ATE478845T1 - Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptor - Google Patents
Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptorInfo
- Publication number
- ATE478845T1 ATE478845T1 AT04740214T AT04740214T ATE478845T1 AT E478845 T1 ATE478845 T1 AT E478845T1 AT 04740214 T AT04740214 T AT 04740214T AT 04740214 T AT04740214 T AT 04740214T AT E478845 T1 ATE478845 T1 AT E478845T1
- Authority
- AT
- Austria
- Prior art keywords
- muscarine
- ligands
- receptor
- pyrrolidinium derivatives
- pyrrolidinium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0314697A GB0314697D0 (en) | 2003-06-24 | 2003-06-24 | Organic compounds |
| GB0327526A GB0327526D0 (en) | 2003-11-26 | 2003-11-26 | Organic compounds |
| PCT/EP2004/006795 WO2005000815A2 (en) | 2003-06-24 | 2004-06-23 | Piperidinium and pyrrolidinium derivatives as ligands for the muscarinic m3 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE478845T1 true ATE478845T1 (de) | 2010-09-15 |
Family
ID=33554160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04740214T ATE478845T1 (de) | 2003-06-24 | 2004-06-23 | Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptor |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7947730B2 (de) |
| EP (1) | EP1638940B1 (de) |
| JP (1) | JP2008529965A (de) |
| AR (1) | AR044851A1 (de) |
| AT (1) | ATE478845T1 (de) |
| AU (1) | AU2004251867B2 (de) |
| BR (1) | BRPI0411738A (de) |
| CA (1) | CA2526991C (de) |
| DE (1) | DE602004028821D1 (de) |
| MX (1) | MXPA05013823A (de) |
| PE (1) | PE20050231A1 (de) |
| PL (1) | PL1638940T3 (de) |
| PT (1) | PT1638940E (de) |
| TW (1) | TW200526573A (de) |
| WO (1) | WO2005000815A2 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0410712D0 (en) | 2004-05-13 | 2004-06-16 | Novartis Ag | Organic compounds |
| GB0428416D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| GB0428418D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| WO2007059021A1 (en) * | 2005-11-10 | 2007-05-24 | Bodor Nicholas S | Soft anticholinergic zwitterions |
| ATE529399T1 (de) | 2005-11-10 | 2011-11-15 | Nicholas S Bodor | Sanfte anticholinerge ester |
| EP1971572A1 (de) * | 2005-12-16 | 2008-09-24 | Argenta Discovery Limited | Cyclische aminderivate und anwendungen davon |
| US20090233965A1 (en) * | 2006-04-24 | 2009-09-17 | Astrazeneca Ab | Alkyl Esters Of Cyclic Amino Alcohols With Muscarinic M3 Receptor Antagonist Activity, Useful For Treating E.G. Chronic Bronchial Obstruction, Asthma And Overactive Bladder |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| EP2114972A2 (de) * | 2006-12-13 | 2009-11-11 | Gilead Sciences, Inc. | Monophosphate als gemeinsame prodrugs für muskarinrezeptorantagonisten und beta-agonisten für die behandlung von copd und chronischer bronchitis |
| CA2675942C (en) * | 2007-02-23 | 2016-04-12 | Theravance, Inc. | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists |
| WO2009035542A2 (en) | 2007-09-07 | 2009-03-19 | Theravance, Inc. | Guanidine-containing compounds useful as muscarinic receptor antagonists |
| EP2222637A1 (de) | 2007-12-14 | 2010-09-01 | Theravance, Inc. | Amidinhaltige verbindungen als muscarinrezeptor-antagonisten |
| EA017627B1 (ru) | 2008-05-13 | 2013-01-30 | Астразенека Аб | Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора |
| WO2010126025A1 (ja) * | 2009-04-30 | 2010-11-04 | 帝人ファーマ株式会社 | 四級アンモニウム塩化合物 |
| US9156833B2 (en) | 2012-07-16 | 2015-10-13 | Barry University, Inc. | Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof |
| PT3111978T (pt) | 2015-07-03 | 2021-12-06 | Novartis Ag | Inalador adaptado para ler informação armazenada num meio de armazenamento de dados de um recipiente |
| EP4118070A4 (de) * | 2020-03-11 | 2024-04-10 | Nocion Therapeutics, Inc. | Geladene ionenkanalblocker und verfahren zur verwendung |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3240784A (en) * | 1966-03-15 | Esters of quaternary z-hydroxy methyl piperidinium compounds | ||
| US2746966A (en) * | 1953-11-02 | 1956-05-22 | Lakeside Lab Inc | Esters of bis-(nu-substituted-3-hydroxypiperidinium) alkanes |
| GB833820A (en) * | 1957-10-17 | 1960-04-27 | Beecham Res Lab | Improvements in or relating to the preparation of pyrrolidyl esters and quaternary compounds thereof |
| JPS6018661B2 (ja) * | 1976-01-01 | 1985-05-11 | 太田製薬株式会社 | １−（１，３−ジオキソラン−４−イルメチル）ピペリジノ−ル誘導体 |
| JPS5427570A (en) * | 1977-07-30 | 1979-03-01 | Ota Pharma | Stereoisomer of 44acyloxyy11 alkyll11*1*33dioxolanee44 ylmethyl* pideridinium salt derivative |
| JPS5679688A (en) * | 1979-12-04 | 1981-06-30 | Ota Seiyaku Kk | 4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production |
| JPS5835177A (ja) * | 1981-08-26 | 1983-03-01 | Dainippon Pharmaceut Co Ltd | ２−環状アミノ−２−（１，２−ベンズイソキサゾ−ル−３−イル）酢酸エステル類並びにその酸付加塩類および第４級アンモニウム塩類 |
| JPS58208270A (ja) * | 1982-05-28 | 1983-12-03 | Dainippon Pharmaceut Co Ltd | α−環状アミノフエニル酢酸エステル類並びにその酸付加塩類及び第４級アンモニウム塩類 |
| GB9023023D0 (en) * | 1990-10-23 | 1990-12-05 | Barlow Richard B | Pharmaceutical compositions |
| KR19990008109A (ko) | 1995-04-28 | 1999-01-25 | 나가사까 겐지로 | 1,4-이치환 피페리딘 유도체 |
| DK0937041T3 (da) * | 1996-11-11 | 2003-08-11 | Christian R Noe | Anvendelse af et farmaceutisk egnet salt af (3R,2'R)-3-[(cyclopentil-hydroxyphenylacetyl)oxyl]-1,1-dimethyl-pyrrolidinium til fremstilling af et lægemiddel |
| EP1302458A4 (de) * | 2000-07-11 | 2005-10-19 | Banyu Pharma Co Ltd | Esterderivate |
| ES2206021B1 (es) * | 2002-04-16 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirrolidinio. |
| WO2007059021A1 (en) * | 2005-11-10 | 2007-05-24 | Bodor Nicholas S | Soft anticholinergic zwitterions |
-
2004
- 2004-06-22 PE PE2004000611A patent/PE20050231A1/es not_active Application Discontinuation
- 2004-06-22 AR ARP040102162A patent/AR044851A1/es not_active Application Discontinuation
- 2004-06-23 US US10/561,366 patent/US7947730B2/en not_active Expired - Fee Related
- 2004-06-23 DE DE602004028821T patent/DE602004028821D1/de not_active Expired - Lifetime
- 2004-06-23 AU AU2004251867A patent/AU2004251867B2/en not_active Ceased
- 2004-06-23 JP JP2006516038A patent/JP2008529965A/ja active Pending
- 2004-06-23 MX MXPA05013823A patent/MXPA05013823A/es active IP Right Grant
- 2004-06-23 EP EP04740214A patent/EP1638940B1/de not_active Expired - Lifetime
- 2004-06-23 PL PL04740214T patent/PL1638940T3/pl unknown
- 2004-06-23 PT PT04740214T patent/PT1638940E/pt unknown
- 2004-06-23 CA CA2526991A patent/CA2526991C/en not_active Expired - Fee Related
- 2004-06-23 TW TW093118142A patent/TW200526573A/zh unknown
- 2004-06-23 BR BRPI0411738-7A patent/BRPI0411738A/pt not_active Application Discontinuation
- 2004-06-23 AT AT04740214T patent/ATE478845T1/de active
- 2004-06-23 WO PCT/EP2004/006795 patent/WO2005000815A2/en active Search and Examination
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004028821D1 (de) | 2010-10-07 |
| AU2004251867A1 (en) | 2005-01-06 |
| MXPA05013823A (es) | 2006-02-28 |
| WO2005000815A3 (en) | 2005-04-14 |
| US7947730B2 (en) | 2011-05-24 |
| EP1638940B1 (de) | 2010-08-25 |
| BRPI0411738A (pt) | 2006-08-08 |
| US20060287362A1 (en) | 2006-12-21 |
| AU2004251867B2 (en) | 2008-08-07 |
| PL1638940T3 (pl) | 2011-02-28 |
| WO2005000815A2 (en) | 2005-01-06 |
| TW200526573A (en) | 2005-08-16 |
| AR044851A1 (es) | 2005-10-05 |
| JP2008529965A (ja) | 2008-08-07 |
| CA2526991A1 (en) | 2005-01-06 |
| PT1638940E (pt) | 2010-11-08 |
| PE20050231A1 (es) | 2005-05-20 |
| CA2526991C (en) | 2012-03-27 |
| EP1638940A2 (de) | 2006-03-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60225274D1 (de) | Chinolinderivate als liganden für den neuropeptid-y-rezeptor | |
| ATE478845T1 (de) | Pyrrolidiniumderivative als liganden für den muscarinen m3-rezeptor | |
| LTC1725537I2 (lt) | Nauji junginiai, kaip opioido receptoriaus moduliatoriai | |
| ATE387202T1 (de) | Pyrrolidinderivate als histaminrezeptor-liganden | |
| DE602004029412D1 (de) | Fahrerhaus für eine Erdbewegungsmaschine | |
| TR200300322T2 (tr) | Kemokin alıcısını bağlayan heterosiklik bileşikler | |
| DK1677795T3 (da) | Muskarine acetylcholin-receptor-antagonister | |
| DE602006016303D1 (de) | 3,4-dihydro-2H-benzoÄ1,4Üoxazin- und 3,4-dihydro-2H-benzoÄ1,4Üthiazin-VERBINDUNGEN ALS ALPHA2C-ADRENOREZEPTOR-ANTAGONISTEN | |
| DE602004015724D1 (de) | Diazepinoindolderivate als kinaseinhibitoren | |
| ATE381334T1 (de) | 2,5-substituiertetetrahydroisochinoline zur verwendung als 5-ht6 modulatoren | |
| DE602004024420D1 (de) | Chinazolinderivate als antitumormittel | |
| DE60209004D1 (de) | Verbindungen verwendbar als zwischenprodukte für 4-aminochinolinderivate | |
| ATE440840T1 (de) | Quinuclidin-derivate bindend an muscarin-m3- rezeptoren | |
| JP2008525358A5 (ja) | Ｍ３ムスカリン受容体としてのピロリジニウム誘導体 | |
| DE602004023251D1 (de) | Phantom für Qualitätskontrolle | |
| ATE400206T1 (de) | Ausziehführungsgarnitur für schubladen | |
| DE112004002056D2 (de) | Hydraulische Schaltung für den Strebausbau | |
| ATE507222T1 (de) | 1,1-dioxo-thiomorpholinyl-indolyl-methanon- derivate zur verwendung als h3-modulatoren | |
| DE602004014772D1 (de) | Pyrrol-2,5-dithionderivate als modulatoren des liver-x-rezeptors | |
| ATE377008T1 (de) | Imidazolderivate als glutamatrezeptorantagonisten | |
| DE60324848D1 (de) | Ausgleichsmechanismus für drehwelle | |
| DE50301232D1 (de) | Skibindung, insbesondere für den langlauf | |
| ATE394372T1 (de) | G-lactamderivate als prostaglandinagonisten | |
| ATE364601T1 (de) | Substituierte pyrazolverbindungen | |
| ATE495168T1 (de) | Heteroarylsubstituierte imidazolderivate als glutamatrezeptorantagonisten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1638940 Country of ref document: EP |