ATE438641T1 - Chinazolinderivate als inhibitoren von egf und/oder erbb2-rezeptortyrosinkinase - Google Patents

Chinazolinderivate als inhibitoren von egf und/oder erbb2-rezeptortyrosinkinase

Info

Publication number
ATE438641T1
ATE438641T1 AT06726940T AT06726940T ATE438641T1 AT E438641 T1 ATE438641 T1 AT E438641T1 AT 06726940 T AT06726940 T AT 06726940T AT 06726940 T AT06726940 T AT 06726940T AT E438641 T1 ATE438641 T1 AT E438641T1
Authority
AT
Austria
Prior art keywords
tyrosine kinase
receptor tyrosine
egf
inhibitors
erbb2 receptor
Prior art date
Application number
AT06726940T
Other languages
English (en)
Inventor
Robert Hugh Bradbury
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE438641T1 publication Critical patent/ATE438641T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06726940T 2005-04-29 2006-04-27 Chinazolinderivate als inhibitoren von egf und/oder erbb2-rezeptortyrosinkinase ATE438641T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0508717.6A GB0508717D0 (en) 2005-04-29 2005-04-29 Chemical compounds
PCT/GB2006/001560 WO2006117521A1 (en) 2005-04-29 2006-04-27 Quinazoline derivatives as inhibitors of egf and/or erbb2 receptor tyrosine kinase

Publications (1)

Publication Number Publication Date
ATE438641T1 true ATE438641T1 (de) 2009-08-15

Family

ID=34674049

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06726940T ATE438641T1 (de) 2005-04-29 2006-04-27 Chinazolinderivate als inhibitoren von egf und/oder erbb2-rezeptortyrosinkinase

Country Status (9)

Country Link
US (1) US20090023759A1 (de)
EP (1) EP1877397B1 (de)
JP (1) JP2008539216A (de)
CN (1) CN101208332A (de)
AT (1) ATE438641T1 (de)
DE (1) DE602006008291D1 (de)
ES (1) ES2329076T3 (de)
GB (1) GB0508717D0 (de)
WO (1) WO2006117521A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005026150A1 (en) 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
GB0326459D0 (en) 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
ES2315834T3 (es) 2004-02-03 2009-04-01 Astrazeneca Ab Derivados de quinazolina.
DE602005026865D1 (de) * 2004-12-14 2011-04-21 Astrazeneca Ab Pyrazolopyrimidinverbindungen als antitumormittel
US20120122928A1 (en) 2010-08-11 2012-05-17 Bayer Cropscience Ag Heteroarylpiperidine and -Piperazine Derivatives as Fungicides
US8759527B2 (en) 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
EP2423210A1 (de) 2010-08-25 2012-02-29 Bayer CropScience AG Heteroarylpiperidin- und -piperazinderivate als Fungizide
EP2632922B1 (de) 2010-10-27 2019-02-27 Bayer CropScience Aktiengesellschaft Heteroarylpiperidin und -piperazinderivate als fungizide
WO2012104273A1 (de) 2011-02-01 2012-08-09 Bayer Cropscience Ag Heteroarylpiperidin und -piperazinderivate als fungizide
BR112014005989B1 (pt) 2011-09-15 2019-11-05 Bayer Ip Gmbh compostos fungicidas piperidina-pirazoles, seus usos, método e composição para controlar fungos fitopatogênicos prejudiciais, e método para produzir composições
MX388854B (es) 2011-12-27 2025-03-20 Bayer Cropscience Ag Derivados de heteroarilpiperidina y de heteroarilpiperazina como fungicidas.
JPWO2015056782A1 (ja) * 2013-10-17 2017-03-09 塩野義製薬株式会社 新規アルキレン誘導体
FR3080620B1 (fr) * 2018-04-27 2021-11-12 Univ Paris Sud Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices
CN111777599A (zh) * 2019-04-03 2020-10-16 药雅科技(上海)有限公司 一种喹唑啉、吡啶并嘧啶或双并嘧啶双芳香环衍生物egfr抑制剂及其制备方法与用途

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JPS5538325A (en) * 1978-09-11 1980-03-17 Sankyo Co Ltd 4-anilinoquinazoline derivative and its preparation
US4335127A (en) * 1979-01-08 1982-06-15 Janssen Pharmaceutica, N.V. Piperidinylalkyl quinazoline compounds, composition and method of use
GB2160201B (en) * 1984-06-14 1988-05-11 Wyeth John & Brother Ltd Quinazoline and cinnoline derivatives
US4921863A (en) * 1988-02-17 1990-05-01 Eisai Co., Ltd. Cyclic amine derivatives
CA1340821C (en) * 1988-10-06 1999-11-16 Nobuyuki Fukazawa Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components
US5721237A (en) * 1991-05-10 1998-02-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US6046206A (en) * 1995-06-07 2000-04-04 Cell Pathways, Inc. Method of treating a patient having a precancerous lesions with amide quinazoline derivatives
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
JPH11503465A (ja) * 1996-01-31 1999-03-26 ギスト ブロカデス ベスローテン フェンノートシャップ 安定化された生物学的に有効な化合物を含む組成物の使用
US6004967A (en) * 1996-09-13 1999-12-21 Sugen, Inc. Psoriasis treatment with quinazoline compounds
US5929080A (en) * 1997-05-06 1999-07-27 American Cyanamid Company Method of treating polycystic kidney disease
US6384223B1 (en) * 1998-07-30 2002-05-07 American Home Products Corporation Substituted quinazoline derivatives
US6297258B1 (en) * 1998-09-29 2001-10-02 American Cyanamid Company Substituted 3-cyanoquinolines
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
EE200100449A (et) * 1999-02-27 2002-12-16 Boehringer Ingelheim Pharma Kg 4-aminokinasoliini ja kinoliini derivaadid inhibeeriva toimega türosiinkinaaside vahendatud signaali ülekandele
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US20020082270A1 (en) * 2000-08-26 2002-06-27 Frank Himmelsbach Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases
US6562319B2 (en) * 2001-03-12 2003-05-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy
WO2002094790A1 (en) * 2001-05-23 2002-11-28 Mitsubishi Pharma Corporation Fused heterocyclic compound and medicinal use thereof
GB0126433D0 (en) * 2001-11-03 2002-01-02 Astrazeneca Ab Compounds
DE60231230D1 (de) * 2001-11-03 2009-04-02 Astrazeneca Ab Quinazolin derivate als antitumor-mittel
TW200813014A (en) * 2002-03-28 2008-03-16 Astrazeneca Ab Quinazoline derivatives
US6924285B2 (en) * 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
GB0309009D0 (en) * 2003-04-22 2003-05-28 Astrazeneca Ab Quinazoline derivatives
GB0309850D0 (en) * 2003-04-30 2003-06-04 Astrazeneca Ab Quinazoline derivatives
WO2005012290A1 (en) * 2003-07-29 2005-02-10 Astrazeneca Ab Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors
GB0317665D0 (en) * 2003-07-29 2003-09-03 Astrazeneca Ab Qinazoline derivatives
CA2539049A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives
WO2005026150A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
AU2004272350A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
GB0321648D0 (en) * 2003-09-16 2003-10-15 Astrazeneca Ab Quinazoline derivatives
ATE353888T1 (de) * 2003-09-19 2007-03-15 Astrazeneca Ab Chinazolinderivate
KR20060100388A (ko) * 2003-09-25 2006-09-20 아스트라제네카 아베 퀴나졸린 유도체
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
GB0326459D0 (en) * 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
ES2315834T3 (es) * 2004-02-03 2009-04-01 Astrazeneca Ab Derivados de quinazolina.
AU2005250224A1 (en) * 2004-06-04 2005-12-15 Astrazeneca Ab Quinazoline derivatives as ERBB receptor tyrosine kinases

Also Published As

Publication number Publication date
GB0508717D0 (en) 2005-06-08
CN101208332A (zh) 2008-06-25
JP2008539216A (ja) 2008-11-13
WO2006117521A1 (en) 2006-11-09
ES2329076T3 (es) 2009-11-20
DE602006008291D1 (de) 2009-09-17
EP1877397A1 (de) 2008-01-16
EP1877397B1 (de) 2009-08-05
US20090023759A1 (en) 2009-01-22

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