AU780027B2 - New indenoindolone compounds, a process for their preparation and pharmaceutical compositions containing them - Google Patents

New indenoindolone compounds, a process for their preparation and pharmaceutical compositions containing them Download PDF

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Publication number
AU780027B2
AU780027B2 AU27469/02A AU2746902A AU780027B2 AU 780027 B2 AU780027 B2 AU 780027B2 AU 27469/02 A AU27469/02 A AU 27469/02A AU 2746902 A AU2746902 A AU 2746902A AU 780027 B2 AU780027 B2 AU 780027B2
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AU
Australia
Prior art keywords
formula
group
compound
branched
linear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU27469/02A
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English (en)
Other versions
AU2746902A (en
Inventor
Marie-Francoise Boussard
Jean-Albert Boutin
Philippe Delagrange
Anne Rousseau
Michel Wierzbicki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
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Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Publication of AU2746902A publication Critical patent/AU2746902A/en
Application granted granted Critical
Publication of AU780027B2 publication Critical patent/AU780027B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU27469/02A 2001-03-19 2002-03-19 New indenoindolone compounds, a process for their preparation and pharmaceutical compositions containing them Ceased AU780027B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0103667 2001-03-19
FR0103667A FR2822153B1 (fr) 2001-03-19 2001-03-19 Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
AU2746902A AU2746902A (en) 2002-09-26
AU780027B2 true AU780027B2 (en) 2005-02-24

Family

ID=8861264

Family Applications (1)

Application Number Title Priority Date Filing Date
AU27469/02A Ceased AU780027B2 (en) 2001-03-19 2002-03-19 New indenoindolone compounds, a process for their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (1) US6844445B2 (show.php)
EP (1) EP1245565B1 (show.php)
JP (1) JP3886829B2 (show.php)
KR (1) KR100453979B1 (show.php)
CN (1) CN1185214C (show.php)
AR (1) AR034861A1 (show.php)
AT (1) ATE250578T1 (show.php)
AU (1) AU780027B2 (show.php)
BR (1) BR0200871A (show.php)
CA (1) CA2378628C (show.php)
DE (1) DE60200041T2 (show.php)
DK (1) DK1245565T3 (show.php)
EA (1) EA004711B1 (show.php)
ES (1) ES2207629T3 (show.php)
FR (1) FR2822153B1 (show.php)
HK (1) HK1049159B (show.php)
HU (1) HU226674B1 (show.php)
MX (1) MXPA02002816A (show.php)
NO (1) NO321890B1 (show.php)
NZ (1) NZ517855A (show.php)
PL (1) PL352866A1 (show.php)
PT (1) PT1245565E (show.php)
SI (1) SI1245565T1 (show.php)
ZA (1) ZA200202220B (show.php)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006047231B4 (de) * 2006-10-04 2009-02-12 Hemmerling, Hans-Jörg, Dr. Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
ES2580702B1 (es) 2015-02-25 2017-06-08 Palobiofarma, S.L. Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina
PL3684767T3 (pl) 2017-09-22 2024-10-14 Jubilant Epipad LLC Związki heterocykliczne jako inhibitory pad
PL3697785T3 (pl) 2017-10-18 2023-08-07 Jubilant Epipad LLC Związki imidazopirydynowe jako inhibitory pad
AU2018362046B2 (en) 2017-11-06 2023-04-13 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
SI3704120T1 (sl) 2017-11-24 2024-07-31 Jubilant Episcribe Llc Heterociklične spojine kot inhibitorji prmt5
EP3765453A1 (en) 2018-03-13 2021-01-20 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ65393A3 (en) * 1990-10-16 1994-02-16 Univ Bath Indenoindole derivative, process of its preparation and pharmaceutical preparation in which said derivative is comprised

Also Published As

Publication number Publication date
EP1245565B1 (fr) 2003-09-24
HU0201024D0 (show.php) 2002-05-29
PL352866A1 (en) 2002-09-23
JP2002322150A (ja) 2002-11-08
HUP0201024A3 (en) 2003-12-29
ES2207629T3 (es) 2004-06-01
JP3886829B2 (ja) 2007-02-28
CA2378628A1 (fr) 2002-09-19
PT1245565E (pt) 2003-12-31
CN1185214C (zh) 2005-01-19
FR2822153A1 (fr) 2002-09-20
NO20021330L (no) 2002-09-20
HK1049159B (zh) 2005-07-29
BR0200871A (pt) 2003-01-07
ATE250578T1 (de) 2003-10-15
NO20021330D0 (no) 2002-03-18
SI1245565T1 (en) 2003-12-31
EA200200263A2 (ru) 2002-10-31
EA004711B1 (ru) 2004-06-24
FR2822153B1 (fr) 2003-10-31
US20020173531A1 (en) 2002-11-21
KR20020074420A (ko) 2002-09-30
DK1245565T3 (da) 2004-01-12
KR100453979B1 (ko) 2004-10-20
HU226674B1 (en) 2009-06-29
NO321890B1 (no) 2006-07-17
MXPA02002816A (es) 2004-11-12
AR034861A1 (es) 2004-03-24
NZ517855A (en) 2002-10-25
DE60200041T2 (de) 2004-06-09
ZA200202220B (en) 2002-10-10
CN1375490A (zh) 2002-10-23
AU2746902A (en) 2002-09-26
CA2378628C (fr) 2007-07-10
HUP0201024A2 (hu) 2002-11-28
US6844445B2 (en) 2005-01-18
EP1245565A1 (fr) 2002-10-02
EA200200263A3 (ru) 2002-12-26
HK1049159A1 (en) 2003-05-02
DE60200041D1 (de) 2003-10-30

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