ES2210219T3 - Derivados de octahidro-2h-pirido- (1,2-a) -pirazina, su procedimiento de preparacion y las composiciones farmaceuticas que lo contienen. - Google Patents

Derivados de octahidro-2h-pirido- (1,2-a) -pirazina, su procedimiento de preparacion y las composiciones farmaceuticas que lo contienen.

Info

Publication number
ES2210219T3
ES2210219T3 ES02291745T ES02291745T ES2210219T3 ES 2210219 T3 ES2210219 T3 ES 2210219T3 ES 02291745 T ES02291745 T ES 02291745T ES 02291745 T ES02291745 T ES 02291745T ES 2210219 T3 ES2210219 T3 ES 2210219T3
Authority
ES
Spain
Prior art keywords
formula
compounds
pyrido
octahydro
linear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02291745T
Other languages
English (en)
Spanish (es)
Inventor
Solo Goldstein
Guillaume Poissonnet
Jean-Gilles Parmentier
Pierre Lestage
Brian Lockhart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Application granted granted Critical
Publication of ES2210219T3 publication Critical patent/ES2210219T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES02291745T 2001-07-12 2002-07-11 Derivados de octahidro-2h-pirido- (1,2-a) -pirazina, su procedimiento de preparacion y las composiciones farmaceuticas que lo contienen. Expired - Lifetime ES2210219T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0109260 2001-07-12
FR0109260A FR2827288B1 (fr) 2001-07-12 2001-07-12 Nouveaux derives d'octahydro-2h-pyrido[1,2-a]pyrazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2210219T3 true ES2210219T3 (es) 2004-07-01

Family

ID=8865405

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02291745T Expired - Lifetime ES2210219T3 (es) 2001-07-12 2002-07-11 Derivados de octahidro-2h-pirido- (1,2-a) -pirazina, su procedimiento de preparacion y las composiciones farmaceuticas que lo contienen.

Country Status (24)

Country Link
US (1) US6992085B2 (enExample)
EP (1) EP1275647B1 (enExample)
JP (1) JP3950018B2 (enExample)
KR (1) KR100485020B1 (enExample)
CN (1) CN1197863C (enExample)
AR (1) AR036166A1 (enExample)
AT (1) ATE254124T1 (enExample)
AU (1) AU2002300094B2 (enExample)
BR (1) BR0202681A (enExample)
CA (1) CA2394027C (enExample)
DE (1) DE60200089T2 (enExample)
DK (1) DK1275647T3 (enExample)
EA (1) EA005160B1 (enExample)
ES (1) ES2210219T3 (enExample)
FR (1) FR2827288B1 (enExample)
HU (1) HUP0202282A3 (enExample)
MX (1) MXPA02006699A (enExample)
NO (1) NO322966B1 (enExample)
NZ (1) NZ520120A (enExample)
PL (1) PL355034A1 (enExample)
PT (1) PT1275647E (enExample)
SI (1) SI1275647T1 (enExample)
TR (1) TR200302001T4 (enExample)
ZA (1) ZA200205596B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2004089410A1 (ja) * 2003-04-03 2006-07-06 協和醗酵工業株式会社 神経因性疼痛の予防及び／または治療剤
MY141255A (en) * 2003-12-11 2010-03-31 Memory Pharm Corp Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
FR2866647B1 (fr) * 2004-02-20 2006-10-27 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BRPI0512567A (pt) * 2004-06-22 2008-03-25 Pfizer Prod Inc compostos antagonistas de receptor de histamina-3 diazabicìclico e respectivas composições farmacêuticas
CN103110635A (zh) * 2005-07-04 2013-05-22 海波因特制药有限责任公司 组胺h3受体拮抗剂
RU2442775C2 (ru) * 2005-07-04 2012-02-20 Хай Пойнт Фармасьютикалс, ЛЛС Антагонисты гистаминовых н3-рецепторов
WO2007106349A2 (en) * 2006-03-10 2007-09-20 Neurogen Corporation Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues
KR100871691B1 (ko) 2006-10-16 2008-12-05 삼성전자주식회사 병렬 비트 테스트 방법 및 그 방법을 사용하는 반도체메모리 장치
EP3495363B1 (en) 2016-07-28 2023-08-23 Shionogi & Co., Ltd Nitrogen-containing condensed ring compounds having dopamine d3 receptor antagonistic effect
CA3089498A1 (en) 2018-01-26 2019-08-01 Shionogi & Co., Ltd. Condensed ring compounds having dopamine d3 receptor antagonistic effect

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388128A (en) * 1965-09-03 1968-06-11 Allan R. Day Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
GB8518236D0 (en) * 1985-07-19 1985-08-29 Beecham Group Plc Compounds
WO1994006794A1 (en) * 1992-09-24 1994-03-31 National Institutes Of Health Aralkyl diazabicycloalkane derivatives for cns disorders
WO1996010570A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
US6231833B1 (en) * 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
ATE344249T1 (de) * 1999-07-19 2006-11-15 Merck Frosst Canada Ltd Pyrazinone, diese verbindungen enthaltende zusammenstellungen

Also Published As

Publication number Publication date
CN1397557A (zh) 2003-02-19
HUP0202282A2 (hu) 2003-03-28
CN1197863C (zh) 2005-04-20
SI1275647T1 (en) 2004-02-29
ZA200205596B (en) 2003-03-27
US6992085B2 (en) 2006-01-31
CA2394027C (fr) 2008-01-08
PT1275647E (pt) 2004-03-31
HU0202282D0 (enExample) 2002-09-28
HK1050682A1 (en) 2003-07-04
FR2827288B1 (fr) 2003-10-31
EP1275647A1 (fr) 2003-01-15
EA200200663A1 (ru) 2003-02-27
NO20023345L (no) 2003-01-13
NZ520120A (en) 2004-03-26
AU2002300094B2 (en) 2007-06-14
EP1275647B1 (fr) 2003-11-12
BR0202681A (pt) 2003-05-06
AR036166A1 (es) 2004-08-18
HUP0202282A3 (en) 2003-11-28
DE60200089D1 (de) 2003-12-18
TR200302001T4 (tr) 2004-01-21
US20030195216A1 (en) 2003-10-16
DK1275647T3 (da) 2004-03-15
JP3950018B2 (ja) 2007-07-25
DE60200089T2 (de) 2004-09-09
KR100485020B1 (ko) 2005-04-25
MXPA02006699A (es) 2005-08-16
NO322966B1 (no) 2006-12-18
EA005160B1 (ru) 2004-12-30
PL355034A1 (en) 2003-01-13
KR20030007159A (ko) 2003-01-23
NO20023345D0 (no) 2002-07-11
CA2394027A1 (fr) 2003-01-12
FR2827288A1 (fr) 2003-01-17
JP2003064081A (ja) 2003-03-05
ATE254124T1 (de) 2003-11-15

Similar Documents

Publication Publication Date Title
CN1882541B (zh) N-[苯基(烷基-2-哌啶基)甲基]苯甲酰胺衍生物,其制备和治疗用途
US5583149A (en) Antimigraine derivatives of indolylcycloalkanylamines
JPH08333363A (ja) インドール誘導体
IL109234A (en) Indole derivatives, their preparation and pharmaceutical compositions containing them
US20130210827A1 (en) Novel benzenesulfonamides as calcium channel blockers
MXPA00007058A (es) Nuevos compuestos de -carbolina, un proceso para su preparacion y composiciones farmaceuticas que los contienen.
MX2011003533A (es) Compuestos novedosos como bloqueadores del canal de calcio.
WO1999009025A2 (en) 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor
US7446123B2 (en) Azabicyclo derivatives as muscarinic receptor antagonists
ES2552463T3 (es) Compuestos aromáticos de sulfona útiles para el tratamiento de enfermedades del sistema nervioso central
CN100406009C (zh) 作为毒蕈碱受体拮抗剂的取代的氮杂双环己烷衍生物
EP1275647B1 (fr) Dérivés d'octahydro-2H-pyrido[1,2-a]pyrazine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
JP4505135B2 (ja) Ｄ２及びｄ３ドーパミンならびに５ｈｔ１ａ及び５ｈｔ２セロトニンのレセプターのリガンドとしての８−アザビシクロ［３．２．１］オクタン−３−メタンアミン誘導体
US7947714B2 (en) Piperidine glycine transporter inhibitors
US20080108663A1 (en) Cyclopropyl Piperidine Glycine Transporter Inhibitors
US20090029979A1 (en) 5-htx modulators
FI94863B (fi) Menetelmä terapeuttisesti käyttökelpoisten halogeeni-3,4-dihydro-bentsotiopyranyyliamiinien valmistamiseksi
WO1998042710A1 (fr) Derives de dihydropyrazino[1,2-a]indole-1-one, leur preparation et leur application en therapeutique
CN1161696A (zh) 作为nmda拮抗剂的杂环取代的丙烯酸衍生物
WO2004080965A1 (ja) ニューロペプチドff受容体拮抗剤
EP0746556B1 (en) Tricyclic compounds having affinity for the 5-ht1a receptor
KR20050023400A (ko) 무스카린 수용체 길항제로서의 아자비시클로 유도체