DE60129965T2 - Lagerstabile iontophorese reservoirelektrode sowie iontophoretisches system - Google Patents
Lagerstabile iontophorese reservoirelektrode sowie iontophoretisches system Download PDFInfo
- Publication number
- DE60129965T2 DE60129965T2 DE60129965T DE60129965T DE60129965T2 DE 60129965 T2 DE60129965 T2 DE 60129965T2 DE 60129965 T DE60129965 T DE 60129965T DE 60129965 T DE60129965 T DE 60129965T DE 60129965 T2 DE60129965 T2 DE 60129965T2
- Authority
- DE
- Germany
- Prior art keywords
- electrode
- reservoir
- reservoir electrode
- polymeric material
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000003860 storage Methods 0.000 title description 22
- 239000000463 material Substances 0.000 claims abstract description 64
- 239000000853 adhesive Substances 0.000 claims abstract description 19
- 230000001070 adhesive effect Effects 0.000 claims abstract description 19
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 229910001514 alkali metal chloride Inorganic materials 0.000 claims abstract description 5
- 150000003841 chloride salts Chemical class 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims description 57
- 229940079593 drug Drugs 0.000 claims description 52
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 32
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 24
- 230000007797 corrosion Effects 0.000 claims description 20
- 238000005260 corrosion Methods 0.000 claims description 20
- 230000002745 absorbent Effects 0.000 claims description 18
- 239000002250 absorbent Substances 0.000 claims description 18
- 239000000017 hydrogel Substances 0.000 claims description 18
- 239000011780 sodium chloride Substances 0.000 claims description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 13
- 239000004332 silver Substances 0.000 claims description 13
- -1 alkali metal halide salt Chemical class 0.000 claims description 12
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 claims description 12
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 11
- 229910052709 silver Inorganic materials 0.000 claims description 11
- YLXIPWWIOISBDD-NDAAPVSOSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;4-[(1r)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.CNC[C@H](O)C1=CC=C(O)C(O)=C1 YLXIPWWIOISBDD-NDAAPVSOSA-N 0.000 claims description 10
- 229960003157 epinephrine bitartrate Drugs 0.000 claims description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 239000012458 free base Substances 0.000 claims description 5
- 150000002500 ions Chemical class 0.000 claims description 5
- 229960004393 lidocaine hydrochloride Drugs 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 229960005323 phenoxyethanol Drugs 0.000 claims description 5
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 4
- 125000005907 alkyl ester group Chemical group 0.000 claims description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 230000006870 function Effects 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 239000010409 thin film Substances 0.000 claims description 3
- 229960004106 citric acid Drugs 0.000 claims description 2
- 229940045641 monobasic sodium phosphate Drugs 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 2
- 229940001584 sodium metabisulfite Drugs 0.000 claims description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 2
- 239000011243 crosslinked material Substances 0.000 claims 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 238000004026 adhesive bonding Methods 0.000 claims 1
- 229910001508 alkali metal halide Inorganic materials 0.000 claims 1
- 239000008365 aqueous carrier Substances 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims 1
- RMGVZKRVHHSUIM-UHFFFAOYSA-L dithionate(2-) Chemical compound [O-]S(=O)(=O)S([O-])(=O)=O RMGVZKRVHHSUIM-UHFFFAOYSA-L 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 abstract 2
- 238000004132 cross linking Methods 0.000 description 18
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 10
- 229910052783 alkali metal Inorganic materials 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 230000005865 ionizing radiation Effects 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 238000012377 drug delivery Methods 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 4
- 229930182837 (R)-adrenaline Natural products 0.000 description 4
- HYKGUEIYMKVUSR-NPULLEENSA-N 2-(diethylamino)-n-(2,6-dimethylphenyl)acetamide;4-[(1r)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C HYKGUEIYMKVUSR-NPULLEENSA-N 0.000 description 4
- 239000003792 electrolyte Substances 0.000 description 4
- 238000010894 electron beam technology Methods 0.000 description 4
- 229960005139 epinephrine Drugs 0.000 description 4
- 230000002787 reinforcement Effects 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000013065 commercial product Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 229940126534 drug product Drugs 0.000 description 2
- 239000007772 electrode material Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 description 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 238000003411 electrode reaction Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000010416 ion conductor Substances 0.000 description 1
- 238000010884 ion-beam technique Methods 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000010970 precious metal Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/0436—Material of the electrode
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Electrotherapy Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US610563 | 1996-03-06 | ||
| US09/610,563 US6629968B1 (en) | 2000-06-30 | 2000-06-30 | Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode |
| PCT/US2001/020886 WO2002002182A2 (en) | 2000-06-30 | 2001-06-29 | Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60129965D1 DE60129965D1 (de) | 2007-09-27 |
| DE60129965T2 true DE60129965T2 (de) | 2008-05-15 |
Family
ID=24445534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60129965T Expired - Lifetime DE60129965T2 (de) | 2000-06-30 | 2001-06-29 | Lagerstabile iontophorese reservoirelektrode sowie iontophoretisches system |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6629968B1 (https=) |
| EP (1) | EP1294439B1 (https=) |
| JP (1) | JP4024673B2 (https=) |
| AT (1) | ATE369891T1 (https=) |
| AU (1) | AU2001273104A1 (https=) |
| CA (1) | CA2413624C (https=) |
| DE (1) | DE60129965T2 (https=) |
| WO (1) | WO2002002182A2 (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6757560B1 (en) * | 1999-04-09 | 2004-06-29 | Novosis Pharma Ag | Transdermal delivery system (TDS) with electrode network |
| JP4033382B2 (ja) * | 2002-04-08 | 2008-01-16 | 久光製薬株式会社 | インスリン投与装置 |
| AU2003218271A1 (en) | 2002-04-18 | 2003-11-03 | Carnegie Mellon University | Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids |
| US7776600B2 (en) | 2002-04-18 | 2010-08-17 | Carnegie Mellon University | Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids |
| JP4089875B2 (ja) * | 2002-06-12 | 2008-05-28 | 共同印刷株式会社 | 凹部を含む電極装置 |
| US7917205B2 (en) * | 2003-03-20 | 2011-03-29 | Nobuyoshi Karashima | Iontophoresis-based medical device |
| JP3493359B1 (ja) * | 2003-03-20 | 2004-02-03 | 宣美 辛島 | イオン泳動式治療装置 |
| ATE424884T1 (de) * | 2003-03-31 | 2009-03-15 | Alza Corp | Elektrotransportvorrichtung mit einem behältergehäuse mit einem biegsamen leitfähigen element |
| WO2005020967A1 (ja) * | 2003-08-29 | 2005-03-10 | Hisamitsu Pharmaceutical Co., Inc. | 電気的薬物移送製剤 |
| CA2553901C (en) | 2004-01-22 | 2015-01-20 | Rehabtronics Inc. | Method of routing electrical current to bodily tissues via implanted passive conductors |
| US20100016929A1 (en) * | 2004-01-22 | 2010-01-21 | Arthur Prochazka | Method and system for controlled nerve ablation |
| US20050234516A1 (en) * | 2004-02-16 | 2005-10-20 | Gueret Jean-Louis H | Treatment kit, composite structure, electric exciter, and cosmetic treatment method |
| FR2866240B1 (fr) * | 2004-02-16 | 2006-06-23 | Oreal | Kit de traitement comportant une structure composite a appliquer sur la peau et un excitateur electrique |
| US20050228335A1 (en) * | 2004-04-07 | 2005-10-13 | Reddy Vilambi N | Physical, structural, mechanical, electrical and electromechanical features for use in association with electrically assisted delivery devices and systems |
| US20050228336A1 (en) * | 2004-04-07 | 2005-10-13 | Preston Keusch | Electrically assisted lidocaine and epinephrine delivery device having extended shelf-stability |
| US7537590B2 (en) * | 2004-07-30 | 2009-05-26 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
| JP4728631B2 (ja) * | 2004-11-30 | 2011-07-20 | Ｔｔｉ・エルビュー株式会社 | イオントフォレーシス装置 |
| US7590444B2 (en) * | 2004-12-09 | 2009-09-15 | Tti Ellebeau, Inc. | Iontophoresis device |
| JP4731931B2 (ja) * | 2005-02-03 | 2011-07-27 | Ｔｔｉ・エルビュー株式会社 | イオントフォレーシス装置 |
| JP4793806B2 (ja) * | 2005-03-22 | 2011-10-12 | Ｔｔｉ・エルビュー株式会社 | イオントフォレーシス装置 |
| US8386029B2 (en) | 2005-03-31 | 2013-02-26 | Encore Medical Asset Corporation | Apparatus for electrotherapy drug delivery with added impurities |
| US20070027426A1 (en) * | 2005-06-24 | 2007-02-01 | Transcutaneous Technologies Inc. | Iontophoresis device to deliver active agents to biological interfaces |
| US8386030B2 (en) | 2005-08-08 | 2013-02-26 | Tti Ellebeau, Inc. | Iontophoresis device |
| US8295922B2 (en) | 2005-08-08 | 2012-10-23 | Tti Ellebeau, Inc. | Iontophoresis device |
| US20070088331A1 (en) * | 2005-08-18 | 2007-04-19 | Transcutaneous Technologies Inc. | Method and apparatus for managing active agent usage, and active agent injecting device |
| EP1925336A4 (en) | 2005-09-15 | 2011-01-19 | Tti Ellebeau Inc | ROD TYPE IONTOPHORESIS APPARATUS |
| US20070078434A1 (en) * | 2005-09-30 | 2007-04-05 | Vyteris, Inc. | Indications For Local Transport of Anaesthetic Agents By Electrotransport Devices |
| JP2009509682A (ja) * | 2005-09-30 | 2009-03-12 | バイテリス，インコーポレイテッド | 予め充填された結合電気搬送パッチからの性腺刺激ホルモン放出ホルモンのパルス状搬送 |
| EP1931416A2 (en) * | 2005-09-30 | 2008-06-18 | Tti Ellebeau, Inc. | Iontophoresis method and apparatus for systemic delivery of active agents |
| US20070078372A1 (en) * | 2005-09-30 | 2007-04-05 | Vyteris, Inc. | Iontophoresis Drug Delivery Formulation Providing Acceptable Sensation and Dermal Anesthesia |
| US20070093743A1 (en) * | 2005-09-30 | 2007-04-26 | Vyteris, Inc. | Iontophoresis Drug Delivery Device Providing Acceptable Depth and Duration of Dermal Anesthesia |
| US20070083147A1 (en) * | 2005-09-30 | 2007-04-12 | Transcutaneous Technologies Inc. | Iontophoresis apparatus and method to deliver antibiotics to biological interfaces |
| JP2009509657A (ja) | 2005-09-30 | 2009-03-12 | Ｔｔｉ・エルビュー株式会社 | 生体界面への活性物質の送達のイオントフォレーシス装置及び方法 |
| JP5116482B2 (ja) * | 2005-11-14 | 2013-01-09 | 帝國製薬株式会社 | イオントフォレーシス用製剤 |
| US7848801B2 (en) | 2005-12-30 | 2010-12-07 | Tti Ellebeau, Inc. | Iontophoretic systems, devices, and methods of delivery of active agents to biological interface |
| US8483820B2 (en) * | 2006-10-05 | 2013-07-09 | Bioness Inc. | System and method for percutaneous delivery of electrical stimulation to a target body tissue |
| US8332028B2 (en) * | 2006-11-28 | 2012-12-11 | Polyplus Battery Company | Protected lithium electrodes for electro-transport drug delivery |
| US8062783B2 (en) | 2006-12-01 | 2011-11-22 | Tti Ellebeau, Inc. | Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices |
| EP2123259A1 (en) * | 2007-01-16 | 2009-11-25 | Hokkaido University | Liposome preparation for iontophoresis having antioxidant component encapsulated therein |
| US7844345B2 (en) * | 2007-02-08 | 2010-11-30 | Neuropace, Inc. | Drug eluting lead systems |
| US7813811B2 (en) * | 2007-02-08 | 2010-10-12 | Neuropace, Inc. | Refillable reservoir lead systems |
| WO2008101171A2 (en) * | 2007-02-16 | 2008-08-21 | Thermage, Inc. | Temperature sensing apparatus and methods for treatment devices used to deliver high frequency energy to tissue |
| US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
| WO2009006349A2 (en) * | 2007-06-29 | 2009-01-08 | Polyplus Battery Company | Electrotransport devices, methods and drug electrode assemblies |
| US7945320B2 (en) * | 2007-08-17 | 2011-05-17 | Isis Biopolymer, Inc. | Iontophoretic drug delivery system |
| US8738137B2 (en) * | 2007-08-23 | 2014-05-27 | Bioness Inc. | System for transmitting electrical current to a bodily tissue |
| US9757554B2 (en) | 2007-08-23 | 2017-09-12 | Bioness Inc. | System for transmitting electrical current to a bodily tissue |
| CA2697381A1 (en) * | 2007-08-23 | 2009-02-26 | Bioness, Inc. | System for transmitting electrical current to a bodily tissue |
| US20090069740A1 (en) * | 2007-09-07 | 2009-03-12 | Polyplus Battery Company | Protected donor electrodes for electro-transport drug delivery |
| US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
| WO2010027771A1 (en) | 2008-08-27 | 2010-03-11 | Edwards Lifesciences Corporation | Analyte sensor |
| PL2401027T3 (pl) | 2009-02-26 | 2018-04-30 | The University Of North Carolina At Chapel Hill | Układ do interwencyjnego dostarczania leku |
| US20110092881A1 (en) * | 2009-05-08 | 2011-04-21 | Isis Biopolymer Inc. | Iontophoretic device with contact sensor |
| CN102421480A (zh) * | 2009-05-08 | 2012-04-18 | 伊思伊思生物高分子公司 | 具有改善的反电极的离子电渗设备 |
| WO2011002776A1 (en) * | 2009-06-29 | 2011-01-06 | Nitric Biotherapeutics, Inc. | Pharmaceutical formulations for iontophoretic delivery of an immunomodulator |
| JP5463136B2 (ja) | 2009-12-22 | 2014-04-09 | 帝國製薬株式会社 | イオントフォレーシス療法に用いる電極装置 |
| USD678534S1 (en) | 2010-07-20 | 2013-03-19 | Iontera, Inc. | Iontophoretic device for application to the brow/forehead of a person |
| WO2012086700A1 (ja) * | 2010-12-22 | 2012-06-28 | 帝國製薬株式会社 | イオントフォレシス用の電極パッド |
| US9610440B2 (en) * | 2013-06-10 | 2017-04-04 | Iontera, Inc | Systems, devices, and methods for transdermal delivery |
| GB2524777A (en) * | 2014-04-02 | 2015-10-07 | Microarray Ltd | Dressing comprising electrodes |
| CN104287714A (zh) * | 2014-11-10 | 2015-01-21 | 青岛柏恩鸿泰电子科技有限公司 | 一种银/氯化银粉末电极 |
| CN107405483A (zh) * | 2015-03-09 | 2017-11-28 | 皇家飞利浦有限公司 | 离子电渗的设备、装置和方法 |
| EP3400985A4 (en) * | 2016-01-05 | 2019-07-31 | Biosensor Laboratories Inc. | IONTOPHORESIS DEVICE FOR DISPOSING A MEDICAMENT AND METHOD FOR THE PRODUCTION THEREOF |
| US12324792B2 (en) | 2020-12-28 | 2025-06-10 | Smith & Nephew, Inc. | Methods for making and using pharmaceutical compositions for iontophoresis |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4416274A (en) | 1981-02-23 | 1983-11-22 | Motion Control, Inc. | Ion mobility limiting iontophoretic bioelectrode |
| JPS5810066A (ja) * | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | イオントフオレ−ゼ用プラスタ−構造体 |
| CA1262564A (en) * | 1983-09-01 | 1989-10-31 | Minoru Sasaki | Iontophoresis device |
| US5135477A (en) | 1984-10-29 | 1992-08-04 | Medtronic, Inc. | Iontophoretic drug delivery |
| US4752285B1 (en) | 1986-03-19 | 1995-08-22 | Univ Utah Res Found | Methods and apparatus for iontophoresis application of medicaments |
| US5496266A (en) * | 1990-04-30 | 1996-03-05 | Alza Corporation | Device and method of iontophoretic drug delivery |
| US4989607A (en) * | 1989-03-30 | 1991-02-05 | Preston Keusch | Highly conductive non-stringy adhesive hydrophilic gels and medical electrode assemblies manufactured therefrom |
| US5143071A (en) * | 1989-03-30 | 1992-09-01 | Nepera, Inc. | Non-stringy adhesive hydrophilic gels |
| US5328455A (en) * | 1989-07-21 | 1994-07-12 | Iomed, Inc. | Rehydratable product and method of preparation thereof |
| US5374241A (en) | 1989-07-21 | 1994-12-20 | Iomed, Inc. | Electrodes for iontophoresis |
| US5084008A (en) * | 1989-12-22 | 1992-01-28 | Medtronic, Inc. | Iontophoresis electrode |
| US5125894A (en) * | 1990-03-30 | 1992-06-30 | Alza Corporation | Method and apparatus for controlled environment electrotransport |
| US5362308A (en) * | 1990-09-25 | 1994-11-08 | Rutgers, The State University Of New Jersey | Disposable dosage unit for iontophoresis-facilitated transdermal delivery, related devices and processes |
| US5158537A (en) | 1990-10-29 | 1992-10-27 | Alza Corporation | Iontophoretic delivery device and method of hydrating same |
| PT99344A (pt) | 1990-10-29 | 1993-12-31 | Alza Corp | Dispositivo para aplicacao iontoforetica e metodo para o hidratar |
| ES2065181T3 (es) * | 1991-03-11 | 1995-02-01 | Alza Corp | Dispositivo de suministro iontoforetico y procedimiento para su fabricacion. |
| US5405317A (en) * | 1991-05-03 | 1995-04-11 | Alza Corporation | Iontophoretic delivery device |
| US5464387A (en) * | 1991-07-24 | 1995-11-07 | Alza Corporation | Transdermal delivery device |
| US5203768A (en) * | 1991-07-24 | 1993-04-20 | Alza Corporation | Transdermal delivery device |
| US5310404A (en) * | 1992-06-01 | 1994-05-10 | Alza Corporation | Iontophoretic delivery device and method of hydrating same |
| FI944321L (fi) | 1992-11-05 | 1994-11-16 | Becton Dickinson Co | Käyttäjäaktivoitu iontoforeettinen laite ja menetelmä sen käyttämiseksi |
| US6377847B1 (en) | 1993-09-30 | 2002-04-23 | Vyteris, Inc. | Iontophoretic drug delivery device and reservoir and method of making same |
| AU2286995A (en) * | 1994-04-08 | 1995-10-30 | Alza Corporation | Electrotransport system with ion exchange competitive ion capture |
| JPH08155041A (ja) * | 1994-12-05 | 1996-06-18 | Advance Co Ltd | イオントフォレシス用新規高能率電極システム |
| US5837281A (en) * | 1995-03-17 | 1998-11-17 | Takeda Chemical Industries, Ltd. | Stabilized interface for iontophoresis |
| US5990179A (en) * | 1995-04-28 | 1999-11-23 | Alza Corporation | Composition and method of enhancing electrotransport agent delivery |
| US5853383A (en) * | 1995-05-03 | 1998-12-29 | Alza Corporation | Preparation for formulations for electrotransport drug delivery |
| US5983130A (en) * | 1995-06-07 | 1999-11-09 | Alza Corporation | Electrotransport agent delivery method and apparatus |
| US5908400A (en) * | 1996-06-20 | 1999-06-01 | Hisamitsu Pharmaceutical Co., Inc. | Device structure for iontophoresis |
| US6350259B1 (en) * | 1996-09-30 | 2002-02-26 | Vyteris, Inc. | Selected drug delivery profiles using competing ions |
| FR2755372B1 (fr) * | 1996-11-07 | 1998-12-24 | Elf Aquitaine | Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet |
| DE69721293T2 (de) | 1996-11-14 | 2004-01-29 | Alza Corp | Einrichtung zur verabreichung von substanzen wie lidocain und epinephrin mit unterstuetzung von elektrischem strom |
| US6004577A (en) * | 1997-08-12 | 1999-12-21 | Murdock; Thomas O. | Enhanced electrotransport of therapeutic agents having polybasic anionic counter ions |
| US5882677A (en) * | 1997-09-30 | 1999-03-16 | Becton Dickinson And Company | Iontophoretic patch with hydrogel reservoir |
| US6295469B1 (en) * | 1997-11-14 | 2001-09-25 | Alza Corporation | Formulation for electrically assisted delivery of lidocaine and epinephrine |
| US6496727B1 (en) * | 2000-05-31 | 2002-12-17 | Becton, Dickinson And Company | Medicament-loaded transdermal reservoir and method for its formation |
-
2000
- 2000-06-30 US US09/610,563 patent/US6629968B1/en not_active Expired - Fee Related
-
2001
- 2001-06-29 JP JP2002506803A patent/JP4024673B2/ja not_active Expired - Fee Related
- 2001-06-29 CA CA002413624A patent/CA2413624C/en not_active Expired - Fee Related
- 2001-06-29 US US09/897,698 patent/US6635045B2/en not_active Expired - Fee Related
- 2001-06-29 WO PCT/US2001/020886 patent/WO2002002182A2/en not_active Ceased
- 2001-06-29 DE DE60129965T patent/DE60129965T2/de not_active Expired - Lifetime
- 2001-06-29 AT AT01952340T patent/ATE369891T1/de not_active IP Right Cessation
- 2001-06-29 AU AU2001273104A patent/AU2001273104A1/en not_active Abandoned
- 2001-06-29 EP EP01952340A patent/EP1294439B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60129965D1 (de) | 2007-09-27 |
| EP1294439A2 (en) | 2003-03-26 |
| US6635045B2 (en) | 2003-10-21 |
| EP1294439B1 (en) | 2007-08-15 |
| CA2413624C (en) | 2007-09-18 |
| ATE369891T1 (de) | 2007-09-15 |
| JP2004501727A (ja) | 2004-01-22 |
| WO2002002182A3 (en) | 2002-06-27 |
| JP4024673B2 (ja) | 2007-12-19 |
| AU2001273104A1 (en) | 2002-01-14 |
| US20020062102A1 (en) | 2002-05-23 |
| CA2413624A1 (en) | 2002-01-10 |
| WO2002002182A2 (en) | 2002-01-10 |
| US6629968B1 (en) | 2003-10-07 |
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