DE60200089T2 - Octahydro-2H-pyrido[1,2-a]pyrazinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen - Google Patents

Octahydro-2H-pyrido[1,2-a]pyrazinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen Download PDF

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Publication number
DE60200089T2
DE60200089T2 DE60200089T DE60200089T DE60200089T2 DE 60200089 T2 DE60200089 T2 DE 60200089T2 DE 60200089 T DE60200089 T DE 60200089T DE 60200089 T DE60200089 T DE 60200089T DE 60200089 T2 DE60200089 T2 DE 60200089T2
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DE
Germany
Prior art keywords
formula
compounds
octahydro
pyrido
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60200089T
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German (de)
English (en)
Other versions
DE60200089D1 (de
Inventor
Solo Goldstein
Guillaume Poissonnet
Jean-Gilles Parmentier
Pierre Lestage
Brian Lockhart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
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Les Laboratoires Servier SAS
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Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Publication of DE60200089D1 publication Critical patent/DE60200089D1/de
Application granted granted Critical
Publication of DE60200089T2 publication Critical patent/DE60200089T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60200089T 2001-07-12 2002-07-11 Octahydro-2H-pyrido[1,2-a]pyrazinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen Expired - Fee Related DE60200089T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0109260 2001-07-12
FR0109260A FR2827288B1 (fr) 2001-07-12 2001-07-12 Nouveaux derives d'octahydro-2h-pyrido[1,2-a]pyrazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DE60200089D1 DE60200089D1 (de) 2003-12-18
DE60200089T2 true DE60200089T2 (de) 2004-09-09

Family

ID=8865405

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60200089T Expired - Fee Related DE60200089T2 (de) 2001-07-12 2002-07-11 Octahydro-2H-pyrido[1,2-a]pyrazinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Country Status (24)

Country Link
US (1) US6992085B2 (enExample)
EP (1) EP1275647B1 (enExample)
JP (1) JP3950018B2 (enExample)
KR (1) KR100485020B1 (enExample)
CN (1) CN1197863C (enExample)
AR (1) AR036166A1 (enExample)
AT (1) ATE254124T1 (enExample)
AU (1) AU2002300094B2 (enExample)
BR (1) BR0202681A (enExample)
CA (1) CA2394027C (enExample)
DE (1) DE60200089T2 (enExample)
DK (1) DK1275647T3 (enExample)
EA (1) EA005160B1 (enExample)
ES (1) ES2210219T3 (enExample)
FR (1) FR2827288B1 (enExample)
HU (1) HUP0202282A3 (enExample)
MX (1) MXPA02006699A (enExample)
NO (1) NO322966B1 (enExample)
NZ (1) NZ520120A (enExample)
PL (1) PL355034A1 (enExample)
PT (1) PT1275647E (enExample)
SI (1) SI1275647T1 (enExample)
TR (1) TR200302001T4 (enExample)
ZA (1) ZA200205596B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2004089410A1 (ja) * 2003-04-03 2006-07-06 協和醗酵工業株式会社 神経因性疼痛の予防及び／または治療剤
MY141255A (en) * 2003-12-11 2010-03-31 Memory Pharm Corp Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
FR2866647B1 (fr) * 2004-02-20 2006-10-27 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BRPI0512567A (pt) * 2004-06-22 2008-03-25 Pfizer Prod Inc compostos antagonistas de receptor de histamina-3 diazabicìclico e respectivas composições farmacêuticas
CN103110635A (zh) * 2005-07-04 2013-05-22 海波因特制药有限责任公司 组胺h3受体拮抗剂
RU2442775C2 (ru) * 2005-07-04 2012-02-20 Хай Пойнт Фармасьютикалс, ЛЛС Антагонисты гистаминовых н3-рецепторов
WO2007106349A2 (en) * 2006-03-10 2007-09-20 Neurogen Corporation Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues
KR100871691B1 (ko) 2006-10-16 2008-12-05 삼성전자주식회사 병렬 비트 테스트 방법 및 그 방법을 사용하는 반도체메모리 장치
EP3495363B1 (en) 2016-07-28 2023-08-23 Shionogi & Co., Ltd Nitrogen-containing condensed ring compounds having dopamine d3 receptor antagonistic effect
CA3089498A1 (en) 2018-01-26 2019-08-01 Shionogi & Co., Ltd. Condensed ring compounds having dopamine d3 receptor antagonistic effect

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388128A (en) * 1965-09-03 1968-06-11 Allan R. Day Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
GB8518236D0 (en) * 1985-07-19 1985-08-29 Beecham Group Plc Compounds
WO1994006794A1 (en) * 1992-09-24 1994-03-31 National Institutes Of Health Aralkyl diazabicycloalkane derivatives for cns disorders
WO1996010570A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
US6231833B1 (en) * 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
ATE344249T1 (de) * 1999-07-19 2006-11-15 Merck Frosst Canada Ltd Pyrazinone, diese verbindungen enthaltende zusammenstellungen

Also Published As

Publication number Publication date
CN1397557A (zh) 2003-02-19
HUP0202282A2 (hu) 2003-03-28
CN1197863C (zh) 2005-04-20
SI1275647T1 (en) 2004-02-29
ZA200205596B (en) 2003-03-27
US6992085B2 (en) 2006-01-31
CA2394027C (fr) 2008-01-08
ES2210219T3 (es) 2004-07-01
PT1275647E (pt) 2004-03-31
HU0202282D0 (enExample) 2002-09-28
HK1050682A1 (en) 2003-07-04
FR2827288B1 (fr) 2003-10-31
EP1275647A1 (fr) 2003-01-15
EA200200663A1 (ru) 2003-02-27
NO20023345L (no) 2003-01-13
NZ520120A (en) 2004-03-26
AU2002300094B2 (en) 2007-06-14
EP1275647B1 (fr) 2003-11-12
BR0202681A (pt) 2003-05-06
AR036166A1 (es) 2004-08-18
HUP0202282A3 (en) 2003-11-28
DE60200089D1 (de) 2003-12-18
TR200302001T4 (tr) 2004-01-21
US20030195216A1 (en) 2003-10-16
DK1275647T3 (da) 2004-03-15
JP3950018B2 (ja) 2007-07-25
KR100485020B1 (ko) 2005-04-25
MXPA02006699A (es) 2005-08-16
NO322966B1 (no) 2006-12-18
EA005160B1 (ru) 2004-12-30
PL355034A1 (en) 2003-01-13
KR20030007159A (ko) 2003-01-23
NO20023345D0 (no) 2002-07-11
CA2394027A1 (fr) 2003-01-12
FR2827288A1 (fr) 2003-01-17
JP2003064081A (ja) 2003-03-05
ATE254124T1 (de) 2003-11-15

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8339 Ceased/non-payment of the annual fee