BG66118B1 - Метод за получаване мелоксикам и калиева сол на мелоксикам с висока чистота - Google Patents

Метод за получаване мелоксикам и калиева сол на мелоксикам с висока чистота

Info

Publication number
BG66118B1
BG66118B1 BG109916A BG10991607A BG66118B1 BG 66118 B1 BG66118 B1 BG 66118B1 BG 109916 A BG109916 A BG 109916A BG 10991607 A BG10991607 A BG 10991607A BG 66118 B1 BG66118 B1 BG 66118B1
Authority
BG
Bulgaria
Prior art keywords
meloxicam
purity
obtaining
potassium salt
potassium
Prior art date
Application number
BG109916A
Other languages
English (en)
Other versions
BG109916A (bg
Inventor
Tibor Mezei
Gyula Simig
Gyula Lukacs
Marta Porcs-Makkay
Balazs Volk
Eniko Molnar
Fekete Valeria Hofmanne
Kalman Nagy
Donath Gyoergyi Vereczkeyne
Norbert Mesterhazy
Gyorgy Krasznai
Gyulane Koertvelyessy
Eva Pecsi
Original Assignee
Egis Gyogyszergyar Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyrt filed Critical Egis Gyogyszergyar Nyrt
Publication of BG109916A publication Critical patent/BG109916A/bg
Publication of BG66118B1 publication Critical patent/BG66118B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретението се отнася до метод за получаването на мелоксикам с формула (II) @с висока чистота. Мелоксикамният суров продукт взаимодейства с разтвор на калиев хидроксид или калиев карбонат, чрез което се произвежда мелоксикамова калиева сол монохидрат с висока чистота. След това посочената сол се обработва с неорганична или органична киселина до получаване на мелоксикам с висока чистота.
BG109916A 2004-12-18 2007-07-18 Метод за получаване мелоксикам и калиева сол на мелоксикам с висока чистота BG66118B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0402634A HU227359B1 (en) 2004-12-18 2004-12-18 Process for producing meloxicam and meloxicam potassium salt of high purity
PCT/HU2005/000136 WO2006064298A1 (en) 2004-12-18 2005-12-16 Process for preparation of high-purity meloxicam and meloxicam potassium salt

Publications (2)

Publication Number Publication Date
BG109916A BG109916A (bg) 2008-02-29
BG66118B1 true BG66118B1 (bg) 2011-05-31

Family

ID=89985699

Family Applications (1)

Application Number Title Priority Date Filing Date
BG109916A BG66118B1 (bg) 2004-12-18 2007-07-18 Метод за получаване мелоксикам и калиева сол на мелоксикам с висока чистота

Country Status (23)

Country Link
US (2) US8097616B2 (bg)
EP (1) EP1828178B1 (bg)
JP (1) JP5329812B2 (bg)
CN (1) CN101090900B (bg)
AT (1) ATE486867T1 (bg)
BG (1) BG66118B1 (bg)
CY (1) CY1112714T1 (bg)
CZ (1) CZ2007465A3 (bg)
DE (1) DE602005024612D1 (bg)
DK (1) DK1828178T3 (bg)
EA (1) EA013791B1 (bg)
ES (1) ES2356840T3 (bg)
HK (1) HK1114848A1 (bg)
HU (1) HU227359B1 (bg)
IL (1) IL183739A (bg)
NO (1) NO20073602L (bg)
PL (2) PL1828178T3 (bg)
PT (1) PT1828178E (bg)
RU (1) RU2394032C2 (bg)
SI (1) SI1828178T1 (bg)
SK (1) SK50932007A3 (bg)
UA (1) UA89657C2 (bg)
WO (1) WO2006064298A1 (bg)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2443891B (en) * 2006-11-20 2009-04-08 Norbrook Lab Ltd Process for the purification of meloxicam
WO2011025849A1 (en) * 2009-08-27 2011-03-03 Merck Sharp & Dohme Corp. Processes for preparing protease inhibitors of hepatitis c virus
RU2465892C1 (ru) * 2011-09-21 2012-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет (НГУ)" Способ получения высокодисперсного мелоксикама
CN103772378B (zh) * 2014-01-26 2016-02-24 悦康药业集团有限公司 一种美洛昔康化合物及其片剂
CN106896162B (zh) * 2015-12-17 2019-10-18 瑞普（天津）生物药业有限公司 一种检测美洛昔康片中杂质的hplc方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002482A1 (de) * 1977-12-16 1979-06-27 Dr. Karl Thomae GmbH 4-Hydroxy-2H-1,2-benzothiazin-3-carboxamid-1,1-dioxide, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0945134A1 (de) * 1998-03-27 1999-09-29 Boehringer Ingelheim Pharma KG Neue galenische Zubereitungsformen von Meloxicam zur oralen Applikation
ES2223209B1 (es) * 2001-12-11 2005-10-01 Esteve Quimica, S.A. Nuevas formas cristalinas del meloxicam y procedimientos para su preparacion e interconversion.
US8992980B2 (en) * 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
ITMI20041918A1 (it) * 2004-10-11 2005-01-11 A M S A Anonima Materie Sintetiche Affini Spa Processo di purificazione di meloxicam

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002482A1 (de) * 1977-12-16 1979-06-27 Dr. Karl Thomae GmbH 4-Hydroxy-2H-1,2-benzothiazin-3-carboxamid-1,1-dioxide, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
JP2008524197A (ja) 2008-07-10
SK50932007A3 (sk) 2008-03-05
US8097616B2 (en) 2012-01-17
IL183739A (en) 2011-12-29
EA013791B1 (ru) 2010-06-30
EP1828178B1 (en) 2010-11-03
PL1828178T3 (pl) 2011-07-29
WO2006064298A1 (en) 2006-06-22
BG109916A (bg) 2008-02-29
RU2007126723A (ru) 2009-01-27
US20120035162A1 (en) 2012-02-09
EP1828178A1 (en) 2007-09-05
ATE486867T1 (de) 2010-11-15
CY1112714T1 (el) 2016-02-10
DE602005024612D1 (de) 2010-12-16
SI1828178T1 (sl) 2011-03-31
PL382907A1 (pl) 2008-02-04
CZ2007465A3 (cs) 2007-12-05
ES2356840T3 (es) 2011-04-13
CN101090900A (zh) 2007-12-19
EA200701256A1 (ru) 2007-12-28
CN101090900B (zh) 2013-11-20
NO20073602L (no) 2007-09-14
HK1114848A1 (en) 2008-11-14
DK1828178T3 (da) 2011-02-14
UA89657C2 (ru) 2010-02-25
HU227359B1 (en) 2011-04-28
IL183739A0 (en) 2007-09-20
US20090215757A1 (en) 2009-08-27
HU0402634D0 (en) 2005-02-28
JP5329812B2 (ja) 2013-10-30
HUP0402634A3 (en) 2008-10-28
RU2394032C2 (ru) 2010-07-10
HUP0402634A2 (en) 2006-11-28
PT1828178E (pt) 2011-02-07

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