ES2246829T3 - Inhibidores purinicos de cinasa 2 y de ikb-alfa dependientes de ciclina. - Google Patents

Inhibidores purinicos de cinasa 2 y de ikb-alfa dependientes de ciclina.

Info

Publication number
ES2246829T3
ES2246829T3 ES00908325T ES00908325T ES2246829T3 ES 2246829 T3 ES2246829 T3 ES 2246829T3 ES 00908325 T ES00908325 T ES 00908325T ES 00908325 T ES00908325 T ES 00908325T ES 2246829 T3 ES2246829 T3 ES 2246829T3
Authority
ES
Spain
Prior art keywords
cinasa
purinic
cycline
dependents
ikb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00908325T
Other languages
English (en)
Inventor
Robert T Lum
Cheri Lynn Blum
Richard Mackman
Michael M Wick
Steven R Schow
Jeffery A Zablocki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Palo Alto Inc
Original Assignee
CV Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CV Therapeutics Inc filed Critical CV Therapeutics Inc
Application granted granted Critical
Publication of ES2246829T3 publication Critical patent/ES2246829T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Abstract

Compuesto seleccionado de entre el grupo constituido por: {2-[(2-aminoetil)amino]-9-(metiletil)purin-6- il}[{4-clorofenil}metil]amina; {2-[(2-aminopropil)amino]-9-(metiletil)purin-6- il}[(4-clorofenil)metil]amina; {2-[(2-aminoetil)(6-{[(4- clorofenil)metil]amino}-9-(metiletil)purin-2- il)amino]etan-1-ol; y 2-[(2-hidroxietil)(6-{[(4- clorofenil)metil]amino}-9-(metiletil)purin-2- il)amino]etan-1-ol.
ES00908325T 1999-02-01 2000-01-20 Inhibidores purinicos de cinasa 2 y de ikb-alfa dependientes de ciclina. Expired - Lifetime ES2246829T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24122499A 1999-02-01 1999-02-01

Publications (1)

Publication Number Publication Date
ES2246829T3 true ES2246829T3 (es) 2006-03-01

Family

ID=22909777

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00908325T Expired - Lifetime ES2246829T3 (es) 1999-02-01 2000-01-20 Inhibidores purinicos de cinasa 2 y de ikb-alfa dependientes de ciclina.

Country Status (26)

Country Link
EP (1) EP1150982B1 (es)
JP (1) JP3681984B2 (es)
KR (1) KR20010093308A (es)
CN (1) CN1353713A (es)
AR (1) AR029612A1 (es)
AT (1) ATE306487T1 (es)
AU (1) AU2969300A (es)
BR (1) BR0007919A (es)
CA (1) CA2361518A1 (es)
CZ (1) CZ20012765A3 (es)
DE (1) DE60023268T2 (es)
DK (1) DK1150982T3 (es)
ES (1) ES2246829T3 (es)
GE (1) GEP20033092B (es)
HK (1) HK1044334A1 (es)
HU (1) HUP0200535A3 (es)
IL (2) IL144675A0 (es)
MX (1) MXPA01007851A (es)
NO (1) NO327776B1 (es)
NZ (1) NZ513371A (es)
PL (1) PL350001A1 (es)
RU (1) RU2001124352A (es)
TR (1) TR200102714T2 (es)
TW (1) TW538044B (es)
UA (1) UA74142C2 (es)
WO (1) WO2000044750A1 (es)

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US6413974B1 (en) 1998-02-26 2002-07-02 Aventis Pharmaceuticals Inc. 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
JP2002523498A (ja) 1998-08-29 2002-07-30 アストラゼネカ・アクチエボラーグ ピリミジン化合物
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GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
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GB9907658D0 (en) 1999-04-06 1999-05-26 Zeneca Ltd Chemical compounds
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
JP2003531111A (ja) 1999-12-17 2003-10-21 アライアッド・ファーマシューティカルズ・インコーポレーテッド プロトンポンプインヒビター
GB0004888D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004886D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0007371D0 (en) 2000-03-28 2000-05-17 Astrazeneca Uk Ltd Chemical compounds
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US6861524B2 (en) 2000-10-31 2005-03-01 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
GB0113041D0 (en) 2001-05-30 2001-07-18 Astrazeneca Ab Chemical compounds
DE60205376T2 (de) 2001-06-27 2006-04-06 Cyclacel Ltd. 2,6,9-substituierte purinderivate und ihre verwendung bei der behandlung proliferativer krankheiten
CA2464031A1 (en) 2001-10-30 2003-05-08 Conforma Therapeutics Corporation Purine analogs having hsp90-inhibiting activity
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DE60218525T2 (de) * 2001-12-18 2007-11-22 CV Therapeutics, Inc., Palo Alto A2a adenosinrezeptorantagonisten
CA2476431A1 (en) 2002-02-15 2003-08-21 Cv Therapeutics, Inc. Coating having polymerized silane derivatives for medical devices
GB0205693D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
WO2003076434A1 (en) 2002-03-09 2003-09-18 Astrazeneca Ab 4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity
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FR2851248B1 (fr) * 2003-02-18 2005-04-08 Aventis Pharma Sa Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
US7476670B2 (en) 2003-02-18 2009-01-13 Aventis Pharma S.A. Purine derivatives, method for preparing, pharmaceutical compositions and novel use
GB0311274D0 (en) 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
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US7138401B2 (en) 2003-09-18 2006-11-21 Conforma Therapeutics Corporation 2-aminopurine analogs having HSP90-inhibiting activity
TW200528101A (en) 2004-02-03 2005-09-01 Astrazeneca Ab Chemical compounds
GB0407723D0 (en) * 2004-04-05 2004-05-12 Novartis Ag Organic compounds
EP1674467A1 (en) * 2004-12-22 2006-06-28 4Sc Ag 2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors
FR2880626B1 (fr) * 2005-01-13 2008-04-18 Aventis Pharma Sa Derives de la purine, compositions les contenant et utilisation
EA013522B1 (ru) 2005-03-30 2010-06-30 Конформа Терапьютикс Корпорейшн Алкинилпирролопиримидины и их применение в качестве ингибиторов hsp90
MX2007014297A (es) * 2005-05-16 2008-04-21 Prometic Biosciences Inc Derivados de purina y su uso para el tratamiento de enfermedades autoinmunes.
JP4992716B2 (ja) * 2005-08-12 2012-08-08 アステラス製薬株式会社 薬剤の標的蛋白質を同定する方法及び標的蛋白質を用いた糖尿病治療薬のスクリーニング方法
US7745428B2 (en) 2005-09-30 2010-06-29 Astrazeneca Ab Imidazo[1,2-A]pyridine having anti-cell-proliferation activity
GB0706632D0 (en) 2007-04-04 2007-05-16 Cyclacel Ltd New purine derivatives
PE20100362A1 (es) * 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
CZ302122B6 (cs) * 2009-01-28 2010-10-20 Univerzita Palackého v Olomouci Substituované deriváty 6-(2-aminobenzylamino)purinu, jejich použití jako léciva a prípravky tyto slouceniny obsahující
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EP2558463A1 (en) 2010-04-14 2013-02-20 Incyte Corporation Fused derivatives as i3 inhibitors
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
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CZ306894B6 (cs) * 2013-02-08 2017-08-30 Univerzita PalackĂ©ho v Olomouci 2-Substituované-6-biarylmethylamino-9-cyklopentyl-9H-purinové deriváty, jejich použití jako léčiva a farmaceutické přípravky tyto sloučeniny obsahující
WO2014134750A1 (zh) * 2013-03-08 2014-09-12 中国人民解放军军事医学科学院放射与辐射医学研究所 2,6,9-三取代嘌呤衍生物及其制备方法与应用
US9879014B2 (en) * 2013-07-12 2018-01-30 Kyoto University Method for screening substance capable of inhibiting abnormal splicing causative of onset or progress of disease
FR3011240A1 (fr) * 2013-10-01 2015-04-03 Centre Nat Rech Scient Inhibiteurs de 5'-nucleotidases et leurs utilisations therapeutiques
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
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WO2016183060A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
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CN107235981B (zh) * 2017-05-25 2019-10-25 北京工业大学 低氧激活o6-苄基-2-硝基嘌呤衍生物及制法和应用
CN107903274A (zh) * 2017-12-28 2018-04-13 窦玉玲 一种胺类化合物及其在抗肿瘤药物中的应用
CN110256436B (zh) * 2019-06-27 2020-06-09 南京雷正医药科技有限公司 作为Trk激酶抑制剂的嘌呤类化合物
CN117479944A (zh) * 2021-04-02 2024-01-30 泰州亿腾景昂药业股份有限公司 周期蛋白依赖性激酶抑制剂
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FR2741881B1 (fr) * 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
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Also Published As

Publication number Publication date
BR0007919A (pt) 2002-04-09
NZ513371A (en) 2003-08-29
CN1353713A (zh) 2002-06-12
NO327776B1 (no) 2009-09-21
HUP0200535A2 (hu) 2002-07-29
TW538044B (en) 2003-06-21
WO2000044750A1 (en) 2000-08-03
DE60023268D1 (de) 2006-03-02
DE60023268T2 (de) 2006-06-01
TR200102714T2 (tr) 2002-01-21
UA74142C2 (uk) 2005-11-15
JP2002535405A (ja) 2002-10-22
IL144675A0 (en) 2002-05-23
GEP20033092B (en) 2003-10-27
KR20010093308A (ko) 2001-10-27
PL350001A1 (en) 2002-10-21
NO20013751D0 (no) 2001-07-31
JP3681984B2 (ja) 2005-08-10
EP1150982A1 (en) 2001-11-07
HUP0200535A3 (en) 2002-11-28
EP1150982B1 (en) 2005-10-12
NO20013751L (no) 2001-09-27
RU2001124352A (ru) 2004-02-20
AR029612A1 (es) 2003-07-10
CZ20012765A3 (cs) 2002-08-14
IL144675A (en) 2008-11-26
ATE306487T1 (de) 2005-10-15
MXPA01007851A (es) 2003-06-04
AU2969300A (en) 2000-08-18
CA2361518A1 (en) 2000-08-03
HK1044334A1 (zh) 2002-10-18
DK1150982T3 (da) 2005-12-27

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