DE602006008291D1 - Chinazolinderivate als inhibitoren von egf und/oder erbb2-rezeptortyrosinkinase - Google Patents
Chinazolinderivate als inhibitoren von egf und/oder erbb2-rezeptortyrosinkinaseInfo
- Publication number
- DE602006008291D1 DE602006008291D1 DE602006008291T DE602006008291T DE602006008291D1 DE 602006008291 D1 DE602006008291 D1 DE 602006008291D1 DE 602006008291 T DE602006008291 T DE 602006008291T DE 602006008291 T DE602006008291 T DE 602006008291T DE 602006008291 D1 DE602006008291 D1 DE 602006008291D1
- Authority
- DE
- Germany
- Prior art keywords
- kinase
- receptortosrosine
- erbb2
- egf
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0508717.6A GB0508717D0 (en) | 2005-04-29 | 2005-04-29 | Chemical compounds |
PCT/GB2006/001560 WO2006117521A1 (en) | 2005-04-29 | 2006-04-27 | Quinazoline derivatives as inhibitors of egf and/or erbb2 receptor tyrosine kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006008291D1 true DE602006008291D1 (de) | 2009-09-17 |
Family
ID=34674049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006008291T Expired - Fee Related DE602006008291D1 (de) | 2005-04-29 | 2006-04-27 | Chinazolinderivate als inhibitoren von egf und/oder erbb2-rezeptortyrosinkinase |
Country Status (9)
Country | Link |
---|---|
US (1) | US20090023759A1 (de) |
EP (1) | EP1877397B1 (de) |
JP (1) | JP2008539216A (de) |
CN (1) | CN101208332A (de) |
AT (1) | ATE438641T1 (de) |
DE (1) | DE602006008291D1 (de) |
ES (1) | ES2329076T3 (de) |
GB (1) | GB0508717D0 (de) |
WO (1) | WO2006117521A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0322409D0 (en) * | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
ATE501148T1 (de) * | 2004-12-14 | 2011-03-15 | Astrazeneca Ab | Pyrazolopyrimidinverbindungen als antitumormittel |
US20120122928A1 (en) | 2010-08-11 | 2012-05-17 | Bayer Cropscience Ag | Heteroarylpiperidine and -Piperazine Derivatives as Fungicides |
US8759527B2 (en) | 2010-08-25 | 2014-06-24 | Bayer Cropscience Ag | Heteroarylpiperidine and -piperazine derivatives as fungicides |
EP2423210A1 (de) | 2010-08-25 | 2012-02-29 | Bayer CropScience AG | Heteroarylpiperidin- und -piperazinderivate als Fungizide |
CN103492379B (zh) | 2010-10-27 | 2018-06-15 | 拜耳知识产权有限责任公司 | 作为杀真菌剂的杂芳基哌啶和杂芳基哌嗪衍生物 |
CN103492380A (zh) | 2011-02-01 | 2014-01-01 | 拜耳知识产权有限责任公司 | 作为杀真菌剂的杂芳基哌啶和杂芳基哌嗪衍生物 |
BR112014005989B1 (pt) | 2011-09-15 | 2019-11-05 | Bayer Ip Gmbh | compostos fungicidas piperidina-pirazoles, seus usos, método e composição para controlar fungos fitopatogênicos prejudiciais, e método para produzir composições |
EP2921485B1 (de) | 2011-12-27 | 2018-07-18 | Bayer CropScience AG | Isoxazolderivate |
WO2015056782A1 (ja) * | 2013-10-17 | 2015-04-23 | 塩野義製薬株式会社 | 新規アルキレン誘導体 |
FR3080620B1 (fr) * | 2018-04-27 | 2021-11-12 | Univ Paris Sud | Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices |
CN111777599A (zh) * | 2019-04-03 | 2020-10-16 | 药雅科技(上海)有限公司 | 一种喹唑啉、吡啶并嘧啶或双并嘧啶双芳香环衍生物egfr抑制剂及其制备方法与用途 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5538325A (en) * | 1978-09-11 | 1980-03-17 | Sankyo Co Ltd | 4-anilinoquinazoline derivative and its preparation |
US4335127A (en) * | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
GB2160201B (en) * | 1984-06-14 | 1988-05-11 | Wyeth John & Brother Ltd | Quinazoline and cinnoline derivatives |
US4921863A (en) * | 1988-02-17 | 1990-05-01 | Eisai Co., Ltd. | Cyclic amine derivatives |
CA1340821C (en) * | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
US5721237A (en) * | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
US5747498A (en) * | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
US6046206A (en) * | 1995-06-07 | 2000-04-04 | Cell Pathways, Inc. | Method of treating a patient having a precancerous lesions with amide quinazoline derivatives |
GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
ID18666A (id) * | 1996-01-31 | 1998-04-30 | Gist Brocades Bv | Penggunaan komposisi komposisi yang terdiri dari senyawa senyawa stabil yang efektif secara biologi |
US6004967A (en) * | 1996-09-13 | 1999-12-21 | Sugen, Inc. | Psoriasis treatment with quinazoline compounds |
US5929080A (en) * | 1997-05-06 | 1999-07-27 | American Cyanamid Company | Method of treating polycystic kidney disease |
US6384223B1 (en) * | 1998-07-30 | 2002-05-07 | American Home Products Corporation | Substituted quinazoline derivatives |
US6297258B1 (en) * | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
UA71945C2 (en) * | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
HUP0301132A3 (en) * | 1999-02-27 | 2004-03-29 | Boehringer Ingelheim Pharma | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases, process for their preparation their use and pharmaceutical compositions containing them |
US6080747A (en) * | 1999-03-05 | 2000-06-27 | Hughes Institute | JAK-3 inhibitors for treating allergic disorders |
US20020082270A1 (en) * | 2000-08-26 | 2002-06-27 | Frank Himmelsbach | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
US6562319B2 (en) * | 2001-03-12 | 2003-05-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy |
JPWO2002094790A1 (ja) * | 2001-05-23 | 2004-09-09 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
GB0126433D0 (en) * | 2001-11-03 | 2002-01-02 | Astrazeneca Ab | Compounds |
MXPA04004219A (es) * | 2001-11-03 | 2004-09-10 | Astrazeneca Ab | Derivados de quinazolina como agentes antitumorales. |
TWI324597B (en) * | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
US6924285B2 (en) * | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
GB0309009D0 (en) * | 2003-04-22 | 2003-05-28 | Astrazeneca Ab | Quinazoline derivatives |
GB0309850D0 (en) * | 2003-04-30 | 2003-06-04 | Astrazeneca Ab | Quinazoline derivatives |
AU2004261477A1 (en) * | 2003-07-29 | 2005-02-10 | Astrazeneca Ab | Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors |
GB0317665D0 (en) * | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
CN1882573A (zh) * | 2003-09-16 | 2006-12-20 | 阿斯利康(瑞典)有限公司 | 作为酪氨酸激酶抑制剂的喹唑啉衍生物 |
GB0321648D0 (en) * | 2003-09-16 | 2003-10-15 | Astrazeneca Ab | Quinazoline derivatives |
DE602004013806D1 (en) * | 2003-09-16 | 2008-06-26 | Astrazeneca Ab | Chinazolinderivate als tyrosinkinaseinhibitoren |
ES2328696T3 (es) * | 2003-09-16 | 2009-11-17 | Astrazeneca Ab | Derivados de quinazolina. |
CN1882570B (zh) * | 2003-09-19 | 2010-12-08 | 阿斯利康(瑞典)有限公司 | 喹唑啉衍生物 |
GB0322409D0 (en) * | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
JP2007506716A (ja) * | 2003-09-25 | 2007-03-22 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
GB0326459D0 (en) * | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
CN1914182B (zh) * | 2004-02-03 | 2011-09-07 | 阿斯利康(瑞典)有限公司 | 喹唑啉衍生物 |
KR20070038500A (ko) * | 2004-06-04 | 2007-04-10 | 아스트라제네카 아베 | erbB 수용체 타이로신 키나제로서의 퀴나졸린 유도체 |
-
2005
- 2005-04-29 GB GBGB0508717.6A patent/GB0508717D0/en not_active Ceased
-
2006
- 2006-04-27 ES ES06726940T patent/ES2329076T3/es active Active
- 2006-04-27 JP JP2008508301A patent/JP2008539216A/ja active Pending
- 2006-04-27 EP EP06726940A patent/EP1877397B1/de not_active Not-in-force
- 2006-04-27 CN CNA2006800233541A patent/CN101208332A/zh active Pending
- 2006-04-27 DE DE602006008291T patent/DE602006008291D1/de not_active Expired - Fee Related
- 2006-04-27 US US11/912,794 patent/US20090023759A1/en not_active Abandoned
- 2006-04-27 WO PCT/GB2006/001560 patent/WO2006117521A1/en active Application Filing
- 2006-04-27 AT AT06726940T patent/ATE438641T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2329076T3 (es) | 2009-11-20 |
WO2006117521A1 (en) | 2006-11-09 |
EP1877397A1 (de) | 2008-01-16 |
CN101208332A (zh) | 2008-06-25 |
JP2008539216A (ja) | 2008-11-13 |
GB0508717D0 (en) | 2005-06-08 |
EP1877397B1 (de) | 2009-08-05 |
US20090023759A1 (en) | 2009-01-22 |
ATE438641T1 (de) | 2009-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |