DE60023268D1 - INHIBITEURS PURIQUES DE KINASE 2 DEPENDANTE DES CYCLINES et IkB-alpha - Google Patents
INHIBITEURS PURIQUES DE KINASE 2 DEPENDANTE DES CYCLINES et IkB-alphaInfo
- Publication number
- DE60023268D1 DE60023268D1 DE60023268T DE60023268T DE60023268D1 DE 60023268 D1 DE60023268 D1 DE 60023268D1 DE 60023268 T DE60023268 T DE 60023268T DE 60023268 T DE60023268 T DE 60023268T DE 60023268 D1 DE60023268 D1 DE 60023268D1
- Authority
- DE
- Germany
- Prior art keywords
- puriques
- dependants
- inhibiteurs
- cyclines
- ikb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US241224 | 1994-05-10 | ||
US24122499A | 1999-02-01 | 1999-02-01 | |
PCT/US2000/001407 WO2000044750A1 (en) | 1999-02-01 | 2000-01-20 | PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND Iλ-A$g(a) |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60023268D1 true DE60023268D1 (de) | 2006-03-02 |
DE60023268T2 DE60023268T2 (de) | 2006-06-01 |
Family
ID=22909777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60023268T Expired - Fee Related DE60023268T2 (de) | 1999-02-01 | 2000-01-20 | INHIBITEURS PURIQUES DE KINASE 2 DEPENDANTE DES CYCLINES et IkB-alpha |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP1150982B1 (de) |
JP (1) | JP3681984B2 (de) |
KR (1) | KR20010093308A (de) |
CN (1) | CN1353713A (de) |
AR (1) | AR029612A1 (de) |
AT (1) | ATE306487T1 (de) |
AU (1) | AU2969300A (de) |
BR (1) | BR0007919A (de) |
CA (1) | CA2361518A1 (de) |
CZ (1) | CZ20012765A3 (de) |
DE (1) | DE60023268T2 (de) |
DK (1) | DK1150982T3 (de) |
ES (1) | ES2246829T3 (de) |
GE (1) | GEP20033092B (de) |
HK (1) | HK1044334A1 (de) |
HU (1) | HUP0200535A3 (de) |
IL (2) | IL144675A0 (de) |
MX (1) | MXPA01007851A (de) |
NO (1) | NO327776B1 (de) |
NZ (1) | NZ513371A (de) |
PL (1) | PL350001A1 (de) |
RU (1) | RU2001124352A (de) |
TR (1) | TR200102714T2 (de) |
TW (1) | TW538044B (de) |
UA (1) | UA74142C2 (de) |
WO (1) | WO2000044750A1 (de) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6413974B1 (en) | 1998-02-26 | 2002-07-02 | Aventis Pharmaceuticals Inc. | 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines |
US6479487B1 (en) | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
US6632820B1 (en) | 1998-08-29 | 2003-10-14 | Astrazeneca Ab | Pyrimidine compounds |
WO2000012485A1 (en) | 1998-08-29 | 2000-03-09 | Astrazeneca Ab | Pyrimidine compounds |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
JP2003531111A (ja) | 1999-12-17 | 2003-10-21 | アライアッド・ファーマシューティカルズ・インコーポレーテッド | プロトンポンプインヒビター |
GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
US6861524B2 (en) | 2000-10-31 | 2005-03-01 | Aventis Pharmaceuticals Inc. | Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents |
GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
DE60205376T2 (de) | 2001-06-27 | 2006-04-06 | Cyclacel Ltd. | 2,6,9-substituierte purinderivate und ihre verwendung bei der behandlung proliferativer krankheiten |
EP1440072A4 (de) | 2001-10-30 | 2005-02-02 | Conforma Therapeutic Corp | Purinanaloga mit hsp90-inhibierender wirkung |
US20050154046A1 (en) * | 2004-01-12 | 2005-07-14 | Longgui Wang | Methods of treating an inflammatory-related disease |
US7189730B2 (en) | 2001-12-18 | 2007-03-13 | Cv Therapeutics, Inc. | A2A adenosine receptor antagonists |
DK1764118T3 (da) | 2002-02-15 | 2010-11-08 | Gilead Palo Alto Inc | Polymer-coating til medicinske anordninger |
US7442697B2 (en) | 2002-03-09 | 2008-10-28 | Astrazeneca Ab | 4-imidazolyl substituted pyrimidine derivatives with CDK inhibitory activity |
GB0205688D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
GB0205693D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
GB0205690D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
GB0219052D0 (en) * | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New puring derivatives |
GB0219054D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New purine derivatives |
US7138402B2 (en) | 2003-09-18 | 2006-11-21 | Conforma Therapeutics Corporation | Pyrrolopyrimidines and related analogs as HSP90-inhibitors |
US7476670B2 (en) | 2003-02-18 | 2009-01-13 | Aventis Pharma S.A. | Purine derivatives, method for preparing, pharmaceutical compositions and novel use |
FR2851248B1 (fr) * | 2003-02-18 | 2005-04-08 | Aventis Pharma Sa | Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation |
GB0311276D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
GB0311274D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
TW200528101A (en) | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
GB0407723D0 (en) * | 2004-04-05 | 2004-05-12 | Novartis Ag | Organic compounds |
EP1674467A1 (de) * | 2004-12-22 | 2006-06-28 | 4Sc Ag | 2,5- und 2,6-disubstituierte Benzazol-Derivate zur Verwendung als Protein Kinase Inhibitoren |
FR2880626B1 (fr) * | 2005-01-13 | 2008-04-18 | Aventis Pharma Sa | Derives de la purine, compositions les contenant et utilisation |
JP2008534609A (ja) | 2005-03-30 | 2008-08-28 | コンフォーマ・セラピューティクス・コーポレイション | Hsp90阻害剤としてのアルキニルピロロピリミジンおよび関連類似体 |
AU2006261527B2 (en) * | 2005-05-16 | 2012-11-22 | Prometic Pharma Smt Limited | Purine derivatives and their use for treatment of autoimmune diseases |
JP4992716B2 (ja) * | 2005-08-12 | 2012-08-08 | アステラス製薬株式会社 | 薬剤の標的蛋白質を同定する方法及び標的蛋白質を用いた糖尿病治療薬のスクリーニング方法 |
WO2007036732A1 (en) | 2005-09-30 | 2007-04-05 | Astrazeneca Ab | Imidazo [1,2-a] pyridine having anti-cell-proliferation activity |
GB0706632D0 (en) * | 2007-04-04 | 2007-05-16 | Cyclacel Ltd | New purine derivatives |
PE20100362A1 (es) * | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
CZ302122B6 (cs) * | 2009-01-28 | 2010-10-20 | Univerzita Palackého v Olomouci | Substituované deriváty 6-(2-aminobenzylamino)purinu, jejich použití jako léciva a prípravky tyto slouceniny obsahující |
EP2845856A1 (de) | 2009-06-29 | 2015-03-11 | Incyte Corporation | Pyrimidone als PI3K-Hemmer |
WO2011075643A1 (en) | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
AR081823A1 (es) | 2010-04-14 | 2012-10-24 | Incyte Corp | DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd |
US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
US9096600B2 (en) | 2010-12-20 | 2015-08-04 | Incyte Corporation | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
BR112014004971B1 (pt) | 2011-09-02 | 2021-02-09 | Incyte Holdings Corporation | compostos heterociclilaminas, sua composição farmacêutica e seus usos |
SG2014014450A (en) | 2011-09-22 | 2014-09-26 | Pfizer | Pyrrolopyrimidine and purine derivatives |
WO2013130461A1 (en) | 2012-02-29 | 2013-09-06 | The Scripps Research Institute | Wee1 degradation inhibitors |
EP2634190A1 (de) * | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazole-Triazin-Derivate als Cyclin-abhängige Kinasen Inhibitoren |
AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
CZ306894B6 (cs) * | 2013-02-08 | 2017-08-30 | Univerzita PalackĂ©ho v Olomouci | 2-Substituované-6-biarylmethylamino-9-cyklopentyl-9H-purinové deriváty, jejich použití jako léčiva a farmaceutické přípravky tyto sloučeniny obsahující |
WO2014134750A1 (zh) * | 2013-03-08 | 2014-09-12 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 2,6,9-三取代嘌呤衍生物及其制备方法与应用 |
JPWO2015005491A1 (ja) * | 2013-07-12 | 2017-03-02 | 国立大学法人京都大学 | 疾病の発症又は進行の一因となる異常スプライシングを抑制できる物質のスクリーニング方法 |
FR3011240A1 (fr) | 2013-10-01 | 2015-04-03 | Centre Nat Rech Scient | Inhibiteurs de 5'-nucleotidases et leurs utilisations therapeutiques |
WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
SI3831833T1 (sl) | 2015-02-27 | 2023-03-31 | Incyte Holdings Corporation | Postopki za pripravo inhibitorja PI3K |
WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
CN107235981B (zh) * | 2017-05-25 | 2019-10-25 | 北京工业大学 | 低氧激活o6-苄基-2-硝基嘌呤衍生物及制法和应用 |
CN107903274A (zh) * | 2017-12-28 | 2018-04-13 | 窦玉玲 | 一种胺类化合物及其在抗肿瘤药物中的应用 |
CN110256436B (zh) * | 2019-06-27 | 2020-06-09 | 南京雷正医药科技有限公司 | 作为Trk激酶抑制剂的嘌呤类化合物 |
WO2022206795A1 (en) * | 2021-04-02 | 2022-10-06 | Taizhou Eoc Pharma Co., Ltd. | A cyclin-dependent kinase inhibitor |
WO2023046128A1 (en) * | 2021-09-27 | 2023-03-30 | Taizhou Eoc Pharma Co., Ltd. | A cyclin-dependent kinase inhibitor |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2741881B1 (fr) * | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
WO1999007705A1 (en) * | 1997-08-07 | 1999-02-18 | The Regents Of The University Of California | Purine inhibitor of protein kinases, g proteins and polymerases |
-
2000
- 2000-01-20 NZ NZ513371A patent/NZ513371A/en unknown
- 2000-01-20 KR KR1020017009707A patent/KR20010093308A/ko not_active Application Discontinuation
- 2000-01-20 RU RU2001124352/04A patent/RU2001124352A/ru unknown
- 2000-01-20 MX MXPA01007851A patent/MXPA01007851A/es not_active IP Right Cessation
- 2000-01-20 DE DE60023268T patent/DE60023268T2/de not_active Expired - Fee Related
- 2000-01-20 GE GEAP20006078A patent/GEP20033092B/en unknown
- 2000-01-20 CZ CZ20012765A patent/CZ20012765A3/cs unknown
- 2000-01-20 WO PCT/US2000/001407 patent/WO2000044750A1/en active IP Right Grant
- 2000-01-20 EP EP00908325A patent/EP1150982B1/de not_active Expired - Lifetime
- 2000-01-20 HU HU0200535A patent/HUP0200535A3/hu unknown
- 2000-01-20 TR TR2001/02714T patent/TR200102714T2/xx unknown
- 2000-01-20 BR BR0007919-7A patent/BR0007919A/pt active Pending
- 2000-01-20 JP JP2000596006A patent/JP3681984B2/ja not_active Expired - Fee Related
- 2000-01-20 UA UA2001085511A patent/UA74142C2/uk unknown
- 2000-01-20 DK DK00908325T patent/DK1150982T3/da active
- 2000-01-20 AT AT00908325T patent/ATE306487T1/de not_active IP Right Cessation
- 2000-01-20 IL IL14467500A patent/IL144675A0/xx active IP Right Grant
- 2000-01-20 PL PL00350001A patent/PL350001A1/xx not_active Application Discontinuation
- 2000-01-20 ES ES00908325T patent/ES2246829T3/es not_active Expired - Lifetime
- 2000-01-20 CN CN00805567A patent/CN1353713A/zh active Pending
- 2000-01-20 CA CA002361518A patent/CA2361518A1/en not_active Abandoned
- 2000-01-20 AU AU29693/00A patent/AU2969300A/en not_active Abandoned
- 2000-01-31 AR ARP000100411A patent/AR029612A1/es active IP Right Grant
- 2000-04-19 TW TW089101723A patent/TW538044B/zh not_active IP Right Cessation
-
2001
- 2001-07-31 NO NO20013751A patent/NO327776B1/no not_active IP Right Cessation
- 2001-07-31 IL IL144675A patent/IL144675A/en not_active IP Right Cessation
-
2002
- 2002-08-10 HK HK02105857.9A patent/HK1044334A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP1150982A1 (de) | 2001-11-07 |
RU2001124352A (ru) | 2004-02-20 |
IL144675A0 (en) | 2002-05-23 |
AU2969300A (en) | 2000-08-18 |
CZ20012765A3 (cs) | 2002-08-14 |
NO20013751L (no) | 2001-09-27 |
TR200102714T2 (tr) | 2002-01-21 |
TW538044B (en) | 2003-06-21 |
JP3681984B2 (ja) | 2005-08-10 |
DK1150982T3 (da) | 2005-12-27 |
UA74142C2 (uk) | 2005-11-15 |
CN1353713A (zh) | 2002-06-12 |
HUP0200535A2 (hu) | 2002-07-29 |
HUP0200535A3 (en) | 2002-11-28 |
GEP20033092B (en) | 2003-10-27 |
CA2361518A1 (en) | 2000-08-03 |
DE60023268T2 (de) | 2006-06-01 |
EP1150982B1 (de) | 2005-10-12 |
HK1044334A1 (zh) | 2002-10-18 |
KR20010093308A (ko) | 2001-10-27 |
PL350001A1 (en) | 2002-10-21 |
MXPA01007851A (es) | 2003-06-04 |
NO20013751D0 (no) | 2001-07-31 |
AR029612A1 (es) | 2003-07-10 |
ATE306487T1 (de) | 2005-10-15 |
NZ513371A (en) | 2003-08-29 |
JP2002535405A (ja) | 2002-10-22 |
WO2000044750A1 (en) | 2000-08-03 |
NO327776B1 (no) | 2009-09-21 |
ES2246829T3 (es) | 2006-03-01 |
BR0007919A (pt) | 2002-04-09 |
IL144675A (en) | 2008-11-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60023268D1 (de) | INHIBITEURS PURIQUES DE KINASE 2 DEPENDANTE DES CYCLINES et IkB-alpha | |
FR20C1039I2 (fr) | Derives de l'uk-2a | |
MA27126A1 (fr) | 3'PROMEDICAMENTS DE 2'-DESOXY- β-L-NUCLEOSIDES | |
NO20021382D0 (no) | Fremgangsmåter og mikroorganismer for fremstilling av panto- forbindelser | |
ID24372A (id) | SENYAWA-SENYAWA 4-AMINO-TIAZOL-2-IL SEBAGAI PENGHAMBAT-PENGHAMBAT CDKs | |
PT1109558E (pt) | Formulacoes de ranolazina de libertacao controlada | |
ATE512594T1 (de) | Verbesserung des zustandes älterer haustiere | |
NO20030012L (no) | Fremgangsmåte for fremstilling av substituerte oktanoylamider | |
EE200200571A (et) | Hüdroksüfenüülpiperidiin-4-ülideenmetüülbensamiidi derivaadid valu raviks | |
NO20015542D0 (no) | Fremgangsmåte for fremstilling og anvendelse av N- desmetylzopikloner | |
NO20010490L (no) | Inhibisjon av ''graft-versus-host''-sykdom | |
FR2818979B1 (fr) | Procede de preparation d'imidaclopride | |
DE69906921D1 (de) | Erweiterung des Farbtonumfangs | |
NO20026219L (no) | Forbindelser for behandling av svekket fundisk relaksasjon | |
EE200200577A (et) | Kinolinüülpiperidiin-4-ülideenmetüülbensamiidi derivaadid valu raviks | |
NO20024776D0 (no) | Hydroksyfenyl-piperazinyl-metyl-benzamidderivater til behandling av smerte | |
NO20016151D0 (no) | Fremstilling av substituerte piperidin-4-oner | |
ID28032A (id) | TRISIKLIK PIPERIDIN-Δ3-SEBAGAI ANTAGONIS-α2 | |
NO20012099D0 (no) | Fremgangsmåte for fremstilling av 4-arylpiperidin-3- carbinoler og beslektede forbindelser | |
NO20030515D0 (no) | Fremgangsmåte for fremstilling av dinapsolin | |
NO20013795D0 (no) | Regulering av anestesi | |
EE200200670A (et) | S-metüüldihüdroziprasidoon psühhiaatriliste ja silmahaiguste raviks | |
FR2791876B1 (fr) | Parure de lit | |
NO20014845D0 (no) | Anvendelse av arylalkanoylpyridaziner | |
NO20016030D0 (no) | Derivater av 4'-demykarosyl-8a-aza-8a-homotylosin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |