DE60134196D1 - Verfahren zur selektiven herstellung eines 1-phosphoryliertem zuckerderivativ-anomers und verfahren zur herstellung von nukleosiden - Google Patents

Verfahren zur selektiven herstellung eines 1-phosphoryliertem zuckerderivativ-anomers und verfahren zur herstellung von nukleosiden

Info

Publication number
DE60134196D1
DE60134196D1 DE60134196T DE60134196T DE60134196D1 DE 60134196 D1 DE60134196 D1 DE 60134196D1 DE 60134196 T DE60134196 T DE 60134196T DE 60134196 T DE60134196 T DE 60134196T DE 60134196 D1 DE60134196 D1 DE 60134196D1
Authority
DE
Germany
Prior art keywords
anomer
nucleosides
production
sugar derivative
selective preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60134196T
Other languages
English (en)
Inventor
Hironori Komatsu
Hirokazu Awano
Nobuyuki Fukazawa
Kiyoshi Ito
Ichirou Ikeda
Tadashi Araki
Takeshi Nakamura
Tamotsu Asano
Junya Fujiwara
Tomoyuki Ando
Katsutoshi Tsuchiya
Kyoko Maruyama
Hideki Umetani
Takahiro Yamauchi
Hitoki Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Inc
Original Assignee
Mitsui Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Application granted granted Critical
Publication of DE60134196D1 publication Critical patent/DE60134196D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60134196T 2000-02-10 2001-02-13 Verfahren zur selektiven herstellung eines 1-phosphoryliertem zuckerderivativ-anomers und verfahren zur herstellung von nukleosiden Expired - Lifetime DE60134196D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2000033212 2000-02-10
JP2000067333 2000-03-10
JP2000341960 2000-11-09
PCT/JP2001/000968 WO2001058920A2 (fr) 2000-02-10 2001-02-13 Procede de production selective d'un anomere derive d'un sucre 1-phosphoryle

Publications (1)

Publication Number Publication Date
DE60134196D1 true DE60134196D1 (de) 2008-07-10

Family

ID=27342316

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60134196T Expired - Lifetime DE60134196D1 (de) 2000-02-10 2001-02-13 Verfahren zur selektiven herstellung eines 1-phosphoryliertem zuckerderivativ-anomers und verfahren zur herstellung von nukleosiden

Country Status (10)

Country Link
US (2) US7038039B2 (de)
EP (1) EP1178051B1 (de)
JP (1) JP2010031037A (de)
KR (1) KR100517163B1 (de)
CN (1) CN1372564A (de)
AT (1) ATE397001T1 (de)
BR (1) BR0104461A (de)
CA (1) CA2366513A1 (de)
DE (1) DE60134196D1 (de)
WO (1) WO2001058920A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002031176A1 (fr) * 2000-10-12 2002-04-18 Mitsui Chemicals, Inc. Procédé permettant la production de nucléosides
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
JP2003055392A (ja) * 2001-08-08 2003-02-26 Mitsui Chemicals Inc １−リン酸化糖の製造法並びにヌクレオシドの製造法
WO2005040181A1 (ja) * 2003-10-24 2005-05-06 Yamasa Corporation α−１−リン酸化２−デオキシ−２−フルオロアラビノシド及び２’−デオシキ−２’−フルオロ−β−Ｄ−アラビノヌクレオシドの製造法
JP4518867B2 (ja) * 2004-08-18 2010-08-04 三井化学株式会社 ２’−デオキシリボース−１−リン酸２アンモニウム塩の製造方法
SI1932918T1 (sl) * 2006-12-15 2010-02-26 Explora Lab Sa Postopek izdelave kladribina
SG192252A1 (en) * 2011-02-03 2013-09-30 Mirna Therapeutics Inc Synthetic mimics of mir-34
EP2679593B1 (de) * 2012-06-26 2018-03-21 Umicore AG & Co. KG Verfahren zur Herstellung von Ruthenium-Indenyliden-Komplexes
BR112021000202B1 (pt) 2018-07-09 2023-03-28 Merck Sharp & Dohme Llc Métodos para síntese enzimática de nucleosídeo 4'-etinila 2-desóxi e compostos

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794136A (fr) * 1972-01-19 1973-07-17 Roussel Uclaf Procede de preparation de sels de l'acide alpha-d-glucose-1- phosphorique et produits obtenus
US4476301A (en) * 1982-04-29 1984-10-09 Centre National De La Recherche Scientifique Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
AU580061B2 (en) * 1984-04-21 1988-12-22 Sandoz Ag 2,3-diamino-2,3-didesoxyhexose derivatives, processes for their preparation and their use
DE3529497A1 (de) * 1985-08-17 1987-02-26 Boehringer Mannheim Gmbh N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3731953A1 (de) * 1987-09-23 1989-04-06 Sandoz Ag Neue saccharide, verfahren zu ihrer herstellung und ihre verwendung
DE3712735A1 (de) 1987-04-15 1988-11-10 Boehringer Mannheim Gmbh Neue pyrazolo(3,4-d)pyrimidine, verfahren zu ihrer herstellung und verwendung als arzneimittel
DE3834877A1 (de) * 1988-10-13 1990-05-03 Sandoz Ag Neue saccharide, verfahren zu ihrer herstellung und ihre verwendung
US5674998A (en) 1989-09-15 1997-10-07 Gensia Inc. C-4' modified adenosine kinase inhibitors
PT94481B (pt) * 1989-12-11 1997-02-28 Sankyo Co Processo para a preparacao de analogos de lipidos a tendo imunoactividade e actividade anti-tumoral
CA2095613C (en) * 1990-11-13 2001-01-02 Bernard Belleau Substituted 1, 3-oxathiolanes and substituted 1, 3-dithiolanes with antiviral properties
US5587480A (en) * 1990-11-13 1996-12-24 Biochem Pharma, Inc. Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
DE4102817A1 (de) 1991-01-31 1992-08-06 Merck Patent Gmbh Verfahren zur stereoselektiven herstellung von (beta)-fucopyranosyl-phosphaten und sehr reiner gdp-fucose
JPH05247078A (ja) * 1992-03-03 1993-09-24 Japan Tobacco Inc 糖化合物、シアル酸含有糖鎖類生合成阻害剤、その製造方法、並びに新規な中間体
JPH08160781A (ja) * 1994-12-12 1996-06-21 Ricoh Co Ltd 画像形成装置
GB9525606D0 (en) * 1995-12-14 1996-02-14 Iaf Biochem Int Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
JP2767408B2 (ja) * 1996-02-21 1998-06-18 農林水産省食品総合研究所長 リン酸糖の製造法
US5770407A (en) * 1996-12-10 1998-06-23 The Scripps Research Institute Process for preparing nucleotide inhibitors of glycosyltransferases
JP3864357B2 (ja) * 1997-08-04 2006-12-27 有機合成薬品工業株式会社 プリンヌクレオシド化合物の製造方法
DE19740357A1 (de) * 1997-09-13 1999-03-18 Martin Wilhelm Phosphoryliertes Zuckermolekül
JP4066121B2 (ja) * 2000-03-27 2008-03-26 有機合成薬品工業株式会社 グアノシン類及びその中間体の製造方法
WO2002031176A1 (fr) * 2000-10-12 2002-04-18 Mitsui Chemicals, Inc. Procédé permettant la production de nucléosides
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel

Also Published As

Publication number Publication date
CN1372564A (zh) 2002-10-02
EP1178051A4 (de) 2003-05-28
WO2001058920A3 (fr) 2001-11-08
US20060094869A1 (en) 2006-05-04
WO2001058920A2 (fr) 2001-08-16
US20020193314A1 (en) 2002-12-19
KR100517163B1 (ko) 2005-09-26
EP1178051A2 (de) 2002-02-06
ATE397001T1 (de) 2008-06-15
BR0104461A (pt) 2002-08-06
KR20020013524A (ko) 2002-02-20
JP2010031037A (ja) 2010-02-12
CA2366513A1 (en) 2001-08-16
US7038039B2 (en) 2006-05-02
EP1178051B1 (de) 2008-05-28

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