DE602004028821D1 - Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptor - Google Patents
Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptorInfo
- Publication number
- DE602004028821D1 DE602004028821D1 DE602004028821T DE602004028821T DE602004028821D1 DE 602004028821 D1 DE602004028821 D1 DE 602004028821D1 DE 602004028821 T DE602004028821 T DE 602004028821T DE 602004028821 T DE602004028821 T DE 602004028821T DE 602004028821 D1 DE602004028821 D1 DE 602004028821D1
- Authority
- DE
- Germany
- Prior art keywords
- muscarin
- ligands
- receptor
- pyrrolidinium derivatives
- pyrrolidinium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0314697A GB0314697D0 (en) | 2003-06-24 | 2003-06-24 | Organic compounds |
| GB0327526A GB0327526D0 (en) | 2003-11-26 | 2003-11-26 | Organic compounds |
| PCT/EP2004/006795 WO2005000815A2 (en) | 2003-06-24 | 2004-06-23 | Piperidinium and pyrrolidinium derivatives as ligands for the muscarinic m3 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004028821D1 true DE602004028821D1 (de) | 2010-10-07 |
Family
ID=33554160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004028821T Active DE602004028821D1 (de) | 2003-06-24 | 2004-06-23 | Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptor |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7947730B2 (de) |
| EP (1) | EP1638940B1 (de) |
| JP (1) | JP2008529965A (de) |
| AR (1) | AR044851A1 (de) |
| AT (1) | ATE478845T1 (de) |
| AU (1) | AU2004251867B2 (de) |
| BR (1) | BRPI0411738A (de) |
| CA (1) | CA2526991C (de) |
| DE (1) | DE602004028821D1 (de) |
| MX (1) | MXPA05013823A (de) |
| PE (1) | PE20050231A1 (de) |
| PL (1) | PL1638940T3 (de) |
| PT (1) | PT1638940E (de) |
| TW (1) | TW200526573A (de) |
| WO (1) | WO2005000815A2 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0410712D0 (en) | 2004-05-13 | 2004-06-16 | Novartis Ag | Organic compounds |
| GB0428416D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| GB0428418D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| ATE529400T1 (de) * | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Weiche anticholinerge zwitterionen |
| ATE529399T1 (de) * | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Sanfte anticholinerge ester |
| JP2009519310A (ja) * | 2005-12-16 | 2009-05-14 | アージェンタ ディスカバリー リミテッド | 環状アミン誘導体およびそれらの使用 |
| US20090233965A1 (en) * | 2006-04-24 | 2009-09-17 | Astrazeneca Ab | Alkyl Esters Of Cyclic Amino Alcohols With Muscarinic M3 Receptor Antagonist Activity, Useful For Treating E.G. Chronic Bronchial Obstruction, Asthma And Overactive Bladder |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| WO2008076269A2 (en) * | 2006-12-13 | 2008-06-26 | Gilead Sciences, Inc. | MONOPHOSPHATES AS MUTUAL PRODRUGS OF MUSCARINIC RECEPTOR ANTAGONISTS AND β-AGONISTS FOR THE TREATMENT OF COPD AND CHRONIC BRONCHITIS |
| BRPI0807615A8 (pt) * | 2007-02-23 | 2017-12-05 | Theravance Inc | Compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínico |
| CA2697752C (en) | 2007-09-07 | 2016-01-26 | Theravance, Inc. | Guanidine-containing compounds useful as muscarinic receptor antagonists |
| EP2222637A1 (de) | 2007-12-14 | 2010-09-01 | Theravance, Inc. | Amidinhaltige verbindungen als muscarinrezeptor-antagonisten |
| CN102089304A (zh) | 2008-05-13 | 2011-06-08 | 阿斯利康(瑞典)有限公司 | 作为m3毒蕈碱性受体拮抗剂的奎宁环衍生物 |
| AU2010242646A1 (en) * | 2009-04-30 | 2011-11-03 | Teijin Pharma Limited | Quaternary ammonium salt compound |
| US9156833B2 (en) | 2012-07-16 | 2015-10-13 | Barry University, Inc. | Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof |
| PL3111978T3 (pl) | 2015-07-03 | 2022-01-24 | Novartis Ag | Inhalator przystosowany do odczytu informacji przechowywanych w środkach przechowywania danych pojemnika |
| CN115279731A (zh) * | 2020-03-11 | 2022-11-01 | 诺西恩医疗公司 | 带电的离子通道阻滞剂及其使用方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3240784A (en) | 1966-03-15 | Esters of quaternary z-hydroxy methyl piperidinium compounds | ||
| US2746966A (en) | 1953-11-02 | 1956-05-22 | Lakeside Lab Inc | Esters of bis-(nu-substituted-3-hydroxypiperidinium) alkanes |
| GB833820A (en) * | 1957-10-17 | 1960-04-27 | Beecham Res Lab | Improvements in or relating to the preparation of pyrrolidyl esters and quaternary compounds thereof |
| JPS6018661B2 (ja) * | 1976-01-01 | 1985-05-11 | 太田製薬株式会社 | １−（１，３−ジオキソラン−４−イルメチル）ピペリジノ−ル誘導体 |
| JPS5427570A (en) * | 1977-07-30 | 1979-03-01 | Ota Pharma | Stereoisomer of 44acyloxyy11 alkyll11*1*33dioxolanee44 ylmethyl* pideridinium salt derivative |
| JPS5679688A (en) * | 1979-12-04 | 1981-06-30 | Ota Seiyaku Kk | 4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production |
| JPS5835177A (ja) * | 1981-08-26 | 1983-03-01 | Dainippon Pharmaceut Co Ltd | ２−環状アミノ−２−（１，２−ベンズイソキサゾ−ル−３−イル）酢酸エステル類並びにその酸付加塩類および第４級アンモニウム塩類 |
| JPS58208270A (ja) * | 1982-05-28 | 1983-12-03 | Dainippon Pharmaceut Co Ltd | α−環状アミノフエニル酢酸エステル類並びにその酸付加塩類及び第４級アンモニウム塩類 |
| GB9023023D0 (en) * | 1990-10-23 | 1990-12-05 | Barlow Richard B | Pharmaceutical compositions |
| KR19990008109A (ko) | 1995-04-28 | 1999-01-25 | 나가사까 겐지로 | 1,4-이치환 피페리딘 유도체 |
| EP0937041B1 (de) | 1996-11-11 | 2003-04-23 | Christian R. Noe | Verwendung eines pharmazeutisch geeigneten Salzes von (3R,2'R)-3-[(Cyclopentyl-hydroxyphenylacetyl)oxy]-1,1-dimethyl-pyrrolidinium zur Herstellung eines Arzneimittels |
| EP1302458A4 (de) * | 2000-07-11 | 2005-10-19 | Banyu Pharma Co Ltd | Esterderivate |
| ES2206021B1 (es) | 2002-04-16 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirrolidinio. |
| ATE529400T1 (de) * | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Weiche anticholinerge zwitterionen |
-
2004
- 2004-06-22 AR ARP040102162A patent/AR044851A1/es not_active Application Discontinuation
- 2004-06-22 PE PE2004000611A patent/PE20050231A1/es not_active Application Discontinuation
- 2004-06-23 CA CA2526991A patent/CA2526991C/en not_active Expired - Fee Related
- 2004-06-23 MX MXPA05013823A patent/MXPA05013823A/es active IP Right Grant
- 2004-06-23 AT AT04740214T patent/ATE478845T1/de active
- 2004-06-23 EP EP04740214A patent/EP1638940B1/de not_active Not-in-force
- 2004-06-23 AU AU2004251867A patent/AU2004251867B2/en not_active Ceased
- 2004-06-23 BR BRPI0411738-7A patent/BRPI0411738A/pt not_active Application Discontinuation
- 2004-06-23 JP JP2006516038A patent/JP2008529965A/ja active Pending
- 2004-06-23 PL PL04740214T patent/PL1638940T3/pl unknown
- 2004-06-23 TW TW093118142A patent/TW200526573A/zh unknown
- 2004-06-23 WO PCT/EP2004/006795 patent/WO2005000815A2/en active Search and Examination
- 2004-06-23 PT PT04740214T patent/PT1638940E/pt unknown
- 2004-06-23 US US10/561,366 patent/US7947730B2/en not_active Expired - Fee Related
- 2004-06-23 DE DE602004028821T patent/DE602004028821D1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1638940B1 (de) | 2010-08-25 |
| AU2004251867A1 (en) | 2005-01-06 |
| MXPA05013823A (es) | 2006-02-28 |
| ATE478845T1 (de) | 2010-09-15 |
| CA2526991C (en) | 2012-03-27 |
| CA2526991A1 (en) | 2005-01-06 |
| BRPI0411738A (pt) | 2006-08-08 |
| PT1638940E (pt) | 2010-11-08 |
| PL1638940T3 (pl) | 2011-02-28 |
| AR044851A1 (es) | 2005-10-05 |
| AU2004251867B2 (en) | 2008-08-07 |
| WO2005000815A2 (en) | 2005-01-06 |
| US20060287362A1 (en) | 2006-12-21 |
| EP1638940A2 (de) | 2006-03-29 |
| PE20050231A1 (es) | 2005-05-20 |
| TW200526573A (en) | 2005-08-16 |
| US7947730B2 (en) | 2011-05-24 |
| WO2005000815A3 (en) | 2005-04-14 |
| JP2008529965A (ja) | 2008-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |