DE60200041T2 - Indenoindolon-Derivate, Verfahren zu ihrer Herstellung und die enthaltenden pharmazeutischen Zusammensetzungen - Google Patents

Indenoindolon-Derivate, Verfahren zu ihrer Herstellung und die enthaltenden pharmazeutischen Zusammensetzungen Download PDF

Info

Publication number
DE60200041T2
DE60200041T2 DE60200041T DE60200041T DE60200041T2 DE 60200041 T2 DE60200041 T2 DE 60200041T2 DE 60200041 T DE60200041 T DE 60200041T DE 60200041 T DE60200041 T DE 60200041T DE 60200041 T2 DE60200041 T2 DE 60200041T2
Authority
DE
Germany
Prior art keywords
formula
branched
straight
group
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60200041T
Other languages
German (de)
English (en)
Other versions
DE60200041D1 (de
Inventor
Michel Wierzbicki
Marie-Francoise Boussard
Anne Rousseau
Jean-Albert Boutin
Philippe Delagrange
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Application granted granted Critical
Publication of DE60200041D1 publication Critical patent/DE60200041D1/de
Publication of DE60200041T2 publication Critical patent/DE60200041T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60200041T 2001-03-19 2002-03-18 Indenoindolon-Derivate, Verfahren zu ihrer Herstellung und die enthaltenden pharmazeutischen Zusammensetzungen Expired - Fee Related DE60200041T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0103667 2001-03-19
FR0103667A FR2822153B1 (fr) 2001-03-19 2001-03-19 Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DE60200041D1 DE60200041D1 (de) 2003-10-30
DE60200041T2 true DE60200041T2 (de) 2004-06-09

Family

ID=8861264

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60200041T Expired - Fee Related DE60200041T2 (de) 2001-03-19 2002-03-18 Indenoindolon-Derivate, Verfahren zu ihrer Herstellung und die enthaltenden pharmazeutischen Zusammensetzungen

Country Status (24)

Country Link
US (1) US6844445B2 (show.php)
EP (1) EP1245565B1 (show.php)
JP (1) JP3886829B2 (show.php)
KR (1) KR100453979B1 (show.php)
CN (1) CN1185214C (show.php)
AR (1) AR034861A1 (show.php)
AT (1) ATE250578T1 (show.php)
AU (1) AU780027B2 (show.php)
BR (1) BR0200871A (show.php)
CA (1) CA2378628C (show.php)
DE (1) DE60200041T2 (show.php)
DK (1) DK1245565T3 (show.php)
EA (1) EA004711B1 (show.php)
ES (1) ES2207629T3 (show.php)
FR (1) FR2822153B1 (show.php)
HK (1) HK1049159B (show.php)
HU (1) HU226674B1 (show.php)
MX (1) MXPA02002816A (show.php)
NO (1) NO321890B1 (show.php)
NZ (1) NZ517855A (show.php)
PL (1) PL352866A1 (show.php)
PT (1) PT1245565E (show.php)
SI (1) SI1245565T1 (show.php)
ZA (1) ZA200202220B (show.php)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006047231B4 (de) * 2006-10-04 2009-02-12 Hemmerling, Hans-Jörg, Dr. Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
ES2580702B1 (es) 2015-02-25 2017-06-08 Palobiofarma, S.L. Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina
PL3684767T3 (pl) 2017-09-22 2024-10-14 Jubilant Epipad LLC Związki heterocykliczne jako inhibitory pad
PL3697785T3 (pl) 2017-10-18 2023-08-07 Jubilant Epipad LLC Związki imidazopirydynowe jako inhibitory pad
AU2018362046B2 (en) 2017-11-06 2023-04-13 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
SI3704120T1 (sl) 2017-11-24 2024-07-31 Jubilant Episcribe Llc Heterociklične spojine kot inhibitorji prmt5
EP3765453A1 (en) 2018-03-13 2021-01-20 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ65393A3 (en) * 1990-10-16 1994-02-16 Univ Bath Indenoindole derivative, process of its preparation and pharmaceutical preparation in which said derivative is comprised

Also Published As

Publication number Publication date
EP1245565B1 (fr) 2003-09-24
HU0201024D0 (show.php) 2002-05-29
PL352866A1 (en) 2002-09-23
JP2002322150A (ja) 2002-11-08
HUP0201024A3 (en) 2003-12-29
ES2207629T3 (es) 2004-06-01
JP3886829B2 (ja) 2007-02-28
CA2378628A1 (fr) 2002-09-19
PT1245565E (pt) 2003-12-31
CN1185214C (zh) 2005-01-19
FR2822153A1 (fr) 2002-09-20
NO20021330L (no) 2002-09-20
HK1049159B (zh) 2005-07-29
BR0200871A (pt) 2003-01-07
ATE250578T1 (de) 2003-10-15
NO20021330D0 (no) 2002-03-18
SI1245565T1 (en) 2003-12-31
EA200200263A2 (ru) 2002-10-31
EA004711B1 (ru) 2004-06-24
FR2822153B1 (fr) 2003-10-31
US20020173531A1 (en) 2002-11-21
KR20020074420A (ko) 2002-09-30
DK1245565T3 (da) 2004-01-12
KR100453979B1 (ko) 2004-10-20
HU226674B1 (en) 2009-06-29
NO321890B1 (no) 2006-07-17
MXPA02002816A (es) 2004-11-12
AR034861A1 (es) 2004-03-24
NZ517855A (en) 2002-10-25
ZA200202220B (en) 2002-10-10
CN1375490A (zh) 2002-10-23
AU2746902A (en) 2002-09-26
AU780027B2 (en) 2005-02-24
CA2378628C (fr) 2007-07-10
HUP0201024A2 (hu) 2002-11-28
US6844445B2 (en) 2005-01-18
EP1245565A1 (fr) 2002-10-02
EA200200263A3 (ru) 2002-12-26
HK1049159A1 (en) 2003-05-02
DE60200041D1 (de) 2003-10-30

Similar Documents

Publication Publication Date Title
EP0546388B1 (de) Azaheterocyclylmethyl-chromane als Wirkstoffe zur Behandlung von Erkrankungen des Zentralnervensystems
DE69425273T2 (de) N-substituierte azabicycloalkanderivate als neuroleptika usw.
DE69613240T2 (de) N-aminoalkylfluorencarboxamide, neue klasse von dopaminerezeptor subtype spezifische liganden
DE69425736T2 (de) Formyl- oder Cyano- substituierte Indolderivate mit dopaminergischer Wirkung
DE602004006891T2 (de) Derivate von n-äphenyl(pyrrolidin-2-yl)methylübenzamid und n-ä(azepan-2-yl)phenylmethylübenzamid, verfahren zu deren herstellung und deren anwendung in therapeutika
DE69706660T2 (de) N-aminoalkyldibenzofuran-carboxamide als dopaminrezeptor-subtyp spezifische liganden
DE60309057T2 (de) Azabicycloderivate als antagonisten des muscarinischen rezeptors
PL213669B1 (pl) Pochodna 2-okso-1-pirolidyny, srodek farmaceutyczny i zastosowanie pochodnej 2-okso-1-pirolidyny
DE69713124T2 (de) 1H-PYRIDO[3,4-b]INDOLCARBOXAMIDDERIVATE, IHRE HERSTELLUNG UND THERAPEUTISCHE VERWENDUNG
DE69820102T2 (de) Substituierte chromanderivate
DE69820103T2 (de) Substituierte chromanderivate
DE3430284A1 (de) Neue tryptamin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung
DE69814735T2 (de) Carbazolcarboxamide als 5-HT1F Agonisten
WO1994000458A1 (de) N-substituierte 3-azabicyclo[3.2.0]heptanderivate als neuroleptika usw.
DE4430091A1 (de) Verwendung von N-substituierten Phenothiazinen
DE60200041T2 (de) Indenoindolon-Derivate, Verfahren zu ihrer Herstellung und die enthaltenden pharmazeutischen Zusammensetzungen
EP0802195B1 (de) Substituierte 2,3-Benzodiazepinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate sowie ihre Verwendung
DE60200023T2 (de) Isoindoloindolon-Derivate, Verfahren zu ihrer Herstellung und die enthaltende pharmazeutische Zusammensetzungen
DE60200089T2 (de) Octahydro-2H-pyrido[1,2-a]pyrazinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
EP0646110B1 (de) N-substituierte 3-azabicyclo[3.2.0]heptan-derivate als neuroleptika
DE2556457C3 (de) N-(Pyrrolidin-2-yl-methyl)-2-methoxybenzamide, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE69919575T2 (de) Benzoxazolderivate und medikamente die diese als aktiven wirkstoff enthalten
DE69115954T2 (de) Kondensierte 7-gliedrige zyklische Verbindungen und diese enthaltende antipsychotische Zubereitung
DE68918832T2 (de) Benzoxazepinderivate.
DE68905363T2 (de) Heterotetracyclische laktamderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee