CN1197863C - 新的八氢－2H－吡啶并[1,2－a]吡嗪化合物、它们的制备方法和含有它们的药物组合物 - Google Patents

新的八氢－2H－吡啶并[1,2－a]吡嗪化合物、它们的制备方法和含有它们的药物组合物 Download PDF

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Publication number
CN1197863C
CN1197863C CNB021241481A CN02124148A CN1197863C CN 1197863 C CN1197863 C CN 1197863C CN B021241481 A CNB021241481 A CN B021241481A CN 02124148 A CN02124148 A CN 02124148A CN 1197863 C CN1197863 C CN 1197863C
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CN
China
Prior art keywords
octahydro
pyrido
pyrazin
formula
branched
Prior art date
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Expired - Fee Related
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CNB021241481A
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English (en)
Chinese (zh)
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CN1397557A (zh
Inventor
S·戈尔德施泰因
G·波森尼特
J-G·帕尔芒捷
P·莱塔热
B·洛克哈特
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Les Laboratoires Servier SAS
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Les Laboratoires Servier SAS
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Publication of CN1397557A publication Critical patent/CN1397557A/zh
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Publication of CN1197863C publication Critical patent/CN1197863C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB021241481A 2001-07-12 2002-07-12 新的八氢－2H－吡啶并[1,2－a]吡嗪化合物、它们的制备方法和含有它们的药物组合物 Expired - Fee Related CN1197863C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0109260A FR2827288B1 (fr) 2001-07-12 2001-07-12 Nouveaux derives d'octahydro-2h-pyrido[1,2-a]pyrazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR0109260 2001-07-12

Publications (2)

Publication Number Publication Date
CN1397557A CN1397557A (zh) 2003-02-19
CN1197863C true CN1197863C (zh) 2005-04-20

Family

ID=8865405

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB021241481A Expired - Fee Related CN1197863C (zh) 2001-07-12 2002-07-12 新的八氢－2H－吡啶并[1,2－a]吡嗪化合物、它们的制备方法和含有它们的药物组合物

Country Status (24)

Country Link
US (1) US6992085B2 (enExample)
EP (1) EP1275647B1 (enExample)
JP (1) JP3950018B2 (enExample)
KR (1) KR100485020B1 (enExample)
CN (1) CN1197863C (enExample)
AR (1) AR036166A1 (enExample)
AT (1) ATE254124T1 (enExample)
AU (1) AU2002300094B2 (enExample)
BR (1) BR0202681A (enExample)
CA (1) CA2394027C (enExample)
DE (1) DE60200089T2 (enExample)
DK (1) DK1275647T3 (enExample)
EA (1) EA005160B1 (enExample)
ES (1) ES2210219T3 (enExample)
FR (1) FR2827288B1 (enExample)
HU (1) HUP0202282A3 (enExample)
MX (1) MXPA02006699A (enExample)
NO (1) NO322966B1 (enExample)
NZ (1) NZ520120A (enExample)
PL (1) PL355034A1 (enExample)
PT (1) PT1275647E (enExample)
SI (1) SI1275647T1 (enExample)
TR (1) TR200302001T4 (enExample)
ZA (1) ZA200205596B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089410A1 (ja) * 2003-04-03 2004-10-21 Kyowa Hakko Kogyo Co., Ltd. 神経因性疼痛の予防及び／または治療剤
MY141255A (en) * 2003-12-11 2010-03-31 Memory Pharm Corp Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
FR2866647B1 (fr) * 2004-02-20 2006-10-27 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1761267A1 (en) * 2004-06-22 2007-03-14 Pfizer Products Incorporated Diazabicyclic histamine-3 receptor antagonists
RU2442775C2 (ru) * 2005-07-04 2012-02-20 Хай Пойнт Фармасьютикалс, ЛЛС Антагонисты гистаминовых н3-рецепторов
EP2386554A1 (en) * 2005-07-04 2011-11-16 High Point Pharmaceuticals, LLC Compounds active at the histamine H3 receptor
EP1998620B1 (en) * 2006-03-10 2011-01-12 Neurogen Corporation Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues
KR100871691B1 (ko) 2006-10-16 2008-12-05 삼성전자주식회사 병렬 비트 테스트 방법 및 그 방법을 사용하는 반도체메모리 장치
JP7015092B2 (ja) 2016-07-28 2022-02-02 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物
US11578084B2 (en) 2018-01-26 2023-02-14 Shionogi & Co., Ltd. Condensed ring compounds having dopamine D3 receptor antagonistic effect

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388128A (en) * 1965-09-03 1968-06-11 Allan R. Day Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
GB8518236D0 (en) * 1985-07-19 1985-08-29 Beecham Group Plc Compounds
AU5291793A (en) * 1992-09-24 1994-04-12 National Institutes Of Health Aralkyl diazabicycloalkane derivatives for cns disorders
US6231833B1 (en) * 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
WO1996010570A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
ES2274795T3 (es) * 1999-07-19 2007-06-01 Merck Frosst Canada Ltd. Pirazinonas, composiciones que contienen tales compuestos.

Also Published As

Publication number Publication date
EP1275647A1 (fr) 2003-01-15
PT1275647E (pt) 2004-03-31
HUP0202282A2 (hu) 2003-03-28
EA200200663A1 (ru) 2003-02-27
CA2394027C (fr) 2008-01-08
KR20030007159A (ko) 2003-01-23
EA005160B1 (ru) 2004-12-30
CN1397557A (zh) 2003-02-19
NO20023345D0 (no) 2002-07-11
US6992085B2 (en) 2006-01-31
MXPA02006699A (es) 2005-08-16
JP2003064081A (ja) 2003-03-05
HK1050682A1 (en) 2003-07-04
HUP0202282A3 (en) 2003-11-28
DE60200089D1 (de) 2003-12-18
DE60200089T2 (de) 2004-09-09
ATE254124T1 (de) 2003-11-15
DK1275647T3 (da) 2004-03-15
US20030195216A1 (en) 2003-10-16
ES2210219T3 (es) 2004-07-01
ZA200205596B (en) 2003-03-27
HU0202282D0 (enExample) 2002-09-28
TR200302001T4 (tr) 2004-01-21
PL355034A1 (en) 2003-01-13
FR2827288B1 (fr) 2003-10-31
CA2394027A1 (fr) 2003-01-12
AR036166A1 (es) 2004-08-18
EP1275647B1 (fr) 2003-11-12
AU2002300094B2 (en) 2007-06-14
BR0202681A (pt) 2003-05-06
FR2827288A1 (fr) 2003-01-17
KR100485020B1 (ko) 2005-04-25
NZ520120A (en) 2004-03-26
NO20023345L (no) 2003-01-13
NO322966B1 (no) 2006-12-18
SI1275647T1 (en) 2004-02-29
JP3950018B2 (ja) 2007-07-25

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Granted publication date: 20050420