PT1276431E - Método para a expansão de células estaminais epiteliais - Google Patents
Método para a expansão de células estaminais epiteliais Download PDFInfo
- Publication number
- PT1276431E PT1276431E PT01927340T PT01927340T PT1276431E PT 1276431 E PT1276431 E PT 1276431E PT 01927340 T PT01927340 T PT 01927340T PT 01927340 T PT01927340 T PT 01927340T PT 1276431 E PT1276431 E PT 1276431E
- Authority
- PT
- Portugal
- Prior art keywords
- stem cells
- epithelial stem
- amniotic membrane
- membrane
- graft
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title claims abstract description 17
- 210000001691 amnion Anatomy 0.000 claims abstract description 37
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- 210000004027 cell Anatomy 0.000 claims abstract description 11
- 238000001574 biopsy Methods 0.000 claims abstract description 10
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims abstract 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims abstract 3
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- 230000000735 allogeneic effect Effects 0.000 abstract description 2
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
- C12N2533/92—Amnion; Decellularised dermis or mucosa
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Vascular Medicine (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20003600P | 2000-04-27 | 2000-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1276431E true PT1276431E (pt) | 2006-11-30 |
Family
ID=22740051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01927340T PT1276431E (pt) | 2000-04-27 | 2001-04-25 | Método para a expansão de células estaminais epiteliais |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1276431B1 (enExample) |
| JP (1) | JP5612801B2 (enExample) |
| CN (1) | CN1296102C (enExample) |
| AT (1) | ATE329632T1 (enExample) |
| AU (2) | AU5380201A (enExample) |
| CA (1) | CA2406282C (enExample) |
| DE (1) | DE60120676T2 (enExample) |
| ES (1) | ES2266193T3 (enExample) |
| PT (1) | PT1276431E (enExample) |
| TW (1) | TW506827B (enExample) |
| WO (1) | WO2001080760A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1454600B1 (en) * | 2001-11-19 | 2011-08-31 | ArBlast Co., Ltd. | Ectocornea-like sheet and method of constructing the same |
| KR101203434B1 (ko) * | 2003-02-06 | 2012-11-21 | 가부시키가이샤 셀시드 | 전안부 관련 세포 시트, 3 차원 구조체, 및 그들의 제조법 |
| CN1747753B (zh) | 2003-02-06 | 2010-11-10 | 赛尔斯德株式会社 | 用于形成角膜上皮的细胞片、及其制造方法和使用方法 |
| US20050186672A1 (en) * | 2004-01-27 | 2005-08-25 | Reliance Life Sciences Pvt. Ltd. | Tissue system with undifferentiated stem cells derived from corneal limbus |
| CA2559585A1 (en) * | 2004-03-11 | 2005-09-22 | Arblast Co., Ltd. | Biological tissue sheet, method of forming the same and transplantation method by using the sheet |
| JP4576545B2 (ja) * | 2004-05-27 | 2010-11-10 | 独立行政法人理化学研究所 | 羊膜由来因子による胚性幹細胞の培養方法 |
| CN100336567C (zh) * | 2004-10-19 | 2007-09-12 | 北京科宇联合干细胞生物技术有限公司 | 医用角膜贴片 |
| KR20070093991A (ko) * | 2005-01-14 | 2007-09-19 | 아르브라스트 가부시키가이샤 | 양막을 이용한 시트형 조성물 및 그 제작 방법 |
| JP4863655B2 (ja) * | 2005-06-17 | 2012-01-25 | 国立大学法人 東京医科歯科大学 | 細胞含有シート |
| TWI407967B (zh) * | 2006-04-28 | 2013-09-11 | Ray Jui Fang Tsai | 人類角膜內皮幹細胞之擴增方法 |
| CN102166375B (zh) * | 2011-02-16 | 2013-04-10 | 中国海洋大学 | 一种组织工程人角膜上皮的重建方法 |
| CN103007349B (zh) * | 2012-12-13 | 2014-07-09 | 吉林省拓华生物科技有限公司 | 负载干细胞的大面积羊膜贴片的制备方法 |
| CN115671398B (zh) * | 2022-11-22 | 2024-03-01 | 首都医科大学附属北京同仁医院 | 一种3d打印仿生角膜缘移植物及其制备方法和用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL47062A (en) * | 1975-04-10 | 1979-07-25 | Yeda Res & Dev | Process for diminishing antigenicity of tissues to be usedas transplants by treatment with glutaraldehyde |
| JPS63260549A (ja) * | 1987-04-17 | 1988-10-27 | 石川 統一 | 補綴材料およびその製造方法 |
| US5135915A (en) * | 1988-10-14 | 1992-08-04 | Genentech, Inc. | Method for the treatment of grafts prior to transplantation using TGF-.beta. |
| JP2905719B2 (ja) * | 1995-03-31 | 1999-06-14 | 東洋紡績株式会社 | 複合医用材料 |
| US6152142A (en) * | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
| US5932205A (en) * | 1997-07-24 | 1999-08-03 | Wang; Ming X. | Biochemical contact lens for treating photoablated corneal tissue |
-
2001
- 2001-04-25 WO PCT/US2001/013321 patent/WO2001080760A1/en not_active Ceased
- 2001-04-25 PT PT01927340T patent/PT1276431E/pt unknown
- 2001-04-25 AT AT01927340T patent/ATE329632T1/de active
- 2001-04-25 ES ES01927340T patent/ES2266193T3/es not_active Expired - Lifetime
- 2001-04-25 DE DE60120676T patent/DE60120676T2/de not_active Expired - Lifetime
- 2001-04-25 AU AU5380201A patent/AU5380201A/xx active Pending
- 2001-04-25 AU AU2001253802A patent/AU2001253802B2/en not_active Ceased
- 2001-04-25 CA CA2406282A patent/CA2406282C/en not_active Expired - Lifetime
- 2001-04-25 JP JP2001577863A patent/JP5612801B2/ja not_active Expired - Fee Related
- 2001-04-25 CN CNB018081649A patent/CN1296102C/zh not_active Expired - Fee Related
- 2001-04-25 EP EP01927340A patent/EP1276431B1/en not_active Expired - Lifetime
- 2001-04-26 TW TW090110005A patent/TW506827B/zh not_active IP Right Cessation
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|---|---|
| DE60120676T2 (de) | 2007-05-24 |
| TW506827B (en) | 2002-10-21 |
| WO2001080760A1 (en) | 2001-11-01 |
| CA2406282C (en) | 2012-06-12 |
| ES2266193T3 (es) | 2007-03-01 |
| JP5612801B2 (ja) | 2014-10-22 |
| JP2003532466A (ja) | 2003-11-05 |
| EP1276431A4 (en) | 2003-08-06 |
| HK1056989A1 (en) | 2004-03-12 |
| ATE329632T1 (de) | 2006-07-15 |
| AU2001253802B2 (en) | 2006-11-30 |
| CA2406282A1 (en) | 2001-11-01 |
| CN1296102C (zh) | 2007-01-24 |
| AU5380201A (en) | 2001-11-07 |
| CN1426289A (zh) | 2003-06-25 |
| DE60120676D1 (de) | 2006-07-27 |
| WO2001080760A8 (en) | 2003-05-30 |
| EP1276431B1 (en) | 2006-06-14 |
| EP1276431A1 (en) | 2003-01-22 |
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