CN1231471C - 4－氨基－5－氰基－2－苯胺基－嘧啶衍生物和它们作为细胞周期激酶的抑制剂的用途 - Google Patents

4－氨基－5－氰基－2－苯胺基－嘧啶衍生物和它们作为细胞周期激酶的抑制剂的用途 Download PDF

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CN1231471C
CN1231471C CNB018071570A CN01807157A CN1231471C CN 1231471 C CN1231471 C CN 1231471C CN B018071570 A CNB018071570 A CN B018071570A CN 01807157 A CN01807157 A CN 01807157A CN 1231471 C CN1231471 C CN 1231471C
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sulfamyl
alkyl
amino
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CN1419548A (zh
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A·P·托马斯
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AstraZeneca AB
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB018071570A 2000-03-28 2001-03-23 4－氨基－5－氰基－2－苯胺基－嘧啶衍生物和它们作为细胞周期激酶的抑制剂的用途 Expired - Fee Related CN1231471C (zh)

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GB0007371.8 2000-03-28
GBGB0007371.8A GB0007371D0 (en) 2000-03-28 2000-03-28 Chemical compounds

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CN1419548A CN1419548A (zh) 2003-05-21
CN1231471C true CN1231471C (zh) 2005-12-14

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US (1) US6906065B2 (enExample)
EP (1) EP1268445B1 (enExample)
JP (1) JP2003528861A (enExample)
KR (1) KR100802367B1 (enExample)
CN (1) CN1231471C (enExample)
AT (1) ATE303366T1 (enExample)
AU (2) AU2001239414B2 (enExample)
BR (1) BR0109577A (enExample)
CA (1) CA2399864A1 (enExample)
DE (1) DE60113080T2 (enExample)
DK (1) DK1268445T3 (enExample)
ES (1) ES2247078T3 (enExample)
GB (1) GB0007371D0 (enExample)
IL (2) IL151392A0 (enExample)
MX (1) MXPA02009255A (enExample)
MY (1) MY124527A (enExample)
NO (1) NO324228B1 (enExample)
NZ (1) NZ521032A (enExample)
PT (1) PT1268445E (enExample)
WO (1) WO2001072717A1 (enExample)
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IL151392A0 (en) 2003-04-10
IL151392A (en) 2007-06-17
EP1268445B1 (en) 2005-08-31
MY124527A (en) 2006-06-30
DK1268445T3 (da) 2005-11-07
MXPA02009255A (es) 2003-03-12
PT1268445E (pt) 2005-11-30
AU2001239414B2 (en) 2004-09-02
NZ521032A (en) 2004-05-28
CA2399864A1 (en) 2001-10-04
NO20024644L (no) 2002-11-27
ATE303366T1 (de) 2005-09-15
WO2001072717A1 (en) 2001-10-04
KR100802367B1 (ko) 2008-02-13
US20030087923A1 (en) 2003-05-08
DE60113080D1 (de) 2005-10-06
NO20024644D0 (no) 2002-09-27
GB0007371D0 (en) 2000-05-17
ZA200206957B (en) 2003-12-01
EP1268445A1 (en) 2003-01-02
KR20020083532A (ko) 2002-11-02
AU3941401A (en) 2001-10-08
CN1419548A (zh) 2003-05-21
JP2003528861A (ja) 2003-09-30
BR0109577A (pt) 2003-01-28
US6906065B2 (en) 2005-06-14

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