DE602004020070D1 - Thienopyrimidin-derivate als kaliumkanal-inhibitoren - Google Patents
Thienopyrimidin-derivate als kaliumkanal-inhibitorenInfo
- Publication number
- DE602004020070D1 DE602004020070D1 DE602004020070T DE602004020070T DE602004020070D1 DE 602004020070 D1 DE602004020070 D1 DE 602004020070D1 DE 602004020070 T DE602004020070 T DE 602004020070T DE 602004020070 T DE602004020070 T DE 602004020070T DE 602004020070 D1 DE602004020070 D1 DE 602004020070D1
- Authority
- DE
- Germany
- Prior art keywords
- channel inhibitors
- thienopyrimidine derivatives
- kalium
- kalium channel
- thienopyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- RBNBDIMXFJYDLQ-UHFFFAOYSA-N thieno[3,2-d]pyrimidine Chemical class C1=NC=C2SC=CC2=N1 RBNBDIMXFJYDLQ-UHFFFAOYSA-N 0.000 title abstract 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 title 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47751803P | 2003-06-11 | 2003-06-11 | |
| GBGB0315950.6A GB0315950D0 (en) | 2003-06-11 | 2003-06-11 | Compounds |
| PCT/GB2004/002454 WO2004111057A1 (en) | 2003-06-11 | 2004-06-10 | Thienopyrimidine derivatives as potassium channel inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004020070D1 true DE602004020070D1 (de) | 2010-10-07 |
Family
ID=33554173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004020070T Expired - Lifetime DE602004020070D1 (de) | 2003-06-11 | 2004-06-10 | Thienopyrimidin-derivate als kaliumkanal-inhibitoren |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1641803B3 (de) |
| KR (1) | KR101186678B1 (de) |
| CN (1) | CN1823071B (de) |
| AT (1) | ATE425982T1 (de) |
| AU (1) | AU2004247470B2 (de) |
| BR (1) | BRPI0411239A (de) |
| CA (1) | CA2528848C (de) |
| DE (1) | DE602004020070D1 (de) |
| DK (1) | DK1641803T3 (de) |
| ES (1) | ES2324536T7 (de) |
| HK (1) | HK1093064A1 (de) |
| MX (1) | MXPA05013549A (de) |
| PL (1) | PL1641803T6 (de) |
| SI (1) | SI1641803T1 (de) |
| WO (1) | WO2004111057A1 (de) |
| ZA (1) | ZA200600225B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| WO2006004658A2 (en) * | 2004-06-29 | 2006-01-12 | Amgen Inc. | Furanopyrimidines |
| EP1802632B1 (de) * | 2004-10-21 | 2011-07-13 | Dow AgroSciences LLC | Thenopyrimidin-verbindungen mit fungizider aktivität |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| US7576080B2 (en) | 2004-12-23 | 2009-08-18 | Memory Pharmaceuticals Corporation | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors |
| JP2009507849A (ja) * | 2005-09-09 | 2009-02-26 | ブリストル−マイヤーズ スクイブ カンパニー | 非環状ＩＫｕｒインヒビター |
| GB0525164D0 (en) * | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| DE102007027800A1 (de) * | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung |
| US8883852B2 (en) | 2008-10-22 | 2014-11-11 | University of Pittburgh—Of the Commonwealth System of Higher Education | Radioprotective agents |
| EP2405973B1 (de) | 2009-03-13 | 2015-04-22 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Thiazolopyrimidin-modulatoren als immunsuppressive mittel |
| HUE032983T2 (en) | 2009-09-03 | 2017-11-28 | Bristol Myers Squibb Co | Quinazoline as potassium ion channel inhibitor |
| LT2540728T (lt) * | 2010-02-17 | 2019-06-25 | Takeda Pharmaceutical Company Limited | Heterociklinis junginys |
| GB201012889D0 (en) | 2010-08-02 | 2010-09-15 | Univ Leuven Kath | Antiviral activity of novel bicyclic heterocycles |
| GB201015411D0 (en) | 2010-09-15 | 2010-10-27 | Univ Leuven Kath | Anti-cancer activity of novel bicyclic heterocycles |
| WO2012044993A1 (en) * | 2010-09-30 | 2012-04-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders |
| GB201105659D0 (en) * | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
| NO3175985T3 (de) | 2011-07-01 | 2018-04-28 | ||
| AR090037A1 (es) * | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| WO2013072693A1 (en) * | 2011-11-15 | 2013-05-23 | Xention Limited | Thieno [2, 3 - c] pyrazoles for use as potassium channel inhibitors |
| WO2013078126A1 (en) | 2011-11-23 | 2013-05-30 | Cancer Research Technology Limited | Thienopyrimidine inhibitors of atypical protein kinase c |
| EP2806865A1 (de) | 2012-01-27 | 2014-12-03 | Gilead Sciences, Inc. | Kombinationstherapien mit späten ionenkanalblockern und kaliumionenkanalblockern |
| WO2014134419A1 (en) | 2013-03-01 | 2014-09-04 | Gilead Sciences, Inc. | Use of ikach blockers for the treatment of cardiac diseases |
| US20160002273A1 (en) * | 2013-03-07 | 2016-01-07 | Glaxosmithkline Llc | Thieno[3,2-d]pyrimidine-6-carboxamides and analogues as sirtuin modulators |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN106727587A (zh) * | 2016-11-28 | 2017-05-31 | 李娜 | 一种治疗心律失常的药物组合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD248593A1 (de) * | 1985-01-11 | 1987-08-12 | Univ Halle Wittenberg | Verfahren zur herstellung von 4-basischsubstituierten thieno/2,3-d/pyrimidin-6-ylcarbonsaeureestern |
| WO2001046155A1 (en) * | 1999-12-21 | 2001-06-28 | Icagen, Inc. | Potassium channel inhibitors |
| US6566380B2 (en) | 2000-07-25 | 2003-05-20 | Icagen, Inc. | Potassium channel inhibitors |
| US6849634B2 (en) | 2000-12-21 | 2005-02-01 | Icagen | Potassium channel inhibitors |
-
2004
- 2004-06-10 SI SI200431150T patent/SI1641803T1/sl unknown
- 2004-06-10 AT AT04736524T patent/ATE425982T1/de active
- 2004-06-10 ES ES04736524T patent/ES2324536T7/es active Active
- 2004-06-10 MX MXPA05013549A patent/MXPA05013549A/es active IP Right Grant
- 2004-06-10 DE DE602004020070T patent/DE602004020070D1/de not_active Expired - Lifetime
- 2004-06-10 DK DK04736524T patent/DK1641803T3/da active
- 2004-06-10 EP EP04736524A patent/EP1641803B3/de not_active Expired - Lifetime
- 2004-06-10 CA CA2528848A patent/CA2528848C/en not_active Expired - Fee Related
- 2004-06-10 PL PL04736524T patent/PL1641803T6/pl unknown
- 2004-06-10 KR KR1020057023928A patent/KR101186678B1/ko not_active IP Right Cessation
- 2004-06-10 AU AU2004247470A patent/AU2004247470B2/en not_active Ceased
- 2004-06-10 WO PCT/GB2004/002454 patent/WO2004111057A1/en active Application Filing
- 2004-06-10 CN CN2004800201950A patent/CN1823071B/zh not_active Expired - Fee Related
- 2004-06-10 BR BRPI0411239-3A patent/BRPI0411239A/pt not_active Application Discontinuation
-
2006
- 2006-01-10 ZA ZA200600225A patent/ZA200600225B/en unknown
- 2006-10-04 HK HK06110995.8A patent/HK1093064A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1823071B (zh) | 2012-12-19 |
| ZA200600225B (en) | 2007-04-25 |
| KR101186678B1 (ko) | 2012-09-27 |
| PL1641803T3 (pl) | 2009-08-31 |
| DK1641803T3 (da) | 2009-06-29 |
| PL1641803T6 (pl) | 2011-04-29 |
| ES2324536T3 (es) | 2009-08-10 |
| ATE425982T1 (de) | 2009-04-15 |
| AU2004247470B2 (en) | 2009-04-23 |
| CA2528848C (en) | 2012-09-04 |
| EP1641803A1 (de) | 2006-04-05 |
| SI1641803T1 (sl) | 2009-08-31 |
| MXPA05013549A (es) | 2006-04-05 |
| AU2004247470A1 (en) | 2004-12-23 |
| EP1641803B1 (de) | 2009-03-18 |
| CA2528848A1 (en) | 2004-12-23 |
| ES2324536T7 (es) | 2012-03-16 |
| WO2004111057A1 (en) | 2004-12-23 |
| EP1641803B3 (de) | 2010-12-08 |
| KR20060057539A (ko) | 2006-05-26 |
| CN1823071A (zh) | 2006-08-23 |
| HK1093064A1 (en) | 2007-02-23 |
| BRPI0411239A (pt) | 2006-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |