DE602004025612D1 - Koordinationskomplex von diaminocyclohexanplatin(ii) mit einem blockcopolymer mit einem poly(carbonsäure)segment und diesen enthaltendes antitumormittel - Google Patents

Koordinationskomplex von diaminocyclohexanplatin(ii) mit einem blockcopolymer mit einem poly(carbonsäure)segment und diesen enthaltendes antitumormittel

Info

Publication number
DE602004025612D1
DE602004025612D1 DE602004025612T DE602004025612T DE602004025612D1 DE 602004025612 D1 DE602004025612 D1 DE 602004025612D1 DE 602004025612 T DE602004025612 T DE 602004025612T DE 602004025612 T DE602004025612 T DE 602004025612T DE 602004025612 D1 DE602004025612 D1 DE 602004025612D1
Authority
DE
Germany
Prior art keywords
poly
segment
carboxylic acid
block copolymer
diaminocyclohexanplatine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004025612T
Other languages
English (en)
Inventor
Kazunori Kataoka
Nobuhiro Nishiyama
Horacio Cabral
Soichiro Okazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Todai TLO Ltd
Original Assignee
Todai TLO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Todai TLO Ltd filed Critical Todai TLO Ltd
Publication of DE602004025612D1 publication Critical patent/DE602004025612D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G85/00—General processes for preparing compounds provided for in this subclass
    • C08G85/002—Post-polymerisation treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/10—Metal compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602004025612T 2003-12-10 2004-12-08 Koordinationskomplex von diaminocyclohexanplatin(ii) mit einem blockcopolymer mit einem poly(carbonsäure)segment und diesen enthaltendes antitumormittel Active DE602004025612D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003412315 2003-12-10
PCT/JP2004/018679 WO2005056641A1 (ja) 2003-12-10 2004-12-08 ジアミノシクロヘキサン白金(ii)とポリ(カルボン酸)セグメント含有ブロック共重合体との配位錯体、その抗腫瘍剤

Publications (1)

Publication Number Publication Date
DE602004025612D1 true DE602004025612D1 (de) 2010-04-01

Family

ID=34675022

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004025612T Active DE602004025612D1 (de) 2003-12-10 2004-12-08 Koordinationskomplex von diaminocyclohexanplatin(ii) mit einem blockcopolymer mit einem poly(carbonsäure)segment und diesen enthaltendes antitumormittel

Country Status (17)

Country Link
US (1) US8012463B2 (de)
EP (1) EP1695991B1 (de)
JP (1) JP3955992B2 (de)
KR (1) KR100982933B1 (de)
CN (1) CN100457185C (de)
AT (1) ATE458022T1 (de)
AU (1) AU2004297126B2 (de)
CA (1) CA2548457C (de)
CY (1) CY1110233T1 (de)
DE (1) DE602004025612D1 (de)
DK (1) DK1695991T3 (de)
ES (1) ES2337904T3 (de)
PL (1) PL1695991T3 (de)
PT (1) PT1695991E (de)
RU (1) RU2335512C2 (de)
SI (1) SI1695991T1 (de)
WO (1) WO2005056641A1 (de)

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WO2005079861A2 (en) * 2004-02-13 2005-09-01 Safeway Investments Ltd. Polymeric water soluble prodrugs
EP1867673B1 (de) * 2005-03-18 2011-11-16 The University of Tokyo Koordinationsverbindung aus diaminocyclohexan-platin(ii) und blockcopolymer und diese enthaltendes antikrebsmittel
EP1878766B1 (de) * 2005-05-02 2020-01-01 The University of Tokyo Polymervesikel vom typ elektrostatische bindung
CA2606939C (en) * 2005-05-11 2013-09-03 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of cytidine metabolic antagonist
US7781607B2 (en) * 2005-06-09 2010-08-24 Nanocarrier Co., Ltd. Method for producing polymerized coordination compounds of platinum complex
WO2007067417A1 (en) * 2005-12-05 2007-06-14 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
JP5046060B2 (ja) * 2007-03-29 2012-10-10 国立大学法人大阪大学 光学活性有機酸架橋二核白金（ｉｉ）錯体
EP2144631A2 (de) * 2007-04-10 2010-01-20 Nitto Denko Corporation Multifunktionale polyglutamat-wirkstoffträger
DK2155254T3 (da) * 2007-05-09 2013-03-04 Nitto Denko Corp Med platinlægemidler konjugerede polymere
WO2008141107A2 (en) 2007-05-09 2008-11-20 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
CN104689336A (zh) 2008-01-28 2015-06-10 那野伽利阿株式会社 医药组合物或组合剂
EP2262537A1 (de) * 2008-03-06 2010-12-22 Nitto Denko Corporation Polymer-paclitaxel-konjugate und verfahren zur behandlung von krebs
US20090232762A1 (en) * 2008-03-11 2009-09-17 May Pang Xiong Compositions for delivery of therapeutic agents
EP2308916B1 (de) * 2008-06-26 2016-11-09 Japan Science and Technology Agency Polymer/metallkomplex-verbundwerkstoff mit mrt-kontrastvermögen und mri-kontrastierungs- und/oder antitumorzusammensetzung unter verwendung davon
JP2011105792A (ja) * 2009-11-12 2011-06-02 Japan Science & Technology Agency ブロックコポリマー、ブロックコポリマー−金属錯体複合体、及びそれを用いた中空構造体キャリア
CN102091025B (zh) * 2009-12-14 2012-07-11 中国科学院化学研究所 抗肿瘤可注射水凝胶及其制备方法和用途
JP5594730B2 (ja) * 2010-11-02 2014-09-24 学校法人東京理科大学 金属高分子錯体からなるミセルの分散液
MX348798B (es) * 2011-03-31 2017-06-29 Nanocarrier Co Ltd Composicion farmaceutica que contiene copolimero en bloque que comprende compuesto de acido boronico.
US8785569B2 (en) 2011-11-22 2014-07-22 Original Biomedicals Co., Ltd. Drug carrier with chelating complex micelles and the application thereof
TWI568453B (zh) * 2011-11-22 2017-02-01 原創生醫股份有限公司 具有螯合型複合微胞之藥物載體及其應用
CN105997878B (zh) * 2012-11-22 2019-03-22 原创生医股份有限公司 降低自由基伤害的复合微胞载体医药组成物
EP2740737B1 (de) * 2012-12-05 2015-09-16 Heraeus Deutschland GmbH & Co. KG 1,2-Cyclohexandiaminplatin(II) bis-(4-methylbenzolsulfonat) und dessen Hydrate
CN103394095B (zh) * 2013-08-19 2016-03-23 中国科学院长春应用化学研究所 二氯-1,2-环己二胺合铂配合物及其制备方法
RU2695357C1 (ru) 2015-06-24 2019-07-23 Ниппон Каяку Кабусики Каися Новый комплекс платины (iv)
JP6725520B2 (ja) 2015-09-14 2020-07-22 日本化薬株式会社 ６配位白金錯体の高分子結合体
EP3395857B1 (de) * 2015-12-22 2021-05-26 Nippon Kayaku Kabushiki Kaisha Polymerkonjugat eines sulfoxidderivat-koordinierten platin(ii)-komplexes
WO2022120147A1 (en) * 2020-12-04 2022-06-09 The Methodist Hospital System Amino acid polymer-platinum anticancer drug conjugates
CN113929898B (zh) * 2021-10-09 2023-03-24 苏州大学 一种金属基纳米聚合物及其制备方法与应用

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US4115418A (en) 1976-09-02 1978-09-19 Government Of The United States Of America 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity
JPS5829957B2 (ja) * 1977-09-12 1983-06-25 喜徳 喜谷 新規な白金錯体
GR75598B (de) 1980-04-29 1984-08-01 Sanofi Sa
US4485093A (en) 1982-08-13 1984-11-27 Runge Richard G Immunotoxin conjugate which comprises arsanilic acid, useful for treating malignant tumors, particularly pancreatic cancer
IN165717B (de) 1986-08-07 1989-12-23 Battelle Memorial Institute
US4931553A (en) 1988-05-11 1990-06-05 Gill Devinder S Platinum-polymer complexes and their use as antitumor agents
JP2517760B2 (ja) 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
JPH05301884A (ja) * 1992-04-22 1993-11-16 Tanaka Kikinzoku Kogyo Kk 白金錯化合物の製造方法
JP3044512B2 (ja) * 1993-03-15 2000-05-22 デビオファーム エス．アー． 白金錯体の製造方法
JP3025602B2 (ja) * 1993-05-21 2000-03-27 デビオファーム エス．アー． 光学的に高純度なシス−オキザラート（トランス−ｌ−１，２−シクロヘキサンジアミン）白金（ＩＩ）錯体の製造方法
CN1039588C (zh) * 1995-03-29 1998-08-26 邹娟 新的抗肿瘤铂络合物
DE69713763T2 (de) 1996-03-11 2003-03-13 Yoshinori Kidani Binukleare platinkomplexe, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die diese komplexe enthalten
EP1319403A4 (de) * 2000-08-11 2009-07-08 Dainippon Sumitomo Pharma Co Mittel gegen cisplatin-toleranten krebs
KR100363394B1 (ko) * 2000-08-21 2002-12-05 한국과학기술연구원 온도감응성을 갖는 포스파젠삼량체-백금착물 복합체, 그의제조방법 및 그를 함유하는 항암제 조성물
ATE330619T1 (de) * 2000-09-26 2006-07-15 Toudai Tlo Ltd Polymere mizelle mit darin eingeschlossenem cisplatin und ihre verwendung
US20030109432A1 (en) * 2001-12-10 2003-06-12 Zuo William W. Anticancer polypeptide-metal complexes and compositions, methods of making, and methods of using same

Also Published As

Publication number Publication date
KR100982933B1 (ko) 2010-09-17
PL1695991T3 (pl) 2010-05-31
RU2335512C2 (ru) 2008-10-10
KR20060123299A (ko) 2006-12-01
PT1695991E (pt) 2010-03-02
ES2337904T3 (es) 2010-04-30
ATE458022T1 (de) 2010-03-15
AU2004297126B2 (en) 2010-11-25
EP1695991A4 (de) 2009-06-24
US8012463B2 (en) 2011-09-06
US20070148125A1 (en) 2007-06-28
DK1695991T3 (da) 2010-04-19
CA2548457C (en) 2010-08-24
CN1890295A (zh) 2007-01-03
JP3955992B2 (ja) 2007-08-08
AU2004297126A1 (en) 2005-06-23
RU2006124552A (ru) 2008-01-20
EP1695991B1 (de) 2010-02-17
JPWO2005056641A1 (ja) 2007-07-05
CY1110233T1 (el) 2015-01-14
SI1695991T1 (sl) 2010-04-30
EP1695991A1 (de) 2006-08-30
CA2548457A1 (en) 2005-06-23
CN100457185C (zh) 2009-02-04
WO2005056641A1 (ja) 2005-06-23

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