ATE425982T1 - Thienopyrimidin-derivate als kaliumkanal- inhibitoren - Google Patents

Thienopyrimidin-derivate als kaliumkanal- inhibitoren

Info

Publication number
ATE425982T1
ATE425982T1 AT04736524T AT04736524T ATE425982T1 AT E425982 T1 ATE425982 T1 AT E425982T1 AT 04736524 T AT04736524 T AT 04736524T AT 04736524 T AT04736524 T AT 04736524T AT E425982 T1 ATE425982 T1 AT E425982T1
Authority
AT
Austria
Prior art keywords
potassium channel
channel inhibitors
thienopyrimidine derivatives
thienopyrimidine
derivatives
Prior art date
Application number
AT04736524T
Other languages
English (en)
Inventor
John Ford
Nicholas Palmer
John Frederick Atherall
David John Madge
Brad Sherborne
Mark Bushfield
Edward Benedict Stevens
Original Assignee
Xention Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0315950.6A external-priority patent/GB0315950D0/en
Application filed by Xention Ltd filed Critical Xention Ltd
Application granted granted Critical
Publication of ATE425982T1 publication Critical patent/ATE425982T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
AT04736524T 2003-06-11 2004-06-10 Thienopyrimidin-derivate als kaliumkanal- inhibitoren ATE425982T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47751803P 2003-06-11 2003-06-11
GBGB0315950.6A GB0315950D0 (en) 2003-06-11 2003-06-11 Compounds

Publications (1)

Publication Number Publication Date
ATE425982T1 true ATE425982T1 (de) 2009-04-15

Family

ID=33554173

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04736524T ATE425982T1 (de) 2003-06-11 2004-06-10 Thienopyrimidin-derivate als kaliumkanal- inhibitoren

Country Status (16)

Country Link
EP (1) EP1641803B3 (de)
KR (1) KR101186678B1 (de)
CN (1) CN1823071B (de)
AT (1) ATE425982T1 (de)
AU (1) AU2004247470B2 (de)
BR (1) BRPI0411239A (de)
CA (1) CA2528848C (de)
DE (1) DE602004020070D1 (de)
DK (1) DK1641803T3 (de)
ES (1) ES2324536T7 (de)
HK (1) HK1093064A1 (de)
MX (1) MXPA05013549A (de)
PL (1) PL1641803T6 (de)
SI (1) SI1641803T1 (de)
WO (1) WO2004111057A1 (de)
ZA (1) ZA200600225B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
JP2008505084A (ja) 2004-06-29 2008-02-21 アムゲン インコーポレイティッド フラノピリミジン
KR20140008471A (ko) * 2004-10-21 2014-01-21 다우 아그로사이언시즈 엘엘씨 살진균 활성을 갖는 티에노-피리미딘 화합물
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
US7576080B2 (en) * 2004-12-23 2009-08-18 Memory Pharmaceuticals Corporation Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
CN101277939A (zh) 2005-09-09 2008-10-01 布里斯托尔-迈尔斯斯奎布公司 无环ikur抑制剂
GB0525164D0 (en) * 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
DE102007027800A1 (de) * 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung
WO2010048287A2 (en) 2008-10-22 2010-04-29 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Radioprotective agents
CA2754890C (en) 2009-03-13 2018-01-16 Piet Herdewijn Bicyclic heterocycles
PL2473487T3 (pl) 2009-09-03 2017-07-31 Bristol-Myers Squibb Company Chinazoliny jako inhibitory kanałów jonowych potasowych
GEP20146202B (en) * 2010-02-17 2014-11-25 Takeda Pharmaceuticals Co Heteroaromatic aryl triazole derivatives as pde10a enzyme inhibitors
GB201012889D0 (en) 2010-08-02 2010-09-15 Univ Leuven Kath Antiviral activity of novel bicyclic heterocycles
GB201015411D0 (en) 2010-09-15 2010-10-27 Univ Leuven Kath Anti-cancer activity of novel bicyclic heterocycles
WO2012044993A1 (en) * 2010-09-30 2012-04-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (de) 2011-07-01 2018-04-28
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
JP2014533258A (ja) * 2011-11-15 2014-12-11 ゼンション・リミテッドＸｅｎｔｉｏｎ Ｌｉｍｉｔｅｄ カリウムチャネル阻害剤としてのチエノ［２，３−ｃ］ピラゾールの使用
AU2012340869B2 (en) 2011-11-23 2017-03-02 Cancer Research Technology Limited Thienopyrimidine inhibitors of atypical protein kinase C
WO2013112932A1 (en) 2012-01-27 2013-08-01 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases
WO2014138562A1 (en) * 2013-03-07 2014-09-12 Glaxosmithkline Llc Thieno[3,2-d]pyrimidine-6-carboxamides and analogues as sirtuin modulators
FR3015483B1 (fr) * 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN106727587A (zh) * 2016-11-28 2017-05-31 李娜 一种治疗心律失常的药物组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD248593A1 (de) * 1985-01-11 1987-08-12 Univ Halle Wittenberg Verfahren zur herstellung von 4-basischsubstituierten thieno/2,3-d/pyrimidin-6-ylcarbonsaeureestern
AU781365B2 (en) 1999-12-21 2005-05-19 Icagen, Inc. Potassium channel inhibitors
US6566380B2 (en) * 2000-07-25 2003-05-20 Icagen, Inc. Potassium channel inhibitors
US6849634B2 (en) * 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors

Also Published As

Publication number Publication date
BRPI0411239A (pt) 2006-07-18
EP1641803B3 (de) 2010-12-08
CA2528848C (en) 2012-09-04
AU2004247470A1 (en) 2004-12-23
DE602004020070D1 (de) 2010-10-07
ES2324536T3 (es) 2009-08-10
MXPA05013549A (es) 2006-04-05
CN1823071B (zh) 2012-12-19
DK1641803T3 (da) 2009-06-29
SI1641803T1 (sl) 2009-08-31
KR20060057539A (ko) 2006-05-26
EP1641803B1 (de) 2009-03-18
AU2004247470B2 (en) 2009-04-23
KR101186678B1 (ko) 2012-09-27
PL1641803T3 (pl) 2009-08-31
CN1823071A (zh) 2006-08-23
ZA200600225B (en) 2007-04-25
WO2004111057A1 (en) 2004-12-23
HK1093064A1 (en) 2007-02-23
PL1641803T6 (pl) 2011-04-29
ES2324536T7 (es) 2012-03-16
EP1641803A1 (de) 2006-04-05
CA2528848A1 (en) 2004-12-23

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