DE602004025668D1 - Methoden der verhinderung und behandlung der alzheimer'schen krankheit - Google Patents
Methoden der verhinderung und behandlung der alzheimer'schen krankheitInfo
- Publication number
- DE602004025668D1 DE602004025668D1 DE602004025668T DE602004025668T DE602004025668D1 DE 602004025668 D1 DE602004025668 D1 DE 602004025668D1 DE 602004025668 T DE602004025668 T DE 602004025668T DE 602004025668 T DE602004025668 T DE 602004025668T DE 602004025668 D1 DE602004025668 D1 DE 602004025668D1
- Authority
- DE
- Germany
- Prior art keywords
- arg
- glu
- asp
- tyr
- phe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 5
- 230000002265 prevention Effects 0.000 title 1
- 229960005486 vaccine Drugs 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- RBXSZQRSEGYDFG-GUBZILKMSA-N Glu-Lys-Ser Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O RBXSZQRSEGYDFG-GUBZILKMSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 108010064539 amyloid beta-protein (1-42) Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 230000001777 nootropic effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Marine Sciences & Fisheries (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT362003 | 2003-01-14 | ||
| AT0146403A AT413945B (de) | 2003-01-14 | 2003-09-17 | Impfstoff für die alzheimer-krankheit |
| PCT/EP2004/000162 WO2004062556A2 (en) | 2003-01-14 | 2004-01-13 | Methods for preventing and treating alzheimer’s disease (ad) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004025668D1 true DE602004025668D1 (de) | 2010-04-08 |
Family
ID=32714004
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004025668T Expired - Lifetime DE602004025668D1 (de) | 2003-01-14 | 2004-01-13 | Methoden der verhinderung und behandlung der alzheimer'schen krankheit |
| DE602004009705T Expired - Lifetime DE602004009705T2 (de) | 2003-01-14 | 2004-01-13 | Methoden der Verhinderung und Behandlung der Alzheimer'schen Krankheit |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004009705T Expired - Lifetime DE602004009705T2 (de) | 2003-01-14 | 2004-01-13 | Methoden der Verhinderung und Behandlung der Alzheimer'schen Krankheit |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7732568B2 (da) |
| EP (2) | EP1583774B1 (da) |
| JP (2) | JP4547373B2 (da) |
| CN (2) | CN102526699A (da) |
| AT (3) | AT413945B (da) |
| CA (1) | CA2513218C (da) |
| CY (2) | CY1107146T1 (da) |
| DE (2) | DE602004025668D1 (da) |
| DK (2) | DK1583774T3 (da) |
| ES (2) | ES2339447T3 (da) |
| HK (1) | HK1091499A1 (da) |
| PL (1) | PL209989B1 (da) |
| PT (2) | PT1583774E (da) |
| SI (1) | SI1583774T1 (da) |
| WO (1) | WO2004062556A2 (da) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003303198A1 (en) | 2002-12-19 | 2004-07-14 | New York University | Method for treating amyloid disease |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| AT413336B (de) * | 2003-09-12 | 2006-02-15 | Mattner Frank Dr | Apherese-vorrichtung |
| EP1711208A2 (en) * | 2004-01-28 | 2006-10-18 | Curix APS | Conjugates of amyloid proteins as vaccines for amyloid-related diseases |
| AT413946B (de) * | 2004-07-13 | 2006-07-15 | Mattner Frank Dr | Impfstoff gegen die alzheimer-krankheit |
| AT500483B1 (de) * | 2004-07-13 | 2006-01-15 | Mattner Frank Dr | Set zur vorbeugung oder behandlung der alzheimer'schen erkrankung |
| RU2442793C2 (ru) | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
| KR101667623B1 (ko) | 2005-11-30 | 2016-10-19 | 애브비 인코포레이티드 | 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도 |
| KR20150098683A (ko) | 2005-12-12 | 2015-08-28 | 에이씨 이뮨 에스.에이. | 치료적 특성을 갖는 베타 1-42 특이적인 단일클론성 항체 |
| EP1878747A1 (en) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-engineered antibodies |
| SG173385A1 (en) | 2006-07-14 | 2011-08-29 | Ac Immune S A Ch | Humanized antibody against amyloid beta |
| US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| RS53793B1 (en) * | 2007-06-12 | 2015-06-30 | Ac Immune S.A. | HUMANIZED ANTIBODIES AGAINST BETA AMYLOID |
| US8048420B2 (en) * | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| US20100297012A1 (en) * | 2007-10-05 | 2010-11-25 | Andrea Pfeifer | Humanized antibody |
| ES2612788T3 (es) * | 2007-10-05 | 2017-05-18 | Genentech, Inc. | Métodos y composiciones para el diagnóstico y tratamiento de la amiloidosis |
| RU2604181C2 (ru) * | 2007-10-05 | 2016-12-10 | Дженентек, Инк. | Применение антитела против амилоида бета при глазных заболеваниях |
| US8586706B2 (en) * | 2007-10-25 | 2013-11-19 | Kagoshima University | Peptide vaccine using mimic molecules of amyloid β peptide |
| EP2224000B1 (en) * | 2007-10-29 | 2020-05-13 | TAO Health Life Pharma Co., Ltd. | Antibody and use thereof |
| NZ589302A (en) | 2008-04-17 | 2012-11-30 | Declion Pharmaceuticals Inc | Design and synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders |
| AT509611B1 (de) * | 2008-06-12 | 2012-04-15 | Affiris Forschungs-Und Entwicklungs Gmbh | Vakzin |
| AT506819B1 (de) * | 2008-06-12 | 2011-06-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzin zur behandlung von alzheimer-krankheit |
| CN102123726A (zh) * | 2008-06-12 | 2011-07-13 | 阿费里斯股份公司 | 用于治疗与帕金森氏病有关的症状的化合物 |
| MX360403B (es) | 2010-04-15 | 2018-10-31 | Abbvie Inc | Proteinas de union a amiloide beta. |
| RU2607368C2 (ru) | 2010-07-30 | 2017-01-10 | Ац Иммуне С.А. | Безопасные и функциональные гуманизированные антитела |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| US20120321694A1 (en) * | 2010-10-27 | 2012-12-20 | Daniel Larocque | Compositions and uses |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| SI2579042T1 (sl) | 2011-10-04 | 2014-09-30 | Affiris Ag | Postopek za detektiranje Ass-specifičnih protiteles v biološkem vzorcu |
| EP2787347A1 (en) | 2013-04-03 | 2014-10-08 | Affiris AG | Method for detecting Aß-specific antibodies in a biological sample |
| US10381614B2 (en) * | 2013-04-17 | 2019-08-13 | Samsung Sdi Co., Ltd. | Battery module |
| WO2015165961A1 (en) | 2014-04-29 | 2015-11-05 | Affiris Ag | Treatment and prevention of alzheimer's disease (ad) |
| RU2734924C2 (ru) | 2015-11-03 | 2020-10-26 | Аффирис Аг | Способ вакцинации против аутоантигена у пациента-человека |
| CN105237628B (zh) * | 2015-11-17 | 2018-08-07 | 南开大学 | 一种用于治疗阿尔兹海默症的多肽 |
| CN107022019B (zh) * | 2016-11-24 | 2020-10-30 | 桂林医学院 | 一种用于脑内降铁除自由基的多肽、制备方法与应用 |
| WO2023161526A1 (en) | 2022-02-28 | 2023-08-31 | Tridem Bioscience Gmbh & Co Kg | A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK590288D0 (da) * | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| GB9022190D0 (en) * | 1990-10-12 | 1990-11-28 | Perham Richard N | Immunogenic material |
| US5639603A (en) * | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6088993A (en) | 1999-02-05 | 2000-07-18 | Irace; Francisco D. | Closure system |
| CA2363118A1 (en) | 1999-02-25 | 2000-08-31 | Smithkline Beecham Biologicals S.A. | Immunogens comprising a peptide and a carrier derived from h.influenzae protein d |
| US6703491B1 (en) * | 1999-03-17 | 2004-03-09 | Exelixis, Inc. | Drosophila sequences |
| JP2003509020A (ja) * | 1999-09-03 | 2003-03-11 | ラモット・ユニバーシティ・オーソリティ・フォー・アプライド・リサーチ・アンド・インダストリアル・ディベロップメント・リミテッド | プラーク形成疾患の診断、治療、予防に有用な薬剤、組成物、その使用法 |
| CN1418106A (zh) * | 2000-03-03 | 2003-05-14 | 史密丝克莱恩比彻姆生物有限公司 | 疫苗 |
| GB0024200D0 (en) * | 2000-10-03 | 2000-11-15 | Smithkline Beecham Sa | Component vaccine |
| EP1287831B1 (de) | 2001-09-03 | 2006-11-22 | Bio Life Science Forschungs- und Entwicklungsges.m.b.H. | Antigen-Mimotope und Vakzine gegen Krebserkrankungen |
| DE60232691D1 (de) | 2002-05-07 | 2009-07-30 | Agronomique Inst Nat Rech | Screeningverfahren für PP1-wechselwirkende Polypeptide oder Proteine, Peptide, die die Bindung von PP1c an die Proteine Bcl-2, BCL-XL und BCL-W hemmen, und ihre Verwendung |
-
2003
- 2003-09-17 AT AT0146403A patent/AT413945B/de not_active IP Right Cessation
-
2004
- 2004-01-13 SI SI200431399T patent/SI1583774T1/sl unknown
- 2004-01-13 DE DE602004025668T patent/DE602004025668D1/de not_active Expired - Lifetime
- 2004-01-13 PL PL378333A patent/PL209989B1/pl unknown
- 2004-01-13 CA CA2513218A patent/CA2513218C/en not_active Expired - Fee Related
- 2004-01-13 WO PCT/EP2004/000162 patent/WO2004062556A2/en active Application Filing
- 2004-01-13 EP EP04701585A patent/EP1583774B1/en not_active Expired - Lifetime
- 2004-01-13 EP EP05107898A patent/EP1679319B1/en not_active Expired - Lifetime
- 2004-01-13 ES ES04701585T patent/ES2339447T3/es not_active Expired - Lifetime
- 2004-01-13 ES ES05107898T patent/ES2296084T3/es not_active Expired - Lifetime
- 2004-01-13 DK DK04701585.4T patent/DK1583774T3/da active
- 2004-01-13 DK DK05107898T patent/DK1679319T3/da active
- 2004-01-13 AT AT04701585T patent/ATE458753T1/de active
- 2004-01-13 DE DE602004009705T patent/DE602004009705T2/de not_active Expired - Lifetime
- 2004-01-13 AT AT05107898T patent/ATE376559T1/de active
- 2004-01-13 PT PT04701585T patent/PT1583774E/pt unknown
- 2004-01-13 CN CN2011103110387A patent/CN102526699A/zh active Pending
- 2004-01-13 PT PT05107898T patent/PT1679319E/pt unknown
- 2004-01-13 US US10/540,551 patent/US7732568B2/en not_active Expired - Fee Related
- 2004-01-13 JP JP2006500553A patent/JP4547373B2/ja not_active Expired - Fee Related
- 2004-01-13 CN CN200480002213.2A patent/CN1826354B/zh not_active Expired - Fee Related
-
2006
- 2006-10-27 HK HK06111905.5A patent/HK1091499A1/xx not_active IP Right Cessation
-
2008
- 2008-01-17 CY CY20081100069T patent/CY1107146T1/el unknown
-
2010
- 2010-03-08 JP JP2010051012A patent/JP5282058B2/ja not_active Expired - Fee Related
- 2010-04-01 US US12/752,451 patent/US20110015131A1/en not_active Abandoned
- 2010-05-07 CY CY20101100399T patent/CY1110634T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |