DE602004028821D1 - Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptor - Google Patents
Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptorInfo
- Publication number
- DE602004028821D1 DE602004028821D1 DE602004028821T DE602004028821T DE602004028821D1 DE 602004028821 D1 DE602004028821 D1 DE 602004028821D1 DE 602004028821 T DE602004028821 T DE 602004028821T DE 602004028821 T DE602004028821 T DE 602004028821T DE 602004028821 D1 DE602004028821 D1 DE 602004028821D1
- Authority
- DE
- Germany
- Prior art keywords
- muscarin
- ligands
- receptor
- pyrrolidinium derivatives
- pyrrolidinium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0314697A GB0314697D0 (en) | 2003-06-24 | 2003-06-24 | Organic compounds |
| GB0327526A GB0327526D0 (en) | 2003-11-26 | 2003-11-26 | Organic compounds |
| PCT/EP2004/006795 WO2005000815A2 (en) | 2003-06-24 | 2004-06-23 | Piperidinium and pyrrolidinium derivatives as ligands for the muscarinic m3 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004028821D1 true DE602004028821D1 (de) | 2010-10-07 |
Family
ID=33554160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004028821T Expired - Lifetime DE602004028821D1 (de) | 2003-06-24 | 2004-06-23 | Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptor |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7947730B2 (de) |
| EP (1) | EP1638940B1 (de) |
| JP (1) | JP2008529965A (de) |
| AR (1) | AR044851A1 (de) |
| AT (1) | ATE478845T1 (de) |
| AU (1) | AU2004251867B2 (de) |
| BR (1) | BRPI0411738A (de) |
| CA (1) | CA2526991C (de) |
| DE (1) | DE602004028821D1 (de) |
| MX (1) | MXPA05013823A (de) |
| PE (1) | PE20050231A1 (de) |
| PL (1) | PL1638940T3 (de) |
| PT (1) | PT1638940E (de) |
| TW (1) | TW200526573A (de) |
| WO (1) | WO2005000815A2 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0410712D0 (en) | 2004-05-13 | 2004-06-16 | Novartis Ag | Organic compounds |
| GB0428418D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| GB0428416D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| EP1957451B1 (de) | 2005-11-10 | 2011-10-19 | Nicholas S. Bodor | Weiche anticholinerge zwitterionen |
| CA2627982C (en) | 2005-11-10 | 2013-09-10 | Nicholas S. Bodor | Soft anticholinergic esters |
| JP2009519310A (ja) * | 2005-12-16 | 2009-05-14 | アージェンタ ディスカバリー リミテッド | 環状アミン誘導体およびそれらの使用 |
| JP2009534463A (ja) * | 2006-04-24 | 2009-09-24 | アストラゼネカ・アクチエボラーグ | 例えば慢性気管支閉塞、喘息および過活動膀胱の処置に有用な、ムスカリンｍ３受容体アンタゴニスト活性を有する環状アミノアルコールの新規アルキルエステル |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| JP2010513277A (ja) * | 2006-12-13 | 2010-04-30 | ギリード・サイエンシズ・インコーポレーテッド | ＣＯＰＤおよび慢性気管支炎の治療のためのムスカリン受容体アンタゴニストおよびβ−アゴニストの共通プロドラッグとしてのモノホスフェート |
| ES2554646T3 (es) | 2007-02-23 | 2015-12-22 | Theravance Biopharma R&D Ip, Llc | Compuestos de difenilmetilo de amonio cuaternario, de utilidad como antagonistas de receptores muscarínicos |
| DK2197841T3 (da) | 2007-09-07 | 2012-02-06 | Theravance Inc | Guanidinholdige forbindelser anvendelige som muscariniske receptorantagonister |
| JP2011506477A (ja) | 2007-12-14 | 2011-03-03 | セラヴァンス， インコーポレーテッド | ムスカリン受容体拮抗薬として有用なアミジン含有化合物 |
| CA2723981A1 (en) | 2008-05-13 | 2009-11-19 | Astrazeneca Ab | New compounds 273 |
| US9072734B2 (en) * | 2009-04-30 | 2015-07-07 | Teijin Pharma Limited | Quaternary ammonium salt compounds |
| WO2014014698A2 (en) * | 2012-07-16 | 2014-01-23 | Barry University Inc. | Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof |
| EP3111978B1 (de) | 2015-07-03 | 2021-09-01 | Novartis AG | Zum lesen von in einem datenspeichermittel eines behälters gespeicherten informationen angepasster inhalator |
| CN115279731A (zh) * | 2020-03-11 | 2022-11-01 | 诺西恩医疗公司 | 带电的离子通道阻滞剂及其使用方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3240784A (en) | 1966-03-15 | Esters of quaternary z-hydroxy methyl piperidinium compounds | ||
| US2746966A (en) | 1953-11-02 | 1956-05-22 | Lakeside Lab Inc | Esters of bis-(nu-substituted-3-hydroxypiperidinium) alkanes |
| GB833820A (en) * | 1957-10-17 | 1960-04-27 | Beecham Res Lab | Improvements in or relating to the preparation of pyrrolidyl esters and quaternary compounds thereof |
| JPS6018661B2 (ja) * | 1976-01-01 | 1985-05-11 | 太田製薬株式会社 | １−（１，３−ジオキソラン−４−イルメチル）ピペリジノ−ル誘導体 |
| JPS5427570A (en) * | 1977-07-30 | 1979-03-01 | Ota Pharma | Stereoisomer of 44acyloxyy11 alkyll11*1*33dioxolanee44 ylmethyl* pideridinium salt derivative |
| JPS5679688A (en) * | 1979-12-04 | 1981-06-30 | Ota Seiyaku Kk | 4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production |
| JPS5835177A (ja) * | 1981-08-26 | 1983-03-01 | Dainippon Pharmaceut Co Ltd | ２−環状アミノ−２−（１，２−ベンズイソキサゾ−ル−３−イル）酢酸エステル類並びにその酸付加塩類および第４級アンモニウム塩類 |
| JPS58208270A (ja) * | 1982-05-28 | 1983-12-03 | Dainippon Pharmaceut Co Ltd | α−環状アミノフエニル酢酸エステル類並びにその酸付加塩類及び第４級アンモニウム塩類 |
| GB9023023D0 (en) * | 1990-10-23 | 1990-12-05 | Barlow Richard B | Pharmaceutical compositions |
| WO1996033973A1 (fr) * | 1995-04-28 | 1996-10-31 | Banyu Pharmaceutical Co., Ltd. | Derives disubstitues en position 1,4 de piperidine |
| JP2001504459A (ja) | 1996-11-11 | 2001-04-03 | ノエ・クリスティアン・エル | 対掌体純粋な、塩基性アリール―シクロアルキル―ヒドロキシカルボン酸エステル、その製造方法及びこれを薬剤に使用する方法 |
| CA2415468A1 (en) * | 2000-07-11 | 2003-01-10 | Yoshio Ogino | Ester derivatives |
| ES2206021B1 (es) * | 2002-04-16 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirrolidinio. |
| EP1957451B1 (de) * | 2005-11-10 | 2011-10-19 | Nicholas S. Bodor | Weiche anticholinerge zwitterionen |
-
2004
- 2004-06-22 PE PE2004000611A patent/PE20050231A1/es not_active Application Discontinuation
- 2004-06-22 AR ARP040102162A patent/AR044851A1/es not_active Application Discontinuation
- 2004-06-23 JP JP2006516038A patent/JP2008529965A/ja active Pending
- 2004-06-23 PT PT04740214T patent/PT1638940E/pt unknown
- 2004-06-23 WO PCT/EP2004/006795 patent/WO2005000815A2/en active Search and Examination
- 2004-06-23 BR BRPI0411738-7A patent/BRPI0411738A/pt not_active Application Discontinuation
- 2004-06-23 US US10/561,366 patent/US7947730B2/en not_active Expired - Fee Related
- 2004-06-23 PL PL04740214T patent/PL1638940T3/pl unknown
- 2004-06-23 AT AT04740214T patent/ATE478845T1/de active
- 2004-06-23 MX MXPA05013823A patent/MXPA05013823A/es active IP Right Grant
- 2004-06-23 EP EP04740214A patent/EP1638940B1/de not_active Expired - Lifetime
- 2004-06-23 CA CA2526991A patent/CA2526991C/en not_active Expired - Fee Related
- 2004-06-23 TW TW093118142A patent/TW200526573A/zh unknown
- 2004-06-23 DE DE602004028821T patent/DE602004028821D1/de not_active Expired - Lifetime
- 2004-06-23 AU AU2004251867A patent/AU2004251867B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US7947730B2 (en) | 2011-05-24 |
| EP1638940B1 (de) | 2010-08-25 |
| BRPI0411738A (pt) | 2006-08-08 |
| PT1638940E (pt) | 2010-11-08 |
| PE20050231A1 (es) | 2005-05-20 |
| MXPA05013823A (es) | 2006-02-28 |
| WO2005000815A2 (en) | 2005-01-06 |
| TW200526573A (en) | 2005-08-16 |
| WO2005000815A3 (en) | 2005-04-14 |
| US20060287362A1 (en) | 2006-12-21 |
| AR044851A1 (es) | 2005-10-05 |
| AU2004251867B2 (en) | 2008-08-07 |
| PL1638940T3 (pl) | 2011-02-28 |
| EP1638940A2 (de) | 2006-03-29 |
| AU2004251867A1 (en) | 2005-01-06 |
| CA2526991C (en) | 2012-03-27 |
| JP2008529965A (ja) | 2008-08-07 |
| ATE478845T1 (de) | 2010-09-15 |
| CA2526991A1 (en) | 2005-01-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60225274D1 (de) | Chinolinderivate als liganden für den neuropeptid-y-rezeptor | |
| DE602004028821D1 (de) | Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptor | |
| DE602004015724D1 (de) | Diazepinoindolderivate als kinaseinhibitoren | |
| DE602004029412D1 (de) | Fahrerhaus für eine Erdbewegungsmaschine | |
| DE602004024420D1 (de) | Chinazolinderivate als antitumormittel | |
| DE60209004D1 (de) | Verbindungen verwendbar als zwischenprodukte für 4-aminochinolinderivate | |
| IS8108A (is) | Ný efnasambönd | |
| ATE387202T1 (de) | Pyrrolidinderivate als histaminrezeptor-liganden | |
| ATE335426T1 (de) | Ausziehführungsgarnitur für schubladen | |
| DE602004005498D1 (de) | Fluoreffiziente appreturen für textilien | |
| IS8228A (is) | Ný asetídínefnasambönd | |
| JP2008525358A5 (ja) | Ｍ３ムスカリン受容体としてのピロリジニウム誘導体 | |
| ATE400206T1 (de) | Ausziehführungsgarnitur für schubladen | |
| ATE421506T1 (de) | Neue benzimidazolderivate | |
| IS8292A (is) | Ný efnasambönd | |
| DE112004002056D2 (de) | Hydraulische Schaltung für den Strebausbau | |
| DE602004014772D1 (de) | Pyrrol-2,5-dithionderivate als modulatoren des liver-x-rezeptors | |
| DE602004011446D1 (de) | Kleiderbügel für Strickware | |
| ATE377008T1 (de) | Imidazolderivate als glutamatrezeptorantagonisten | |
| DE602004004295D1 (de) | 6-ä(substituiertes)phenylütriazolopyrimidine als antikrebsmittel | |
| DE50301232D1 (de) | Skibindung, insbesondere für den langlauf | |
| ATE394372T1 (de) | G-lactamderivate als prostaglandinagonisten | |
| DE60324848D1 (de) | Ausgleichsmechanismus für drehwelle | |
| ATE433956T1 (de) | Cannabinoid-rezeptorliganden | |
| DE502004008685D1 (de) | Fadenführervorrichtung für ringspindel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |