DE60139382D1 - 2-hydroxy-mutilin-carbamat derivate und ihre anwendung als antibakterielle mittel - Google Patents
2-hydroxy-mutilin-carbamat derivate und ihre anwendung als antibakterielle mittelInfo
- Publication number
- DE60139382D1 DE60139382D1 DE60139382T DE60139382T DE60139382D1 DE 60139382 D1 DE60139382 D1 DE 60139382D1 DE 60139382 T DE60139382 T DE 60139382T DE 60139382 T DE60139382 T DE 60139382T DE 60139382 D1 DE60139382 D1 DE 60139382D1
- Authority
- DE
- Germany
- Prior art keywords
- mutiline
- hydroxy
- carbamate derivatives
- antibacterial agents
- sup
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0008260.2A GB0008260D0 (en) | 2000-04-04 | 2000-04-04 | Novel compounds |
| GB0027182A GB0027182D0 (en) | 2000-11-04 | 2000-11-04 | Novel comounds |
| PCT/EP2001/003594 WO2001074788A1 (en) | 2000-04-04 | 2001-03-29 | 2-hydroxy-mutilin carbamate derivatives for antibacterial use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60139382D1 true DE60139382D1 (de) | 2009-09-10 |
Family
ID=26244040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60139382T Expired - Lifetime DE60139382D1 (de) | 2000-04-04 | 2001-03-29 | 2-hydroxy-mutilin-carbamat derivate und ihre anwendung als antibakterielle mittel |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6972297B2 (https=) |
| EP (1) | EP1268443B1 (https=) |
| JP (1) | JP2003529593A (https=) |
| KR (1) | KR100758441B1 (https=) |
| CN (1) | CN1210267C (https=) |
| AR (1) | AR030203A1 (https=) |
| AT (1) | ATE437860T1 (https=) |
| AU (2) | AU2001263827B2 (https=) |
| BR (1) | BR0109809A (https=) |
| CA (1) | CA2405132A1 (https=) |
| CO (1) | CO5280223A1 (https=) |
| CZ (1) | CZ20023290A3 (https=) |
| DE (1) | DE60139382D1 (https=) |
| ES (1) | ES2328109T3 (https=) |
| HU (1) | HUP0300370A3 (https=) |
| IL (1) | IL151887A0 (https=) |
| MX (1) | MXPA02009816A (https=) |
| NO (1) | NO324229B1 (https=) |
| NZ (1) | NZ521536A (https=) |
| PL (1) | PL358666A1 (https=) |
| WO (1) | WO2001074788A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0024811D0 (en) * | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
| US7176310B1 (en) | 2002-04-09 | 2007-02-13 | Ucb Sa | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents |
| GB0209262D0 (en) * | 2002-04-23 | 2002-06-05 | Biochemie Gmbh | Organic compounds |
| DE60317208T2 (de) * | 2002-07-24 | 2008-08-07 | Nabriva Therapeutics Forschungs Gmbh | Pleuromutilinderivate als antimikrobielle mittel |
| GB0218578D0 (en) * | 2002-08-09 | 2002-09-18 | Glaxo Group Ltd | Novel method |
| GB0308114D0 (en) * | 2003-04-08 | 2003-05-14 | Glaxo Group Ltd | Novel compounds |
| FR2856685B1 (fr) * | 2003-06-25 | 2005-09-23 | Merck Sante Sas | Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1863768A1 (en) * | 2004-12-13 | 2007-12-12 | Glaxo Group Limited | Novel polymorph of (5-amino-6-methoxy-3-pyridincarbonyl)carbamic acid 2-(s)-hydroxymutilin 14-ester |
| CA2591898A1 (en) * | 2004-12-27 | 2006-07-06 | Kyorin Pharmaceutical Co., Ltd. | Mutilin-derivative substituted at position 12 |
| JP2008534443A (ja) * | 2005-03-10 | 2008-08-28 | スミスクライン・ビーチャム・コーポレイション | 新規な方法 |
| TW200738701A (en) | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| KR100695541B1 (ko) * | 2005-10-31 | 2007-03-16 | 한국단자공업 주식회사 | 연결터미널 |
| WO2007079173A2 (en) * | 2005-12-30 | 2007-07-12 | Emergent Biosolutions Inc. | Novel 2-heteroaryloxy-phenol derivatives as antibacterial agents |
| JP5322927B2 (ja) * | 2007-05-24 | 2013-10-23 | 杏林製薬株式会社 | １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 |
| EP2014640A1 (en) * | 2007-07-13 | 2009-01-14 | Nabriva Therapeutics AG | Pleuromutilin derivatives |
| JP2010100582A (ja) * | 2008-10-24 | 2010-05-06 | Kyorin Pharmaceut Co Ltd | １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体 |
| EP2184273A1 (de) | 2008-11-05 | 2010-05-12 | Bayer CropScience AG | Halogen-substituierte Verbindungen als Pestizide |
| EP2253617A1 (de) | 2009-05-20 | 2010-11-24 | Bayer CropScience AG | Halogen-substituierte Verbindungen als Pestizide |
| ES2843723T3 (es) * | 2015-06-17 | 2021-07-20 | Nabriva Therapeutics GmbH | Formulaciones farmacéuticas inyectables de lefamulina |
| JP7631212B2 (ja) | 2019-02-27 | 2025-02-18 | オティカラ，インコーポレーテッド | 鼻、副鼻腔、および鼻咽頭組織の感染および／または炎症を治療するための方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4163254B2 (ja) | 1996-01-03 | 2008-10-08 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ムチリンのカルバモイルオキシ誘導体および抗細菌剤としてのそれらの使用 |
| HUP0001741A3 (en) | 1996-08-02 | 2000-11-28 | Smithkline Beecham Plc | Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use |
| UY25225A1 (es) * | 1997-10-29 | 2000-12-29 | Smithkline Beecham Plc | Derivados de pleuromutilina utiles como agentes antimicrobianos |
| FR2771008B1 (fr) | 1997-11-17 | 2000-04-28 | Hoechst Marion Roussel Inc | Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose |
| GB9817029D0 (en) * | 1998-08-05 | 1998-09-30 | Smithkline Beecham Plc | Novel compounds |
-
2001
- 2001-03-29 DE DE60139382T patent/DE60139382D1/de not_active Expired - Lifetime
- 2001-03-29 EP EP01938069A patent/EP1268443B1/en not_active Expired - Lifetime
- 2001-03-29 BR BR0109809-8A patent/BR0109809A/pt not_active Application Discontinuation
- 2001-03-29 ES ES01938069T patent/ES2328109T3/es not_active Expired - Lifetime
- 2001-03-29 CN CNB018091989A patent/CN1210267C/zh not_active Expired - Fee Related
- 2001-03-29 AU AU2001263827A patent/AU2001263827B2/en not_active Ceased
- 2001-03-29 WO PCT/EP2001/003594 patent/WO2001074788A1/en not_active Ceased
- 2001-03-29 JP JP2001572483A patent/JP2003529593A/ja active Pending
- 2001-03-29 NZ NZ521536A patent/NZ521536A/en unknown
- 2001-03-29 PL PL01358666A patent/PL358666A1/xx not_active Application Discontinuation
- 2001-03-29 IL IL15188701A patent/IL151887A0/xx unknown
- 2001-03-29 AT AT01938069T patent/ATE437860T1/de not_active IP Right Cessation
- 2001-03-29 US US10/240,908 patent/US6972297B2/en not_active Expired - Fee Related
- 2001-03-29 MX MXPA02009816A patent/MXPA02009816A/es active IP Right Grant
- 2001-03-29 KR KR1020027013202A patent/KR100758441B1/ko not_active Expired - Fee Related
- 2001-03-29 CZ CZ20023290A patent/CZ20023290A3/cs unknown
- 2001-03-29 HU HU0300370A patent/HUP0300370A3/hu unknown
- 2001-03-29 CA CA002405132A patent/CA2405132A1/en not_active Abandoned
- 2001-03-29 AU AU6382701A patent/AU6382701A/xx not_active Withdrawn
- 2001-03-30 AR ARP010101559A patent/AR030203A1/es not_active Application Discontinuation
- 2001-03-30 CO CO01025487A patent/CO5280223A1/es not_active Application Discontinuation
-
2002
- 2002-10-02 NO NO20024745A patent/NO324229B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0300370A3 (en) | 2005-07-28 |
| PL358666A1 (en) | 2004-08-09 |
| HUP0300370A2 (hu) | 2003-06-28 |
| AR030203A1 (es) | 2003-08-13 |
| CN1427827A (zh) | 2003-07-02 |
| MXPA02009816A (es) | 2003-03-27 |
| JP2003529593A (ja) | 2003-10-07 |
| CA2405132A1 (en) | 2001-10-11 |
| EP1268443A1 (en) | 2003-01-02 |
| NO20024745L (no) | 2002-11-19 |
| US6972297B2 (en) | 2005-12-06 |
| CN1210267C (zh) | 2005-07-13 |
| CZ20023290A3 (cs) | 2003-03-12 |
| KR20030011815A (ko) | 2003-02-11 |
| BR0109809A (pt) | 2003-01-21 |
| AU6382701A (en) | 2001-10-15 |
| ES2328109T3 (es) | 2009-11-10 |
| AU2001263827B2 (en) | 2004-06-17 |
| NZ521536A (en) | 2004-05-28 |
| IL151887A0 (en) | 2003-04-10 |
| NO324229B1 (no) | 2007-09-10 |
| ATE437860T1 (de) | 2009-08-15 |
| NO20024745D0 (no) | 2002-10-02 |
| EP1268443B1 (en) | 2009-07-29 |
| CO5280223A1 (es) | 2003-05-30 |
| WO2001074788A8 (en) | 2001-12-20 |
| US20030114674A1 (en) | 2003-06-19 |
| KR100758441B1 (ko) | 2007-09-14 |
| WO2001074788A1 (en) | 2001-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |