DE602004013314D1 - 4-(2-phenyloxyphenyl)-piperidin- oder -1,2,3,6-tetrahydropyridin-derivate als serotonin-wiederaufnahme-hemmer - Google Patents
4-(2-phenyloxyphenyl)-piperidin- oder -1,2,3,6-tetrahydropyridin-derivate als serotonin-wiederaufnahme-hemmerInfo
- Publication number
- DE602004013314D1 DE602004013314D1 DE602004013314T DE602004013314T DE602004013314D1 DE 602004013314 D1 DE602004013314 D1 DE 602004013314D1 DE 602004013314 T DE602004013314 T DE 602004013314T DE 602004013314 T DE602004013314 T DE 602004013314T DE 602004013314 D1 DE602004013314 D1 DE 602004013314D1
- Authority
- DE
- Germany
- Prior art keywords
- phenyloxyphenyl
- piperidine
- disorder
- tetrahydropyridine derivatives
- serotonin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46026503P | 2003-04-04 | 2003-04-04 | |
DK200300519 | 2003-04-04 | ||
DKPA200300519 | 2003-04-04 | ||
US460265P | 2003-04-04 | ||
PCT/DK2004/000241 WO2004087155A1 (en) | 2003-04-04 | 2004-04-02 | 4-(2-phenyloxyphenyl)-piperidine or -1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE602004013314D1 true DE602004013314D1 (de) | 2008-06-05 |
DE602004013314T2 DE602004013314T2 (de) | 2008-08-07 |
Family
ID=33132908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004013314T Expired - Fee Related DE602004013314T2 (de) | 2003-04-04 | 2004-04-02 | 4-(2-phenyloxyphenyl)-piperidin- oder -1,2,3,6-tetrahydropyridin-derivate als serotonin-wiederaufnahme-hemmer |
Country Status (18)
Country | Link |
---|---|
US (1) | US20060293360A1 (de) |
EP (1) | EP1635828B1 (de) |
JP (1) | JP2006522027A (de) |
AT (1) | ATE392896T1 (de) |
AU (1) | AU2004226837A1 (de) |
BR (1) | BRPI0408320A (de) |
CO (1) | CO5640133A2 (de) |
DE (1) | DE602004013314T2 (de) |
DK (1) | DK1635828T3 (de) |
ES (1) | ES2303062T3 (de) |
HR (1) | HRP20080262T3 (de) |
MX (1) | MXPA05010627A (de) |
NO (1) | NO20055206L (de) |
NZ (1) | NZ540891A (de) |
PL (1) | PL1635828T3 (de) |
PT (1) | PT1635828E (de) |
SI (1) | SI1635828T1 (de) |
WO (1) | WO2004087155A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1626720T1 (sl) | 2003-04-04 | 2008-12-31 | Lundbeck & Co As H | Derivati 4-(2-fenilsulfanil-fenil)-piperidina kotzaviralci ponovnega vnosa serotonina |
JP5318757B2 (ja) | 2006-06-16 | 2013-10-16 | ハー・ルンドベック・アクチエゼルスカベット | 神経因性疼痛の治療のための、組み合わされたセロトニンおよびノルエピネフリン再取り込み阻害を有する4−[2−(4−メチルフェニルスルファニル)−フェニル]ピペリジンの結晶形 |
TWI432194B (zh) * | 2007-03-20 | 2014-04-01 | Lundbeck & Co As H | 4-〔2-(4-甲基苯硫基)苯基〕哌啶之新穎治療用途 |
DK2358675T3 (da) | 2008-11-14 | 2013-01-14 | Theravance Inc | 4-[2-(2-Fluorphenoxymethyl)phenyl]piperidinforbindelser |
TWI396689B (zh) | 2008-11-14 | 2013-05-21 | Amgen Inc | 作為磷酸二酯酶10抑制劑之吡衍生物 |
AR074343A1 (es) | 2008-11-14 | 2011-01-12 | Amgen Inc | Derivados de piridina y pirimidina como inhibidores de la fosfodiesterasa 10 |
US8637500B2 (en) | 2008-12-17 | 2014-01-28 | Amgen Inc. | Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors |
EP2523945A1 (de) | 2010-01-11 | 2012-11-21 | Theravance, Inc. | 1-(2-phenoxymethylphenyl-)piperazinverbindungen als serotonin- und norepinephrin-wiederaufnahmehemmer |
WO2011119461A1 (en) * | 2010-03-22 | 2011-09-29 | Theravance, Inc. | 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds |
EP2560646B1 (de) * | 2010-04-22 | 2014-12-17 | Theravance Biopharma R&D IP, LLC | Kombination aus einem serotonin- und norepinephrin-wiederaufnahmehemmer sowie einem opioid zur schmerzbehandlung |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4241071A (en) * | 1977-01-27 | 1980-12-23 | American Hoechst Corporation | Antidepressant (α-phenyl-2-tolyl)azacycloalkanes |
US4198417A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Phenoxyphenylpiperidines |
CN1157365C (zh) * | 1999-02-23 | 2004-07-14 | 辉瑞产品公司 | 治疗cns疾病的一元胺摄取抑制剂 |
AU769430B2 (en) * | 1999-10-13 | 2004-01-29 | Pfizer Products Inc. | Biaryl ether derivatives useful as monoamine reuptake inhibitors |
UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
-
2004
- 2004-04-02 PT PT04725298T patent/PT1635828E/pt unknown
- 2004-04-02 AU AU2004226837A patent/AU2004226837A1/en not_active Abandoned
- 2004-04-02 US US10/551,870 patent/US20060293360A1/en not_active Abandoned
- 2004-04-02 BR BRPI0408320-2A patent/BRPI0408320A/pt not_active IP Right Cessation
- 2004-04-02 WO PCT/DK2004/000241 patent/WO2004087155A1/en active IP Right Grant
- 2004-04-02 ES ES04725298T patent/ES2303062T3/es not_active Expired - Lifetime
- 2004-04-02 DK DK04725298T patent/DK1635828T3/da active
- 2004-04-02 EP EP04725298A patent/EP1635828B1/de not_active Expired - Lifetime
- 2004-04-02 SI SI200430746T patent/SI1635828T1/sl unknown
- 2004-04-02 NZ NZ540891A patent/NZ540891A/en unknown
- 2004-04-02 JP JP2006504346A patent/JP2006522027A/ja not_active Withdrawn
- 2004-04-02 PL PL04725298T patent/PL1635828T3/pl unknown
- 2004-04-02 AT AT04725298T patent/ATE392896T1/de not_active IP Right Cessation
- 2004-04-02 MX MXPA05010627A patent/MXPA05010627A/es active IP Right Grant
- 2004-04-02 DE DE602004013314T patent/DE602004013314T2/de not_active Expired - Fee Related
-
2005
- 2005-10-20 CO CO05106876A patent/CO5640133A2/es unknown
- 2005-11-04 NO NO20055206A patent/NO20055206L/no unknown
-
2008
- 2008-06-12 HR HR20080262T patent/HRP20080262T3/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2004226837A1 (en) | 2004-10-14 |
HRP20080262T3 (en) | 2009-04-30 |
ATE392896T1 (de) | 2008-05-15 |
WO2004087155A1 (en) | 2004-10-14 |
US20060293360A1 (en) | 2006-12-28 |
CO5640133A2 (es) | 2006-05-31 |
JP2006522027A (ja) | 2006-09-28 |
SI1635828T1 (sl) | 2008-08-31 |
PL1635828T3 (pl) | 2008-10-31 |
BRPI0408320A (pt) | 2006-03-07 |
NO20055206L (no) | 2005-11-04 |
EP1635828A1 (de) | 2006-03-22 |
ES2303062T3 (es) | 2008-08-01 |
DK1635828T3 (da) | 2008-08-11 |
PT1635828E (pt) | 2008-07-01 |
MXPA05010627A (es) | 2005-12-12 |
NZ540891A (en) | 2008-07-31 |
DE602004013314T2 (de) | 2008-08-07 |
EP1635828B1 (de) | 2008-04-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |