DE60114006T2 - Replikationsdefizienter adenoviraler tnf-vektor - Google Patents

Replikationsdefizienter adenoviraler tnf-vektor Download PDF

Info

Publication number
DE60114006T2
DE60114006T2 DE60114006T DE60114006T DE60114006T2 DE 60114006 T2 DE60114006 T2 DE 60114006T2 DE 60114006 T DE60114006 T DE 60114006T DE 60114006 T DE60114006 T DE 60114006T DE 60114006 T2 DE60114006 T2 DE 60114006T2
Authority
DE
Germany
Prior art keywords
adenoviral
genome
tnf
adenoviral vector
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60114006T
Other languages
German (de)
English (en)
Other versions
DE60114006D1 (de
Inventor
Douglas E. Brough
C. Richter King
Imre Kovesdi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genvec Inc
Original Assignee
Genvec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genvec Inc filed Critical Genvec Inc
Publication of DE60114006D1 publication Critical patent/DE60114006D1/de
Application granted granted Critical
Publication of DE60114006T2 publication Critical patent/DE60114006T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60114006T 2000-06-27 2001-06-27 Replikationsdefizienter adenoviraler tnf-vektor Expired - Lifetime DE60114006T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US604694 1996-02-21
US09/604,694 US6579522B1 (en) 2000-06-27 2000-06-27 Replication deficient adenoviral TNF vector
PCT/US2001/020536 WO2002000906A2 (en) 2000-06-27 2001-06-27 Replication deficient adenoviral tnf vector

Publications (2)

Publication Number Publication Date
DE60114006D1 DE60114006D1 (de) 2006-02-23
DE60114006T2 true DE60114006T2 (de) 2006-07-20

Family

ID=24420637

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60114006T Expired - Lifetime DE60114006T2 (de) 2000-06-27 2001-06-27 Replikationsdefizienter adenoviraler tnf-vektor

Country Status (8)

Country Link
US (2) US6579522B1 (ja)
EP (1) EP1294918B1 (ja)
JP (2) JP2004501650A (ja)
AT (1) ATE306555T1 (ja)
AU (2) AU7154901A (ja)
CA (1) CA2412637A1 (ja)
DE (1) DE60114006T2 (ja)
WO (1) WO2002000906A2 (ja)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003501043A (ja) * 1999-05-28 2003-01-14 ターゲティッド ジェネティクス コーポレイション 腫瘍壊死因子（ｔｎｆ）関連障害において、ｔｎｆのレベルを低下させるための方法および組成物
US6579522B1 (en) * 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
US20030086903A1 (en) 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
US6845929B2 (en) * 2002-03-22 2005-01-25 Ali Dolatabadi High efficiency nozzle for thermal spray of high quality, low oxide content coatings
US20030223962A1 (en) * 2002-06-03 2003-12-04 Cornell Research Foundation, Inc. Delivery of gene products to the lung parenchyma via gene transfer to the pleura
EP1687032B1 (en) * 2003-11-14 2010-02-24 Genvec, Inc. Pharmaceutical composition for treating unresectable, locally advanced pancreatic cancer (lapc).
CN101507822B (zh) * 2003-11-24 2012-06-06 坎吉有限公司 皮肤瘢痕形成的减少
WO2006039045A2 (en) * 2004-09-01 2006-04-13 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adenoviral vectors able to transduce apcs, potential use in immune response generation
EP1943265B1 (en) * 2005-10-01 2012-09-12 Charles Stout Regulatable fusion promoters
DE602008004476D1 (de) * 2007-03-09 2011-02-24 Vectorlogics Inc Zellen für adenovirusvektor- und proteinherstellung
US9605844B2 (en) * 2009-09-01 2017-03-28 Cree, Inc. Lighting device with heat dissipation elements
WO2011054811A1 (en) 2009-11-03 2011-05-12 Santaris Pharma A/S Rna antagonists targeting hsp27 combination therapy
US9458473B2 (en) 2010-06-29 2016-10-04 The Johns Hopkins University Compositions and methods for retargeting virus constructs
KR101429696B1 (ko) 2012-11-21 2014-08-13 국립암센터 안전성 및 항암활성이 증가된 재조합 아데노바이러스 및 이의 용도
WO2014153204A1 (en) 2013-03-14 2014-09-25 Salk Institute For Biological Studies Oncolytic adenovirus compositions
JP7054527B2 (ja) 2016-02-23 2022-04-14 ソーク インスティテュート フォー バイオロジカル スタディーズ アデノウイルスの複製動態を測定するための高スループットアッセイ
KR20180112024A (ko) 2016-02-23 2018-10-11 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현
CN110062630A (zh) 2016-12-12 2019-07-26 萨克生物研究学院 肿瘤靶向合成腺病毒及其用途

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5833975A (en) * 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US4879226A (en) 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
US5763209A (en) 1988-09-26 1998-06-09 Arch Development Corporation Methods and materials relating to the functional domains of DNA binding proteins
US5206152A (en) 1988-04-08 1993-04-27 Arch Development Corporation Cloning and expression of early growth regulatory protein genes
JP3443119B2 (ja) * 1989-08-07 2003-09-02 ペプテック リミテッド 腫瘍壊死因子結合リガンド
CA2055168A1 (en) 1990-11-21 1992-05-22 Walter Fiers Tnf-muteins
US6605712B1 (en) 1990-12-20 2003-08-12 Arch Development Corporation Gene transcription and ionizing radiation: methods and compositions
ATE190354T1 (de) 1990-12-20 2000-03-15 Arch Dev Corp The University O Kontrolle der genexpression durch ionisierende strahlung
US5358866A (en) 1991-07-03 1994-10-25 The United States Of America As Represented By The Department Of Health And Human Services Cytosine deaminase negative selection system for gene transfer techniques and therapies
US5968735A (en) 1992-11-12 1999-10-19 Max Delbruck-Centrum Fur Molekular Medizin Berlin Vector for the expression of therapy-relevant genes
FR2709309B1 (fr) 1993-08-25 1995-11-10 Centre Nat Rech Scient Compositions cellulaires, préparation et utilisations thérapeutiques.
US5641755A (en) 1994-02-04 1997-06-24 Arch Development Corp. Regulation of x-ray mediated gene expression
US5571797A (en) 1994-05-11 1996-11-05 Arch Development Corporation Method of inducing gene expression by ionizing radiation
US5851806A (en) 1994-06-10 1998-12-22 Genvec, Inc. Complementary adenoviral systems and cell lines
CA2192442C (en) 1994-06-10 2007-09-25 Imre Kovesdi Complementary adenoviral vector systems and cell lines
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US5962424A (en) 1995-02-21 1999-10-05 Arch Development Corporation Methods and compositions for targeting selectins
AU4994596A (en) 1995-03-01 1996-09-18 Cornell Research Foundation Inc. Interdependent adenoviral vectors and methods of using same
AU5634696A (en) 1995-04-28 1996-11-18 Genetic Therapy, Inc. Treatment of tumors with cells expressing interferons, tumor necrosis factors, or other cytokines
US6281010B1 (en) * 1995-06-05 2001-08-28 The Trustees Of The University Of Pennsylvania Adenovirus gene therapy vehicle and cell line
EP0862445B2 (en) * 1995-10-06 2017-03-22 Arch Development Corporation Combination of herpes simplex virus and chemotherapy for treating cancer
ATE382694T1 (de) 1995-11-28 2008-01-15 Genvec Inc Vektoren und methoden zum gentransfer in zellen
EP0979101B1 (en) 1996-07-03 2010-10-27 Merial, Inc. Recombinant canine adenovirus 2 (cav2) containing exogenous dna
CA2232743A1 (en) 1997-04-02 1998-10-02 Smithkline Beecham Corporation A tnf homologue, tl5
US5981275A (en) 1997-04-14 1999-11-09 Genzyme Corporation Transgene expression system for increased persistence
US6100086A (en) 1997-04-14 2000-08-08 Genzyme Corporation Transgene expression systems
IL120979A0 (en) 1997-06-02 1997-11-20 Interpharm Lab Ltd Glycosylated TNF
US6171787B1 (en) 1997-06-26 2001-01-09 Abbott Laboratories Member of the TNF family useful for treatment and diagnosis of disease
DE19747718A1 (de) 1997-10-29 1999-05-06 Baltzer Axel Wilhelm August Dr Verfahren zur Therapie knochenresorbierender Erkrankungen mit der molekularbiologischen Methode der Gentherapie
CA2308511C (en) 1997-10-29 2016-01-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of transfected or transduced mammalian cells for treating bone pathologies
WO1999023216A2 (en) 1997-11-03 1999-05-14 The Arizona Board Of Regents On Behalf Of The University Of Arizona Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
CA2322663A1 (en) 1998-03-11 1999-09-16 Board Of Regents, The University Of Texas System Induction of apoptotic or cytotoxic gene expression by adenoviral mediated gene codelivery
CA2323112A1 (en) 1998-03-16 1999-09-23 Introgen Therapeutics, Inc. Multigene vectors
JP2002512785A (ja) 1998-04-24 2002-05-08 オニックス ファーマシューティカルズ，インコーポレイティド 疾患治療用のアデノウイルスベクター
EP1087785A2 (en) 1998-06-15 2001-04-04 Arch Development Corporation Combination of radiotherapy and anti-angiogenic factors
US6337338B1 (en) * 1998-12-15 2002-01-08 Telik, Inc. Heteroaryl-aryl ureas as IGF-1 receptor antagonists
US6579522B1 (en) * 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
US20030086903A1 (en) * 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer

Also Published As

Publication number Publication date
JP2012139220A (ja) 2012-07-26
US6579522B1 (en) 2003-06-17
AU2001271549B2 (en) 2005-06-09
US20030175245A1 (en) 2003-09-18
ATE306555T1 (de) 2005-10-15
EP1294918B1 (en) 2005-10-12
WO2002000906A2 (en) 2002-01-03
CA2412637A1 (en) 2002-01-03
JP2004501650A (ja) 2004-01-22
AU7154901A (en) 2002-01-08
DE60114006D1 (de) 2006-02-23
WO2002000906A3 (en) 2002-06-06
EP1294918A2 (en) 2003-03-26

Similar Documents

Publication Publication Date Title
DE60114006T2 (de) Replikationsdefizienter adenoviraler tnf-vektor
DE69635931T2 (de) Komplementäre adenovirenvectorsysteme und zelllinien
DE69535178T2 (de) Adenoviren-vektor systeme und zelllinien
DE69434594T2 (de) Rekombinante adenoviren-vektor und verfahren zur verwendung
DE69636055T2 (de) Adenovirale vektoren, die nicht von gruppe c adenovirus typen abgeleitet sind
DE69534166T2 (de) Rekombinanter adenovirus und methoden zu dessen verwendung
DE69429260T2 (de) Adenovirale vektoren tierischen ursprungs und ihre verwendung bei der gentherapie
DE69417734T2 (de) Cytopathische viren zur therapie und prophylaxe der neoplasie
DE69434781T2 (de) Defektive rekombinante adenoviren zur tumor-gentherapie
DE69615650T2 (de) Virale vektoren für die gentherapie
DE69834936T2 (de) Vektor zur gewebespezifischen replikation und expression
DE69230993T2 (de) Rekombinante viren vektoren zur expression in muskelzellen
DE69518910T4 (de) Verfahren zur herstellung von viralen vektoren von mindestens 20kb durch intermolekulare homologe rekombination in einer prokaryotischen zelle
DE69534902T2 (de) Rekombinanter viraler DNS Vektor zur Transfektion tierischer Zellen
DE69931391T2 (de) Trans-aktivierung und cis-aktivierung um die dauer der expression eines transgens zu modulieren
DE69637393T2 (de) Vektoren und methoden zum gentransfer in zellen
DE60035124T2 (de) Ein oncolytisches adenovirus
DE69914382T2 (de) Verwendung der Leserahmen der adenoviralen E4-Region zur Verbesserung der Genexpression
DE69616559T2 (de) Hilfsvirus für die herstellung von rekombinanten virusvektoren
DE60017141T2 (de) Replikationskompetente anti-krebs-vektoren
AU2001271549A1 (en) Replication deficient adenoviral TNF vector
DE69431046T2 (de) Rekombinante adenoviren und deren verwendung in der gentherapie zur behandlung von augenerkrankungen
DE60037189T2 (de) Rekombinante, natrium-jodid symporter-kodierende adenoviren
DE69934421T2 (de) Selektiv-replizierende virale vectoren
DE69535093T2 (de) Defektive rekombinante adenoviren mit einem inaktivierten gen iv a 2

Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: BROUGH, DOUGLAS E., GAITHERSBURG, US

Inventor name: KING, C. RICHTER, WASHINGTON, US

Inventor name: KOVESDI, IMRE, ROCKVILLE, US

8364 No opposition during term of opposition