DK1641803T3 - Thienopyrimidinderivater som kaliumkanalinhibitorer - Google Patents

Thienopyrimidinderivater som kaliumkanalinhibitorer

Info

Publication number
DK1641803T3
DK1641803T3 DK04736524T DK04736524T DK1641803T3 DK 1641803 T3 DK1641803 T3 DK 1641803T3 DK 04736524 T DK04736524 T DK 04736524T DK 04736524 T DK04736524 T DK 04736524T DK 1641803 T3 DK1641803 T3 DK 1641803T3
Authority
DK
Denmark
Prior art keywords
potassium channel
channel inhibitors
thienopyrimidine derivatives
thienopyrimidine
derivatives
Prior art date
Application number
DK04736524T
Other languages
Danish (da)
English (en)
Inventor
John Ford
Nicholas John Palmer
John Frederick Atherall
David John Madge
Brad Sherborne
Mark Bushfield
Edward Benedict Stevens
Original Assignee
Xention Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0315950.6A external-priority patent/GB0315950D0/en
Application filed by Xention Ltd filed Critical Xention Ltd
Application granted granted Critical
Publication of DK1641803T3 publication Critical patent/DK1641803T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK04736524T 2003-06-11 2004-06-10 Thienopyrimidinderivater som kaliumkanalinhibitorer DK1641803T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47751803P 2003-06-11 2003-06-11
GBGB0315950.6A GB0315950D0 (en) 2003-06-11 2003-06-11 Compounds
PCT/GB2004/002454 WO2004111057A1 (en) 2003-06-11 2004-06-10 Thienopyrimidine derivatives as potassium channel inhibitors

Publications (1)

Publication Number Publication Date
DK1641803T3 true DK1641803T3 (da) 2009-06-29

Family

ID=33554173

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04736524T DK1641803T3 (da) 2003-06-11 2004-06-10 Thienopyrimidinderivater som kaliumkanalinhibitorer

Country Status (16)

Country Link
EP (1) EP1641803B3 (de)
KR (1) KR101186678B1 (de)
CN (1) CN1823071B (de)
AT (1) ATE425982T1 (de)
AU (1) AU2004247470B2 (de)
BR (1) BRPI0411239A (de)
CA (1) CA2528848C (de)
DE (1) DE602004020070D1 (de)
DK (1) DK1641803T3 (de)
ES (1) ES2324536T7 (de)
HK (1) HK1093064A1 (de)
MX (1) MXPA05013549A (de)
PL (1) PL1641803T6 (de)
SI (1) SI1641803T1 (de)
WO (1) WO2004111057A1 (de)
ZA (1) ZA200600225B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
CA2571857A1 (en) 2004-06-29 2006-01-12 Amgen Inc. Furanopyrimidines
KR101386797B1 (ko) * 2004-10-21 2014-04-21 다우 아그로사이언시즈 엘엘씨 살진균 활성을 갖는 티에노-피리미딘 화합물
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
US7576080B2 (en) * 2004-12-23 2009-08-18 Memory Pharmaceuticals Corporation Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
EP1922311A2 (de) 2005-09-09 2008-05-21 Brystol-Myers Squibb Company Azyklische ikur-hemmer
GB0525164D0 (en) * 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
DE102007027800A1 (de) 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung
US8883852B2 (en) 2008-10-22 2014-11-11 University of Pittburgh—Of the Commonwealth System of Higher Education Radioprotective agents
EP2923734B1 (de) 2009-03-13 2018-01-10 Katholieke Universiteit Leuven, K.U. Leuven R&D Purineanaloga und ihre verwendung als immunosuppressiva
WO2011028741A1 (en) 2009-09-03 2011-03-10 Bristol-Myers Squibb Company Quinazolines as potassium ion channel inhibitors
AU2011216404B2 (en) * 2010-02-17 2016-04-07 Takeda Pharmaceutical Company Limited Heterocyclic compound
GB201012889D0 (en) 2010-08-02 2010-09-15 Univ Leuven Kath Antiviral activity of novel bicyclic heterocycles
GB201015411D0 (en) 2010-09-15 2010-10-27 Univ Leuven Kath Anti-cancer activity of novel bicyclic heterocycles
WO2012044993A1 (en) * 2010-09-30 2012-04-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders
GB201105659D0 (en) * 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (de) 2011-07-01 2018-04-28
WO2013072693A1 (en) * 2011-11-15 2013-05-23 Xention Limited Thieno [2, 3 - c] pyrazoles for use as potassium channel inhibitors
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
EP3048106B1 (de) 2011-11-23 2019-11-06 Cancer Research Technology Limited Thienopyrimidinverbindungen als inhibitoren von atypischer proteinkinase c
US20150045305A1 (en) 2012-01-27 2015-02-12 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases
EP2964654A4 (de) * 2013-03-07 2016-08-10 Glaxosmithkline Llc Thien[3,2-d]pyrimidin-6-carboxamide und analoga als sirtuin-modulatoren
FR3015483B1 (fr) * 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN106727587A (zh) * 2016-11-28 2017-05-31 李娜 一种治疗心律失常的药物组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD248593A1 (de) * 1985-01-11 1987-08-12 Univ Halle Wittenberg Verfahren zur herstellung von 4-basischsubstituierten thieno/2,3-d/pyrimidin-6-ylcarbonsaeureestern
WO2001046155A1 (en) * 1999-12-21 2001-06-28 Icagen, Inc. Potassium channel inhibitors
US6566380B2 (en) 2000-07-25 2003-05-20 Icagen, Inc. Potassium channel inhibitors
US6849634B2 (en) 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors

Also Published As

Publication number Publication date
CN1823071A (zh) 2006-08-23
KR20060057539A (ko) 2006-05-26
PL1641803T6 (pl) 2011-04-29
CA2528848C (en) 2012-09-04
WO2004111057A1 (en) 2004-12-23
EP1641803B1 (de) 2009-03-18
MXPA05013549A (es) 2006-04-05
BRPI0411239A (pt) 2006-07-18
DE602004020070D1 (de) 2010-10-07
CA2528848A1 (en) 2004-12-23
AU2004247470A1 (en) 2004-12-23
PL1641803T3 (pl) 2009-08-31
ES2324536T7 (es) 2012-03-16
KR101186678B1 (ko) 2012-09-27
EP1641803B3 (de) 2010-12-08
EP1641803A1 (de) 2006-04-05
CN1823071B (zh) 2012-12-19
AU2004247470B2 (en) 2009-04-23
SI1641803T1 (sl) 2009-08-31
ATE425982T1 (de) 2009-04-15
HK1093064A1 (en) 2007-02-23
ES2324536T3 (es) 2009-08-10
ZA200600225B (en) 2007-04-25

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