DE60121032D1 - Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktion - Google Patents
Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktionInfo
- Publication number
- DE60121032D1 DE60121032D1 DE60121032T DE60121032T DE60121032D1 DE 60121032 D1 DE60121032 D1 DE 60121032D1 DE 60121032 T DE60121032 T DE 60121032T DE 60121032 T DE60121032 T DE 60121032T DE 60121032 D1 DE60121032 D1 DE 60121032D1
- Authority
- DE
- Germany
- Prior art keywords
- inhibitors
- beta
- amyloid production
- sulphonamides
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25510500P | 2000-12-13 | 2000-12-13 | |
US255105P | 2000-12-13 | ||
PCT/US2001/048375 WO2002057252A2 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60121032D1 true DE60121032D1 (de) | 2006-08-03 |
DE60121032T2 DE60121032T2 (de) | 2007-01-11 |
Family
ID=22966854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60121032T Expired - Lifetime DE60121032T2 (de) | 2000-12-13 | 2001-12-11 | Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktion |
Country Status (28)
Country | Link |
---|---|
US (5) | US6610734B2 (de) |
EP (1) | EP1341779B1 (de) |
JP (2) | JP2004517892A (de) |
KR (1) | KR100869061B1 (de) |
CN (2) | CN1800176A (de) |
AR (1) | AR035516A1 (de) |
AT (1) | ATE330950T1 (de) |
AU (1) | AU2002245123B2 (de) |
BR (1) | BR0116063A (de) |
CA (1) | CA2436526C (de) |
CY (1) | CY1105441T1 (de) |
DE (1) | DE60121032T2 (de) |
DK (1) | DK1341779T3 (de) |
EA (1) | EA009035B1 (de) |
ES (1) | ES2267853T3 (de) |
HK (1) | HK1059619A1 (de) |
HU (1) | HUP0303857A3 (de) |
IL (3) | IL156268A0 (de) |
MX (1) | MXPA03005255A (de) |
NO (1) | NO328885B1 (de) |
NZ (2) | NZ538100A (de) |
PL (1) | PL365950A1 (de) |
PT (1) | PT1341779E (de) |
SG (1) | SG128491A1 (de) |
SI (1) | SI1341779T1 (de) |
TW (1) | TWI235155B (de) |
WO (1) | WO2002057252A2 (de) |
ZA (1) | ZA200304135B (de) |
Families Citing this family (40)
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AU2001240861B2 (en) * | 2000-03-20 | 2006-03-30 | Merck Frosst Canada Ltd | Sulphonamido-substituted bridged bicycloalkyl derivatives |
PT1341779E (pt) | 2000-12-13 | 2006-10-31 | Wyeth Corp | Sulfonamidas heterociclicas inibidoras da producao de beta-amiloide |
US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
NZ533432A (en) * | 2001-12-11 | 2006-01-27 | Wyeth Corp | Process for the synthesis of chirally pure beta-amino-alcohols |
RU2321394C2 (ru) * | 2002-06-11 | 2008-04-10 | Уайт | Замещенные фенилсульфонамидные ингибиторы продуцирования бета-амилоида |
JP4494212B2 (ja) * | 2002-11-12 | 2010-06-30 | メルク・シャープ・エンド・ドーム・コーポレイション | アルツハイマー病の治療用フェニルカルボキサミドベータセクレターゼ阻害剤 |
CL2004000647A1 (es) | 2003-03-31 | 2005-02-04 | Wyeth Corp | Compuestos derivados de heterociclicos de sulfonamida que contienen fluoro y trifluoro alquilo; composicion farmaceutica; kit farmaceutico; procedimiento de preparacion; y su uso como inhibidores de beta amiloides para tratar alzheimer, angiopatia am |
AU2004251987C1 (en) * | 2003-06-30 | 2010-11-18 | Daiichi Sankyo Company, Limited | Heterocyclic methyl sulfone derivative |
CN1910158A (zh) * | 2004-01-16 | 2007-02-07 | 惠氏公司 | 含有氮杂环的β淀粉样蛋白生成的杂环磺酰胺抑制剂 |
WO2006078753A1 (en) | 2005-01-18 | 2006-07-27 | Elan Pharmaceuticals, Inc. | N-substituted heterocyclic sulfonamides |
US20060223849A1 (en) * | 2005-03-14 | 2006-10-05 | Mjalli Adnan M | Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors |
TW200800959A (en) * | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
GB0602951D0 (en) * | 2006-02-14 | 2006-03-29 | Novartis Ag | Organic Compounds |
JP2009527476A (ja) * | 2006-02-17 | 2009-07-30 | ワイス | 2−アミノトリフルオロアルキル置換アルコールの選択的n−スルホニル化 |
KR20080093126A (ko) * | 2006-02-17 | 2008-10-20 | 와이어쓰 | 술폰아미드 치환된 알코올 및 이의 중간체의 제조 방법 |
US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
AU2007243490A1 (en) * | 2006-04-21 | 2007-11-08 | Wyeth | Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof |
US7476762B2 (en) * | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
TW200811144A (en) * | 2006-06-09 | 2008-03-01 | Wyeth Corp | Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline |
TW200808740A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof |
TW200808741A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts |
WO2008059238A1 (en) * | 2006-11-17 | 2008-05-22 | Astrazeneca Ab | Benzenesulfonamide compounds as edg-1 antagonists useful in the treatment of cancer |
WO2008064320A2 (en) * | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity |
AR063984A1 (es) * | 2006-11-28 | 2009-03-04 | Wyeth Corp | Metabolitos de 5-fluoro-8-{4-[4-(6-metoxiquinolin-8-il)piperazin-1-il]piperidin-1-il}quinolina, metodos de preparacion, su uso en la fabricacion de medicamentos para el tratamiento de trastornos relacionados con 5-ht1a, composicion farmaceutica que los comprende, compuestos radioetiquetados derivado |
TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
AU2008215948A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of AD and related conditions |
EP2193117A1 (de) * | 2007-07-16 | 2010-06-09 | Wyeth a Corporation of the State of Delaware | Inhibitoren der beta-amyloidproduktion |
CL2008002058A1 (es) * | 2007-07-16 | 2008-11-14 | Wyeth Corp | Metodo para la preparacion de trifluoralquil-fenil-sulfonamidas y de sulfonamidas heterociclicas usando n-trifluoroacteilmorfolina; su metodo de preparacion y su uso. |
US20090023930A1 (en) * | 2007-07-16 | 2009-01-22 | Wyeth | Processes and intermediates for the preparation of heterocyclic sulfonamide compounds |
US8354446B2 (en) | 2007-12-21 | 2013-01-15 | Ligand Pharmaceuticals Incorporated | Selective androgen receptor modulators (SARMs) and uses thereof |
CL2009000019A1 (es) * | 2008-01-11 | 2009-05-22 | Wyeth Corp | Compuestos derivados de aril sulfonamida que contienen o-sulfato u o-fosfato; procedimiento de preparacion; composicion farmaceutica que los comprende; y uso como profarmacos para incrementar la semivida de circulacion de compuestos inhibidores de la produccion de beta-amiloide, utiles en el tratamiento del alzheimer y cancer. |
US8461389B2 (en) | 2008-04-18 | 2013-06-11 | University College Dublin, National University Of Ireland, Dublin | Psycho-pharmaceuticals |
EP2328572B1 (de) | 2008-07-28 | 2018-06-13 | Blanchette Rockefeller Neurosciences, Institute | Pkc-aktivierende verbindungen zur behandlung von neurodegenerativen erkrankungen |
JP2013514287A (ja) | 2009-12-17 | 2013-04-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | スフィンゴシンキナーゼの阻害薬 |
US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
DK3284463T3 (da) * | 2013-01-18 | 2019-10-28 | Cardioxyl Pharmaceuticals Inc | Nitroxyldonorer med forbedret terapeutisk indeks |
CN104370769B (zh) * | 2013-08-14 | 2017-05-31 | 重庆博腾制药科技股份有限公司 | 一种制备羟基金刚烷甘氨酸衍生物的方法 |
US10441567B2 (en) | 2014-01-17 | 2019-10-15 | Ligand Pharmaceuticals Incorporated | Methods and compositions for modulating hormone levels |
US11046668B2 (en) | 2016-03-11 | 2021-06-29 | Ohio State Innovation Foundation | Small molecule antimicrobials |
DE202022106287U1 (de) | 2022-11-09 | 2022-11-21 | Ahmad Salawi | Eine Methode zur Synthese und biologischen Bewertung von neuen Sulfonamid-Analoga |
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PT1341779E (pt) | 2000-12-13 | 2006-10-31 | Wyeth Corp | Sulfonamidas heterociclicas inibidoras da producao de beta-amiloide |
US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
NZ533432A (en) | 2001-12-11 | 2006-01-27 | Wyeth Corp | Process for the synthesis of chirally pure beta-amino-alcohols |
WO2003050062A2 (en) | 2001-12-11 | 2003-06-19 | Wyeth | PRODUCTION OF CHIRALLY PURE α-AMINO ACIDS ADN N-SULFONYL α-AMINO ACIDS |
RU2321394C2 (ru) | 2002-06-11 | 2008-04-10 | Уайт | Замещенные фенилсульфонамидные ингибиторы продуцирования бета-амилоида |
CL2004000647A1 (es) * | 2003-03-31 | 2005-02-04 | Wyeth Corp | Compuestos derivados de heterociclicos de sulfonamida que contienen fluoro y trifluoro alquilo; composicion farmaceutica; kit farmaceutico; procedimiento de preparacion; y su uso como inhibidores de beta amiloides para tratar alzheimer, angiopatia am |
-
2001
- 2001-12-11 PT PT01993277T patent/PT1341779E/pt unknown
- 2001-12-11 NZ NZ538100A patent/NZ538100A/en unknown
- 2001-12-11 MX MXPA03005255A patent/MXPA03005255A/es active IP Right Grant
- 2001-12-11 CN CNA2005100035919A patent/CN1800176A/zh active Pending
- 2001-12-11 JP JP2002557933A patent/JP2004517892A/ja not_active Withdrawn
- 2001-12-11 US US10/014,304 patent/US6610734B2/en not_active Expired - Fee Related
- 2001-12-11 BR BR0116063-0A patent/BR0116063A/pt not_active Application Discontinuation
- 2001-12-11 EA EA200300674A patent/EA009035B1/ru not_active IP Right Cessation
- 2001-12-11 WO PCT/US2001/048375 patent/WO2002057252A2/en active Application Filing
- 2001-12-11 HU HU0303857A patent/HUP0303857A3/hu unknown
- 2001-12-11 SI SI200130604T patent/SI1341779T1/sl unknown
- 2001-12-11 ES ES01993277T patent/ES2267853T3/es not_active Expired - Lifetime
- 2001-12-11 DE DE60121032T patent/DE60121032T2/de not_active Expired - Lifetime
- 2001-12-11 NZ NZ526213A patent/NZ526213A/en unknown
- 2001-12-11 CA CA2436526A patent/CA2436526C/en not_active Expired - Fee Related
- 2001-12-11 EP EP01993277A patent/EP1341779B1/de not_active Expired - Lifetime
- 2001-12-11 AT AT01993277T patent/ATE330950T1/de active
- 2001-12-11 SG SG200503628A patent/SG128491A1/en unknown
- 2001-12-11 KR KR1020037007928A patent/KR100869061B1/ko not_active IP Right Cessation
- 2001-12-11 AU AU2002245123A patent/AU2002245123B2/en not_active Ceased
- 2001-12-11 CN CNB018205186A patent/CN1263750C/zh not_active Expired - Fee Related
- 2001-12-11 PL PL01365950A patent/PL365950A1/xx not_active IP Right Cessation
- 2001-12-11 DK DK01993277T patent/DK1341779T3/da active
- 2001-12-11 IL IL15626801A patent/IL156268A0/xx active IP Right Review Request
- 2001-12-12 TW TW090130721A patent/TWI235155B/zh active
- 2001-12-12 AR ARP010105782A patent/AR035516A1/es not_active Application Discontinuation
-
2003
- 2003-05-28 ZA ZA200304135A patent/ZA200304135B/en unknown
- 2003-06-02 IL IL156268A patent/IL156268A/en not_active IP Right Cessation
- 2003-06-05 US US10/455,674 patent/US6878742B2/en not_active Expired - Fee Related
- 2003-06-11 NO NO20032645A patent/NO328885B1/no not_active IP Right Cessation
-
2004
- 2004-03-02 HK HK04101538A patent/HK1059619A1/xx not_active IP Right Cessation
-
2005
- 2005-03-16 US US11/081,784 patent/US7691884B2/en not_active Expired - Fee Related
-
2006
- 2006-09-14 CY CY20061101305T patent/CY1105441T1/el unknown
-
2008
- 2008-01-17 IL IL188853A patent/IL188853A0/en unknown
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2009
- 2009-10-09 US US12/576,513 patent/US7842718B2/en not_active Expired - Fee Related
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2010
- 2010-06-24 JP JP2010144307A patent/JP2010265280A/ja not_active Withdrawn
- 2010-10-19 US US12/907,123 patent/US20110034513A1/en not_active Abandoned
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