DE602005020320D1 - Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten - Google Patents

Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten

Info

Publication number
DE602005020320D1
DE602005020320D1 DE602005020320T DE602005020320T DE602005020320D1 DE 602005020320 D1 DE602005020320 D1 DE 602005020320D1 DE 602005020320 T DE602005020320 T DE 602005020320T DE 602005020320 T DE602005020320 T DE 602005020320T DE 602005020320 D1 DE602005020320 D1 DE 602005020320D1
Authority
DE
Germany
Prior art keywords
implant
attachment
promoting
ifbm
module
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005020320T
Other languages
German (de)
English (en)
Inventor
Paul T Hamilton
Mark W Grinstaff
Daniel J Kenan
Dale J Christensen
Wayne Fl Beyer
Robin Hyde-Deruyscher
Ray Edward Benson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affinergy Inc
Original Assignee
Affinergy Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinergy Inc filed Critical Affinergy Inc
Publication of DE602005020320D1 publication Critical patent/DE602005020320D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
DE602005020320T 2004-06-16 2005-06-15 Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten Active DE602005020320D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58001904P 2004-06-16 2004-06-16
US65133805P 2005-02-09 2005-02-09
US65174705P 2005-02-10 2005-02-10
PCT/US2005/021270 WO2006098744A2 (en) 2004-06-16 2005-06-15 Ifbm’s to promote attachment of target analytes

Publications (1)

Publication Number Publication Date
DE602005020320D1 true DE602005020320D1 (de) 2010-05-12

Family

ID=35784316

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005020320T Active DE602005020320D1 (de) 2004-06-16 2005-06-15 Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten

Country Status (8)

Country Link
US (15) US7572766B2 (US07795383-20100914-P00020.png)
EP (4) EP1771214A2 (US07795383-20100914-P00020.png)
JP (1) JP2008504850A (US07795383-20100914-P00020.png)
AT (1) ATE462451T1 (US07795383-20100914-P00020.png)
CA (1) CA2569864A1 (US07795383-20100914-P00020.png)
DE (1) DE602005020320D1 (US07795383-20100914-P00020.png)
ES (1) ES2342551T3 (US07795383-20100914-P00020.png)
WO (2) WO2006007368A2 (US07795383-20100914-P00020.png)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007819A2 (en) 2003-07-09 2005-01-27 Wisconsin Alumni Research Foundation Charge-dynamic polymers and delivery of anionic compounds
ES2438190T3 (es) * 2003-07-30 2014-01-16 Japan Science And Technology Agency Péptido susceptible de unirse a titanio, plata y silicona
EP1771214A2 (en) 2004-06-16 2007-04-11 Affinergy Inc. Biofunctional coatings
US20070099245A1 (en) * 2005-09-29 2007-05-03 Boris Gorovits Assays for neutralizing antibodies
US7807624B2 (en) * 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
US20080015138A1 (en) * 2006-07-17 2008-01-17 Affinergy, Inc. Metal binding compounds, metal binding compositions, and their uses
EP2452700B1 (en) * 2006-09-06 2013-10-16 Boston Scientific Limited Medical devices having a coating for promoting endothelial cell adhesion
US8834918B2 (en) * 2007-01-22 2014-09-16 Wisconsin Alumni Research Foundation Modified multilayered film
US8377360B2 (en) * 2007-02-13 2013-02-19 2Bot Corporation Systems and methods for providing a personal affector machine
JP2010521246A (ja) * 2007-03-15 2010-06-24 ボストン サイエンティフィック リミテッド 細胞接着性のタンパク質及びペプチドの安定性を改善する方法
US7977313B2 (en) * 2007-04-27 2011-07-12 Affinergy, Inc. Methods and compositions for promoting localization of pharmaceutically active agents to bone
EP2160152B1 (en) * 2007-06-01 2016-07-27 Arrow International, Inc. Combined fibrinolytic and antimicrobial catheter and uses thereof
JP2009051773A (ja) * 2007-08-27 2009-03-12 Toyobo Co Ltd 細胞接着能を有するｈｓｐ７０ファミリータンパク質
WO2009032943A2 (en) * 2007-09-04 2009-03-12 Affinergy, Inc. Methods and compositions for delivery of growth factor to fibrous connective tissue
US20090105375A1 (en) * 2007-10-09 2009-04-23 Lynn David M Ultrathin Multilayered Films for Controlled Release of Anionic Reagents
WO2009049092A1 (en) * 2007-10-09 2009-04-16 Wisconsin Alumni Research Foundation Covalent assembly of ultrathin polymeric films
WO2009055313A1 (en) * 2007-10-22 2009-04-30 Affinergy Inc. Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces
US8637455B2 (en) 2007-10-22 2014-01-28 Affinergy, Llc Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces
WO2009054967A2 (en) * 2007-10-22 2009-04-30 Synthes (U.S.A.) Compositions for delivery of glycopeptide antibiotics
WO2009120968A2 (en) * 2008-03-27 2009-10-01 Affinergy Inc. Coating compositions having improved performance
US8324333B2 (en) 2008-06-05 2012-12-04 Wisconsin Alumni Research Foundation Anionic charge-dynamic polymers for release of cationic agents
US8889168B2 (en) 2008-08-07 2014-11-18 Bioactive Surgical Inc. Stem cell capture and immobilization coatings for medical devices and implants
US7700923B2 (en) * 2008-09-20 2010-04-20 Varian Medical Systems, Inc. Apparatus of photoconductor crystal growth
CN102171239B (zh) 2008-09-24 2018-11-13 特尔哈肖梅尔医学研究基础设施和服务有限公司 用于防止细胞粘附的肽和组合物及其使用方法
US20100098737A1 (en) * 2008-10-17 2010-04-22 Affinergy, Inc. methods and compositions for delivery of glycopeptide antibiotics to medical device surfaces
WO2010081201A1 (en) * 2009-01-19 2010-07-22 Cochlear Limited Surface modification for implantable medical device
BRPI1007345A2 (pt) 2009-01-20 2019-04-16 H. ZADEH Homayoun regeneração óssea de anticorpo mediado
US9333280B2 (en) 2009-02-25 2016-05-10 Teleflex Medical Incorporated Stabilized enzyme compositions
US8545459B2 (en) * 2009-02-25 2013-10-01 Teleflex Medical Incorporated Stabilized enzyme compositions
US8574612B2 (en) * 2009-03-04 2013-11-05 Boston Scientific Scimed, Inc. Medical devices having a coating of biologic macromolecules
US20100249783A1 (en) * 2009-03-24 2010-09-30 Warsaw Orthopedic, Inc. Drug-eluting implant cover
US9078712B2 (en) * 2009-04-15 2015-07-14 Warsaw Orthopedic, Inc. Preformed drug-eluting device to be affixed to an anterior spinal plate
US9414864B2 (en) 2009-04-15 2016-08-16 Warsaw Orthopedic, Inc. Anterior spinal plate with preformed drug-eluting device affixed thereto
US8079737B2 (en) * 2009-04-20 2011-12-20 Harvatek Corporation Reflection-type light-emitting module with high heat-dissipating and high light-generating efficiency
EP2499256A4 (en) * 2009-11-10 2013-09-11 Amgen Inc ANTI-C-MPL ANTIBODIES
WO2011063128A1 (en) * 2009-11-18 2011-05-26 Affinergy, Inc. Implantable bone graft materials
US8629106B2 (en) * 2010-03-16 2014-01-14 Janssen Biotech, Inc. Affinity peptides toward BMP-2
US8707950B1 (en) * 2010-08-04 2014-04-29 Darren Rubin Universal medical gas delivery system
US11628267B2 (en) 2010-08-04 2023-04-18 Medline Industries, Lp Universal medical gas delivery system
US9186243B2 (en) * 2011-05-31 2015-11-17 Novartis Ag Accommodative intraocular lens and method of implantation
US9586381B1 (en) 2013-10-25 2017-03-07 Steriplate, LLC Metal plated object with biocidal properties
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
WO2016176146A1 (en) * 2015-04-26 2016-11-03 The Trustees Of Princeton University Surfaces comprising attached quorum sensing modulators
US9999899B2 (en) 2016-11-01 2018-06-19 International Business Machines Corporation Controlled exposure of in-vivo sensors
WO2019232285A1 (en) * 2018-05-30 2019-12-05 Purdue Research Foundation Targeting anabolic drugs for accelerated fracture repair
WO2019243610A1 (en) * 2018-06-20 2019-12-26 Dwi - Leibniz-Institut Für Interaktive Materialien E.V. Fusion peptides or proteins, their use, and systems and kits based thereupon, for the separation and/or detection of plastics, particularly of microplastics
JP2022520139A (ja) 2018-10-12 2022-03-29 セラダプティブ インク β－リン酸三カルシウム結合配列を含むポリペプチドとその使用
WO2020208418A1 (en) * 2019-04-12 2020-10-15 Azura Ophthalmics Ltd. Compositions and methods for the treatment of contact lens discomfort
US20210154403A1 (en) * 2019-11-25 2021-05-27 Thomas Leroy Schmitz Joint capsule fluid delivery
WO2021140417A2 (en) 2020-01-10 2021-07-15 Azura Ophthalmics Ltd. Instructions for composition and sensitivity
US20230174814A1 (en) * 2020-04-27 2023-06-08 Board Of Trustees Of The University Of Arkansas Cellulose Based Anti-Viral Anti-Microbial Spray Coating
US11141528B1 (en) 2020-12-14 2021-10-12 Thomas Leroy Schmitz Therapeutic fluid delivery cartridge

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA92121A (en) 1904-11-07 1905-03-14 William Waid Paddock Pressure filter
US4244946A (en) 1979-06-11 1981-01-13 The Salk Institute For Biological Studies Water-soluble peptides affecting gonadal function
FR2501680A1 (fr) 1981-03-12 1982-09-17 Elf Aquitaine Synthese de tetra mercaptides stanniques
US4472840A (en) 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4442133A (en) * 1982-02-22 1984-04-10 Greco Ralph S Antibiotic bonding of vascular prostheses and other implants
US5217492A (en) * 1982-09-29 1993-06-08 Bio-Metric Systems, Inc. Biomolecule attachment to hydrophobic surfaces
US4526909A (en) 1984-01-09 1985-07-02 Regents Of The University Of California Polymethylmethacrylate delivery system for bone morphogenetic protein
US4563489A (en) 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US5866363A (en) * 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US5079342A (en) * 1986-01-22 1992-01-07 Institut Pasteur Cloned DNA sequences related to the entire genomic RNA of human immunodeficiency virus II (HIV-2), polypeptides encoded by these DNA sequences and use of these DNA clones and polypeptides in diagnostic kits
US5543394A (en) 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5606019A (en) 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
GB2215209B (en) 1988-03-14 1992-08-26 Osmed Inc Method and apparatus for biodegradable, osteogenic, bone graft substitute device
US5344654A (en) 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5019393A (en) * 1988-08-03 1991-05-28 New England Deaconess Hospital Corporation Biocompatible substance with thromboresistance
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US6261271B1 (en) * 1989-01-18 2001-07-17 Becton Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
US5356630A (en) 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
JPH0327172A (ja) 1989-06-19 1991-02-05 Nissan Chem Ind Ltd 布の漂白方法
US5635482A (en) * 1989-08-14 1997-06-03 The Regents Of The University Of California Synthetic compounds and compositions with enhanced cell binding
US5236456A (en) 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
US5314995A (en) 1990-01-22 1994-05-24 Oncogen Therapeutic interleukin-2-antibody based fusion proteins
DE4002897A1 (de) 1990-02-01 1991-08-08 Behringwerke Ag Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken")
US5747334A (en) * 1990-02-15 1998-05-05 The University Of North Carolina At Chapel Hill Random peptide library
US5498538A (en) * 1990-02-15 1996-03-12 The University Of North Carolina At Chapel Hill Totally synthetic affinity reagents
AP237A (en) 1990-05-29 1993-04-29 Cedars Sinai Medical Center Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type 1 (HIV-1) gp120 and methods of use.
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5264563A (en) 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
US5520664A (en) * 1991-03-01 1996-05-28 Spire Corporation Catheter having a long-lasting antimicrobial surface treatment
US5652118A (en) 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
KR0145278B1 (ko) 1991-06-21 1998-07-15 브루스 엠. 에이센 골형성원 단백질 약제
US5667988A (en) 1992-01-27 1997-09-16 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
US5217493A (en) * 1992-03-11 1993-06-08 Board Of Regents, The University Of Texas System Antibacterial coated medical implants
US5681575A (en) * 1992-05-19 1997-10-28 Westaim Technologies Inc. Anti-microbial coating for medical devices
ATE187494T1 (de) * 1992-12-11 1999-12-15 Dow Chemical Co Multivalente einkettige antikörper
WO1995000547A1 (en) * 1993-06-22 1995-01-05 E.I. Du Pont De Nemours And Company Antimicrobial composition of a polymer and a peptide forming amphiphilic helices of the magainin-type
US6361526B1 (en) * 1993-11-01 2002-03-26 Medtronic Xomed, Inc. Antimicrobial tympanostomy tube
CN1117152C (zh) * 1994-03-04 2003-08-06 味之素株式会社 生产l－赖氨酸的方法
US5824483A (en) 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
JPH07313169A (ja) * 1994-05-26 1995-12-05 Nippon Ham Kk 骨形成因子受容体改変体の遺伝子
CA2200684A1 (en) 1994-09-21 1996-03-28 Cytogen Corporation Antigen binding peptides (abtides) from peptide libraries
US6746482B2 (en) * 1994-10-17 2004-06-08 Baxter International Inc. Method for producing medical devices and devices so produced
US6294353B1 (en) * 1994-10-20 2001-09-25 Morphosys Ag Targeted hetero-association of recombinant proteins to multi-functional complexes
DE4441124C2 (de) 1994-11-18 1997-03-27 Heraeus Kulzer Gmbh Verfahren zur Erzeugung eines haftfesten, feuchtigkeitsdichten Überzugs aus Kunststoff auf einer Unterlage und dessen Verwendung
US6071890A (en) 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
AUPN024994A0 (en) * 1994-12-23 1995-01-27 Ludwig Institute For Cancer Research Assay and peptides for use therein
US5817748A (en) * 1995-03-17 1998-10-06 The Research Foundation Of State University Of New York Mimotopes of human Platelet glycoprotein Ib/IX
US5624704A (en) * 1995-04-24 1997-04-29 Baylor College Of Medicine Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent
US5702892A (en) 1995-05-09 1997-12-30 The United States Of America As Represented By The Department Of Health And Human Services Phage-display of immunoglobulin heavy chain libraries
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
US5709672A (en) * 1995-11-01 1998-01-20 Texas Tech University Health Sciences Center Silastic and polymer-based catheters with improved antimicrobial/antifungal properties
IE80466B1 (en) * 1995-11-10 1998-07-29 Elan Corp Plc Peptides which enhance transport across tissues and methods of identifying and using the same
FR2741892B1 (fr) 1995-12-04 1998-02-13 Pasteur Merieux Serums Vacc Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps, banque et systemes d'expression d'anticorps "coliclonaux" obtenus
US6031071A (en) 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
EP0800901B1 (de) 1996-04-10 2003-07-02 Dieffenbacher Schenck Panel GmbH Verfahren zur Herstellung eines Vlieses und Vorrichtung
ES2227730T3 (es) * 1996-09-04 2005-04-01 Syngenta Mogen B.V. Proteinas antifungicas, adn que codifica para las mismas y hospedadores que lo incorporan.
US6617114B1 (en) * 1996-10-31 2003-09-09 Karo Bio Ab Identification of drug complementary combinatorial libraries
US5756332A (en) * 1996-12-26 1998-05-26 Incyte Pharmaceuticals, Inc. Guanosine monophosphate reductase
WO1999043693A1 (en) * 1998-02-26 1999-09-02 Human Genome Sciences, Inc. 36 human secreted proteins
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
CN1256635A (zh) * 1997-05-22 2000-06-14 默克专利股份有限公司 肽包被的植入物及其制备方法
US6281331B1 (en) 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
US6121236A (en) * 1998-03-24 2000-09-19 The Children's Medical Center Corporation Multivalent ligands which modulate angiogenesis
US7208011B2 (en) * 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US6428579B1 (en) * 1998-07-01 2002-08-06 Brown University Research Foundation Implantable prosthetic devices coated with bioactive molecules
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
JP2003513682A (ja) * 1998-07-24 2003-04-15 ファーマカル、バイオテクノロジーズ、インコーポレーテッド 骨組織復元システムおよび方法
US20030236190A1 (en) * 1998-09-02 2003-12-25 Renuka Pillutla Isulin and IGF-1 receptor agonists and antagonists
US7176275B2 (en) * 1998-09-04 2007-02-13 Samuel Bogoch Anthrax and small pox replikins and methods of use
US6410713B1 (en) * 1998-11-20 2002-06-25 Vincent Guerriero DNA encoding proteins that inhibit Hsp70 function
US7090973B1 (en) * 1999-04-09 2006-08-15 Oscient Pharmaceuticals Corporation Nucleic acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics
JP4647792B2 (ja) * 1999-04-28 2011-03-09 イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ 分析用デバイスおよびセンシングデバイスにおけるポリイオン性コーティング
US6544768B1 (en) * 1999-05-11 2003-04-08 Cornell Research Foundation, Inc. Mammalian soluble adenylyl cyclase
EP1203016A2 (en) * 1999-08-09 2002-05-08 Incyte Genomics, Inc. Proteases and protease inhibitors
US7304127B2 (en) * 1999-08-27 2007-12-04 United States Of America As Represented By The Secretary, Department Of Health And Human Services Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use
EP1218408A4 (en) * 1999-09-24 2003-02-26 Human Genome Sciences Inc 32 HUMAN, SECRETED PROTEINS
US7592304B2 (en) * 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
WO2001056627A1 (en) * 2000-01-12 2001-08-09 Am-Pharma B.V. Medical device coated with antimicrobial peptides
US20030229393A1 (en) * 2001-03-15 2003-12-11 Kutryk Michael J. B. Medical device with coating that promotes cell adherence and differentiation
CA2400319C (en) * 2000-03-15 2008-09-16 Orbus Medical Technologies Inc. Coating that promotes endothelial cell adherence
EP1301624A2 (en) * 2000-03-31 2003-04-16 Ludwig Institute For Cancer Research Preprocalcitonin as tumor rejection antigen precursor and uses thereof
EP1142596A1 (en) * 2000-04-03 2001-10-10 Universiteit Gent Compositions of crosslinkable prepolymers for use in therapeutically active biodegradable implants
US20110131679A2 (en) * 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
US6716811B1 (en) * 2000-07-20 2004-04-06 Affymax, Inc. Compounds having affinity for the granulocyte-colony stimulating factor receptor (G-CSFR) and associated uses
US6727223B2 (en) * 2000-08-04 2004-04-27 Urex Biotech, Inc. Treatment of microbial infections with bacterial proteins and peptides
DE10040105A1 (de) * 2000-08-17 2002-02-28 Merck Patent Gmbh Peptid- und Peptidmimetika-Derivate mit Integrin-Inhibitor-Eigenschaften
EP1311664A2 (en) * 2000-08-21 2003-05-21 Incyte Genomics, Inc. Microtubule-associated proteins and tubulins
JP2005500002A (ja) * 2000-10-02 2005-01-06 エリゼク・ファーマシュウティカルズ・インコーポレイテッド 生物学的に活性な薬剤を細胞関門を越えて輸送するための組成物および方法
AU2001297804A1 (en) * 2000-10-27 2002-11-11 Diadexus, Inc. Compositions and methods relating to breast specific genes and proteins
US20030003440A1 (en) * 2001-03-14 2003-01-02 Lucia Lopalco Novel CCR5 epitope and antibodies against it
CN1538850A (zh) * 2001-06-08 2004-10-20 ʷ 用于骨或软骨再生的bmp结合蛋白
JP2005502335A (ja) * 2001-08-08 2005-01-27 インサイト・ゲノミックス・インコーポレイテッド 細胞成長、分化および細胞死関連タンパク質
ATE415412T1 (de) 2001-08-10 2008-12-15 Novartis Pharma Gmbh Peptide, die atherosklerotische schädigungen binden
JP4933708B2 (ja) 2001-08-31 2012-05-16 善彦 西村 骨形成作用を有する新規なペプチドおよびこれを固定化してなる骨形成促進剤
US6596338B2 (en) 2001-10-24 2003-07-22 Howmedica Osteonics Corp. Antibiotic calcium phosphate coating
ES2327398T3 (es) * 2001-11-20 2009-10-29 Duke University Biomateriales interfaciales.
US7381426B2 (en) * 2002-01-24 2008-06-03 Southwest Research Institute Targeted delivery of bioactive factors to the systemic skeleton
US7355022B2 (en) * 2002-02-12 2008-04-08 Licentia Ltd. Gene functionally related to dyslexia
US7314974B2 (en) * 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
AU2003213246A1 (en) * 2002-02-21 2003-09-09 University Of Virginia Patent Foundation Bone targeting peptides
EP2073013B1 (en) * 2002-04-12 2016-01-06 Omeros Corporation Method of identifying transmembrane protein-interacting compounds
ATE479705T1 (de) * 2002-05-03 2010-09-15 Mayo Foundation Reduzierter slam abhängiger zell eintritt
WO2003093314A2 (en) 2002-05-03 2003-11-13 Millenium Biologix Inc. Connective tissue stimulating peptides
US7449480B2 (en) * 2002-05-14 2008-11-11 Baylor College Of Medicine Small molecule inhibitors of HER2 expression
JP2005185101A (ja) * 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長ｃＤＮＡおよびその利用
US7166574B2 (en) 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
EP1534831A2 (en) * 2002-09-04 2005-06-01 Board Of Regents The University Of Texas System Composition, method and use of bi-functional biomaterials
US7238669B2 (en) * 2002-09-11 2007-07-03 The Curators Of The University Of Missouri Phage-display peptides as novel antimicrobial agents against Haemophilus influenzae
US7282214B2 (en) * 2002-12-19 2007-10-16 Johnson & Johnson Vision Care, Inc. Biomedical devices with antimicrobial coatings
US7163920B2 (en) * 2003-09-30 2007-01-16 Ethicon, Inc. Peptide with osteogenic activity
WO2005072403A2 (en) 2004-01-28 2005-08-11 The Regents Of The University Of California Bone morphogenic protein binding peptide
US7528105B1 (en) 2004-02-10 2009-05-05 Biosurface Engineering Technologies Heterodimeric chain synthetic heparin-binding growth factor analogs
KR101013999B1 (ko) 2004-03-19 2011-02-14 재단법인서울대학교산학협력재단 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트
EP1771214A2 (en) 2004-06-16 2007-04-11 Affinergy Inc. Biofunctional coatings
US7807624B2 (en) * 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices

Also Published As

Publication number Publication date
US7994277B2 (en) 2011-08-09
WO2006098744A2 (en) 2006-09-21
US20060051395A1 (en) 2006-03-09
US7786256B2 (en) 2010-08-31
US7795383B2 (en) 2010-09-14
ATE462451T1 (de) 2010-04-15
US20100317828A1 (en) 2010-12-16
EP1793875A2 (en) 2007-06-13
US7608581B2 (en) 2009-10-27
EP1771214A2 (en) 2007-04-11
JP2008504850A (ja) 2008-02-21
US7812119B2 (en) 2010-10-12
CA2569864A1 (en) 2006-09-21
EP1793875B9 (en) 2010-09-08
WO2006007368A3 (en) 2006-05-18
WO2006007368A2 (en) 2006-01-19
EP2255832A3 (en) 2011-02-09
EP2138195A2 (en) 2009-12-30
EP2138195A3 (en) 2010-07-21
US20060051396A1 (en) 2006-03-09
US8030452B2 (en) 2011-10-04
US20100331518A1 (en) 2010-12-30
US20090326197A1 (en) 2009-12-31
US20110263499A1 (en) 2011-10-27
US20090326198A1 (en) 2009-12-31
US20100331519A1 (en) 2010-12-30
US20100324263A1 (en) 2010-12-23
US8022183B2 (en) 2011-09-20
US8022184B2 (en) 2011-09-20
WO2006098744A3 (en) 2006-11-30
US7572766B2 (en) 2009-08-11
US20100317829A1 (en) 2010-12-16
EP2255832A2 (en) 2010-12-01
US20110269687A1 (en) 2011-11-03
US7790844B2 (en) 2010-09-07
US7968677B2 (en) 2011-06-28
US20100136211A1 (en) 2010-06-03
US20090326199A1 (en) 2009-12-31
US8022185B2 (en) 2011-09-20
EP1793875B1 (en) 2010-03-31
US20070104758A1 (en) 2007-05-10
ES2342551T3 (es) 2010-07-08
US20100324262A1 (en) 2010-12-23

Similar Documents

Publication Publication Date Title
DE602005020320D1 (de) Grenzflächenbiomaterialien zur förderung der anhaftung von zielanalyten
ATE531374T1 (de) Vorrichtung auf polymerbasis mit verzögerter freisetzung
BRPI0517692A (pt) elementos de endoprótese de juntas de tornozelo
ATE464074T1 (de) Knochenimplantate
ATE360447T1 (de) Osteoinduktion von allogenen kortikalen knochentransplantaten über biopolymere die mit periostalen knochenzellen besiedelt wurden
DE60323475D1 (de) Medizinische prothesevorrichtungen mit verbesserer biokompatibilität
ATE469621T1 (de) Fusionsimplantat mit kontrollierter senkung
ATE402663T1 (de) Flächiges implantat
DE69819343D1 (de) Zusammensetzungen und ihre verwendung zur verhütung von verklebungen zwischen körpergewebe
DE60043777D1 (de) Ngen, die die befestigung von zellen und proteinen mit den sustraten hemmen.
DE50204293D1 (de) Keramisches dentalimplantat
DE602004024537D1 (de) Multifunktionales implantat
DE602005022589D1 (de) Angiogenische und immunologische verwendungen von anti-cd160 spezifischen stoffen, erhältlich vom monoklonalen antiköper cl1-r2
ATE524202T1 (de) Abstandhalter mit beschichtung zur verwendung mit einer implantatvorrichtung
DE50313465D1 (de) Implantate beschichtet mit Aptameren, die die Adhäsion von endothelialen Vorläuferzellen vermitteln
ATE448811T1 (de) Verfahren zur verbesserung der anhaftung von weichteilgewebe und implantate, die gebrauch von diesem verfahen machen
SE0303169D0 (sv) Fixation system for implant elements
BR0113106A (pt) Método para a produção de filmes à base de quitosan com capacidade de aderência celular acentuada, produto resultante e aplicações
ATE518550T1 (de) Mit biologischem gewebekleber kompatibles biologisches reparaturmaterial
DE602004016008D1 (de) Biosynthetisches implantat und seine verwendung und verfahren zur reduzierung des risikos der bildung von bindegewebe nach der implantation
ES2143938B1 (es) Recubrimientos biocompatibles producidos mediante laser.
DE60017417D1 (de) Hydrophile überzugsmittel, hydrophob gebunden an chirurgische implantate
Yuvaraj Hegde et al. Comparative evaluation of biochemical parameters during fracture healing in dogs.
WO2010034761A3 (fr) Implant prothetique a effet collant retarde
ITTO20020313A1 (it) Dispositivo elettronico per la stimolazione dei processi di riparazione e-o crescita ossea.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition