DE60113080T2 - 4-amino-5-cyano-2-anilino-pyrimidin-derivate zur verwendung als inhibitoren von zellzyklus-kinasen - Google Patents
4-amino-5-cyano-2-anilino-pyrimidin-derivate zur verwendung als inhibitoren von zellzyklus-kinasen Download PDFInfo
- Publication number
- DE60113080T2 DE60113080T2 DE60113080T DE60113080T DE60113080T2 DE 60113080 T2 DE60113080 T2 DE 60113080T2 DE 60113080 T DE60113080 T DE 60113080T DE 60113080 T DE60113080 T DE 60113080T DE 60113080 T2 DE60113080 T2 DE 60113080T2
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- sulfamoyl
- formula
- amino
- sulphamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
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- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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| PCT/GB2001/001264 WO2001072717A1 (en) | 2000-03-28 | 2001-03-23 | 4-amino-5-cyano-2-anilino-pyrimidine derivatives and their use as inhibitors of cell-cycle kinases |
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| DE60113080D1 DE60113080D1 (de) | 2005-10-06 |
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| GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
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| EP1406875B1 (en) * | 2001-06-26 | 2013-07-31 | Bristol-Myers Squibb Company | N-heterocyclic inhibitors of tnf-alpha expression |
| US7115617B2 (en) | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
| US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| DE50212771D1 (de) | 2001-10-17 | 2008-10-23 | Boehringer Ingelheim Pharma | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
| WO2003062246A1 (en) * | 2002-01-22 | 2003-07-31 | Warner-Lambert Company Llc | 2-thia-1,6,8-triaza-naphtalene-2,2-dioxides as cdk inhibitors |
| AU2003208479A1 (en) | 2002-03-09 | 2003-09-22 | Astrazeneca Ab | 4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity |
| GB0205688D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| GB0205690D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| EP1565446A1 (en) | 2002-11-28 | 2005-08-24 | Schering Aktiengesellschaft | Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
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| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
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| GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
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- 2001-03-23 AU AU3941401A patent/AU3941401A/xx active Pending
- 2001-03-23 PT PT01914026T patent/PT1268445E/pt unknown
- 2001-03-23 WO PCT/GB2001/001264 patent/WO2001072717A1/en not_active Ceased
- 2001-03-23 AU AU2001239414A patent/AU2001239414B2/en not_active Ceased
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| AU2001239414B2 (en) | 2004-09-02 |
| CA2399864A1 (en) | 2001-10-04 |
| US20030087923A1 (en) | 2003-05-08 |
| US6906065B2 (en) | 2005-06-14 |
| CN1419548A (zh) | 2003-05-21 |
| JP2003528861A (ja) | 2003-09-30 |
| DE60113080D1 (de) | 2005-10-06 |
| ZA200206957B (en) | 2003-12-01 |
| NZ521032A (en) | 2004-05-28 |
| AU3941401A (en) | 2001-10-08 |
| NO324228B1 (no) | 2007-09-10 |
| GB0007371D0 (en) | 2000-05-17 |
| CN1231471C (zh) | 2005-12-14 |
| WO2001072717A1 (en) | 2001-10-04 |
| DK1268445T3 (da) | 2005-11-07 |
| MXPA02009255A (es) | 2003-03-12 |
| PT1268445E (pt) | 2005-11-30 |
| EP1268445B1 (en) | 2005-08-31 |
| ATE303366T1 (de) | 2005-09-15 |
| IL151392A0 (en) | 2003-04-10 |
| ES2247078T3 (es) | 2006-03-01 |
| NO20024644L (no) | 2002-11-27 |
| NO20024644D0 (no) | 2002-09-27 |
| KR100802367B1 (ko) | 2008-02-13 |
| KR20020083532A (ko) | 2002-11-02 |
| IL151392A (en) | 2007-06-17 |
| BR0109577A (pt) | 2003-01-28 |
| MY124527A (en) | 2006-06-30 |
| EP1268445A1 (en) | 2003-01-02 |
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