物活性を提供する１０’−フッ素化ビンカアルカロイド
EP2987794B1 (de) * 2013-04-19 2018-05-30 Jinan University Vinblastinderivate, herstellungsverfahren dafür und anwendung davon
CN105503907B (zh) * 2016-01-18 2018-01-09 北京大学 对映选择性合成Vinca类生物碱的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU180924B (en) * 1977-05-20 1983-05-30 Richter Gedeon Vegyeszet Process for producing leurosine-type alkaloides
FR2632643B1 (fr) * 1988-06-10 1990-09-07 Adir Nouveau procede de preparation de derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique
JPH0341081A (ja) * 1989-07-10 1991-02-21 Mitsui Petrochem Ind Ltd 二量体アルカロイド類の製造方法
FR2707988B1 (fr) * 1993-07-21 1995-10-13 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca
FR2779146B1 (fr) * 1998-06-02 2002-01-18 Roowin Nouveaux derives de vinca-alcaloides et procedes de preparation
CN1218950C (zh) * 2004-02-18 2005-09-14 东北林业大学 一种长春碱的生产方法

Also Published As

Publication number Publication date
MA31134B1 (fr) 2010-02-01
CA2664040A1 (en) 2008-03-27
RU2448957C2 (ru) 2012-04-27
PT2078017E (pt) 2010-11-09
TN2009000097A1 (en) 2010-08-19
NO20091491L (no) 2009-05-13
RU2009113535A (ru) 2010-10-27
EP2078017B1 (de) 2010-08-25
AU2007298920B2 (en) 2012-03-08
JP5280364B2 (ja) 2013-09-04
IL197640A0 (en) 2009-12-24
MX2009003121A (es) 2009-07-31
FR2905949A1 (fr) 2008-03-21
KR20090063256A (ko) 2009-06-17
AU2007298920A1 (en) 2008-03-27
BRPI0717063A2 (pt) 2013-10-15
CN101522679A (zh) 2009-09-02
IL197640A (en) 2013-03-24
EP2078017B9 (de) 2011-09-07
ATE478871T1 (de) 2010-09-15
JP2010504303A (ja) 2010-02-12
WO2008034882A1 (en) 2008-03-27
US8101748B2 (en) 2012-01-24
PL2078017T3 (pl) 2011-02-28
NZ575884A (en) 2011-09-30
EP2078017A1 (de) 2009-07-15
ES2349387T3 (es) 2010-12-30
CN101522679B (zh) 2013-12-18
FR2905949B1 (fr) 2008-11-21
US20100093997A1 (en) 2010-04-15

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