PL1638940T3 - Pochodne pirolidyniowe jako ligandy dla receptora muskarynowego M3 - Google Patents
Pochodne pirolidyniowe jako ligandy dla receptora muskarynowego M3Info
- Publication number
- PL1638940T3 PL1638940T3 PL04740214T PL04740214T PL1638940T3 PL 1638940 T3 PL1638940 T3 PL 1638940T3 PL 04740214 T PL04740214 T PL 04740214T PL 04740214 T PL04740214 T PL 04740214T PL 1638940 T3 PL1638940 T3 PL 1638940T3
- Authority
- PL
- Poland
- Prior art keywords
- muscarinic
- ligands
- receptor
- pyrrolidinium derivatives
- pyrrolidinium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0314697A GB0314697D0 (en) | 2003-06-24 | 2003-06-24 | Organic compounds |
| GB0327526A GB0327526D0 (en) | 2003-11-26 | 2003-11-26 | Organic compounds |
| PCT/EP2004/006795 WO2005000815A2 (en) | 2003-06-24 | 2004-06-23 | Piperidinium and pyrrolidinium derivatives as ligands for the muscarinic m3 receptor |
| EP04740214A EP1638940B1 (en) | 2003-06-24 | 2004-06-23 | Pyrrolidinium derivatives as ligands for the muscarinic m3 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1638940T3 true PL1638940T3 (pl) | 2011-02-28 |
Family
ID=33554160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04740214T PL1638940T3 (pl) | 2003-06-24 | 2004-06-23 | Pochodne pirolidyniowe jako ligandy dla receptora muskarynowego M3 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7947730B2 (pl) |
| EP (1) | EP1638940B1 (pl) |
| JP (1) | JP2008529965A (pl) |
| AR (1) | AR044851A1 (pl) |
| AT (1) | ATE478845T1 (pl) |
| AU (1) | AU2004251867B2 (pl) |
| BR (1) | BRPI0411738A (pl) |
| CA (1) | CA2526991C (pl) |
| DE (1) | DE602004028821D1 (pl) |
| MX (1) | MXPA05013823A (pl) |
| PE (1) | PE20050231A1 (pl) |
| PL (1) | PL1638940T3 (pl) |
| PT (1) | PT1638940E (pl) |
| TW (1) | TW200526573A (pl) |
| WO (1) | WO2005000815A2 (pl) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0410712D0 (en) | 2004-05-13 | 2004-06-16 | Novartis Ag | Organic compounds |
| GB0428416D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| GB0428418D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| US7417147B2 (en) | 2005-11-10 | 2008-08-26 | Bodor Nicholas S | Soft anticholinergic zwitterions |
| CA2627982C (en) | 2005-11-10 | 2013-09-10 | Nicholas S. Bodor | Soft anticholinergic esters |
| WO2007068929A1 (en) * | 2005-12-16 | 2007-06-21 | Argenta Discovery Ltd. | Cyclic amine derivatives and their uses |
| JP2009534463A (ja) * | 2006-04-24 | 2009-09-24 | アストラゼネカ・アクチエボラーグ | 例えば慢性気管支閉塞、喘息および過活動膀胱の処置に有用な、ムスカリンｍ３受容体アンタゴニスト活性を有する環状アミノアルコールの新規アルキルエステル |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| US20100112061A1 (en) * | 2006-12-13 | 2010-05-06 | William Baker | Monophosphates as Mutual Prodrugs of Muscarinic Receptor Antagonists and Beta-Agonists for the Treatment of COPD And Chronic Bronchitis |
| RU2452728C2 (ru) * | 2007-02-23 | 2012-06-10 | Тереванс, Инк. | Четвертичные аммониевые дифенилметилсоединения, применимые в качестве антагонистов мускариновых рецепторов |
| CA2697752C (en) * | 2007-09-07 | 2016-01-26 | Theravance, Inc. | Guanidine-containing compounds useful as muscarinic receptor antagonists |
| JP2011506477A (ja) | 2007-12-14 | 2011-03-03 | セラヴァンス， インコーポレーテッド | ムスカリン受容体拮抗薬として有用なアミジン含有化合物 |
| AU2008356409B2 (en) | 2008-05-13 | 2012-01-19 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic M3 receptor antagonists |
| NZ595810A (en) * | 2009-04-30 | 2013-05-31 | Teijin Pharma Ltd | Quaternary ammonium salt compound |
| US9156833B2 (en) | 2012-07-16 | 2015-10-13 | Barry University, Inc. | Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof |
| PL3111978T3 (pl) | 2015-07-03 | 2022-01-24 | Novartis Ag | Inhalator przystosowany do odczytu informacji przechowywanych w środkach przechowywania danych pojemnika |
| WO2021183639A1 (en) * | 2020-03-11 | 2021-09-16 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3240784A (en) * | 1966-03-15 | Esters of quaternary z-hydroxy methyl piperidinium compounds | ||
| US2746966A (en) * | 1953-11-02 | 1956-05-22 | Lakeside Lab Inc | Esters of bis-(nu-substituted-3-hydroxypiperidinium) alkanes |
| GB833820A (en) * | 1957-10-17 | 1960-04-27 | Beecham Res Lab | Improvements in or relating to the preparation of pyrrolidyl esters and quaternary compounds thereof |
| JPS6018661B2 (ja) * | 1976-01-01 | 1985-05-11 | 太田製薬株式会社 | １−（１，３−ジオキソラン−４−イルメチル）ピペリジノ−ル誘導体 |
| JPS5427570A (en) * | 1977-07-30 | 1979-03-01 | Ota Pharma | Stereoisomer of 44acyloxyy11 alkyll11*1*33dioxolanee44 ylmethyl* pideridinium salt derivative |
| JPS5679688A (en) * | 1979-12-04 | 1981-06-30 | Ota Seiyaku Kk | 4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production |
| JPS5835177A (ja) | 1981-08-26 | 1983-03-01 | Dainippon Pharmaceut Co Ltd | ２−環状アミノ−２−（１，２−ベンズイソキサゾ−ル−３−イル）酢酸エステル類並びにその酸付加塩類および第４級アンモニウム塩類 |
| JPS58208270A (ja) * | 1982-05-28 | 1983-12-03 | Dainippon Pharmaceut Co Ltd | α−環状アミノフエニル酢酸エステル類並びにその酸付加塩類及び第４級アンモニウム塩類 |
| GB9023023D0 (en) | 1990-10-23 | 1990-12-05 | Barlow Richard B | Pharmaceutical compositions |
| ATE269305T1 (de) | 1995-04-28 | 2004-07-15 | Banyu Pharma Co Ltd | 1,4-disubstituierte piperidinderivate |
| DK1371645T3 (da) * | 1996-11-11 | 2013-06-03 | Meda Pharma Gmbh & Co Kg | Anvendelse af (3S,2'R)-glycopyrronium som lægemiddel |
| AU2001271027B2 (en) * | 2000-07-11 | 2005-07-07 | Msd K.K. | Ester derivatives |
| ES2206021B1 (es) * | 2002-04-16 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirrolidinio. |
| US7417147B2 (en) * | 2005-11-10 | 2008-08-26 | Bodor Nicholas S | Soft anticholinergic zwitterions |
-
2004
- 2004-06-22 PE PE2004000611A patent/PE20050231A1/es not_active Application Discontinuation
- 2004-06-22 AR ARP040102162A patent/AR044851A1/es not_active Application Discontinuation
- 2004-06-23 PT PT04740214T patent/PT1638940E/pt unknown
- 2004-06-23 DE DE602004028821T patent/DE602004028821D1/de not_active Expired - Lifetime
- 2004-06-23 CA CA2526991A patent/CA2526991C/en not_active Expired - Fee Related
- 2004-06-23 WO PCT/EP2004/006795 patent/WO2005000815A2/en active Search and Examination
- 2004-06-23 AT AT04740214T patent/ATE478845T1/de active
- 2004-06-23 JP JP2006516038A patent/JP2008529965A/ja active Pending
- 2004-06-23 US US10/561,366 patent/US7947730B2/en not_active Expired - Fee Related
- 2004-06-23 EP EP04740214A patent/EP1638940B1/en not_active Expired - Lifetime
- 2004-06-23 TW TW093118142A patent/TW200526573A/zh unknown
- 2004-06-23 BR BRPI0411738-7A patent/BRPI0411738A/pt not_active Application Discontinuation
- 2004-06-23 AU AU2004251867A patent/AU2004251867B2/en not_active Ceased
- 2004-06-23 MX MXPA05013823A patent/MXPA05013823A/es active IP Right Grant
- 2004-06-23 PL PL04740214T patent/PL1638940T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2526991C (en) | 2012-03-27 |
| EP1638940A2 (en) | 2006-03-29 |
| PT1638940E (pt) | 2010-11-08 |
| AU2004251867A1 (en) | 2005-01-06 |
| EP1638940B1 (en) | 2010-08-25 |
| JP2008529965A (ja) | 2008-08-07 |
| WO2005000815A3 (en) | 2005-04-14 |
| BRPI0411738A (pt) | 2006-08-08 |
| ATE478845T1 (de) | 2010-09-15 |
| DE602004028821D1 (de) | 2010-10-07 |
| AR044851A1 (es) | 2005-10-05 |
| WO2005000815A2 (en) | 2005-01-06 |
| CA2526991A1 (en) | 2005-01-06 |
| MXPA05013823A (es) | 2006-02-28 |
| AU2004251867B2 (en) | 2008-08-07 |
| US20060287362A1 (en) | 2006-12-21 |
| PE20050231A1 (es) | 2005-05-20 |
| US7947730B2 (en) | 2011-05-24 |
| TW200526573A (en) | 2005-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AP1828A (en) | Muscarinic Acetycholine receptor antagonists | |
| HK1109645A1 (en) | Photochromic compounds | |
| ZA200604645B (en) | Azabicyclic heterocycles as cannabinoid receptor modulators | |
| GB0305559D0 (en) | Compounds | |
| PL1638940T3 (pl) | Pochodne pirolidyniowe jako ligandy dla receptora muskarynowego M3 | |
| AU2002348503A8 (en) | Quinuclidine-substituted heteroaromatic compounds as ligands at nicotic acetylcholine receptors | |
| ZA200600229B (en) | Pyrrole-2,5-dithione derivatives as Liver X receptor modulators | |
| IL172760A0 (en) | Pyrrole-2,5-dithione derivatives as liver x receptor modulators | |
| EP1689389A4 (en) | Indole compounds | |
| EP1689403A4 (en) | HETEROARYL-hydrazone compounds | |
| GB0304665D0 (en) | Compounds | |
| GB0305553D0 (en) | Compounds | |
| GB0306329D0 (en) | Compounds | |
| IL190119A0 (en) | Amino-alkyl-amide derivatives as ccr3 receptor ligands | |
| IL190093A0 (en) | Amino-alkyl-amide derivatives as ccr3 receptor ligands | |
| EP1658301A4 (en) | N-DESMETHYL N-SUBSTITUTED 11-DESOXYERYTHROMYCIN COMPOUNDS | |
| EP1682514A4 (en) | 11-O-METHYLGELDANAMYCIN COMPOUNDS | |
| EP1483237A4 (en) | TROPANE COMPOUNDS | |
| GB0302512D0 (en) | Compounds | |
| GB0304494D0 (en) | Compounds | |
| AU2003256862A1 (en) | Aza-bridged bicyclic amine derivatives for use as novel cholinergic receptor ligands | |
| HU0301894D0 (en) | Wood-protecting composition for general purpose | |
| TW584199U (en) | Improved structure for range hood | |
| TW560368U (en) | Chassis structure for horizontal lathe | |
| AU2003904848A0 (en) | Receptor specific ligands |