DE60121695D1 - Arzneimittel mit chymaseinhibitoren als wirksames mittel zur behandlung von dermatitis mit zweiphasigen hautreaktionen - Google Patents

Arzneimittel mit chymaseinhibitoren als wirksames mittel zur behandlung von dermatitis mit zweiphasigen hautreaktionen

Info

Publication number
DE60121695D1
DE60121695D1 DE60121695T DE60121695T DE60121695D1 DE 60121695 D1 DE60121695 D1 DE 60121695D1 DE 60121695 T DE60121695 T DE 60121695T DE 60121695 T DE60121695 T DE 60121695T DE 60121695 D1 DE60121695 D1 DE 60121695D1
Authority
DE
Germany
Prior art keywords
dermatitis
treatment
chymaseinhibitors
drugs
effective agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60121695T
Other languages
English (en)
Other versions
DE60121695T2 (de
Inventor
Harukazu Fukami
Yoshiaki Tomimori
Yoshiaki Fukuda
Naohiro Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Asubio Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Asubio Pharma Co Ltd filed Critical Daiichi Asubio Pharma Co Ltd
Publication of DE60121695D1 publication Critical patent/DE60121695D1/de
Application granted granted Critical
Publication of DE60121695T2 publication Critical patent/DE60121695T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
DE60121695T 2000-02-22 2001-02-22 Arzneimittel mit chymaseinhibitoren als wirksames mittel zur behandlung von dermatitis mit zweiphasigen hautreaktionen Expired - Lifetime DE60121695T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000050504 2000-02-22
JP2000050504 2000-02-22
PCT/JP2001/001323 WO2001062294A1 (fr) 2000-02-22 2001-02-22 Medicaments preventifs ou therapeutiques contenant des inhibiteurs de chymase en tant que principe actif, pour traiter des dermatites

Publications (2)

Publication Number Publication Date
DE60121695D1 true DE60121695D1 (de) 2006-09-07
DE60121695T2 DE60121695T2 (de) 2007-08-30

Family

ID=18572276

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60121695T Expired - Lifetime DE60121695T2 (de) 2000-02-22 2001-02-22 Arzneimittel mit chymaseinhibitoren als wirksames mittel zur behandlung von dermatitis mit zweiphasigen hautreaktionen

Country Status (11)

Country Link
US (2) US7618977B2 (de)
EP (1) EP1192950B1 (de)
KR (1) KR20010109356A (de)
CN (1) CN1245979C (de)
AT (1) ATE333897T1 (de)
AU (1) AU3413601A (de)
CA (1) CA2368382A1 (de)
DE (1) DE60121695T2 (de)
ES (1) ES2269347T3 (de)
HU (1) HUP0201282A3 (de)
WO (1) WO2001062294A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1192949A4 (de) 2000-02-22 2005-11-09 Daiichi Suntory Pharma Co Ltd Azneimittel mit chymaseinhibitoren als wirksames mittel, zur vorbeugung oder behandlung von fibrosis
EP1174151B1 (de) 2000-02-22 2007-01-24 Daiichi Asubio Pharma Co., Ltd. Therapeutische behandlung von eosinophilie durch verwendung von chymase-inhibitoren als aktiven bestandteilen
US7361767B2 (en) * 2003-11-14 2008-04-22 3M Innovative Properties Company N-sulfonyldicarboximide containing tethering compounds
WO2006059801A1 (ja) 2004-12-02 2006-06-08 Asubio Pharma Co., Ltd. ７員環化合物並びにその製造法および医薬用途
WO2006107031A1 (ja) * 2005-04-04 2006-10-12 Asubio Pharma Co., Ltd. 遺伝子一塩基多型解析によるアトピー性皮膚炎の相対罹患危険率の検出方法
JP5117382B2 (ja) 2006-05-31 2013-01-16 第一三共株式会社 ７員環化合物の製造方法
CN105873919A (zh) * 2013-11-08 2016-08-17 拜耳医药股份有限公司 作为类糜蛋白酶抑制剂的取代的尿嘧啶
CA3059458A1 (en) 2017-05-24 2018-11-29 The University Of Queensland Novel compounds and uses
AU2018376416A1 (en) * 2017-11-30 2020-07-02 Ribomic Inc. Anti-chymase aptamer and use for same

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684654A (en) * 1985-08-14 1987-08-04 American Cyanamid Company 3-heteroalkyl-2,4-quinzaolinediones
IL79249A (en) * 1986-06-26 1992-02-16 Makhteshim Chem Works Ltd Herbicidal compositions containing haloalkylthioquinazoline di(thi)ones and some new such compounds
JP2832923B2 (ja) * 1990-07-13 1998-12-09 吉富製薬株式会社 スチリル化合物およびその医薬用途
IE913473A1 (en) * 1990-10-15 1992-04-22 Fujisawa Pharmaceutical Co Quinazoline derivatives and their preparation
US5199279A (en) 1991-08-13 1993-04-06 Reynolds Martin M Drum contact freezer system and method
JPH05294930A (ja) * 1992-04-21 1993-11-09 Yoshitomi Pharmaceut Ind Ltd スチリル化合物
EP0644892A1 (de) 1992-06-12 1995-03-29 Pfizer Inc. Inhibitoren für Angiotensin I-Chymasen inklusive der menschlichen Herzchymase
SI9420029A (en) 1993-05-12 1996-10-31 Du Pont Fungicidal fused bicyclic pyrimidinones
ATE198743T1 (de) * 1994-07-29 2001-02-15 Suntory Ltd Imidazolidin-derivate und ihre verwendung
EP0826671B1 (de) 1995-04-27 2004-12-29 Mitsubishi Pharma Corporation Heterocyclische amidverbindungen und deren medizinische verwendung
US5596111A (en) 1995-06-05 1997-01-21 North Dakota State University Method for preparation of carboxylic acids
EP0795548B1 (de) 1995-09-28 2002-07-03 Suntory Limited Chinazozin derivate und deren verwendung
AU723234B2 (en) 1996-09-06 2000-08-24 Nippon Kayaku Kabushiki Kaisha Novel acetamide derivatives and protease inhibitors
JPH1087493A (ja) * 1996-09-18 1998-04-07 Shionogi & Co Ltd セフェム系化合物を含有するキマーゼ阻害剤
JPH10101666A (ja) * 1996-10-02 1998-04-21 Shionogi & Co Ltd 新規ベンゾオキサシクロトリデシン化合物およびそれを含有する医薬組成物
EP0940400A4 (de) 1996-10-25 2002-10-02 Mitsubishi Pharma Corp Heterocyklische amidverbindungen und ihre medizinische anwendung
JPH10245384A (ja) * 1997-03-05 1998-09-14 Teijin Ltd 新規トリアジンスルホン誘導体
EP1055683A4 (de) 1998-02-17 2007-07-25 Nippon Kayaku Kk Neuartiges acetamid-derivat und verwendung desselben
CA2336909C (en) 1998-07-15 2009-10-20 Teijin Limited Thiobenzimidazole derivatives which are useful as inhibitors of human chymase activity
ES2259476T3 (es) * 1998-08-21 2006-10-01 Daiichi Asubio Pharma Co., Ltd. Derivados de quinazolina y sus aplicaciones farmaceuticas.
JP2000247908A (ja) * 1999-03-01 2000-09-12 Welfide Corp かゆみ抑制剤
HUP0104952A3 (en) 1999-11-01 2006-02-28 Daiichi Asubio Pharma Co Ltd Inhibitors against vascular lipid deposition containing chymase-inhibiting substances
EP1192949A4 (de) 2000-02-22 2005-11-09 Daiichi Suntory Pharma Co Ltd Azneimittel mit chymaseinhibitoren als wirksames mittel, zur vorbeugung oder behandlung von fibrosis
EP1174151B1 (de) 2000-02-22 2007-01-24 Daiichi Asubio Pharma Co., Ltd. Therapeutische behandlung von eosinophilie durch verwendung von chymase-inhibitoren als aktiven bestandteilen

Also Published As

Publication number Publication date
EP1192950B1 (de) 2006-07-26
US7618977B2 (en) 2009-11-17
HUP0201282A3 (en) 2003-02-28
ES2269347T3 (es) 2007-04-01
HUP0201282A2 (hu) 2002-12-28
US20100029695A1 (en) 2010-02-04
WO2001062294A1 (fr) 2001-08-30
EP1192950A4 (de) 2003-01-22
EP1192950A1 (de) 2002-04-03
CA2368382A1 (en) 2001-08-30
CN1245979C (zh) 2006-03-22
KR20010109356A (ko) 2001-12-08
AU3413601A (en) 2001-09-03
US20020183339A1 (en) 2002-12-05
CN1366460A (zh) 2002-08-28
DE60121695T2 (de) 2007-08-30
ATE333897T1 (de) 2006-08-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASUBIO PHARMA CO., LTD., TOKYO, JP

8327 Change in the person/name/address of the patent owner

Owner name: DAIICHI SANKYO COMPANY, LIMITED, TOKIO, JP