MXPA03011766A - Novedosos derivados de indol. - Google Patents
Novedosos derivados de indol.Info
- Publication number
- MXPA03011766A MXPA03011766A MXPA03011766A MXPA03011766A MXPA03011766A MX PA03011766 A MXPA03011766 A MX PA03011766A MX PA03011766 A MXPA03011766 A MX PA03011766A MX PA03011766 A MXPA03011766 A MX PA03011766A MX PA03011766 A MXPA03011766 A MX PA03011766A
- Authority
- MX
- Mexico
- Prior art keywords
- indole derivatives
- novel indole
- disorders
- disorder
- psychosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Un derivado de heteroarilo que tiene la formula: (ver formula) en la cual A representa O u S; n es 2, 3, 4, 5, 6, 7, 8, 9 o 10; m es 2 o 3; W representa N, C o CH; Q representa N, C o CH; y la linea punteada representa un enlace opcional; R1 representa hidrogeno, alquilo de C1-6, alquenilo de C2-6, alquinilo de C2-6, cicloalquilo de C3-8-alquilo de C1-6, aril-alquilo de C1-6 o acilo; R2, R3, R4, R5 y R6 representan independientemente hidrogeno, halogeno, ciano, nitro, alquilo de C1-6, alcoxi de C1-6, alquilsulfailo de C1-6, alquilsulfonilo de C1-6, hidroxi, hidroxi-alquilo de C1-6, alcoxicarbonilo de C1-6, acilo, cicloalquilo de C3-8, cicloalquilo de C3-8 alquilo de C1-6, trifluorometilo, trifluorometoxi, NR15R16 en donde NR15R16 representan independientemente hidrogeno, alquilo de C1-6, cicloalquilo de C3-8 o fenilo; o R15 y R16 junto con el nitrogeno al cual estan unidos forman un anillo de 5 o 6 miembros que contiene optativamente un heteroatomo adicional; R7 y R7¦ representan independientemente hidrogeno o alquilo de C1-6 o pueden formar en conjunto un puente que consiste en dos o tres grupos metileno; R8, R9, R10 y R11 son cada uno independientemente seleccionados entre hidrogeno, halogeno, nitro, ciano, trifluorometilo, trifluorometoxi, alquilo de C1-6, alquenilo de C2-6, alquinilo de C2-6, cicloalquilo de C3-8, cicloalquilo de C3-8-alquilo de C1-6, fenilo, tiofenilo, alcoxi de C1-6, alquilsulfonilo de C1-6, alquilsulfonilo de C1-6, hidroxi, formilo, acilo, acilamino, aminocarbonilo, alcoxi de C1-6carbonilarnino, aminocarbonilamino, alquilo de C1-6aminocarbonilamino y di (alquilo de C1-6) aminocarbonilamino, NR13R14 en donde R13 y R14 representan independientemente hidrogeno, alquilo de C1-6, cicloalquilo de C3-8 o fenilo; o R13 y R14 junto con el nitrogeno al cual estan adheridos forman un anillo de 5 o 6 miembros que contiene optativamente un heteroatomo adicional; sus enantiomeros, y su sal de adicion de acido farmaceuticamente aceptable. Los compuestos de la invencion son considerados utiles para el tratamiento de trastornos afectivos tal como el trastorno de ansiedad general, trastorno de panico, trastorno obsesivo compulsivo, depresion, fobia social y trastornos de la alimentacion, y trastornos neurologicos tal como la sicosis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101037 | 2001-06-29 | ||
| PCT/DK2002/000436 WO2003002552A1 (en) | 2001-06-29 | 2002-06-27 | Novel indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03011766A true MXPA03011766A (es) | 2004-04-02 |
Family
ID=8160599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03011766A MXPA03011766A (es) | 2001-06-29 | 2002-06-27 | Novedosos derivados de indol. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7342015B2 (es) |
| EP (1) | EP1399434B1 (es) |
| JP (1) | JP2004535448A (es) |
| KR (1) | KR20040019027A (es) |
| CN (1) | CN100338058C (es) |
| AR (1) | AR034658A1 (es) |
| AT (1) | ATE304007T1 (es) |
| AU (1) | AU2002344950B2 (es) |
| BG (1) | BG108538A (es) |
| BR (1) | BR0210407A (es) |
| CA (1) | CA2451229C (es) |
| CZ (1) | CZ2004155A3 (es) |
| DE (1) | DE60206043T2 (es) |
| DK (1) | DK1399434T3 (es) |
| EA (1) | EA006104B1 (es) |
| ES (1) | ES2247347T3 (es) |
| HK (1) | HK1069579A1 (es) |
| HU (1) | HUP0400834A2 (es) |
| IL (1) | IL158830A0 (es) |
| IS (1) | IS2431B (es) |
| MX (1) | MXPA03011766A (es) |
| NO (1) | NO326513B1 (es) |
| NZ (1) | NZ529461A (es) |
| PL (1) | PL366520A1 (es) |
| SK (1) | SK642004A3 (es) |
| UA (1) | UA74651C2 (es) |
| WO (1) | WO2003002552A1 (es) |
| ZA (1) | ZA200308848B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK652004A3 (en) * | 2001-06-29 | 2004-09-08 | Lundbeck & Co As H | Heteroaryl derivatives, pharmaceutical composition with the content thereof and use of the same |
| JP2008521771A (ja) | 2004-11-26 | 2008-06-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 改良された抗精神病活性および抗不安症活性を有するイソキサゾリン−インドール誘導体 |
| AR055203A1 (es) * | 2005-08-31 | 2007-08-08 | Otsuka Pharma Co Ltd | Derivados de benzotiofeno con propiedades antipsicoticas |
| JP4785881B2 (ja) * | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
| CN116554145A (zh) * | 2022-01-29 | 2023-08-08 | 江苏恩华药业股份有限公司 | 芳烷基-4-(1h)吲哚基哌嗪衍生物、其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0900792B1 (en) * | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
| CN1155567C (zh) * | 1998-04-29 | 2004-06-30 | 惠氏公司 | 抑制精神的吲哚基衍生物 |
| AR027134A1 (es) * | 1999-12-30 | 2003-03-12 | Lundbeck & Co As H | Derivados de indol. |
| SK652004A3 (en) | 2001-06-29 | 2004-09-08 | Lundbeck & Co As H | Heteroaryl derivatives, pharmaceutical composition with the content thereof and use of the same |
-
2002
- 2002-06-27 CA CA002451229A patent/CA2451229C/en not_active Expired - Fee Related
- 2002-06-27 EA EA200400104A patent/EA006104B1/ru not_active IP Right Cessation
- 2002-06-27 KR KR10-2003-7017127A patent/KR20040019027A/ko not_active Application Discontinuation
- 2002-06-27 PL PL02366520A patent/PL366520A1/xx not_active Application Discontinuation
- 2002-06-27 ES ES02742850T patent/ES2247347T3/es not_active Expired - Lifetime
- 2002-06-27 BR BR0210407-5A patent/BR0210407A/pt not_active IP Right Cessation
- 2002-06-27 HU HU0400834A patent/HUP0400834A2/hu unknown
- 2002-06-27 AU AU2002344950A patent/AU2002344950B2/en not_active Ceased
- 2002-06-27 US US10/482,762 patent/US7342015B2/en not_active Expired - Fee Related
- 2002-06-27 AT AT02742850T patent/ATE304007T1/de not_active IP Right Cessation
- 2002-06-27 DE DE60206043T patent/DE60206043T2/de not_active Expired - Fee Related
- 2002-06-27 UA UA20031211983A patent/UA74651C2/uk unknown
- 2002-06-27 SK SK64-2004A patent/SK642004A3/sk unknown
- 2002-06-27 CN CNB028131878A patent/CN100338058C/zh not_active Expired - Fee Related
- 2002-06-27 EP EP02742850A patent/EP1399434B1/en not_active Expired - Lifetime
- 2002-06-27 WO PCT/DK2002/000436 patent/WO2003002552A1/en active IP Right Grant
- 2002-06-27 JP JP2003508933A patent/JP2004535448A/ja active Pending
- 2002-06-27 NZ NZ529461A patent/NZ529461A/en unknown
- 2002-06-27 CZ CZ2004155A patent/CZ2004155A3/cs unknown
- 2002-06-27 IL IL15883002A patent/IL158830A0/xx unknown
- 2002-06-27 MX MXPA03011766A patent/MXPA03011766A/es active IP Right Grant
- 2002-06-27 DK DK02742850T patent/DK1399434T3/da active
- 2002-06-28 AR ARP020102449A patent/AR034658A1/es unknown
-
2003
- 2003-11-10 IS IS7022A patent/IS2431B/is unknown
- 2003-11-13 ZA ZA200308848A patent/ZA200308848B/en unknown
- 2003-12-18 NO NO20035672A patent/NO326513B1/no unknown
-
2004
- 2004-01-21 BG BG108538A patent/BG108538A/bg unknown
-
2005
- 2005-03-11 HK HK05102171A patent/HK1069579A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |