DE602005024612D1 - Verfahren zur herstellung von hochreinem meloxicam und meloxicam-kaliumsalz - Google Patents

Verfahren zur herstellung von hochreinem meloxicam und meloxicam-kaliumsalz

Info

Publication number
DE602005024612D1
DE602005024612D1 DE602005024612T DE602005024612T DE602005024612D1 DE 602005024612 D1 DE602005024612 D1 DE 602005024612D1 DE 602005024612 T DE602005024612 T DE 602005024612T DE 602005024612 T DE602005024612 T DE 602005024612T DE 602005024612 D1 DE602005024612 D1 DE 602005024612D1
Authority
DE
Germany
Prior art keywords
meloxicam
purity
production
kalium salt
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602005024612T
Other languages
German (de)
English (en)
Inventor
Tibor Mezei
Gyula Simig
Eniko Molnar
Gyula Lukacs
Marta Porcs-Makkay
Balazs Volk
Fekete Valeria Hofmanne
Kalman Nagy
Norbert Mesterhazy
Gyoergy Krasznai
Donath Gyoergyi Vereczkeyne
Gyulane Koertvelyessy
Eva Pecsi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of DE602005024612D1 publication Critical patent/DE602005024612D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
DE602005024612T 2004-12-18 2005-12-16 Verfahren zur herstellung von hochreinem meloxicam und meloxicam-kaliumsalz Expired - Lifetime DE602005024612D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0402634A HU227359B1 (en) 2004-12-18 2004-12-18 Process for producing meloxicam and meloxicam potassium salt of high purity
PCT/HU2005/000136 WO2006064298A1 (en) 2004-12-18 2005-12-16 Process for preparation of high-purity meloxicam and meloxicam potassium salt

Publications (1)

Publication Number Publication Date
DE602005024612D1 true DE602005024612D1 (de) 2010-12-16

Family

ID=89985699

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005024612T Expired - Lifetime DE602005024612D1 (de) 2004-12-18 2005-12-16 Verfahren zur herstellung von hochreinem meloxicam und meloxicam-kaliumsalz

Country Status (22)

Country Link
US (2) US8097616B2 (https=)
EP (1) EP1828178B1 (https=)
JP (1) JP5329812B2 (https=)
CN (1) CN101090900B (https=)
AT (1) ATE486867T1 (https=)
BG (1) BG66118B1 (https=)
CY (1) CY1112714T1 (https=)
CZ (1) CZ2007465A3 (https=)
DE (1) DE602005024612D1 (https=)
DK (1) DK1828178T3 (https=)
EA (1) EA013791B1 (https=)
ES (1) ES2356840T3 (https=)
HU (1) HU227359B1 (https=)
IL (1) IL183739A (https=)
NO (1) NO20073602L (https=)
PL (2) PL1828178T3 (https=)
PT (1) PT1828178E (https=)
RU (1) RU2394032C2 (https=)
SI (1) SI1828178T1 (https=)
SK (1) SK50932007A3 (https=)
UA (1) UA89657C2 (https=)
WO (1) WO2006064298A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2443891B (en) * 2006-11-20 2009-04-08 Norbrook Lab Ltd Process for the purification of meloxicam
EP2470189A4 (en) * 2009-08-27 2013-01-23 Merck Sharp & Dohme METHOD FOR PRODUCING PROTEASE INHIBITORS OF HEPATITIS C VIRUS
RU2465892C1 (ru) * 2011-09-21 2012-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет (НГУ)" Способ получения высокодисперсного мелоксикама
CN103772378B (zh) * 2014-01-26 2016-02-24 悦康药业集团有限公司 一种美洛昔康化合物及其片剂
CN106896162B (zh) * 2015-12-17 2019-10-18 瑞普（天津）生物药业有限公司 一种检测美洛昔康片中杂质的hplc方法
CN117756797A (zh) * 2023-12-12 2024-03-26 江苏飞马药业有限公司 一种美洛昔康的合成工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2756113A1 (de) * 1977-12-16 1979-06-21 Thomae Gmbh Dr K Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
EP0945134A1 (de) 1998-03-27 1999-09-29 Boehringer Ingelheim Pharma KG Neue galenische Zubereitungsformen von Meloxicam zur oralen Applikation
ES2223209B1 (es) 2001-12-11 2005-10-01 Esteve Quimica, S.A. Nuevas formas cristalinas del meloxicam y procedimientos para su preparacion e interconversion.
US8992980B2 (en) 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
ITMI20041918A1 (it) 2004-10-11 2005-01-11 A M S A Anonima Materie Sintetiche Affini Spa Processo di purificazione di meloxicam

Also Published As

Publication number Publication date
HUP0402634A3 (en) 2008-10-28
PL1828178T3 (pl) 2011-07-29
RU2007126723A (ru) 2009-01-27
EA200701256A1 (ru) 2007-12-28
SI1828178T1 (sl) 2011-03-31
EP1828178B1 (en) 2010-11-03
JP2008524197A (ja) 2008-07-10
PL382907A1 (pl) 2008-02-04
US20120035162A1 (en) 2012-02-09
ATE486867T1 (de) 2010-11-15
HU227359B1 (en) 2011-04-28
HUP0402634A2 (en) 2006-11-28
BG66118B1 (bg) 2011-05-31
EA013791B1 (ru) 2010-06-30
PT1828178E (pt) 2011-02-07
IL183739A (en) 2011-12-29
US20090215757A1 (en) 2009-08-27
ES2356840T3 (es) 2011-04-13
CN101090900B (zh) 2013-11-20
JP5329812B2 (ja) 2013-10-30
EP1828178A1 (en) 2007-09-05
RU2394032C2 (ru) 2010-07-10
SK50932007A3 (sk) 2008-03-05
DK1828178T3 (da) 2011-02-14
HK1114848A1 (en) 2008-11-14
US8097616B2 (en) 2012-01-17
HU0402634D0 (en) 2005-02-28
UA89657C2 (ru) 2010-02-25
NO20073602L (no) 2007-09-14
WO2006064298A1 (en) 2006-06-22
IL183739A0 (en) 2007-09-20
CZ2007465A3 (cs) 2007-12-05
CY1112714T1 (el) 2016-02-10
CN101090900A (zh) 2007-12-19
BG109916A (bg) 2008-02-29

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