ATE425982T1 - Thienopyrimidin-derivate als kaliumkanal- inhibitoren - Google Patents

Thienopyrimidin-derivate als kaliumkanal- inhibitoren

Info

Publication number
ATE425982T1
ATE425982T1 AT04736524T AT04736524T ATE425982T1 AT E425982 T1 ATE425982 T1 AT E425982T1 AT 04736524 T AT04736524 T AT 04736524T AT 04736524 T AT04736524 T AT 04736524T AT E425982 T1 ATE425982 T1 AT E425982T1
Authority
AT
Austria
Prior art keywords
potassium channel
channel inhibitors
thienopyrimidine derivatives
thienopyrimidine
derivatives
Prior art date
Application number
AT04736524T
Other languages
English (en)
Inventor
John Ford
Nicholas Palmer
John Frederick Atherall
David John Madge
Brad Sherborne
Mark Bushfield
Edward Benedict Stevens
Original Assignee
Xention Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0315950.6A external-priority patent/GB0315950D0/en
Application filed by Xention Ltd filed Critical Xention Ltd
Application granted granted Critical
Publication of ATE425982T1 publication Critical patent/ATE425982T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT04736524T 2003-06-11 2004-06-10 Thienopyrimidin-derivate als kaliumkanal- inhibitoren ATE425982T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47751803P 2003-06-11 2003-06-11
GBGB0315950.6A GB0315950D0 (en) 2003-06-11 2003-06-11 Compounds

Publications (1)

Publication Number Publication Date
ATE425982T1 true ATE425982T1 (de) 2009-04-15

Family

ID=33554173

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04736524T ATE425982T1 (de) 2003-06-11 2004-06-10 Thienopyrimidin-derivate als kaliumkanal- inhibitoren

Country Status (15)

Country Link
EP (1) EP1641803B3 (de)
KR (1) KR101186678B1 (de)
CN (1) CN1823071B (de)
AT (1) ATE425982T1 (de)
AU (1) AU2004247470B2 (de)
BR (1) BRPI0411239A (de)
CA (1) CA2528848C (de)
DE (1) DE602004020070D1 (de)
DK (1) DK1641803T3 (de)
ES (1) ES2324536T7 (de)
MX (1) MXPA05013549A (de)
PL (1) PL1641803T6 (de)
SI (1) SI1641803T1 (de)
WO (1) WO2004111057A1 (de)
ZA (1) ZA200600225B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
MXPA06015223A (es) * 2004-06-29 2007-11-09 Amgen Inc Furanopirimidinas.
ATE516291T1 (de) * 2004-10-21 2011-07-15 Dow Agrosciences Llc Thenopyrimidin-verbindungen mit fungizider aktivität
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
US7576080B2 (en) 2004-12-23 2009-08-18 Memory Pharmaceuticals Corporation Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
WO2007030582A2 (en) 2005-09-09 2007-03-15 Bristol-Myers Squibb Company Acyclic ikur inhibitors
GB0525164D0 (en) * 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
DE102007027800A1 (de) * 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung
WO2010048287A2 (en) 2008-10-22 2010-04-29 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Radioprotective agents
WO2010103130A2 (en) 2009-03-13 2010-09-16 Katholieke Universiteit Leuven, K.U.Leuven R&D Novel bicyclic heterocycles
ES2900504T3 (es) 2009-09-03 2022-03-17 Bristol Myers Squibb Co Quinazolinas como inhibidores de los canales iónicos de potasio
US8722660B2 (en) * 2010-02-17 2014-05-13 Takeda Pharmaceutical Company Limited Heterocyclic compound
GB201012889D0 (en) 2010-08-02 2010-09-15 Univ Leuven Kath Antiviral activity of novel bicyclic heterocycles
GB201015411D0 (en) 2010-09-15 2010-10-27 Univ Leuven Kath Anti-cancer activity of novel bicyclic heterocycles
WO2012044993A1 (en) * 2010-09-30 2012-04-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (de) 2011-07-01 2018-04-28
EP2780344A1 (de) * 2011-11-15 2014-09-24 Xention Limited Thieno[2,3-c]pyrazole als kaliumkanalinhibitoren
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
WO2013078126A1 (en) 2011-11-23 2013-05-30 Cancer Research Technology Limited Thienopyrimidine inhibitors of atypical protein kinase c
US20150045305A1 (en) 2012-01-27 2015-02-12 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases
KR20150128768A (ko) * 2013-03-07 2015-11-18 글락소스미스클라인 엘엘씨 시르투인 조절제로서의 티에노[3,2-d]피리미딘-6-카르복스아미드 및 유사체
FR3015483B1 (fr) * 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN106727587A (zh) * 2016-11-28 2017-05-31 李娜 一种治疗心律失常的药物组合物
JP7514005B2 (ja) * 2017-06-21 2024-07-10 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ラソパシー、及び線維性疾患の治療のためのｒａｓスーパーファミリーと相互作用する化合物
EP3898609A1 (de) 2018-12-19 2021-10-27 Shy Therapeutics LLC Mit der ras-superfamilie interagierende verbindungen zur behandlung von krebs, entzündlichen erkrankungen, rasopathien und fibrotischen erkrankungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD248593A1 (de) * 1985-01-11 1987-08-12 Univ Halle Wittenberg Verfahren zur herstellung von 4-basischsubstituierten thieno/2,3-d/pyrimidin-6-ylcarbonsaeureestern
AU781365B2 (en) * 1999-12-21 2005-05-19 Icagen, Inc. Potassium channel inhibitors
US6566380B2 (en) 2000-07-25 2003-05-20 Icagen, Inc. Potassium channel inhibitors
US6849634B2 (en) 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors

Also Published As

Publication number Publication date
PL1641803T3 (pl) 2009-08-31
WO2004111057A1 (en) 2004-12-23
HK1093064A1 (en) 2007-02-23
CN1823071A (zh) 2006-08-23
CN1823071B (zh) 2012-12-19
DK1641803T3 (da) 2009-06-29
SI1641803T1 (sl) 2009-08-31
MXPA05013549A (es) 2006-04-05
ZA200600225B (en) 2007-04-25
KR101186678B1 (ko) 2012-09-27
PL1641803T6 (pl) 2011-04-29
CA2528848A1 (en) 2004-12-23
KR20060057539A (ko) 2006-05-26
AU2004247470B2 (en) 2009-04-23
DE602004020070D1 (de) 2010-10-07
ES2324536T7 (es) 2012-03-16
EP1641803B3 (de) 2010-12-08
BRPI0411239A (pt) 2006-07-18
EP1641803B1 (de) 2009-03-18
EP1641803A1 (de) 2006-04-05
ES2324536T3 (es) 2009-08-10
AU2004247470A1 (en) 2004-12-23
CA2528848C (en) 2012-09-04

Similar Documents

Publication Publication Date Title
ATE425982T1 (de) Thienopyrimidin-derivate als kaliumkanal- inhibitoren
NO2023022I1 (no) cobimetinib, optionally in any form protected by the basic patent, including harmaceutically acceptable salts and sovates thereof, particularly cobimetinib hemifumarate
SG161318A1 (en) Heterocyclic inhibitors of mek and methods of use thereof
SE0301700D0 (sv) Novel compounds
IL181271A0 (en) Triazolophthalazine derivatives and pharmaceutical compositions containing the same
MXPA05013977A (es) Metodos y composiciones para tratar enfermedades relacionadas con amiloide.
TW200600087A (en) Methods and compositions for treating amyloid-related diseases
SG153800A1 (en) Pharmaceutical compositions
MX2009006704A (es) Derivados de amina triciclicos como inhibidores de proteina de tirosina cinasa.
EA200501928A1 (ru) Пирролодигидроизохинолины как ингибиторы pde10
DE502004002571D1 (de) Substituierte 3-pyrrolidin-indol-derivate
ATE527251T1 (de) Bicyclische derivate als modulatoren von ionenkanälen
MXPA05012894A (es) Benzofuranos 3-sustituidos como agentes terapeuticos.
CL2004001678A1 (es) Compuestos derivados de oxazolidinona; composicion farmaceutica; y uso de los compuestos como agentes bacterianos.
CO5660287A2 (es) Derivados de tetrahidrocarbazol y su uso farmaceutico
SE0300457D0 (sv) Novel compounds
NO20063293L (no) Farmasoytiske forbindelser
UA96742C2 (en) Mek inhibitors and use thereof
EA201990219A3 (ru) Ингибиторы mek и способы их применения
EA201791835A2 (ru) Ингибиторы протеасом

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1641803

Country of ref document: EP

UEP Publication of translation of european patent specification

Ref document number: 1641803

Country of ref document: EP