DE60130640D1 - 2-alkylidene-19-nor-vitamin d verbindungen und ihre therapeutische verwendungen - Google Patents
2-alkylidene-19-nor-vitamin d verbindungen und ihre therapeutische verwendungenInfo
- Publication number
- DE60130640D1 DE60130640D1 DE60130640T DE60130640T DE60130640D1 DE 60130640 D1 DE60130640 D1 DE 60130640D1 DE 60130640 T DE60130640 T DE 60130640T DE 60130640 T DE60130640 T DE 60130640T DE 60130640 D1 DE60130640 D1 DE 60130640D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- vitamin
- group
- diseases
- alkylidene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000000694 effects Effects 0.000 abstract 3
- 229930003316 Vitamin D Natural products 0.000 abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 235000019166 vitamin D Nutrition 0.000 abstract 2
- 239000011710 vitamin D Substances 0.000 abstract 2
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 2
- 229940046008 vitamin d Drugs 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000008416 bone turnover Effects 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 238000007429 general method Methods 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000027425 release of sequestered calcium ion into cytosol Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US540686 | 2000-03-31 | ||
| US09/540,686 US6392071B1 (en) | 1997-03-17 | 2000-03-31 | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| PCT/US2001/010317 WO2001074766A1 (en) | 2000-03-31 | 2001-03-29 | 2-alkylidene-19-nor-vitamin d compounds and their therapeutic uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60130640D1 true DE60130640D1 (de) | 2007-11-08 |
| DE60130640T2 DE60130640T2 (de) | 2008-07-17 |
Family
ID=24156520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60130640T Expired - Lifetime DE60130640T2 (de) | 2000-03-31 | 2001-03-29 | 2-alkylidene-19-nor-vitamin d verbindungen und ihre therapeutische verwendungen |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US6392071B1 (de) |
| EP (1) | EP1268416B1 (de) |
| JP (1) | JP4022071B2 (de) |
| KR (1) | KR20020091167A (de) |
| AT (1) | ATE374178T1 (de) |
| AU (2) | AU2001247905B2 (de) |
| CA (1) | CA2404548C (de) |
| DE (1) | DE60130640T2 (de) |
| DK (1) | DK1268416T3 (de) |
| ES (1) | ES2291305T3 (de) |
| IL (1) | IL152020A (de) |
| MX (1) | MXPA02009590A (de) |
| NZ (1) | NZ522160A (de) |
| WO (1) | WO2001074766A1 (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| ATE411283T1 (de) * | 2001-12-13 | 2008-10-15 | Wisconsin Alumni Res Found | (20s)-1 alpha-hydroxy-2-methylen-19-nor- bishomopregnacalciferol und ihre verwendungen |
| US6627622B2 (en) | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US20030195175A1 (en) * | 2002-03-25 | 2003-10-16 | Deluca Hector F. | Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone |
| JPWO2004033420A1 (ja) * | 2002-10-10 | 2006-02-09 | ウイスコンシン アラムナイ リサーチ フオンデーシヨンＷｉｓｃｏｎｓｉｎ Ａｌｕｍｎｉ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | ２，２−ジ置換−１α，２５−ジヒドロキシ−１９−ノルビタミンＤ誘導体 |
| WO2004076468A1 (ja) | 2003-02-25 | 2004-09-10 | Kobe Tennenbutsu Kagaku Kabushiki Kaisha | ビタミンｄ誘導体を合成するための新規な中間体 |
| ATE556999T1 (de) * | 2003-04-10 | 2012-05-15 | Wisconsin Alumni Res Found | 2-propyliden-19-nor-vitamin d verbindungen |
| WO2004098507A2 (en) * | 2003-04-30 | 2004-11-18 | Bioxell S.P.A. | 1,3 aclyated 24-keto-vitamin d3 compounds and methods of use thereof |
| US6894037B2 (en) * | 2003-07-03 | 2005-05-17 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses |
| MXPA06000060A (es) * | 2003-07-03 | 2006-04-07 | Wisconsin Alumni Res Found | 2-metilen-19-nor-20(s)-25-metil-1alfa-hidroxicalciferol y sus usos. |
| US20050009792A1 (en) * | 2003-07-08 | 2005-01-13 | Deluca Hector F. | (20S)-1alpha-hydroxy-2-methylene-19-nor-vitamin D3 and its uses |
| NZ545862A (en) * | 2003-08-20 | 2010-01-29 | Wisconsin Alumni Res Found | 2-Methylene-19-nor-vitamin D2 compounds |
| WO2005027928A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | 2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism |
| WO2005027916A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors |
| WO2005027922A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | 2-alkylidene-19-nor-vitamin d derivatives for the treatment of hypogonadism or andropause |
| WO2005027918A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a cyclooxgenase-2 inhibitor |
| AU2004273658A1 (en) * | 2003-09-19 | 2005-03-31 | Wisconsin Alumni Research Foundation (Warf) | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin D derivatives and an estrogen agonist/antagonist |
| US7214670B2 (en) * | 2003-09-24 | 2007-05-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 to increase the life expectancy of human beings |
| US7704980B2 (en) * | 2003-10-08 | 2010-04-27 | Wisconsin Alumni Research Foundation | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
| JP2007512376A (ja) * | 2003-11-25 | 2007-05-17 | ウイスコンシン アラムニ リサーチ ファンデーション | 肥満症の予防及び治療用ビタミンｄ類似体 |
| JP2007512371A (ja) * | 2003-11-25 | 2007-05-17 | デルタノイド ファーマシューティカルズ，インコーポレイティド | ビタミン化合物を用いる体脂肪の減少方法 |
| US8404667B2 (en) | 2006-12-29 | 2013-03-26 | Wisconsin Alumni Research Foundation | Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog |
| WO2005079464A2 (en) * | 2004-02-17 | 2005-09-01 | Wisconsin Alumni Research Foundation | Vitamin d receptor antagonists and their use in treating asthma |
| US7214671B2 (en) * | 2004-02-19 | 2007-05-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases |
| US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
| WO2006051106A1 (en) | 2004-11-12 | 2006-05-18 | Bioxell Spa | Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer |
| MX2007006094A (es) * | 2004-11-22 | 2007-07-11 | Wisconsin Alumni Res Found | 2-metilen-19,21-dinor-1a-hidroxi-bishomopregnacalciferol. |
| AU2005309818A1 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20R)-1-alpha-hydroxy-bishomopregnacalciferol |
| CA2588060A1 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20s)-1alpha-hydroxy-trishomopregnacalciferol |
| DE602005021538D1 (de) * | 2004-11-22 | 2010-07-08 | Wisconsin Alumni Res Found | 17,20(z)-dehydro-vitamin-d-analoge und deren verwendungen |
| ATE467614T1 (de) * | 2004-11-22 | 2010-05-15 | Wisconsin Alumni Res Found | 2-methylen-19,26,27-trinor-(20s)-1-alpha- hydroxyvitamin d3 and dessen verwendungen |
| US7563783B2 (en) * | 2005-02-11 | 2009-07-21 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20S-24S)-1α,25-dihydroxyvitamin-D2 |
| ATE554774T1 (de) * | 2005-02-11 | 2012-05-15 | Wisconsin Alumni Res Found | 2-methylen-19-nor-(20s-24epi)-1alpha,25- dihydrovitamin-d2 |
| CA2603328A1 (en) * | 2005-03-29 | 2006-10-05 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(23s)-25-dehydro-1.alpha.-hydroxyvitamin d3-26,23-lactone and 2-methylene-19-nor-(23r)-25-dehydro-1.alpha.-hydroxyvitamin d3-26,23-lactone |
| NZ563758A (en) * | 2005-05-03 | 2010-04-30 | Wisconsin Alumni Res Found | 19,26,27-Trinor-1alpha,25-dihydroxyvitamin D3 compounds |
| NZ567015A (en) | 2005-08-30 | 2010-12-24 | Wisconsin Alumni Res Found | Des-C,D analogs of 1alpha,25-dihydroxy-19-norvitamin D3 |
| US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| US7803789B2 (en) | 2006-02-02 | 2010-09-28 | Wisconsin Alumni Research Foundation | Vitamin D analog—RAK, methods and uses thereof |
| US20090281340A1 (en) * | 2006-04-05 | 2009-11-12 | Deluca Hector F | 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and treatment thereof |
| US8058265B2 (en) * | 2006-04-05 | 2011-11-15 | Wisconsin Alumni Research Foundation | 1a-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds and methods of making and treatment thereof |
| EP2001842B1 (de) * | 2006-04-06 | 2012-06-06 | Wisconsin Alumni Research Foundation | 2-methylen-1-alpha-hydroxy-19,21-dinor-vitamin-d3-analoge und deren anwendungen |
| JP2009532460A (ja) | 2006-04-06 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−置換−１α，２５−ジヒドロキシ−１９，２６，２７−トリノルビタミンＤ類縁体およびその使用 |
| US7538098B2 (en) * | 2006-04-06 | 2009-05-26 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2 or 3,2 heterocyclic ring |
| CA2648324A1 (en) | 2006-04-06 | 2007-10-18 | Wisconsin Alumni Research Foundation | 2-methylene-1.alpha.,25-dihydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
| MX2008012913A (es) * | 2006-04-06 | 2009-03-06 | Wisconsin Alumni Res Found | 2-metilen-1a,25-dihidroxi-18,19,21-trinorvitamina d3 y sus usos. |
| AU2007298651A1 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| EP2004597B1 (de) * | 2006-04-10 | 2011-01-26 | Wisconsin Alumni Research Foundation | 1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor-vitamin-d-verbindungen mit einer 1,1-dimethylpropyl-seitenkette |
| WO2008089093A2 (en) * | 2007-01-12 | 2008-07-24 | Quatrx Pharmaceuticals Company | Efficient processes for preparing steroids and vitamin d derivatives with the unnatural configuration at c20 (20 alpha-methyl) from pregnenolone |
| US8377913B2 (en) * | 2007-11-20 | 2013-02-19 | Abbvie Inc. | Vitamin D receptor activators and methods of making |
| MX2010007956A (es) * | 2008-01-22 | 2010-09-14 | Wisconsin Alumni Reasearch Fou | Analogos de 13,13-dimetil-des-c,d de compuestos de 1a,25-dihidroxi-19-nor-vitamina d3 y formas de dosificacion de composicion topica y metodos de tratamiento de condiciones de la piel. |
| MX2010009578A (es) * | 2008-03-06 | 2010-09-24 | Wisconsin Alumni Res Found | Metodos para incrementar el espesor epidermico de la piel mediante la administracion topica de un compuesto de vitamina d que contiene 19-nor. |
| US8222236B2 (en) * | 2008-07-10 | 2012-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs |
| US7893043B2 (en) * | 2008-07-10 | 2011-02-22 | Wisconsin Alumni Research Foundation | 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs |
| US7888339B2 (en) * | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
| EA026334B1 (ru) | 2009-01-27 | 2017-03-31 | БЕРГ ЭлЭлСи | Применение соединения витамина d для предотвращения или снижения развития химиотерапевтически индуцированной нейтропении |
| CN102655869B (zh) | 2009-08-14 | 2016-08-10 | 博格有限责任公司 | 用于治疗脱发的维生素d3及其类似物 |
| CA2776464C (en) * | 2009-10-02 | 2017-10-24 | Wisconsin Alumni Research Foundation | 1-desoxy-2-methylene-19-nor-vitamin d analogs and their uses |
| WO2011041596A2 (en) | 2009-10-02 | 2011-04-07 | Wisconsin Alumni Research Foundation | 19-nor-vitamin d analogs with 1,2-or 3,2-cyclopentene ring |
| EP2490695B1 (de) * | 2009-10-21 | 2013-11-20 | Wisconsin Alumni Research Foundation | Verfahren zur vorbeugung der diabetes typ i |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| ES2545403T3 (es) * | 2010-03-23 | 2015-09-10 | Wisconsin Alumni Research Foundation | (20S)-2-metilen-19-nor-22-dimetil-1alfa,25-dihidroxivitamina D3 y (20R)-2-metilen-19-nor-22-dimetil-1alfa,25-hidroxivitamina D3 |
| CA2793727C (en) * | 2010-03-23 | 2017-01-03 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1.alpha.,25-dihydroxyvitamin d3 |
| CA2837882C (en) | 2011-06-03 | 2019-03-26 | Wisconsin Alumni Research Foundation | (22e)-2-methylene-26,27-cyclo-22-dehydro-1.alpha.-hydroxy-19-norvitamin d3 derivatives |
| EP2721004B1 (de) | 2011-06-14 | 2017-07-26 | Wisconsin Alumni Research Foundation | 3-desoxy-2-methylen-19-nor-vitamin-d-analoga und ihre verwendung |
| US8455467B2 (en) | 2011-10-21 | 2013-06-04 | Wisconsin Alumni Research Foundation | 2-methylene-vitamin D analogs and their uses |
| EP2768804B1 (de) | 2011-10-21 | 2018-02-28 | Wisconsin Alumni Research Foundation | 2-methylen-vitamin-d-analoge und ihre verwendungen |
| US20130295083A1 (en) * | 2012-05-02 | 2013-11-07 | Wisconsin Alumni Research Foundation | 2a-Methyl-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2AMD) or 2 methylene-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2MD) Support Survival and Function of Transplanted Islet Cells In Type 1 Diabetes |
| US8785422B2 (en) | 2012-06-06 | 2014-07-22 | Wisconsin Alumni Research Foundation | A-ring modified 19-nor-vitamin D analogs and their uses |
| CN112156097A (zh) | 2013-05-29 | 2021-01-01 | 博格有限责任公司 | 使用维生素d预防或减轻化疗诱发的脱发 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL67153A (en) | 1981-11-02 | 1986-12-31 | Res Inst Medicine Chem | Intermediates in the production of vitamin d analogues and method for their production |
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US4800198A (en) * | 1985-04-23 | 1989-01-24 | Wisconsin Alumni Research Foundation | Method of inducing the differentiation of malignant cells with secosterol |
| US4851401A (en) | 1988-07-14 | 1989-07-25 | Wisconsin Alumni Research Foundation | Novel cyclopentano-vitamin D analogs |
| GB8904154D0 (en) | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
| NZ232734A (en) | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
| CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| US5246925A (en) | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| AU649057B2 (en) | 1990-08-24 | 1994-05-12 | Wisconsin Alumni Research Foundation | Methods and compositions containing vitamin D compounds for improvement of skin conditions |
| ATE173401T1 (de) | 1990-09-07 | 1998-12-15 | Wisconsin Alumni Res Found | Neue verwendung von 1-alpha-hydroxylierten-19-nor-vitamin-d-verbind ngen zur behandlung von psoriasis |
| US5089641A (en) * | 1991-03-11 | 1992-02-18 | Wisconsin Alumni Research Foundation | Synthesis of 1α-hydroxy-secosterol compounds |
| AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| ZA924811B (en) | 1991-06-28 | 1993-12-29 | Endorecherche Inc | Controlled release systems and low dose androgens |
| JP2898882B2 (ja) | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物 |
| WO1996001811A1 (en) | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
| KR970707089A (ko) | 1994-11-21 | 1997-12-01 | 리차드 에이취. 리이저 | 18, 19-디노르-비타민 D 화합물(18,19-Dinor-Vitamin D Compounds) |
| US5877168A (en) | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
| IL118156A (en) | 1995-05-09 | 2001-08-26 | Duphar Int Res | Vitamin d compounds, their preparation and pharmaceutical compositions containing them |
| DK0833643T3 (da) | 1995-06-06 | 2005-05-30 | Merck & Co Inc | Formuleringer af vandfrit mononatriumsalt af alendronat og deres anvendelse til behandling af knoglesygdomme |
| JPH11507649A (ja) * | 1995-06-14 | 1999-07-06 | シエーリング アクチエンゲゼルシヤフト | ２５位の炭素に置換基を有する新規なビタミンｄ誘導体、その製造方法、中間生成物及び薬剤の製造のためのその使用 |
| KR100382262B1 (ko) * | 1995-12-28 | 2003-08-25 | 쥬가이 세이야쿠 가부시키가이샤 | 악성종양전이억제제 |
| US5849960A (en) * | 1996-11-26 | 1998-12-15 | Shell Oil Company | Highly branched primary alcohol compositions, and biodegradable detergents made therefrom |
| US6503893B2 (en) * | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
| US6573256B2 (en) * | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
| US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5843928A (en) | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6306844B1 (en) * | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US5936105A (en) | 1997-06-13 | 1999-08-10 | Tetrionics, Inc. | 14-EPI-19-nor-vitamin D compounds and methods |
| US6114317A (en) * | 1998-05-21 | 2000-09-05 | Wisconsin Alumni Research Foundation | Method of locking 1α-OH of vitamin D compounds in axial orientation |
| US5972917A (en) * | 1998-05-29 | 1999-10-26 | Bone Care Int Inc | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
| US5962707A (en) | 1998-08-18 | 1999-10-05 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D3 compounds with calcemic activity |
| IL152942A (en) * | 2000-05-31 | 2007-09-20 | Wisconsin Alumni Res Found | Compounds 2 - Ethyl and 2 - Ethylaidine - 19 - Nur - Vitamin D and pharmaceutical preparations containing them |
| ATE273709T1 (de) * | 2000-09-08 | 2004-09-15 | Wisconsin Alumni Res Found | 1alpha-hydroxy-2-methylene-19-nor- homopregnacalciferol und seine therapeutische verwendungen |
| US6835723B2 (en) * | 2001-12-13 | 2004-12-28 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-20(S)-1α-hydroxy-bis-homo-pregnacalciferol in crystalline form |
| US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
-
2000
- 2000-03-31 US US09/540,686 patent/US6392071B1/en not_active Expired - Lifetime
-
2001
- 2001-03-29 KR KR1020027013007A patent/KR20020091167A/ko not_active Application Discontinuation
- 2001-03-29 AU AU2001247905A patent/AU2001247905B2/en not_active Ceased
- 2001-03-29 CA CA002404548A patent/CA2404548C/en not_active Expired - Fee Related
- 2001-03-29 DK DK01920897T patent/DK1268416T3/da active
- 2001-03-29 AT AT01920897T patent/ATE374178T1/de active
- 2001-03-29 ES ES01920897T patent/ES2291305T3/es not_active Expired - Lifetime
- 2001-03-29 MX MXPA02009590A patent/MXPA02009590A/es active IP Right Grant
- 2001-03-29 AU AU4790501A patent/AU4790501A/xx active Pending
- 2001-03-29 DE DE60130640T patent/DE60130640T2/de not_active Expired - Lifetime
- 2001-03-29 IL IL152020A patent/IL152020A/en not_active IP Right Cessation
- 2001-03-29 WO PCT/US2001/010317 patent/WO2001074766A1/en active IP Right Grant
- 2001-03-29 JP JP2001572461A patent/JP4022071B2/ja not_active Expired - Fee Related
- 2001-03-29 NZ NZ522160A patent/NZ522160A/en not_active IP Right Cessation
- 2001-03-29 EP EP01920897A patent/EP1268416B1/de not_active Expired - Lifetime
- 2001-10-31 US US10/001,711 patent/US6537981B2/en not_active Expired - Lifetime
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2003
- 2003-01-28 US US10/352,745 patent/US6696431B2/en not_active Expired - Lifetime
-
2004
- 2004-02-17 US US10/780,103 patent/US7094774B2/en not_active Expired - Lifetime
-
2006
- 2006-08-18 US US11/507,092 patent/US20090143342A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003529581A (ja) | 2003-10-07 |
| AU4790501A (en) | 2001-10-15 |
| CA2404548C (en) | 2009-07-21 |
| DE60130640T2 (de) | 2008-07-17 |
| US20040167104A1 (en) | 2004-08-26 |
| ES2291305T3 (es) | 2008-03-01 |
| US6696431B2 (en) | 2004-02-24 |
| US7094774B2 (en) | 2006-08-22 |
| KR20020091167A (ko) | 2002-12-05 |
| JP4022071B2 (ja) | 2007-12-12 |
| IL152020A0 (en) | 2003-04-10 |
| EP1268416A1 (de) | 2003-01-02 |
| US20030181427A1 (en) | 2003-09-25 |
| WO2001074766A1 (en) | 2001-10-11 |
| US6537981B2 (en) | 2003-03-25 |
| MXPA02009590A (es) | 2004-03-26 |
| ATE374178T1 (de) | 2007-10-15 |
| CA2404548A1 (en) | 2001-10-11 |
| US6392071B1 (en) | 2002-05-21 |
| EP1268416B1 (de) | 2007-09-26 |
| IL152020A (en) | 2008-03-20 |
| AU2001247905B2 (en) | 2005-05-19 |
| US20020087015A1 (en) | 2002-07-04 |
| US20090143342A1 (en) | 2009-06-04 |
| NZ522160A (en) | 2004-11-26 |
| DK1268416T3 (da) | 2008-02-04 |
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