DE602004020070D1 - Thienopyrimidin-derivate als kaliumkanal-inhibitoren - Google Patents

Thienopyrimidin-derivate als kaliumkanal-inhibitoren

Info

Publication number
DE602004020070D1
DE602004020070D1 DE602004020070T DE602004020070T DE602004020070D1 DE 602004020070 D1 DE602004020070 D1 DE 602004020070D1 DE 602004020070 T DE602004020070 T DE 602004020070T DE 602004020070 T DE602004020070 T DE 602004020070T DE 602004020070 D1 DE602004020070 D1 DE 602004020070D1
Authority
DE
Germany
Prior art keywords
channel inhibitors
thienopyrimidine derivatives
kalium
kalium channel
thienopyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004020070T
Other languages
English (en)
Inventor
John Ford
Nicholas John Palmer
John Frederick Atherall
David John Madge
Brad Sherborne
Mark Bushfield
Edward Benedict Stevens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xention Ltd
Original Assignee
Xention Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0315950.6A external-priority patent/GB0315950D0/en
Application filed by Xention Ltd filed Critical Xention Ltd
Publication of DE602004020070D1 publication Critical patent/DE602004020070D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602004020070T 2003-06-11 2004-06-10 Thienopyrimidin-derivate als kaliumkanal-inhibitoren Expired - Lifetime DE602004020070D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47751803P 2003-06-11 2003-06-11
GBGB0315950.6A GB0315950D0 (en) 2003-06-11 2003-06-11 Compounds
PCT/GB2004/002454 WO2004111057A1 (en) 2003-06-11 2004-06-10 Thienopyrimidine derivatives as potassium channel inhibitors

Publications (1)

Publication Number Publication Date
DE602004020070D1 true DE602004020070D1 (de) 2010-10-07

Family

ID=33554173

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004020070T Expired - Lifetime DE602004020070D1 (de) 2003-06-11 2004-06-10 Thienopyrimidin-derivate als kaliumkanal-inhibitoren

Country Status (16)

Country Link
EP (1) EP1641803B3 (de)
KR (1) KR101186678B1 (de)
CN (1) CN1823071B (de)
AT (1) ATE425982T1 (de)
AU (1) AU2004247470B2 (de)
BR (1) BRPI0411239A (de)
CA (1) CA2528848C (de)
DE (1) DE602004020070D1 (de)
DK (1) DK1641803T3 (de)
ES (1) ES2324536T7 (de)
HK (1) HK1093064A1 (de)
MX (1) MXPA05013549A (de)
PL (1) PL1641803T6 (de)
SI (1) SI1641803T1 (de)
WO (1) WO2004111057A1 (de)
ZA (1) ZA200600225B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
US7776867B2 (en) 2004-06-29 2010-08-17 Amgen Inc. Furanopyrimidines
US8008487B2 (en) * 2004-10-21 2011-08-30 Dow Agrosciences Llc Substituted thieno[2,3-D]pyrimidines as fungicides
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
US7576080B2 (en) * 2004-12-23 2009-08-18 Memory Pharmaceuticals Corporation Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
WO2007030582A2 (en) * 2005-09-09 2007-03-15 Bristol-Myers Squibb Company Acyclic ikur inhibitors
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
DE102007027800A1 (de) 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung
US8883852B2 (en) 2008-10-22 2014-11-11 University of Pittburgh—Of the Commonwealth System of Higher Education Radioprotective agents
ES2543216T3 (es) 2009-03-13 2015-08-17 Katholieke Universiteit Leuven, K.U. Leuven R&D Moduladores de tiazolopirimidina como agentes inmunosupresores
SG178592A1 (en) 2009-09-03 2012-04-27 Bristol Myers Squibb Co Quinazolines as potassium ion channel inhibitors
EA020724B1 (ru) * 2010-02-17 2015-01-30 Такеда Фармасьютикал Компани Лимитед Гетероциклическое соединение, лекарственное средство, включающее его, и способы его применения
GB201012889D0 (en) 2010-08-02 2010-09-15 Univ Leuven Kath Antiviral activity of novel bicyclic heterocycles
GB201015411D0 (en) 2010-09-15 2010-10-27 Univ Leuven Kath Anti-cancer activity of novel bicyclic heterocycles
WO2012044993A1 (en) * 2010-09-30 2012-04-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (de) 2011-07-01 2018-04-28
US20140357662A1 (en) * 2011-11-15 2014-12-04 Xention Limited Thieno (2,3 - c) pyrazoles for use as potassium channel inhibitors
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
ES2575143T3 (es) 2011-11-23 2016-06-24 Cancer Research Technology Limited Inhibidores de tienopiridina de la proteína quinasa C atípica
NZ627942A (en) 2012-01-27 2016-03-31 Gilead Sciences Inc Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases
CN105339371A (zh) * 2013-03-07 2016-02-17 葛兰素史密斯克莱有限责任公司 作为沉默调节蛋白调节剂的噻吩并[3,2-d]嘧啶-6-甲酰胺和类似物
FR3015483B1 (fr) * 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN106727587A (zh) * 2016-11-28 2017-05-31 李娜 一种治疗心律失常的药物组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD248593A1 (de) * 1985-01-11 1987-08-12 Univ Halle Wittenberg Verfahren zur herstellung von 4-basischsubstituierten thieno/2,3-d/pyrimidin-6-ylcarbonsaeureestern
US6458794B2 (en) 1999-12-21 2002-10-01 Icagen, Inc. Potassium channel inhibitors
US6566380B2 (en) * 2000-07-25 2003-05-20 Icagen, Inc. Potassium channel inhibitors
US6849634B2 (en) * 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors

Also Published As

Publication number Publication date
PL1641803T6 (pl) 2011-04-29
HK1093064A1 (en) 2007-02-23
ES2324536T7 (es) 2012-03-16
CN1823071B (zh) 2012-12-19
KR101186678B1 (ko) 2012-09-27
CA2528848C (en) 2012-09-04
MXPA05013549A (es) 2006-04-05
SI1641803T1 (sl) 2009-08-31
ZA200600225B (en) 2007-04-25
KR20060057539A (ko) 2006-05-26
CA2528848A1 (en) 2004-12-23
AU2004247470A1 (en) 2004-12-23
PL1641803T3 (pl) 2009-08-31
EP1641803B3 (de) 2010-12-08
AU2004247470B2 (en) 2009-04-23
ES2324536T3 (es) 2009-08-10
EP1641803B1 (de) 2009-03-18
CN1823071A (zh) 2006-08-23
BRPI0411239A (pt) 2006-07-18
WO2004111057A1 (en) 2004-12-23
EP1641803A1 (de) 2006-04-05
DK1641803T3 (da) 2009-06-29
ATE425982T1 (de) 2009-04-15

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