DE60120676T2 - Verfahren zur entwicklung von epithelialen stammzellen - Google Patents
Verfahren zur entwicklung von epithelialen stammzellen Download PDFInfo
- Publication number
- DE60120676T2 DE60120676T2 DE60120676T DE60120676T DE60120676T2 DE 60120676 T2 DE60120676 T2 DE 60120676T2 DE 60120676 T DE60120676 T DE 60120676T DE 60120676 T DE60120676 T DE 60120676T DE 60120676 T2 DE60120676 T2 DE 60120676T2
- Authority
- DE
- Germany
- Prior art keywords
- stem cells
- epithelial stem
- membrane
- amniotic membrane
- graft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000000130 stem cell Anatomy 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 14
- 210000001691 amnion Anatomy 0.000 claims abstract description 35
- 210000001519 tissue Anatomy 0.000 claims abstract description 19
- 238000001574 biopsy Methods 0.000 claims abstract description 10
- 210000004027 cell Anatomy 0.000 claims abstract description 8
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims abstract 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims abstract 3
- 210000002744 extracellular matrix Anatomy 0.000 claims abstract 3
- 210000004379 membrane Anatomy 0.000 claims description 12
- 239000012528 membrane Substances 0.000 claims description 12
- 239000001963 growth medium Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 abstract description 9
- 230000000735 allogeneic effect Effects 0.000 abstract description 3
- 210000004087 cornea Anatomy 0.000 description 7
- 239000000758 substrate Substances 0.000 description 7
- 210000002919 epithelial cell Anatomy 0.000 description 6
- 230000006378 damage Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
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- 210000000981 epithelium Anatomy 0.000 description 3
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- 239000002131 composite material Substances 0.000 description 2
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
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- 230000001413 cellular effect Effects 0.000 description 1
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- 239000011248 coating agent Substances 0.000 description 1
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- 230000007547 defect Effects 0.000 description 1
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- 238000001035 drying Methods 0.000 description 1
- 229940116977 epidermal growth factor Drugs 0.000 description 1
- 230000008378 epithelial damage Effects 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000012757 fluorescence staining Methods 0.000 description 1
- 229960001048 fluorometholone Drugs 0.000 description 1
- FAOZLTXFLGPHNG-KNAQIMQKSA-N fluorometholone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@]2(F)[C@@H](O)C[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FAOZLTXFLGPHNG-KNAQIMQKSA-N 0.000 description 1
- 229940089982 healon Drugs 0.000 description 1
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- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000008629 immune suppression Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
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- 230000000813 microbial effect Effects 0.000 description 1
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- 239000004033 plastic Substances 0.000 description 1
- 229960002800 prednisolone acetate Drugs 0.000 description 1
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- 231100000241 scar Toxicity 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
- C12N2533/92—Amnion; Decellularised dermis or mucosa
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Vascular Medicine (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20003600P | 2000-04-27 | 2000-04-27 | |
| US200036P | 2000-04-27 | ||
| PCT/US2001/013321 WO2001080760A1 (en) | 2000-04-27 | 2001-04-25 | Method for expansion of epithelial stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60120676D1 DE60120676D1 (de) | 2006-07-27 |
| DE60120676T2 true DE60120676T2 (de) | 2007-05-24 |
Family
ID=22740051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60120676T Expired - Lifetime DE60120676T2 (de) | 2000-04-27 | 2001-04-25 | Verfahren zur entwicklung von epithelialen stammzellen |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1276431B1 (enExample) |
| JP (1) | JP5612801B2 (enExample) |
| CN (1) | CN1296102C (enExample) |
| AT (1) | ATE329632T1 (enExample) |
| AU (2) | AU5380201A (enExample) |
| CA (1) | CA2406282C (enExample) |
| DE (1) | DE60120676T2 (enExample) |
| ES (1) | ES2266193T3 (enExample) |
| PT (1) | PT1276431E (enExample) |
| TW (1) | TW506827B (enExample) |
| WO (1) | WO2001080760A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1454600B1 (en) * | 2001-11-19 | 2011-08-31 | ArBlast Co., Ltd. | Ectocornea-like sheet and method of constructing the same |
| KR101203434B1 (ko) * | 2003-02-06 | 2012-11-21 | 가부시키가이샤 셀시드 | 전안부 관련 세포 시트, 3 차원 구조체, 및 그들의 제조법 |
| CN1747753B (zh) | 2003-02-06 | 2010-11-10 | 赛尔斯德株式会社 | 用于形成角膜上皮的细胞片、及其制造方法和使用方法 |
| US20050186672A1 (en) * | 2004-01-27 | 2005-08-25 | Reliance Life Sciences Pvt. Ltd. | Tissue system with undifferentiated stem cells derived from corneal limbus |
| CA2559585A1 (en) * | 2004-03-11 | 2005-09-22 | Arblast Co., Ltd. | Biological tissue sheet, method of forming the same and transplantation method by using the sheet |
| JP4576545B2 (ja) * | 2004-05-27 | 2010-11-10 | 独立行政法人理化学研究所 | 羊膜由来因子による胚性幹細胞の培養方法 |
| CN100336567C (zh) * | 2004-10-19 | 2007-09-12 | 北京科宇联合干细胞生物技术有限公司 | 医用角膜贴片 |
| KR20070093991A (ko) * | 2005-01-14 | 2007-09-19 | 아르브라스트 가부시키가이샤 | 양막을 이용한 시트형 조성물 및 그 제작 방법 |
| JP4863655B2 (ja) * | 2005-06-17 | 2012-01-25 | 国立大学法人 東京医科歯科大学 | 細胞含有シート |
| TWI407967B (zh) * | 2006-04-28 | 2013-09-11 | Ray Jui Fang Tsai | 人類角膜內皮幹細胞之擴增方法 |
| CN102166375B (zh) * | 2011-02-16 | 2013-04-10 | 中国海洋大学 | 一种组织工程人角膜上皮的重建方法 |
| CN103007349B (zh) * | 2012-12-13 | 2014-07-09 | 吉林省拓华生物科技有限公司 | 负载干细胞的大面积羊膜贴片的制备方法 |
| CN115671398B (zh) * | 2022-11-22 | 2024-03-01 | 首都医科大学附属北京同仁医院 | 一种3d打印仿生角膜缘移植物及其制备方法和用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL47062A (en) * | 1975-04-10 | 1979-07-25 | Yeda Res & Dev | Process for diminishing antigenicity of tissues to be usedas transplants by treatment with glutaraldehyde |
| JPS63260549A (ja) * | 1987-04-17 | 1988-10-27 | 石川 統一 | 補綴材料およびその製造方法 |
| US5135915A (en) * | 1988-10-14 | 1992-08-04 | Genentech, Inc. | Method for the treatment of grafts prior to transplantation using TGF-.beta. |
| JP2905719B2 (ja) * | 1995-03-31 | 1999-06-14 | 東洋紡績株式会社 | 複合医用材料 |
| US6152142A (en) * | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
| US5932205A (en) * | 1997-07-24 | 1999-08-03 | Wang; Ming X. | Biochemical contact lens for treating photoablated corneal tissue |
-
2001
- 2001-04-25 WO PCT/US2001/013321 patent/WO2001080760A1/en not_active Ceased
- 2001-04-25 PT PT01927340T patent/PT1276431E/pt unknown
- 2001-04-25 AT AT01927340T patent/ATE329632T1/de active
- 2001-04-25 ES ES01927340T patent/ES2266193T3/es not_active Expired - Lifetime
- 2001-04-25 DE DE60120676T patent/DE60120676T2/de not_active Expired - Lifetime
- 2001-04-25 AU AU5380201A patent/AU5380201A/xx active Pending
- 2001-04-25 AU AU2001253802A patent/AU2001253802B2/en not_active Ceased
- 2001-04-25 CA CA2406282A patent/CA2406282C/en not_active Expired - Lifetime
- 2001-04-25 JP JP2001577863A patent/JP5612801B2/ja not_active Expired - Fee Related
- 2001-04-25 CN CNB018081649A patent/CN1296102C/zh not_active Expired - Fee Related
- 2001-04-25 EP EP01927340A patent/EP1276431B1/en not_active Expired - Lifetime
- 2001-04-26 TW TW090110005A patent/TW506827B/zh not_active IP Right Cessation
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|---|---|
| TW506827B (en) | 2002-10-21 |
| WO2001080760A1 (en) | 2001-11-01 |
| CA2406282C (en) | 2012-06-12 |
| ES2266193T3 (es) | 2007-03-01 |
| JP5612801B2 (ja) | 2014-10-22 |
| JP2003532466A (ja) | 2003-11-05 |
| EP1276431A4 (en) | 2003-08-06 |
| HK1056989A1 (en) | 2004-03-12 |
| ATE329632T1 (de) | 2006-07-15 |
| AU2001253802B2 (en) | 2006-11-30 |
| CA2406282A1 (en) | 2001-11-01 |
| CN1296102C (zh) | 2007-01-24 |
| AU5380201A (en) | 2001-11-07 |
| CN1426289A (zh) | 2003-06-25 |
| DE60120676D1 (de) | 2006-07-27 |
| PT1276431E (pt) | 2006-11-30 |
| WO2001080760A8 (en) | 2003-05-30 |
| EP1276431B1 (en) | 2006-06-14 |
| EP1276431A1 (en) | 2003-01-22 |
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