DE602004022639D1 - Verfahren zur herstellung von lactonase und nutzung davon - Google Patents
Verfahren zur herstellung von lactonase und nutzung davonInfo
- Publication number
- DE602004022639D1 DE602004022639D1 DE602004022639T DE602004022639T DE602004022639D1 DE 602004022639 D1 DE602004022639 D1 DE 602004022639D1 DE 602004022639 T DE602004022639 T DE 602004022639T DE 602004022639 T DE602004022639 T DE 602004022639T DE 602004022639 D1 DE602004022639 D1 DE 602004022639D1
- Authority
- DE
- Germany
- Prior art keywords
- lactonase
- enzyme
- gamma
- stable
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101000693619 Starmerella bombicola Lactone esterase Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 125000000457 gamma-lactone group Chemical group 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 230000002255 enzymatic effect Effects 0.000 abstract 2
- SERHXTVXHNVDKA-UHFFFAOYSA-N pantolactone Chemical compound CC1(C)COC(=O)C1O SERHXTVXHNVDKA-UHFFFAOYSA-N 0.000 abstract 2
- 229940115458 pantolactone Drugs 0.000 abstract 2
- SIEVQTNTRMBCHO-UHFFFAOYSA-N pantolactone Natural products CC1(C)OC(=O)CC1O SIEVQTNTRMBCHO-UHFFFAOYSA-N 0.000 abstract 2
- 238000005215 recombination Methods 0.000 abstract 2
- 230000006798 recombination Effects 0.000 abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 238000011914 asymmetric synthesis Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003055233 | 2003-03-03 | ||
| JP2003371750 | 2003-10-31 | ||
| PCT/JP2004/002643 WO2004078951A1 (ja) | 2003-03-03 | 2004-03-03 | ラクトナーゼの製法およびその利用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004022639D1 true DE602004022639D1 (de) | 2009-10-01 |
Family
ID=32964870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004022639T Expired - Lifetime DE602004022639D1 (de) | 2003-03-03 | 2004-03-03 | Verfahren zur herstellung von lactonase und nutzung davon |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20070134775A1 (de) |
| EP (1) | EP1600499B1 (de) |
| JP (1) | JPWO2004078951A1 (de) |
| KR (1) | KR20050109950A (de) |
| CN (1) | CN100402640C (de) |
| AT (1) | ATE440131T1 (de) |
| AU (1) | AU2004217677B2 (de) |
| BR (1) | BRPI0407947A (de) |
| CA (1) | CA2518402A1 (de) |
| DE (1) | DE602004022639D1 (de) |
| WO (1) | WO2004078951A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101448950B (zh) * | 2006-05-16 | 2014-02-12 | 帝斯曼知识产权资产管理有限公司 | 用于生产泛醇的工艺 |
| CA2790919C (en) | 2010-02-23 | 2019-02-26 | Toray Industries, Inc. | Process for production of cadaverine |
| CN107628963B (zh) * | 2017-10-16 | 2020-08-04 | 宁夏金维制药股份有限公司 | 一种维生素b5粗品的制备方法 |
| CN108191688A (zh) * | 2017-12-28 | 2018-06-22 | 大连韦德生化科技有限公司 | 一种合成及结晶d-泛酸钙的方法 |
| CN110452861B (zh) * | 2019-07-10 | 2021-02-09 | 杭州师范大学 | 一种基因重组工程菌及其在催化合成d-泛酰内酯中的应用 |
| CN112774251A (zh) * | 2019-11-27 | 2021-05-11 | 安徽华恒生物科技股份有限公司 | 酸与酯混合溶液的分离方法 |
| CN112175919B (zh) * | 2020-09-30 | 2024-02-09 | 江西兄弟医药有限公司 | 内酯水解酶突变体及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2844354B2 (ja) | 1989-08-03 | 1999-01-06 | 富士薬品工業株式会社 | Ｄ―パントラクトンの製造法 |
| JP3011449B2 (ja) | 1990-10-05 | 2000-02-21 | 富士薬品工業株式会社 | Ｄ―パントラクトン加水分解酵素およびその製造法 |
| CA2069147A1 (en) * | 1991-05-22 | 1992-11-23 | Kazuaki Kitano | Dna and its use |
| MX221102B (es) * | 1995-09-13 | 2004-06-23 | Fuji Yakuhin Kogyo Kk | D-pantolactona hidrolasa y gen que codifica para la misma. |
| JP2003512015A (ja) * | 1998-11-10 | 2003-04-02 | ノボザイムス バイオテック，インコーポレイティド | ラクトノヒドロラーゼ活性を有するポリペプチド及びそれをコードする核酸 |
| US6395529B1 (en) * | 1998-11-10 | 2002-05-28 | Novozymes Biotech, Inc. | Polypeptides having lactonohydrolase activity and nucleic acids encoding same |
| US7326549B2 (en) * | 2001-03-19 | 2008-02-05 | Cargill, Incorporated | Myo-inositol oxygenases |
-
2004
- 2004-03-03 WO PCT/JP2004/002643 patent/WO2004078951A1/ja active Application Filing
- 2004-03-03 DE DE602004022639T patent/DE602004022639D1/de not_active Expired - Lifetime
- 2004-03-03 AU AU2004217677A patent/AU2004217677B2/en not_active Ceased
- 2004-03-03 JP JP2005503072A patent/JPWO2004078951A1/ja active Pending
- 2004-03-03 CN CNB2004800075765A patent/CN100402640C/zh not_active Expired - Fee Related
- 2004-03-03 CA CA002518402A patent/CA2518402A1/en not_active Abandoned
- 2004-03-03 KR KR1020057016198A patent/KR20050109950A/ko not_active Application Discontinuation
- 2004-03-03 AT AT04716788T patent/ATE440131T1/de not_active IP Right Cessation
- 2004-03-03 EP EP04716788A patent/EP1600499B1/de not_active Expired - Lifetime
- 2004-03-03 US US10/547,424 patent/US20070134775A1/en not_active Abandoned
- 2004-03-03 BR BRPI0407947-7A patent/BRPI0407947A/pt not_active IP Right Cessation
-
2008
- 2008-09-25 US US12/232,870 patent/US20090137012A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070134775A1 (en) | 2007-06-14 |
| AU2004217677B2 (en) | 2008-09-11 |
| ATE440131T1 (de) | 2009-09-15 |
| AU2004217677A1 (en) | 2004-09-16 |
| CN1761742A (zh) | 2006-04-19 |
| BRPI0407947A (pt) | 2006-03-07 |
| EP1600499A4 (de) | 2006-08-30 |
| EP1600499B1 (de) | 2009-08-19 |
| KR20050109950A (ko) | 2005-11-22 |
| JPWO2004078951A1 (ja) | 2006-06-08 |
| WO2004078951A1 (ja) | 2004-09-16 |
| CN100402640C (zh) | 2008-07-16 |
| CA2518402A1 (en) | 2004-09-16 |
| US20090137012A1 (en) | 2009-05-28 |
| EP1600499A1 (de) | 2005-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE493502T1 (de) | Glucosamin und verfahren zur herstellung von glucosamin aus mikrobieller biomasse | |
| DE60301031D1 (de) | Verfahren zur Herstellung von L-Aminosäuren | |
| ATE443757T1 (de) | L-aminosäure produzierender mikroorganismus und verfahren zur l-aminosäureproduktion | |
| ATE421899T1 (de) | Azeotrope destillation zyklischer ester von organischen hydroxysäuren | |
| ATE519841T1 (de) | Lipase, dessen gen, der stamm und verwendung dieser lipase | |
| DE602007004111D1 (de) | Verfahren zur herstellung von enantiomeren angereicherten cyclischen beta-aryl- oder heteroarylcarbonsäuren | |
| ATE488597T1 (de) | Verfahren zur herstellung optisch aktiver aminosäuren unter verwendung eines ganzzellenkatalysators | |
| DE602004022639D1 (de) | Verfahren zur herstellung von lactonase und nutzung davon | |
| JP2542941B2 (ja) | 光学活性ヒドロキシラクトン類の製造方法 | |
| Bizerra et al. | Enzymatic regioselective production of chloramphenicol esters | |
| Wallace et al. | Resolution of a chiral ester by lipase-catalyzed transesterification with polyethylene glycol in organic media | |
| EA200701694A1 (ru) | Ферментативное получение витамина с | |
| DE60225004D1 (de) | Verfahren zur Herstellung von Glutathion | |
| KR100722155B1 (ko) | 효소적 방법에 의한 광학활성 2-클로로만델릭산 에스테르와 2-클로로만델릭산의 제조 방법 | |
| DE60127946D1 (de) | Ein stereoselektives verfahren zur herstellung von nukleosidanalogen | |
| DE60128461D1 (de) | Verfahren zur herstellung von optisch aktiven beta-amino alkoholen | |
| ATE332391T1 (de) | Verfahren zur enzymatischen herstellung enantiomerenangereicherter beta-aminosäuren | |
| DE60103959D1 (de) | Neue azetidin-derivate und ein verfahren zur herstellung derselben | |
| CN103998618A (zh) | 光学活性的α-取代-β-氨基酸的制造方法 | |
| CN107935874A (zh) | 一种(r)‑3‑氨基‑3(2‑萘基)丙酸的合成方法 | |
| KR100758512B1 (ko) | 효소적 방법에 의한 광학활성3-히드록시-3-페닐프로피온산과 광학활성3-아실옥시-3-페닐프로피온산의 제조 방법 | |
| ATE335076T1 (de) | Esterase gen und dessen verwendung | |
| KR20010108982A (ko) | 효소를 이용한 Ｒ-폼 또는 Ｓ-폼의 α-치환헤테로싸이클릭 카르복실산 유도체의 제조방법 | |
| CN102352388B (zh) | 一种制备l-2-氨基己二酸的化学-酶法 | |
| KR100846674B1 (ko) | 효소적 방법에 의한 광학활성 트랜스 알코올 화합물 및 그의 에스테르 화합물 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |